JP2020507582A5 - - Google Patents
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- Publication number
- JP2020507582A5 JP2020507582A5 JP2019543377A JP2019543377A JP2020507582A5 JP 2020507582 A5 JP2020507582 A5 JP 2020507582A5 JP 2019543377 A JP2019543377 A JP 2019543377A JP 2019543377 A JP2019543377 A JP 2019543377A JP 2020507582 A5 JP2020507582 A5 JP 2020507582A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- haloalkyl
- aryl
- cycloalkyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 42
- 150000001875 compounds Chemical class 0.000 claims 19
- 125000003118 aryl group Chemical group 0.000 claims 18
- 125000003545 alkoxy group Chemical group 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 11
- 125000005843 halogen group Chemical group 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 claims 5
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 4
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 4
- -1 C 1-4 diuteroalkyl Chemical group 0.000 claims 4
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 claims 4
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 3
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000006712 (C1-C4) deuteroalkyl group Chemical group 0.000 claims 1
- 102000005403 Casein Kinases Human genes 0.000 claims 1
- 108010031425 Casein Kinases Proteins 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 101001109145 Homo sapiens Receptor-interacting serine/threonine-protein kinase 1 Proteins 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 102100022501 Receptor-interacting serine/threonine-protein kinase 1 Human genes 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000005201 cycloalkylcarbonyloxy group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762458144P | 2017-02-13 | 2017-02-13 | |
| US62/458,144 | 2017-02-13 | ||
| PCT/US2018/017755 WO2018148626A1 (en) | 2017-02-13 | 2018-02-12 | Aminotriazolopyridines as kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020507582A JP2020507582A (ja) | 2020-03-12 |
| JP2020507582A5 true JP2020507582A5 (OSRAM) | 2021-03-18 |
| JP7097373B2 JP7097373B2 (ja) | 2022-07-07 |
Family
ID=61283335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019543377A Active JP7097373B2 (ja) | 2017-02-13 | 2018-02-12 | キナーゼ阻害剤としてのアミノトリアゾロピリジン |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US10913738B2 (OSRAM) |
| EP (1) | EP3580220B1 (OSRAM) |
| JP (1) | JP7097373B2 (OSRAM) |
| KR (1) | KR102549952B1 (OSRAM) |
| CN (1) | CN110520423B (OSRAM) |
| AU (1) | AU2018217488B2 (OSRAM) |
| BR (1) | BR112019016635A2 (OSRAM) |
| CA (1) | CA3053484A1 (OSRAM) |
| CY (1) | CY1124978T1 (OSRAM) |
| DK (1) | DK3580220T3 (OSRAM) |
| EA (1) | EA039808B1 (OSRAM) |
| ES (1) | ES2902676T3 (OSRAM) |
| HR (1) | HRP20212000T1 (OSRAM) |
| HU (1) | HUE057801T2 (OSRAM) |
| IL (1) | IL268614B (OSRAM) |
| LT (1) | LT3580220T (OSRAM) |
| MA (1) | MA47460A (OSRAM) |
| MX (1) | MX378515B (OSRAM) |
| PL (1) | PL3580220T3 (OSRAM) |
| PT (1) | PT3580220T (OSRAM) |
| RS (1) | RS62801B1 (OSRAM) |
| SG (1) | SG11201907335UA (OSRAM) |
| SI (1) | SI3580220T1 (OSRAM) |
| SM (1) | SMT202200001T1 (OSRAM) |
| WO (1) | WO2018148626A1 (OSRAM) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA47460A (fr) * | 2017-02-13 | 2019-12-18 | Bristol Myers Squibb Co | Aminotriazolopyridines utilisées en tant qu'inhibiteurs de kinase |
