JP2020507744A - デジタルアッセイのために横からの照射を使用した光学イメージングシステム - Google Patents

デジタルアッセイのために横からの照射を使用した光学イメージングシステム Download PDF

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JP2020507744A
JP2020507744A JP2019533657A JP2019533657A JP2020507744A JP 2020507744 A JP2020507744 A JP 2020507744A JP 2019533657 A JP2019533657 A JP 2019533657A JP 2019533657 A JP2019533657 A JP 2019533657A JP 2020507744 A JP2020507744 A JP 2020507744A
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light source
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specific binding
light
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JP2020507744A5 (enExample
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朋宏 池田
朋宏 池田
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アボットジャパン株式会社
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G01N2201/0621—Supply
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/063—Illuminating optical parts

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Optics & Photonics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
JP2019533657A 2016-12-21 2017-12-20 デジタルアッセイのために横からの照射を使用した光学イメージングシステム Pending JP2020507744A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022140509A JP7425138B2 (ja) 2016-12-21 2022-09-05 デジタルアッセイのために横からの照射を使用した光学イメージングシステム
JP2024005071A JP7713044B2 (ja) 2016-12-21 2024-01-17 デジタルアッセイのために横からの照射を使用した光学イメージングシステム

Applications Claiming Priority (3)

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US201662437534P 2016-12-21 2016-12-21
US62/437,534 2016-12-21
PCT/JP2017/045823 WO2018117191A1 (en) 2016-12-21 2017-12-20 Optical imaging system using lateral illumination for digital assays

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JP2022140509A Active JP7425138B2 (ja) 2016-12-21 2022-09-05 デジタルアッセイのために横からの照射を使用した光学イメージングシステム
JP2024005071A Active JP7713044B2 (ja) 2016-12-21 2024-01-17 デジタルアッセイのために横からの照射を使用した光学イメージングシステム

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JP2024005071A Active JP7713044B2 (ja) 2016-12-21 2024-01-17 デジタルアッセイのために横からの照射を使用した光学イメージングシステム

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US (3) US10324041B2 (enExample)
EP (1) EP3559640A4 (enExample)
JP (3) JP2020507744A (enExample)
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WO (1) WO2018117191A1 (enExample)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
WO2021222667A1 (en) * 2020-04-29 2021-11-04 Abbott Laboratories Systems and methods for sample analysis
US12049662B2 (en) * 2021-02-01 2024-07-30 Arizona Board Of Regents On Behalf Of Arizona State University Rapid antimicrobial susceptibility testing by video-based object scattering intensity detection
JP7734442B2 (ja) * 2021-03-26 2025-09-05 国立研究開発法人産業技術総合研究所 ウエルアレイを用いたウイルス検出方法、ウエルアレイ及び検出装置
JP7626121B2 (ja) 2022-10-27 2025-02-04 セイコーエプソン株式会社 投射方法、処理装置、プロジェクションシステム、及びプログラム
WO2025096384A1 (en) * 2023-10-31 2025-05-08 Board Of Regents For The Oklahoma Agricultural And Mechanical Colleges Colorimetric insulin immunosensor and methods of producing and using same
CN122295570A (zh) * 2023-11-21 2026-06-26 雅培制药有限公司 荧光底物及其使用方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009529681A (ja) * 2006-03-09 2009-08-20 テッサラエ、リミテッド、ライアビリティー、カンパニー マイクロアレイ撮像システムおよび関連した方法
JP2010523973A (ja) * 2007-03-30 2010-07-15 エス アール ユー バイオシステムズ,インコーポレイテッド バイオセンサのための較正および正規化の方法
JP2011242392A (ja) * 2010-05-17 2011-12-01 Luminex Corp 1以上の材料の測定を行うためのシステム及び方法

