JP2020504096A5 - - Google Patents
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- JP2020504096A5 JP2020504096A5 JP2019531196A JP2019531196A JP2020504096A5 JP 2020504096 A5 JP2020504096 A5 JP 2020504096A5 JP 2019531196 A JP2019531196 A JP 2019531196A JP 2019531196 A JP2019531196 A JP 2019531196A JP 2020504096 A5 JP2020504096 A5 JP 2020504096A5
- Authority
- JP
- Japan
- Prior art keywords
- library
- oligonucleotides
- oligonucleotide
- domain
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091034117 Oligonucleotide Proteins 0.000 claims 70
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 41
- 239000003446 ligand Substances 0.000 claims 14
- 125000003729 nucleotide group Chemical group 0.000 claims 10
- LDCYZAJDBXYCGN-VIFPVBQESA-N 5-hydroxy-L-tryptophan Chemical compound C1=C(O)C=C2C(C[C@H](N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-VIFPVBQESA-N 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 108020001756 ligand binding domains Proteins 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 4
- 230000000368 destabilizing effect Effects 0.000 claims 3
- 229940088597 hormone Drugs 0.000 claims 3
- 239000005556 hormone Substances 0.000 claims 3
- 239000002858 neurotransmitter agent Substances 0.000 claims 3
- LDCYZAJDBXYCGN-UHFFFAOYSA-N oxitriptan Natural products C1=C(O)C=C2C(CC(N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-UHFFFAOYSA-N 0.000 claims 3
- 108020004422 Riboswitch Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000002585 base Substances 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 239000002777 nucleoside Substances 0.000 claims 2
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 2
- 229940076279 serotonin Drugs 0.000 claims 2
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 claims 1
- 108091027075 5S-rRNA precursor Proteins 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 244000063299 Bacillus subtilis Species 0.000 claims 1
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 1
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 claims 1
- 235000017647 Brassica oleracea var italica Nutrition 0.000 claims 1
- 240000003259 Brassica oleracea var. botrytis Species 0.000 claims 1
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 claims 1
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical group C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims 1
- 108090001102 Hammerhead ribozyme Proteins 0.000 claims 1
- 241000242680 Schistosoma mansoni Species 0.000 claims 1
- 241000607626 Vibrio cholerae Species 0.000 claims 1
- PKFDLKSEZWEFGL-MHARETSRSA-N c-di-GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]3[C@@H](O)[C@H](N4C5=C(C(NC(N)=N5)=O)N=C4)O[C@@H]3COP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 PKFDLKSEZWEFGL-MHARETSRSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical compound [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 claims 1
- 101150013480 pbuE gene Proteins 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023064371A JP2023093572A (ja) | 2016-12-12 | 2023-04-11 | 遺伝学的にコード化可能なバイオセンサーのための頑強な小分子結合アプタマーを生成するためのインビトロ選択を用いた生物学的ｒｎａ足場の使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662432879P | 2016-12-12 | 2016-12-12 | |
| US62/432,879 | 2016-12-12 | ||
| PCT/US2017/065526 WO2018111745A1 (en) | 2016-12-12 | 2017-12-11 | Use of biological rna scaffolds with in vitro selection to generate robust small molecule binding aptamers for genetically encodable biosensors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023064371A Division JP2023093572A (ja) | 2016-12-12 | 2023-04-11 | 遺伝学的にコード化可能なバイオセンサーのための頑強な小分子結合アプタマーを生成するためのインビトロ選択を用いた生物学的ｒｎａ足場の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020504096A JP2020504096A (ja) | 2020-02-06 |
| JP2020504096A5 true JP2020504096A5 (enExample) | 2021-01-28 |
| JP7418210B2 JP7418210B2 (ja) | 2024-01-19 |
Family
ID=62559449
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531196A Active JP7418210B2 (ja) | 2016-12-12 | 2017-12-11 | 遺伝学的にコード化可能なバイオセンサーのための頑強な小分子結合アプタマーを生成するためのインビトロ選択を用いた生物学的ｒｎａ足場の使用 |
| JP2023064371A Pending JP2023093572A (ja) | 2016-12-12 | 2023-04-11 | 遺伝学的にコード化可能なバイオセンサーのための頑強な小分子結合アプタマーを生成するためのインビトロ選択を用いた生物学的ｒｎａ足場の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023064371A Pending JP2023093572A (ja) | 2016-12-12 | 2023-04-11 | 遺伝学的にコード化可能なバイオセンサーのための頑強な小分子結合アプタマーを生成するためのインビトロ選択を用いた生物学的ｒｎａ足場の使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20200208142A1 (enExample) |
| EP (1) | EP3551755A4 (enExample) |
| JP (2) | JP7418210B2 (enExample) |
| KR (1) | KR102612226B1 (enExample) |
| CN (1) | CN110462039A (enExample) |
| AU (1) | AU2017378078B2 (enExample) |
| BR (1) | BR112019012012A2 (enExample) |
| CA (1) | CA3056218A1 (enExample) |
