JP2020504715A5 - - Google Patents
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- JP2020504715A5 JP2020504715A5 JP2019530439A JP2019530439A JP2020504715A5 JP 2020504715 A5 JP2020504715 A5 JP 2020504715A5 JP 2019530439 A JP2019530439 A JP 2019530439A JP 2019530439 A JP2019530439 A JP 2019530439A JP 2020504715 A5 JP2020504715 A5 JP 2020504715A5
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- JP
- Japan
- Prior art keywords
- alkyl
- membered
- halo
- cycloalkyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 193
- 125000005843 halogen group Chemical group 0.000 claims description 116
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 76
- 125000000217 alkyl group Chemical group 0.000 claims description 68
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 50
- 229910052799 carbon Inorganic materials 0.000 claims description 46
- 125000003545 alkoxy group Chemical group 0.000 claims description 44
- 125000003118 aryl group Chemical group 0.000 claims description 39
- -1 cyano, hydroxyl Chemical group 0.000 claims description 38
- 125000005842 heteroatom Chemical group 0.000 claims description 38
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 36
- 125000001072 heteroaryl group Chemical group 0.000 claims description 32
- 229910052739 hydrogen Inorganic materials 0.000 claims description 32
- 229910052760 oxygen Inorganic materials 0.000 claims description 29
- 150000003839 salts Chemical class 0.000 claims description 29
- 229910052717 sulfur Inorganic materials 0.000 claims description 27
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 24
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 24
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 20
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 20
- 229910052757 nitrogen Inorganic materials 0.000 claims description 20
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims description 19
- 206010028980 Neoplasm Diseases 0.000 claims description 19
- 201000011510 cancer Diseases 0.000 claims description 19
- 125000004043 oxo group Chemical group O=* 0.000 claims description 18
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 16
- 208000019838 Blood disease Diseases 0.000 claims description 16
- 125000000304 alkynyl group Chemical group 0.000 claims description 16
- 208000014951 hematologic disease Diseases 0.000 claims description 16
- 208000018706 hematopoietic system disease Diseases 0.000 claims description 16
- 230000005764 inhibitory process Effects 0.000 claims description 15
- 102100035042 Histone-lysine N-methyltransferase EHMT2 Human genes 0.000 claims description 13
- 101000877312 Homo sapiens Histone-lysine N-methyltransferase EHMT2 Proteins 0.000 claims description 13
- 201000005787 hematologic cancer Diseases 0.000 claims description 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 12
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 10
- 206010011703 Cyanosis Diseases 0.000 claims description 10
- 102100035043 Histone-lysine N-methyltransferase EHMT1 Human genes 0.000 claims description 10
- 101000877314 Homo sapiens Histone-lysine N-methyltransferase EHMT1 Proteins 0.000 claims description 10
- 206010025323 Lymphomas Diseases 0.000 claims description 10
- 108060004795 Methyltransferase Proteins 0.000 claims description 10
- 102000016397 Methyltransferase Human genes 0.000 claims description 10
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 10
- 208000032839 leukemia Diseases 0.000 claims description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 7
- 108091000080 Phosphotransferase Proteins 0.000 claims description 6
- 102000020233 phosphotransferase Human genes 0.000 claims description 6