Family Cites Families (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5026159A (en) 1989-05-19 1991-06-25 Acrogen, Inc. Area-modulated luminescence (AML)
US5162990A (en) 1990-06-15 1992-11-10 The United States Of America As Represented By The United States Navy System and method for quantifying macrophage phagocytosis by computer image analysis
US5260578A (en) 1991-04-10 1993-11-09 Mayo Foundation For Medical Education And Research Confocal imaging system for visible and ultraviolet light
JP3324780B2 (ja) 1991-05-16 2002-09-17 オリンパス光学工業株式会社 紫外線顕微鏡
JP3326708B2 (ja) 1993-08-31 2002-09-24 日水製薬株式会社 光学的測定装置およびその方法
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5880473A (en) 1997-07-28 1999-03-09 Applied Imaging, Inc. Multifluor-fluorescence in-situ hybridization (M-FISH) imaging techniques using multiple multiband filters with image registration
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6169816B1 (en) 1997-05-14 2001-01-02 Applied Imaging, Inc. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
US6259807B1 (en) 1997-05-14 2001-07-10 Applied Imaging Corp. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US7079241B2 (en) * 2000-04-06 2006-07-18 Invitrogen Corp. Spatial positioning of spectrally labeled beads
WO2000039329A1 (en) 1998-12-28 2000-07-06 Sapporo Breweries Ltd. Method of counting microorganisms and device for accomplishing the counting
US6867851B2 (en) * 1999-11-04 2005-03-15 Regents Of The University Of Minnesota Scanning of biological samples
SK12942002A3 (sk) 2000-02-10 2003-05-02 Abbott Laboratories Protilátky viažuce ľudský interleukín-18, spôsoby ich výroby a použitia
WO2001084197A1 (en) * 2000-04-28 2001-11-08 Edgelight Biosciences, Inc. Micro-array evanescent wave fluorescence detection device
US7361472B2 (en) * 2001-02-23 2008-04-22 Invitrogen Corporation Methods for providing extended dynamic range in analyte assays
DE60228165D1 (de) * 2001-05-16 2008-09-25 Olympus Corp Endoskop mit Bildverarbeitungseinrichtung
US7280207B2 (en) * 2001-07-25 2007-10-09 Applera Corporation Time-delay integration in a flow cytometry system
ATE437216T1 (de) * 2001-09-06 2009-08-15 Genomic Profiling Systems Inc Schnellnachweis replizierender zellen
WO2003031972A1 (en) 2001-10-05 2003-04-17 Bml, Inc. Sensing board
US7272252B2 (en) 2002-06-12 2007-09-18 Clarient, Inc. Automated system for combining bright field and fluorescent microscopy
US7050613B2 (en) 2002-11-07 2006-05-23 Fujitsu Limited Method for supporting cell image analysis
US7597936B2 (en) 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
JP3727026B2 (ja) 2003-04-10 2005-12-14 博行 野地 一分子酵素活性検出に用いられるマイクロチャンバと1000fL以下の液滴を調製する方法
US7224468B2 (en) * 2003-10-20 2007-05-29 Agilent Technologies, Inc. En-face functional imaging using multiple wavelengths
JP2005147826A (ja) 2003-11-14 2005-06-09 Hamamatsu Photonics Kk 蛍光測定装置
JP4041458B2 (ja) * 2003-12-12 2008-01-30 日立ソフトウエアエンジニアリング株式会社 蛍光ビーズ検出方法及び蛍光ビーズ検出装置
WO2005096059A1 (ja) * 2004-03-31 2005-10-13 Olympus Corporation 観察装置および蛍光観察装置
JP4599941B2 (ja) 2004-08-20 2010-12-15 株式会社ニコン 自動焦点検出装置およびこれを備える顕微鏡システム
JP2006098129A (ja) * 2004-09-28 2006-04-13 Aisin Seiki Co Ltd マイクロチャネルチップシステム及び検出チップ
WO2006047038A1 (en) 2004-09-28 2006-05-04 Trustees Of Tufts College Apparatus and method for cell migration assays
US7602952B2 (en) 2004-11-16 2009-10-13 Illumina, Inc. Scanner having spatial light modulator
JP2006194730A (ja) 2005-01-13 2006-07-27 Moritex Corp エバネッセント波励起蛍光検出方法
JP4733433B2 (ja) * 2005-06-03 2011-07-27 株式会社日立ソリューションズ ビーズアレイ用蛍光読取装置及びビーズアレイ用蛍光読取方法
EP4071458B1 (en) 2005-09-21 2025-11-05 Luminex Corporation Methods and systems for image data processing
US7749722B2 (en) 2005-12-15 2010-07-06 Mitsubishi Kagaku Istron, Inc. Measuring method using whole blood
EP1963853B1 (en) * 2005-12-21 2016-03-09 Meso Scale Technologies, LLC Assay modules having assay reagents and methods of making and using same
