JP2020506670A5 - - Google Patents

Info

Publication number

JP2020506670A5

JP2020506670A5 JP2019534112A JP2019534112A JP2020506670A5 JP 2020506670 A5 JP2020506670 A5 JP 2020506670A5 JP 2019534112 A JP2019534112 A JP 2019534112A JP 2019534112 A JP2019534112 A JP 2019534112A JP 2020506670 A5 JP2020506670 A5 JP 2020506670A5

Authority

JP

Japan

Prior art keywords

amino acid

seq

acid sequence

antigen

antibody

Prior art date

2017-12-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 125000003275 alpha amino acid group Chemical group 0.000 claims 120
• 239000012634 fragment Substances 0.000 claims 29
• 239000000427 antigen Substances 0.000 claims 27
• 102000036639 antigens Human genes 0.000 claims 27
• 108091007433 antigens Proteins 0.000 claims 27
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 16
• 101001098868 Homo sapiens Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 claims 6
• 235000012000 cholesterol Nutrition 0.000 claims 6
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 238000008214 LDL Cholesterol Methods 0.000 claims 5
• 108010028554 LDL Cholesterol Proteins 0.000 claims 5
• 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 claims 5
• 210000004027 cell Anatomy 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 5
• 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 229940079593 drug Drugs 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 108020004707 nucleic acids Proteins 0.000 claims 4
• 150000007523 nucleic acids Chemical class 0.000 claims 4
• 101001051093 Homo sapiens Low-density lipoprotein receptor Proteins 0.000 claims 3
• 102100024640 Low-density lipoprotein receptor Human genes 0.000 claims 3
• FJLGEFLZQAZZCD-MCBHFWOFSA-N (3R,5S)-fluvastatin Chemical compound C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-MCBHFWOFSA-N 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 2
• XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims 2
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
• 208000035150 Hypercholesterolemia Diseases 0.000 claims 2
• 208000031226 Hyperlipidaemia Diseases 0.000 claims 2
• PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims 2
• TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims 2
• RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims 2
• AJLFOPYRIVGYMJ-UHFFFAOYSA-N SJ000287055 Natural products C12C(OC(=O)C(C)CC)CCC=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 AJLFOPYRIVGYMJ-UHFFFAOYSA-N 0.000 claims 2
• 229960005370 atorvastatin Drugs 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 229960003765 fluvastatin Drugs 0.000 claims 2
• 229960004844 lovastatin Drugs 0.000 claims 2
• PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims 2
• QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims 2
• 229950009116 mevastatin Drugs 0.000 claims 2
• AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 claims 2
• BOZILQFLQYBIIY-UHFFFAOYSA-N mevastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CCC=C21 BOZILQFLQYBIIY-UHFFFAOYSA-N 0.000 claims 2
• 229960002797 pitavastatin Drugs 0.000 claims 2
• VGYFMXBACGZSIL-MCBHFWOFSA-N pitavastatin Chemical compound OC(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 VGYFMXBACGZSIL-MCBHFWOFSA-N 0.000 claims 2
• 229960002965 pravastatin Drugs 0.000 claims 2
• TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims 2
• 229960000672 rosuvastatin Drugs 0.000 claims 2
• BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 claims 2
• 210000002966 serum Anatomy 0.000 claims 2
• 229960002855 simvastatin Drugs 0.000 claims 2
• RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims 2
• 239000013598 vector Substances 0.000 claims 2
• 241000894006 Bacteria Species 0.000 claims 1
• 241000206602 Eukaryota Species 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 102000053786 human PCSK9 Human genes 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 210000004962 mammalian cell Anatomy 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 210000005253 yeast cell Anatomy 0.000 claims 1