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 5
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims description 5
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 5
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims description 5
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 5
- 206010006187 Breast cancer Diseases 0.000 claims description 5
- 208000026310 Breast neoplasm Diseases 0.000 claims description 5
- 208000011691 Burkitt lymphomas Diseases 0.000 claims description 5
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims description 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 5
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 5
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 5
- 206010033128 Ovarian cancer Diseases 0.000 claims description 5
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 5
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 5
- 206010060862 Prostate cancer Diseases 0.000 claims description 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 5
- 208000018020 Sickle cell-beta-thalassemia disease syndrome Diseases 0.000 claims description 5
- 206010043391 Thalassaemia beta Diseases 0.000 claims description 5
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims description 5
- 201000003444 follicular lymphoma Diseases 0.000 claims description 5
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 5
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 5
- 201000005202 lung cancer Diseases 0.000 claims description 5
- 208000020816 lung neoplasm Diseases 0.000 claims description 5
- 201000001441 melanoma Diseases 0.000 claims description 5
- 208000007056 sickle cell anemia Diseases 0.000 claims description 5
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims description 4
- 125000002947 alkylene group Chemical group 0.000 claims description 4
- 125000002619 bicyclic group Chemical group 0.000 claims description 4
- 125000006580 bicyclic heterocycloalkyl group Chemical group 0.000 claims description 4
- 150000001721 carbon Chemical group 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 125000006574 non-aromatic ring group Chemical group 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 4
- 230000002489 hematologic effect Effects 0.000 claims description 3
- 230000001404 mediated effect Effects 0.000 claims description 3
- KRQUFUKTQHISJB-YYADALCUSA-N 2-[(E)-N-[2-(4-chlorophenoxy)propoxy]-C-propylcarbonimidoyl]-3-hydroxy-5-(thian-3-yl)cyclohex-2-en-1-one Chemical compound CCC\C(=N/OCC(C)OC1=CC=C(Cl)C=C1)C1=C(O)CC(CC1=O)C1CCCSC1 KRQUFUKTQHISJB-YYADALCUSA-N 0.000 claims description 2
- 108010055196 EphA2 Receptor Proteins 0.000 claims description 2
- 102100030340 Ephrin type-A receptor 2 Human genes 0.000 claims description 2
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims description 2
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims description 2
- 101000977771 Homo sapiens Interleukin-1 receptor-associated kinase 4 Proteins 0.000 claims description 2
- 101000777293 Homo sapiens Serine/threonine-protein kinase Chk1 Proteins 0.000 claims description 2
- 101001059443 Homo sapiens Serine/threonine-protein kinase MARK1 Proteins 0.000 claims description 2
- 101000934996 Homo sapiens Tyrosine-protein kinase JAK3 Proteins 0.000 claims description 2
- 102100023533 Interleukin-1 receptor-associated kinase 4 Human genes 0.000 claims description 2
- 101150028321 Lck gene Proteins 0.000 claims description 2
- 101710138999 MAP kinase-interacting serine/threonine-protein kinase 2 Proteins 0.000 claims description 2