US8492098B2 (en) 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
US7764361B2 (en) * 2006-07-27 2010-07-27 Northwestern University Systems and methods to analyze multiplexed bead-based assays using backscattered light
JP5074044B2 (ja) * 2007-01-18 2012-11-14 オリンパス株式会社 蛍光観察装置および蛍光観察装置の作動方法
US7659968B2 (en) * 2007-01-19 2010-02-09 Purdue Research Foundation System with extended range of molecular sensing through integrated multi-modal data acquisition
US7700928B2 (en) * 2007-01-25 2010-04-20 Etaluma, Inc. Apparatus and method for interleaving detection of fluorescence and luminescence
EP1978363B1 (en) 2007-04-03 2010-02-24 Sysmex Corporation Immunoassay method, reagent kit for detecting alkaline phosphatase, and reagent kit for immunoassay
US8013991B2 (en) * 2007-08-08 2011-09-06 Chemimage Corporation Raman difference spectra based disease classification
US20120078524A1 (en) * 2007-08-08 2012-03-29 Chemlmage Corporation System and method for diagnosis tissue samples using fluorescence and raman techniques
EP2201374B1 (en) 2007-08-30 2015-10-07 Trustees Of Tufts College Methods for determining the concentration of an analyte in solution.
WO2009053902A2 (en) * 2007-10-25 2009-04-30 Koninklijke Philips Electronics N. V. Sensor device for target particles in a sample
US20090137058A1 (en) * 2007-11-28 2009-05-28 General Electric Company Chemical and biological detection method and device based on measurements of fluorescence and reflectivity
US8791427B2 (en) 2007-12-26 2014-07-29 Olympus Corporation Biological-specimen observation apparatus
EP2331941B1 (en) * 2008-09-25 2014-11-12 Koninklijke Philips N.V. Detection system and method
DE102008054317A1 (de) 2008-11-03 2010-05-06 Carl Zeiss Microlmaging Gmbh Kombinationsmikroskopie
WO2010121381A1 (en) * 2009-04-21 2010-10-28 The University Of British Columbia System and methods for detection of particles
JP5338573B2 (ja) 2009-08-31 2013-11-13 ソニー株式会社 蛍光像取得方法、蛍光像取得装置及び蛍光像取得プログラム
JP5278252B2 (ja) 2009-08-31 2013-09-04 ソニー株式会社 組織切片像取得表示装置、組織切片像取得表示方法及び組織切片像取得表示プログラム
AU2010307140B2 (en) 2009-10-12 2014-05-15 Ventana Medical Systems, Inc. Multi-modality contrast and brightfield context rendering for enhanced pathology determination and multi-analyte detection in tissue
US8314377B2 (en) * 2009-12-23 2012-11-20 Mcneil-Ppc, Inc. Device and method for detecting plaque in the oral cavity
WO2011109379A1 (en) * 2010-03-01 2011-09-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) * 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US9224031B2 (en) 2010-05-21 2015-12-29 Chemometec A/S Compact dark field light source and dark field image analysis at low magnification
WO2012019104A1 (en) * 2010-08-05 2012-02-09 Abbott Point Of Care Inc. Immunoassay method and device with magnetically susceptible bead capture
US11402375B2 (en) * 2010-08-05 2022-08-02 Abbott Point Of Care Inc. Magnetic immunosensor with trench configuration and method of use
DE102010044503B4 (de) * 2010-09-06 2017-11-02 Leica Microsystems (Schweiz) Ag Fluoreszenz-Operations-Stereomikroskop
CA3139049C (en) * 2010-10-14 2024-10-15 Meso Scale Technologies, Llc REAGENT STORAGE IN A TEST DEVICE
US20120225475A1 (en) * 2010-11-16 2012-09-06 1087 Systems, Inc. Cytometry system with quantum cascade laser source, acoustic detector, and micro-fluidic cell handling system configured for inspection of individual cells
JP5644447B2 (ja) 2010-12-06 2014-12-24 ソニー株式会社 顕微鏡、領域判定方法、及びプログラム
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
RU2548619C1 (ru) 2011-03-08 2015-04-20 Японское Агентство По Науке И Технике Способ герметизации гранул, способ обнаружения молекулы-мишени, матрица, набор и устройство для обнаружения молекулы-мишени
US8681215B2 (en) * 2011-04-29 2014-03-25 ProteinSimple Method and particle analyzer for determining a broad particle size distribution