| EA (1) | EA201991446A1 (enExample) |
| IL (1) | IL267216B2 (enExample) |
| MX (1) | MX2019006825A (enExample) |
| MY (1) | MY205553A (enExample) |
| PH (1) | PH12019501302A1 (enExample) |
| WO (1) | WO2018111745A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10852274B2 (en) | 2017-03-09 | 2020-12-01 | Auburn University | Differential circuit for background correction in electrochemical measurements |
| US11505799B2 (en) | 2017-07-07 | 2022-11-22 | Innamed, Inc. | Aptamers for measuring lipoprotein levels |
| US11560565B2 (en) | 2018-06-13 | 2023-01-24 | Auburn University | Electrochemical detection nanostructure, systems, and uses thereof |
| WO2020264444A2 (en) * | 2019-06-27 | 2020-12-30 | Innamed, Inc. | Assay method for point of care quantification of an immunophilin-binding immunosuppressant drug |
| CN113430203A (zh) * | 2020-03-23 | 2021-09-24 | 华东理工大学 | 一种新型rna检测与定量的方法 |
| WO2021256582A1 (ko) * | 2020-06-17 | 2021-12-23 | 포항공과대학교 산학협력단 | 전사 활성 인자 및 토홀드 스위치를 포함하는 트립토판 검출용 바이오센서 |
| WO2022006042A1 (en) * | 2020-06-29 | 2022-01-06 | President And Fellows Of Harvard College | Methods, compositions, and kits for nucleic acid barcoding of biomolecules |
| CN115177740A (zh) * | 2021-04-01 | 2022-10-14 | 安升（上海）医药科技有限公司 | 核酸自组装介导的adc药物的构建方法及应用 |
| CN113512089B (zh) * | 2021-06-30 | 2023-06-13 | 兰州大学 | 一种水溶性量子点的多肽稳定剂及应用 |
| CN115704029A (zh) * | 2021-08-06 | 2023-02-17 | 纳莹(上海)生物科技有限公司 | 一种rna检测与定量的方法 |
| CN114518359B (zh) * | 2022-03-08 | 2024-08-20 | 山东理工大学 | 一种基于g-四联体的双模式卡那霉素适配体传感器的制备方法 |
| CN115791726B (zh) * | 2022-11-25 | 2024-11-15 | 海南大学 | 一种基于g-四联体dna超灵敏高选择性检测锶离子的方法 |
| WO2024118806A1 (en) * | 2022-11-29 | 2024-06-06 | The Johns Hopkins University | Aptamer regulated transcription for in-vitro sensing and transduction |
| CN116170470B (zh) * | 2023-02-28 | 2023-07-04 | 北京科易为科技有限公司 | 移液器系统的数据通讯方法及其通讯系统 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060121510A1 (en) * | 1998-11-03 | 2006-06-08 | Breaker Ronald R | Multidomain polynucleotide molecular sensors |
| US20030162190A1 (en) * | 2001-11-15 | 2003-08-28 | Gorenstein David G. | Phosphoromonothioate and phosphorodithioate oligonucleotide aptamer chip for functional proteomics |
| US20060121466A1 (en) * | 2002-06-13 | 2006-06-08 | Amgen Inc. | Hammerhead ribozymes |
| US20050019916A1 (en) * | 2003-04-14 | 2005-01-27 | Stojanovic Milan N. | Cross reactive arrays of three-way junction sensors for steriod determination |
| MX2007005491A (es) * | 2004-11-08 | 2007-09-27 | Univ Yale | Diseno de compuesto basado en la estructura que involucra riboconmutadores. |
| SG174103A1 (en) * | 2007-05-29 | 2011-09-29 | Univ Yale | Riboswitches and methods and compositions for use of and with riboswitches |
| WO2012021554A1 (en) * | 2010-08-09 | 2012-02-16 | Yale University | Cyclic di-gmp-ii riboswitches, motifs, and compounds, and methods for their use |
| US8383794B2 (en) * | 2010-10-08 | 2013-02-26 | Li Niu | Conformation-selective nucleic acid inhibitors of AMPA glutamate receptors |
| US20120248666A1 (en) * | 2011-03-30 | 2012-10-04 | Firestone Industrial Products Company, Llc | Gas spring and damper assembly and suspension system including same |
| US10294478B2 (en) * | 2011-08-16 | 2019-05-21 | The Research Foundation For The State University Of New York | Aptamer modulators of estrogen receptors |
| US9664676B2 (en) * | 2013-09-06 | 2017-05-30 | Cornell University | RNA sequences that induce fluorescence of small molecule fluorophores |
| CN104293793B (zh) * | 2014-07-24 | 2018-05-18 | 江南大学 | 一种特异识别t-2毒素的寡核苷酸适配体 |
-
2017
- 2017-12-11 WO PCT/US2017/065526 patent/WO2018111745A1/en not_active Ceased
- 2017-12-11 CA CA3056218A patent/CA3056218A1/en active Pending
- 2017-12-11 EP EP17880409.2A patent/EP3551755A4/en active Pending
- 2017-12-11 IL IL267216A patent/IL267216B2/en unknown
- 2017-12-11 CN CN201780085607.6A patent/CN110462039A/zh active Pending
- 2017-12-11 BR BR112019012012-2A patent/BR112019012012A2/pt active Search and Examination
- 2017-12-11 KR KR1020197019421A patent/KR102612226B1/ko active Active
- 2017-12-11 AU AU2017378078A patent/AU2017378078B2/en active Active
- 2017-12-11 MX MX2019006825A patent/MX2019006825A/es unknown
- 2017-12-11 JP JP2019531196A patent/JP7418210B2/ja active Active
- 2017-12-11 MY MYPI2019003292A patent/MY205553A/en unknown
- 2017-12-11 EA EA201991446A patent/EA201991446A1/ru unknown
- 2017-12-11 US US16/468,945 patent/US20200208142A1/en not_active Abandoned
-
2019
- 2019-06-10 PH PH12019501302A patent/PH12019501302A1/en unknown
-
2021
- 2021-12-02 US US17/541,068 patent/US20220170009A1/en active Pending
-
2023
- 2023-04-11 JP JP2023064371A patent/JP2023093572A/ja active Pending
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