- 102100033610 MAP kinase-interacting serine/threonine-protein kinase 2 Human genes 0.000 claims description 2
- 102000001253 Protein Kinase Human genes 0.000 claims description 2
- 102100031081 Serine/threonine-protein kinase Chk1 Human genes 0.000 claims description 2
- 102100028921 Serine/threonine-protein kinase MARK1 Human genes 0.000 claims description 2
- 102100025387 Tyrosine-protein kinase JAK3 Human genes 0.000 claims description 2
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims description 2
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims description 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 108060006633 protein kinase Proteins 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 5
- 238000000034 method Methods 0.000 description 11
- 125000004450 alkenylene group Chemical group 0.000 description 4
- 229940124639 Selective inhibitor Drugs 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022080211A JP2022110080A (ja) | 2016-12-19 | 2022-05-16 | Ｅｈｍｔ２阻害剤としてのアミン置換複素環化合物およびその使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662436139P | 2016-12-19 | 2016-12-19 | |
| US62/436,139 | 2016-12-19 | ||
| US201762517840P | 2017-06-09 | 2017-06-09 | |
| US62/517,840 | 2017-06-09 | ||
| PCT/US2017/067192 WO2018118842A1 (en) | 2016-12-19 | 2017-12-19 | Amine-substituted heterocyclic compounds as ehmt2 inhibitors and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080211A Division JP2022110080A (ja) | 2016-12-19 | 2022-05-16 | Ｅｈｍｔ２阻害剤としてのアミン置換複素環化合物およびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020504715A JP2020504715A (ja) | 2020-02-13 |
| JP2020504715A5 true JP2020504715A5 (https=) | 2021-02-04 |
Family
ID=60972416
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019530439A Pending JP2020504715A (ja) | 2016-12-19 | 2017-12-19 | Ｅｈｍｔ２阻害剤としてのアミン置換複素環化合物およびその使用方法 |
| JP2022080211A Pending JP2022110080A (ja) | 2016-12-19 | 2022-05-16 | Ｅｈｍｔ２阻害剤としてのアミン置換複素環化合物およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022080211A Pending JP2022110080A (ja) | 2016-12-19 | 2022-05-16 | Ｅｈｍｔ２阻害剤としてのアミン置換複素環化合物およびその使用方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US20200039998A1 (https=) |
| EP (2) | EP3555070B1 (https=) |
| JP (2) | JP2020504715A (https=) |
| KR (1) | KR102693367B1 (https=) |
| CN (2) | CN116041346A (https=) |
| AU (3) | AU2017382830A1 (https=) |
| BR (1) | BR112019012140A2 (https=) |
| CA (1) | CA3045032A1 (https=) |
| CL (2) | CL2019001664A1 (https=) |
| CO (1) | CO2019006787A2 (https=) |
| DK (1) | DK3555070T3 (https=) |
| ES (1) | ES2955132T3 (https=) |
| FI (1) | FI3555070T3 (https=) |
| HU (1) | HUE063405T2 (https=) |
| IL (1) | IL267090A (https=) |
| LT (1) | LT3555070T (https=) |
| MA (1) | MA47233A (https=) |
| MX (1) | MX2019007234A (https=) |
| PL (1) | PL3555070T3 (https=) |
| PT (1) | PT3555070T (https=) |
| SG (1) | SG10201913464TA (https=) |
| SI (1) | SI3555070T1 (https=) |
| TW (2) | TWI808067B (https=) |
| WO (1) | WO2018118842A1 (https=) |
| ZA (1) | ZA201904234B (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| CA3037587A1 (en) * | 2016-09-30 | 2018-04-05 | Epizyme, Inc. | Substituted fused bi- or tri- heterocyclic compounds as ehmt2 inhibitors |
| CA3053493A1 (en) * | 2017-02-14 | 2018-08-23 | Effector Therapeutics, Inc. | Piperidine-substituted mnk inhibitors and methods related thereto |
| US20200113901A1 (en) * | 2017-03-31 | 2020-04-16 | Epizyme, Inc. | Methods of using ehmt2 inhibitors |
| CN110621316B (zh) | 2017-04-21 | 2024-01-26 | Epizyme股份有限公司 | 用ehmt2抑制剂进行的组合疗法 |
| US11344543B2 (en) * | 2017-07-14 | 2022-05-31 | Innate Tumor Immunity, Inc. | NLRP3 modulators |