US9168523B2 (en) * 2011-05-18 2015-10-27 3M Innovative Properties Company Systems and methods for detecting the presence of a selected volume of material in a sample processing device
CN102243165B (zh) * 2011-06-20 2013-07-17 东南大学 光子晶体编码微球生物芯片检测装置
EP4450644A3 (en) * 2012-08-08 2025-01-08 F. Hoffmann-La Roche AG Increasing dynamic range for identifying multiple epitopes in cells
US20150185152A1 (en) * 2012-08-09 2015-07-02 Life Technologies Corporation Illumination Systems
CA2887206A1 (en) * 2012-10-05 2014-04-10 Rustem F. Ismagilov Methods and systems for microfluidics imaging and analysis
US9488576B2 (en) 2013-01-22 2016-11-08 Tecan Trading Ag Optical measuring apparatus and method for the analysis of samples contained in liquid drops
US8912007B2 (en) 2013-01-22 2014-12-16 Tecan Trading Ag Optical measuring apparatus and method for the analysis of samples contained in liquid drops
US9488579B2 (en) 2013-01-22 2016-11-08 Tecan Trading Ag Optical measuring apparatus and method for the analysis of samples contained in liquid drops
US11366061B2 (en) * 2013-01-24 2022-06-21 Grace Bio-Labs, Inc. Protein microarray assay imager
KR101568573B1 (ko) * 2013-03-13 2015-11-20 고려대학교 산학협력단 혈중 희소 세포의 검출 및 계수 장치와 방법
WO2014176435A2 (en) * 2013-04-25 2014-10-30 Bergo Vladislav B Microarray compositions and methods of their use
KR101514204B1 (ko) * 2013-07-12 2015-04-23 한국전기연구원 감시림프절의 근적외선 형광 검출 장치 및 방법
CN105940096B (zh) 2014-01-31 2019-11-05 凸版印刷株式会社 生物分子分析试剂盒及生物分子分析方法
WO2015115151A1 (ja) * 2014-01-31 2015-08-06 オリンパス株式会社 蛍光観察装置
FR3019900B1 (fr) 2014-04-09 2017-12-22 Bio-Rad Innovations Utilisation de particules absorbantes pour ameliorer la detection du signal dans un procede d'analyse
ES2831360T3 (es) 2014-07-08 2021-06-08 Japan Science & Tech Agency Método de sellado de sustancia y método de detección de molécula diana
US9574989B2 (en) * 2014-08-08 2017-02-21 Omnivision Technologies, Inc. Lens-free imaging system and method for detecting particles in sample deposited on image sensor
WO2016083898A1 (en) * 2014-11-28 2016-06-02 Chipcare Corporation Multiplex bead array assay
US10078778B2 (en) * 2015-01-15 2018-09-18 Massachusetts Institute Of Technology Systems, methods, and apparatus for in vitro single-cell identification and recovery
JP6800864B2 (ja) * 2015-02-06 2020-12-16 ライフ テクノロジーズ コーポレーション 生物学的分析のためのシステムおよび方法
EP3719481B1 (en) * 2015-02-06 2023-03-29 Life Technologies Corporation An optical instrument for biological analysis
WO2016134191A1 (en) * 2015-02-18 2016-08-25 Singular Bio, Inc. Assays for single molecule detection and use thereof
CN114277081A (zh) * 2015-02-22 2022-04-05 里兰斯坦福初级大学理事会 微筛选装置、方法和产品
US9557270B2 (en) * 2015-03-04 2017-01-31 Ecolab Usa Inc. Multi-channel fluorometric sensor and method of using same
CN107406888A (zh) * 2015-03-30 2017-11-28 赛卢拉研究公司 用于组合条形编码的方法和组合物
DK3245517T3 (en) * 2015-10-07 2019-01-14 Selma Diagnostics Aps Flow system and method for digital counting
US20170343476A1 (en) * 2016-05-31 2017-11-30 Molecular Devices, Llc Imaging system with oblique illumination
CN106226247A (zh) * 2016-07-15 2016-12-14 暨南大学 一种基于高光谱显微成像技术的细胞检测方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009529681A (ja) * 2006-03-09 2009-08-20 テッサラエ、リミテッド、ライアビリティー、カンパニー マイクロアレイ撮像システムおよび関連した方法
JP2010523973A (ja) * 2007-03-30 2010-07-15 エス アール ユー バイオシステムズ,インコーポレイテッド バイオセンサのための較正および正規化の方法
JP2011242392A (ja) * 2010-05-17 2011-12-01 Luminex Corp 1以上の材料の測定を行うためのシステム及び方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MEROUANE A ET AL.: ""Automated profiling of individual cell - cell interactions from high-throughput time-lapse imaging", BIOINFORMATICS, vol. 31, no. 19, JPN7021005275, 9 June 2015 (2015-06-09), pages 3189 - 3197, ISSN: 0004656971 *

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