JP7097373B2 - キナーゼ阻害剤としてのアミノトリアゾロピリジン - Google Patents

キナーゼ阻害剤としてのアミノトリアゾロピリジン Download PDF

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Publication number
JP7097373B2
JP7097373B2 JP2019543377A JP2019543377A JP7097373B2 JP 7097373 B2 JP7097373 B2 JP 7097373B2 JP 2019543377 A JP2019543377 A JP 2019543377A JP 2019543377 A JP2019543377 A JP 2019543377A JP 7097373 B2 JP7097373 B2 JP 7097373B2
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Prior art keywords
triazolo
amino
pyridine
pyridin
methyl
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JP2019543377A
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Japanese (ja)
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JP2020507582A5 (OSRAM
JP2020507582A (ja
Inventor
ジュンチン・グオ
エイミー・シー・ハート
ジョン・イー・マコー
マイケル・イー・マーツマン
ウィリアム・ジェイ・ピッツ
スティーブン・エイチ・スパーゲル
スコット・ハンター・ワターソン
ムルガイア・アンダッパン・ムルガイア・スッバイア
チェン・ジエ
キャロリン・ダイアン・ジアーバ
グアンリン・ルオ
ジャンリアン・シ
シン－ユエン・シット
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2019543377A 2017-02-13 2018-02-12 キナーゼ阻害剤としてのアミノトリアゾロピリジン Active JP7097373B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762458144P 2017-02-13 2017-02-13
US62/458,144 2017-02-13
PCT/US2018/017755 WO2018148626A1 (en) 2017-02-13 2018-02-12 Aminotriazolopyridines as kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2020507582A JP2020507582A (ja) 2020-03-12
JP2020507582A5 JP2020507582A5 (OSRAM) 2021-03-18
JP7097373B2 true JP7097373B2 (ja) 2022-07-07

Family

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JP2019543377A Active JP7097373B2 (ja) 2017-02-13 2018-02-12 キナーゼ阻害剤としてのアミノトリアゾロピリジン

Country Status (25)

Country Link
US (3) US10913738B2 (OSRAM)
EP (1) EP3580220B1 (OSRAM)
JP (1) JP7097373B2 (OSRAM)
KR (1) KR102549952B1 (OSRAM)
CN (1) CN110520423B (OSRAM)
AU (1) AU2018217488B2 (OSRAM)
BR (1) BR112019016635A2 (OSRAM)
CA (1) CA3053484A1 (OSRAM)
CY (1) CY1124978T1 (OSRAM)
DK (1) DK3580220T3 (OSRAM)
EA (1) EA039808B1 (OSRAM)
ES (1) ES2902676T3 (OSRAM)
HR (1) HRP20212000T1 (OSRAM)
HU (1) HUE057801T2 (OSRAM)
IL (1) IL268614B (OSRAM)
LT (1) LT3580220T (OSRAM)
MA (1) MA47460A (OSRAM)
MX (1) MX378515B (OSRAM)
PL (1) PL3580220T3 (OSRAM)
PT (1) PT3580220T (OSRAM)
RS (1) RS62801B1 (OSRAM)
SG (1) SG11201907335UA (OSRAM)
SI (1) SI3580220T1 (OSRAM)
SM (1) SMT202200001T1 (OSRAM)
WO (1) WO2018148626A1 (OSRAM)