| LT3704118T (lt) * | 2017-10-30 | 2022-02-25 | Bristol-Myers Squibb Company | Aminoimidazopiridazinai, kaip kinazės inhibitoriai |
| MX2020007531A (es) | 2018-01-26 | 2020-09-09 | Bristol Myers Squibb Co | Aminopirrolotriazinas como inhibidores de cinasa. |
| AU2019302534B2 (en) * | 2018-07-09 | 2024-10-03 | Lieber Institute, Inc. | Pyridazine compounds for inhibiting NaV1.8 |
| JP2021530478A (ja) | 2018-07-09 | 2021-11-11 | リーバー インスティチュート インコーポレイテッドLieber Institute, Inc. | ＮａＶ１．８を阻害するためのピリジンカルボキシアミド化合物 |
| US12084426B2 (en) | 2018-09-13 | 2024-09-10 | Bristol-Myers Squibb Company | Indazole carboxamides as kinase inhibitors |
| EA202190718A1 (ru) | 2018-09-13 | 2021-07-01 | Бристол-Маерс Сквибб Компани | Индазолкарбоксамиды в качестве ингибиторов киназ |
| KR102769633B1 (ko) * | 2019-01-25 | 2025-02-19 | 베이징 사이텍-엠큐 파마슈티컬즈 리미티드 | 아실아미노 가교된 헤테로사이클릭 화합물, 및 이의 조성물 및 응용 |
| JP7323637B2 (ja) * | 2019-03-22 | 2023-08-08 | ▲勁▼方医▲薬▼科技（上海）有限公司 | 置換複素環式アミド化合物、その調製方法、及びその医薬的使用 |
| WO2021067654A1 (en) | 2019-10-03 | 2021-04-08 | Bristol-Myers Squibb Company | Indazole carboxamides as kinase inhibitors |
| BR112022016124A2 (pt) * | 2020-02-13 | 2022-10-25 | Genfleet Therapeutics Shanghai Inc | Composto de di-hidronaftiridinona, e método de preparação para este e uso médico deste |
| CN114230565B (zh) * | 2020-09-09 | 2023-10-27 | 成都奥睿药业有限公司 | 5-取代吲哚3-酰胺衍生物及其制备方法和用途 |
| CN114262322A (zh) * | 2020-09-16 | 2022-04-01 | 中国科学院上海有机化学研究所 | 一类细胞程序性坏死抑制剂及其制备方法和用途 |
| AR123793A1 (es) | 2020-10-19 | 2023-01-11 | Bristol Myers Squibb Co | Compuestos de triazolopiridinilo como inhibidores de quinasas |
| TWI824626B (zh) * | 2021-08-02 | 2023-12-01 | 大陸商勁方醫藥科技(上海)有限公司 | Ripk1抑制劑的晶型及其酸式鹽和其酸式鹽的晶型 |
| AU2022328136A1 (en) | 2021-08-10 | 2023-11-30 | Abbvie Inc. | Nicotinamide ripk1 inhibitors |
| WO2023174374A1 (zh) | 2022-03-16 | 2023-09-21 | 江苏恒瑞医药股份有限公司 | 稠杂环类化合物、其制备方法及其在医药上的应用 |
| CN116574053A (zh) * | 2022-06-21 | 2023-08-11 | 中国药科大学 | Ripk1激酶靶点抑制剂及其医药用途 |
| AR131541A1 (es) | 2023-01-07 | 2025-04-09 | Syngenta Crop Protection Ag | Compuestos de carboxamida novedosos |
| TW202521107A (zh) * | 2023-09-27 | 2025-06-01 | 美商必治妥美雅史谷比公司 | 作為激酶抑制劑之三唑并吡啶化合物 |
| WO2025109114A1 (en) | 2023-11-24 | 2025-05-30 | Syngenta Crop Protection Ag | Novel carboxamide compounds |
| WO2025149637A1 (en) | 2024-01-12 | 2025-07-17 | Syngenta Crop Protection Ag | Novel carboxamide compounds |
| WO2025149629A1 (en) | 2024-01-12 | 2025-07-17 | Syngenta Crop Protection Ag | Novel carboxamide compounds |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06014637A (es) | 2004-06-25 | 2007-02-12 | Amgen Inc | Triazoles e indazoles condensados utiles en el tratamiento de enfermedades mediadas por citocinas y otras enfermedades. |
| EP2001480A4 (en) * | 2006-03-31 | 2011-06-15 | Abbott Lab | Indazole CONNECTIONS |
| ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
| EA201000797A1 (ru) | 2007-11-27 | 2011-02-28 | Целльзом Лимитид | Аминотриазолы в качестве ингибиторов pi3k |
| WO2010007100A1 (en) * | 2008-07-15 | 2010-01-21 | Cellzome Ltd | 7-substituted amino triazoles as pi3k inhibitors |
| WO2010057877A1 (en) | 2008-11-18 | 2010-05-27 | Cellzome Limited | 7-pyridinyl- or phenyl- substituted triazolo [1, 5 -a] pyridines as pi3k inhibitors |