| CA3079260A1 (en) * | 2017-10-17 | 2019-04-25 | Epizyme, Inc. | Amine-substituted heterocyclic compounds as ehmt2 inhibitors and derivatives thereof |
| JP2021500334A (ja) * | 2017-10-18 | 2021-01-07 | エピザイム，インコーポレイティド | Ｅｈｍｔ２阻害剤としてのアミン置換複素環化合物、その塩、及びそれらの合成方法 |
| JP2021500326A (ja) * | 2017-10-18 | 2021-01-07 | エピザイム，インコーポレイティド | 血液障害の予防又は処置にｅｈｍｔ２阻害剤を使用する方法 |
| KR101954370B1 (ko) | 2018-07-25 | 2019-03-05 | 한미약품 주식회사 | 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
| CN113286592A (zh) | 2018-10-24 | 2021-08-20 | 效应治疗股份有限公司 | Mnk抑制剂的结晶形式 |
| US12522583B2 (en) | 2018-11-07 | 2026-01-13 | Dana-Farber Cancer Institute, Inc. | Benzimidazole derivatives and aza-benzimidazole derivatives as Janus kinase 2 inhibitors and uses thereof |
| EP3876939A4 (en) | 2018-11-07 | 2022-08-10 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| EP3877371A4 (en) | 2018-11-07 | 2022-07-27 | Dana-Farber Cancer Institute, Inc. | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF |
| US12338228B2 (en) * | 2019-01-14 | 2025-06-24 | Innate Tumor Immunity, Inc. | NLRP3 modulators |
| BR112021016522A2 (pt) | 2019-02-22 | 2021-10-26 | Hanmi Pharm. Co., Ltd. | Composição farmacêutica para o tratamento da leucemia mieloide aguda |
| KR20210151849A (ko) * | 2019-03-28 | 2021-12-14 | 에피자임, 인코포레이티드 | 퀴놀린 유도체 및 암의 치료를 위한 그의 용도 |
| EA202290154A1 (ru) | 2019-06-27 | 2022-03-29 | Ханми Фарм. Ко., Лтд. | Фармацевтическая композиция для лечения острого миелоидного лейкоза, содержащая ингибитор flt3 и химиотерапевтические агенты |
| US11691963B2 (en) | 2020-05-06 | 2023-07-04 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| US12492184B2 (en) | 2020-12-22 | 2025-12-09 | InventisBio Co., Ltd. | Heteroaryl compounds, preparation methods and uses thereof |
| US12043632B2 (en) | 2020-12-23 | 2024-07-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| EP4347046A1 (en) * | 2021-05-26 | 2024-04-10 | Alkermes, Inc. | Substituted fused bicyclic macrocyclic compounds and related methods of treatment |
| JP2024538128A (ja) * | 2021-10-15 | 2024-10-18 | タンゴ セラピューティクス， インコーポレイテッド | Ｅｈｍｔ１及びｅｈｍｔ２の新規調節因子及びその治療用途 |
| WO2023086319A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| US12162881B2 (en) | 2021-11-09 | 2024-12-10 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of JAK2 |
| CN119585255A (zh) * | 2022-07-20 | 2025-03-07 | S2C生物株式会社 | 杂芳基衍生化合物及其用途 |
| CN115974727B (zh) * | 2023-01-17 | 2024-03-12 | 青岛前线生物工程有限公司 | 一种联苯肼酯的合成方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
| WO2000025780A1 (en) * | 1998-10-29 | 2000-05-11 | Bristol-Myers Squibb Company | Compounds derived from an amine nucleus that are inhibitors of impdh enzyme |
| US6596747B2 (en) * | 1998-10-29 | 2003-07-22 | Bristol-Myers Squibb Company | Compounds derived from an amine nucleus and pharmaceutical compositions comprising same |
| ATE337312T1 (de) * | 2001-07-03 | 2006-09-15 | Vertex Pharma | Isoxazolyl-pyrimidines als inhibitoren von src- und lck-protein-kinasen |
| WO2003040141A1 (en) * | 2001-09-28 | 2003-05-15 | Bayer Pharmaceuticals Corporation | Oxazolyl-phenyl-2,4-diamino-pyrimidine compounds and methods for treating hyperproliferative disorders |
| ATE506953T1 (de) | 2003-08-07 | 2011-05-15 | Rigel Pharmaceuticals Inc | 2,4-pyrimidindiamin-verbindungen und verwendungen als antiproliferative mittel |
| CA2615420A1 (en) * | 2005-07-15 | 2007-01-25 | 4Sc Ag | 2-arylbenzothiazoles and uses thereof |
| GEP20105074B (en) * | 2005-12-21 | 2010-09-10 | Novartis Ag | Pyrimidinyl aryl urea derivatives being fgf inhibitors |
| PE20081636A1 (es) * | 2007-01-26 | 2009-01-10 | Smithkline Beecham Corp | Inhibidores de antranilamida para aurora quinasa |
| CN101903357A (zh) * | 2007-07-17 | 2010-12-01 | 里格尔药品股份有限公司 | 作为pkc抑制剂的环状胺取代的嘧啶二胺 |