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EP3580220B1 (en) * 2017-02-13 2021-11-17 Bristol-Myers Squibb Company Aminotriazolopyridines as kinase inhibitors
WO2019089442A1 (en) * 2017-10-30 2019-05-09 Bristol-Myers Squibb Company Aminoimidazopyridines as kinase inhibitors
MX2020007531A (es) 2018-01-26 2020-09-09 Bristol Myers Squibb Co Aminopirrolotriazinas como inhibidores de cinasa.
SG11202100130QA (en) 2018-07-09 2021-02-25 Lieber Institute Inc Pyridine carboxamide compounds for inhibiting nav1.8
KR102840599B1 (ko) * 2018-07-09 2025-07-29 리버 인스티튜트, 아이엔씨 Nav1.8을 억제하기 위한 피리다진(PYRIDAZINE) 화합물
WO2020056072A1 (en) 2018-09-13 2020-03-19 Bristol-Myers Squibb Company 1h-indazole carboxamides as receptor-interacting protein kinase 1 inhibitors (ripk1)
US12084426B2 (en) * 2018-09-13 2024-09-10 Bristol-Myers Squibb Company Indazole carboxamides as kinase inhibitors
SG11202108064XA (en) * 2019-01-25 2021-08-30 Beijing Scitech Mq Pharmaceuticals Ltd Acylamino bridged heterocyclic compound, and composition and application thereof
EP3943488A4 (en) * 2019-03-22 2022-09-07 Genfleet Therapeutics (Shanghai) Inc. SUBSTITUTED HETEROCYCLIC AMIDE COMPOUND AND METHOD FOR PREPARATION AND PHARMACEUTICAL USE
MX2022003769A (es) 2019-10-03 2022-04-20 Bristol Myers Squibb Co Indazol carboxamidas como inhibidores de cinasas.
AU2021219832B9 (en) * 2020-02-13 2024-02-15 Genfleet Therapeutics (Shanghai) Inc. Dihydronaphthyridinone compound, and preparation method therefor and medical use thereof
CN114230565B (zh) * 2020-09-09 2023-10-27 成都奥睿药业有限公司 5-取代吲哚3-酰胺衍生物及其制备方法和用途
CN114262322A (zh) * 2020-09-16 2022-04-01 中国科学院上海有机化学研究所 一类细胞程序性坏死抑制剂及其制备方法和用途
AR123793A1 (es) * 2020-10-19 2023-01-11 Bristol Myers Squibb Co Compuestos de triazolopiridinilo como inhibidores de quinasas
TWI824626B (zh) * 2021-08-02 2023-12-01 大陸商勁方醫藥科技(上海)有限公司 Ripk1抑制劑的晶型及其酸式鹽和其酸式鹽的晶型
WO2023018643A1 (en) 2021-08-10 2023-02-16 Abbvie Inc. Nicotinamide ripk1 inhibitors
TW202345852A (zh) 2022-03-16 2023-12-01 大陸商江蘇恆瑞醫藥股份有限公司 稠雜環類化合物、其製備方法及其在醫藥上的應用
CN114989079B (zh) * 2022-06-21 2023-06-23 中国药科大学 Ripk1激酶靶点抑制剂及其医药用途
AR131541A1 (es) 2023-01-07 2025-04-09 Syngenta Crop Protection Ag Compuestos de carboxamida novedosos
AR133939A1 (es) * 2023-09-27 2025-11-19 Bristol Myers Squibb Co Compuestos de triazolopiridinilo como inhibidores de cinasa
WO2025109114A1 (en) 2023-11-24 2025-05-30 Syngenta Crop Protection Ag Novel carboxamide compounds
WO2025149637A1 (en) 2024-01-12 2025-07-17 Syngenta Crop Protection Ag Novel carboxamide compounds
WO2025149629A1 (en) 2024-01-12 2025-07-17 Syngenta Crop Protection Ag Novel carboxamide compounds

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JP2009532370A (ja) 2006-03-31 2009-09-10 アボット・ラボラトリーズ インダゾール化合物
WO2010007100A1 (en) 2008-07-15 2010-01-21 Cellzome Ltd 7-substituted amino triazoles as pi3k inhibitors
WO2016027253A1 (en) 2014-08-21 2016-02-25 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as rip1 kinase inhibitors as medicaments

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WO2010007100A1 (en) 2008-07-15 2010-01-21 Cellzome Ltd 7-substituted amino triazoles as pi3k inhibitors
WO2016027253A1 (en) 2014-08-21 2016-02-25 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as rip1 kinase inhibitors as medicaments

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Also Published As

Publication number Publication date
SI3580220T1 (sl) 2022-01-31
RS62801B1 (sr) 2022-02-28
WO2018148626A1 (en) 2018-08-16
IL268614B (en) 2021-12-01
EP3580220A1 (en) 2019-12-18
LT3580220T (lt) 2021-12-27
IL268614A (en) 2019-10-31
SG11201907335UA (en) 2019-09-27
CN110520423A (zh) 2019-11-29
CY1124978T1 (el) 2023-01-05
EA039808B1 (ru) 2022-03-16
HRP20212000T1 (hr) 2022-04-01
AU2018217488B2 (en) 2021-09-23
CA3053484A1 (en) 2018-08-16
MA47460A (fr) 2019-12-18
PL3580220T3 (pl) 2022-02-07
EP3580220B1 (en) 2021-11-17
KR102549952B1 (ko) 2023-06-29
AU2018217488A1 (en) 2019-10-03
CN110520423B (zh) 2022-08-23
US20250074909A1 (en) 2025-03-06
KR20190117006A (ko) 2019-10-15
EA201991915A1 (ru) 2019-12-30
ES2902676T3 (es) 2022-03-29
PT3580220T (pt) 2022-01-03
US10913738B2 (en) 2021-02-09
US12157733B2 (en) 2024-12-03
MX378515B (es) 2025-03-11
DK3580220T3 (da) 2022-01-10
US20220315580A1 (en) 2022-10-06
HUE057801T2 (hu) 2022-06-28
SMT202200001T1 (it) 2022-03-21
BR112019016635A2 (pt) 2020-04-07
US20190389859A1 (en) 2019-12-26
MX2019009555A (es) 2019-10-02
JP2020507582A (ja) 2020-03-12

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