| CA2750517A1 (en) | 2009-02-04 | 2010-08-12 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2897949B1 (en) | 2012-09-18 | 2018-01-10 | Bristol-Myers Squibb Company | Iap antagonists |
| CN105246891A (zh) | 2013-06-10 | 2016-01-13 | 拜耳制药股份公司 | 用于治疗癌症的新化合物 |
| EP3182974A1 (en) * | 2014-08-21 | 2017-06-28 | GlaxoSmithKline Intellectual Property Development Limited | Heterocyclic amides as rip1 kinase inhibitors as medicaments |
| BR112018008765B1 (pt) * | 2015-11-05 | 2022-05-24 | Sumitomo Chemical Company, Limited | Composto heterocíclico condensado, composição e método para o controle de um artrópode nocivo |
| WO2018017435A1 (en) | 2016-07-22 | 2018-01-25 | Accro Bioscience Inc. | Heteroaryl compounds as inhibitors of necrosis, composition and application thereof |
| JP7190906B2 (ja) | 2017-01-24 | 2022-12-16 | 住友化学株式会社 | 縮合複素環化合物及びそれを含有する組成物 |
| MA47460A (fr) * | 2017-02-13 | 2019-12-18 | Bristol Myers Squibb Co | Aminotriazolopyridines utilisées en tant qu'inhibiteurs de kinase |
| LT3704118T (lt) | 2017-10-30 | 2022-02-25 | Bristol-Myers Squibb Company | Aminoimidazopiridazinai, kaip kinazės inhibitoriai |
| MX2020007531A (es) | 2018-01-26 | 2020-09-09 | Bristol Myers Squibb Co | Aminopirrolotriazinas como inhibidores de cinasa. |
| AR123793A1 (es) * | 2020-10-19 | 2023-01-11 | Bristol Myers Squibb Co | Compuestos de triazolopiridinilo como inhibidores de quinasas |
-
2018
- 2018-02-12 MA MA047460A patent/MA47460A/fr unknown
- 2018-02-12 PL PL18707498T patent/PL3580220T3/pl unknown
- 2018-02-12 LT LTEPPCT/US2018/017755T patent/LT3580220T/lt unknown
- 2018-02-12 DK DK18707498.4T patent/DK3580220T3/da active
- 2018-02-12 PT PT187074984T patent/PT3580220T/pt unknown
- 2018-02-12 BR BR112019016635A patent/BR112019016635A2/pt not_active Application Discontinuation
- 2018-02-12 CA CA3053484A patent/CA3053484A1/en active Pending
- 2018-02-12 SG SG11201907335UA patent/SG11201907335UA/en unknown
- 2018-02-12 JP JP2019543377A patent/JP7097373B2/ja active Active
- 2018-02-12 ES ES18707498T patent/ES2902676T3/es active Active
- 2018-02-12 SI SI201830511T patent/SI3580220T1/sl unknown
- 2018-02-12 HU HUE18707498A patent/HUE057801T2/hu unknown
- 2018-02-12 WO PCT/US2018/017755 patent/WO2018148626A1/en not_active Ceased
- 2018-02-12 SM SM20220001T patent/SMT202200001T1/it unknown
- 2018-02-12 US US16/484,604 patent/US10913738B2/en active Active
- 2018-02-12 CN CN201880024064.1A patent/CN110520423B/zh active Active
- 2018-02-12 MX MX2019009555A patent/MX378515B/es unknown
- 2018-02-12 AU AU2018217488A patent/AU2018217488B2/en not_active Ceased
- 2018-02-12 EP EP18707498.4A patent/EP3580220B1/en active Active
- 2018-02-12 RS RS20220021A patent/RS62801B1/sr unknown
- 2018-02-12 HR HRP20212000TT patent/HRP20212000T1/hr unknown
- 2018-02-12 EA EA201991915A patent/EA039808B1/ru unknown
- 2018-02-12 KR KR1020197026464A patent/KR102549952B1/ko active Active
-
2019
- 2019-08-09 IL IL268614A patent/IL268614B/en unknown
-
2020
- 2020-12-09 US US17/116,016 patent/US12157733B2/en active Active
-
2022
- 2022-01-18 CY CY20221100043T patent/CY1124978T1/el unknown
-
2024
- 2024-10-28 US US18/928,275 patent/US20250074909A1/en active Pending
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