| JP5328816B2 (ja) * | 2008-02-22 | 2013-10-30 | エフ．ホフマン−ラ ロシュ アーゲー | アミロイドβの調節薬 |
| BRPI1006942A2 (pt) * | 2009-01-23 | 2016-04-12 | Rigel Pharmaceuticals Inc | composto, composição farmacêutica, kit, métodos para inibir uma atividade de uma jak quinase, para tratar uma doença, para tratar a rejeição de transplante de aloenxerto em um receptor de transplante, para tratar uma reação de hipersensibilidade, e para inibir uma cascata de transdução de sinal, e, uso do composto |
| US8367689B2 (en) * | 2009-05-06 | 2013-02-05 | Portola Pharmaceuticals, Inc. | Inhibitors of JAK |
| CN104640863B (zh) * | 2012-09-20 | 2016-06-08 | 山东亨利医药科技有限责任公司 | 嘧啶胺衍生物及其制备方法和应用 |
| EP2928891B1 (en) * | 2012-12-04 | 2019-02-20 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
| CA2904610A1 (en) * | 2013-03-14 | 2014-09-25 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
| WO2014152768A1 (en) * | 2013-03-15 | 2014-09-25 | Portola Pharmaceuticals, Inc. | Cyclohexanediamine compounds and methods for their preparation |
| WO2016175264A1 (ja) * | 2015-04-28 | 2016-11-03 | カルナバイオサイエンス株式会社 | 抗マラリア活性を有する新規ヘテロアリール誘導体 |
| PL3442947T3 (pl) * | 2016-04-15 | 2023-10-02 | Epizyme, Inc. | Związki arylowe lub heteroarylowe podstawione aminą jako inhibitory ehmt1 i ehmt2 |
| CN106083828A (zh) * | 2016-06-30 | 2016-11-09 | 浙江大学 | 含吖丙啶环侧链的芳胺嘧啶衍生物及制备和应用 |
-
2017
- 2017-12-19 US US16/471,151 patent/US20200039998A1/en not_active Abandoned
- 2017-12-19 SG SG10201913464TA patent/SG10201913464TA/en unknown
- 2017-12-19 PT PT178294542T patent/PT3555070T/pt unknown
- 2017-12-19 PL PL17829454.2T patent/PL3555070T3/pl unknown
- 2017-12-19 CN CN202310013963.4A patent/CN116041346A/zh active Pending
- 2017-12-19 SI SI201731407T patent/SI3555070T1/sl unknown
- 2017-12-19 ES ES17829454T patent/ES2955132T3/es active Active
- 2017-12-19 JP JP2019530439A patent/JP2020504715A/ja active Pending
- 2017-12-19 MX MX2019007234A patent/MX2019007234A/es unknown
- 2017-12-19 TW TW106144660A patent/TWI808067B/zh active
- 2017-12-19 MA MA047233A patent/MA47233A/fr unknown
- 2017-12-19 TW TW112121399A patent/TW202411220A/zh unknown
- 2017-12-19 EP EP17829454.2A patent/EP3555070B1/en active Active
- 2017-12-19 CA CA3045032A patent/CA3045032A1/en active Pending
- 2017-12-19 WO PCT/US2017/067192 patent/WO2018118842A1/en not_active Ceased
- 2017-12-19 HU HUE17829454A patent/HUE063405T2/hu unknown
- 2017-12-19 EP EP23186749.0A patent/EP4285906A3/en not_active Withdrawn
- 2017-12-19 LT LTEPPCT/US2017/067192T patent/LT3555070T/lt unknown
- 2017-12-19 KR KR1020197020233A patent/KR102693367B1/ko active Active
- 2017-12-19 FI FIEP17829454.2T patent/FI3555070T3/fi active
- 2017-12-19 AU AU2017382830A patent/AU2017382830A1/en not_active Abandoned
- 2017-12-19 CN CN201780078660.3A patent/CN110088099B/zh active Active
- 2017-12-19 DK DK17829454.2T patent/DK3555070T3/da active
- 2017-12-19 BR BR112019012140-4A patent/BR112019012140A2/pt not_active Application Discontinuation
-
2019
- 2019-06-04 IL IL267090A patent/IL267090A/en unknown
- 2019-06-17 CL CL2019001664A patent/CL2019001664A1/es unknown
- 2019-06-26 CO CONC2019/0006787A patent/CO2019006787A2/es unknown
- 2019-06-27 ZA ZA2019/04234A patent/ZA201904234B/en unknown
-
2020
- 2020-04-29 CL CL2020001133A patent/CL2020001133A1/es unknown
-
2021
- 2021-11-15 US US17/526,058 patent/US20220235065A1/en not_active Abandoned
-
2022
- 2022-04-14 AU AU2022202494A patent/AU2022202494B2/en active Active
- 2022-05-16 JP JP2022080211A patent/JP2022110080A/ja active Pending
-
2024
- 2024-08-01 AU AU2024205290A patent/AU2024205290A1/en active Pending
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