CN110462039A - 使用在体外选择的生物rna支架来产生用于可遗传编码的生物传感器的稳健小分子结合适体 - Google Patents

使用在体外选择的生物rna支架来产生用于可遗传编码的生物传感器的稳健小分子结合适体 Download PDF

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CN110462039A
CN110462039A CN201780085607.6A CN201780085607A CN110462039A CN 110462039 A CN110462039 A CN 110462039A CN 201780085607 A CN201780085607 A CN 201780085607A CN 110462039 A CN110462039 A CN 110462039A
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oligonucleotide
library
sequence
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oligonucleotide library
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R·T·贝蒂
E·B·波特
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Colorado Board Of Directors Corporate Organizations, University of
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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CN201780085607.6A 2016-12-12 2017-12-11 使用在体外选择的生物rna支架来产生用于可遗传编码的生物传感器的稳健小分子结合适体 Pending CN110462039A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662432879P 2016-12-12 2016-12-12
US62/432879 2016-12-12
PCT/US2017/065526 WO2018111745A1 (en) 2016-12-12 2017-12-11 Use of biological rna scaffolds with in vitro selection to generate robust small molecule binding aptamers for genetically encodable biosensors

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CN110462039A true CN110462039A (zh) 2019-11-15

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US (2) US20200208142A1 (enExample)
EP (1) EP3551755A4 (enExample)
JP (2) JP7418210B2 (enExample)
KR (1) KR102612226B1 (enExample)
CN (1) CN110462039A (enExample)
AU (1) AU2017378078B2 (enExample)
BR (1) BR112019012012A2 (enExample)
CA (1) CA3056218A1 (enExample)
EA (1) EA201991446A1 (enExample)
IL (1) IL267216B2 (enExample)
MX (1) MX2019006825A (enExample)
MY (1) MY205553A (enExample)
PH (1) PH12019501302A1 (enExample)
WO (1) WO2018111745A1 (enExample)

Cited By (4)

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CN113512089A (zh) * 2021-06-30 2021-10-19 兰州大学 一种水溶性量子点的多肽稳定剂及应用
CN115704029A (zh) * 2021-08-06 2023-02-17 纳莹(上海)生物科技有限公司 一种rna检测与定量的方法
CN115791726A (zh) * 2022-11-25 2023-03-14 海南大学 一种基于g-四联体dna超灵敏高选择性检测锶离子的方法
CN116170470A (zh) * 2023-02-28 2023-05-26 北京科易为科技有限公司 移液器系统的数据通讯方法及其通讯系统

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US10852274B2 (en) 2017-03-09 2020-12-01 Auburn University Differential circuit for background correction in electrochemical measurements
US11505799B2 (en) 2017-07-07 2022-11-22 Innamed, Inc. Aptamers for measuring lipoprotein levels
US11560565B2 (en) 2018-06-13 2023-01-24 Auburn University Electrochemical detection nanostructure, systems, and uses thereof
WO2020264444A2 (en) * 2019-06-27 2020-12-30 Innamed, Inc. Assay method for point of care quantification of an immunophilin-binding immunosuppressant drug
CN113430203A (zh) * 2020-03-23 2021-09-24 华东理工大学 一种新型rna检测与定量的方法
WO2021256582A1 (ko) * 2020-06-17 2021-12-23 포항공과대학교 산학협력단 전사 활성 인자 및 토홀드 스위치를 포함하는 트립토판 검출용 바이오센서
WO2022006042A1 (en) * 2020-06-29 2022-01-06 President And Fellows Of Harvard College Methods, compositions, and kits for nucleic acid barcoding of biomolecules
CN115177740A (zh) * 2021-04-01 2022-10-14 安升（上海）医药科技有限公司 核酸自组装介导的adc药物的构建方法及应用
CN114518359B (zh) * 2022-03-08 2024-08-20 山东理工大学 一种基于g-四联体的双模式卡那霉素适配体传感器的制备方法
WO2024118806A1 (en) * 2022-11-29 2024-06-06 The Johns Hopkins University Aptamer regulated transcription for in-vitro sensing and transduction

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113512089A (zh) * 2021-06-30 2021-10-19 兰州大学 一种水溶性量子点的多肽稳定剂及应用
CN113512089B (zh) * 2021-06-30 2023-06-13 兰州大学 一种水溶性量子点的多肽稳定剂及应用
CN115704029A (zh) * 2021-08-06 2023-02-17 纳莹(上海)生物科技有限公司 一种rna检测与定量的方法
CN115791726A (zh) * 2022-11-25 2023-03-14 海南大学 一种基于g-四联体dna超灵敏高选择性检测锶离子的方法
CN115791726B (zh) * 2022-11-25 2024-11-15 海南大学 一种基于g-四联体dna超灵敏高选择性检测锶离子的方法
CN116170470A (zh) * 2023-02-28 2023-05-26 北京科易为科技有限公司 移液器系统的数据通讯方法及其通讯系统
CN116170470B (zh) * 2023-02-28 2023-07-04 北京科易为科技有限公司 移液器系统的数据通讯方法及其通讯系统

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EP3551755A4 (en) 2020-06-24
JP2023093572A (ja) 2023-07-04
JP2020504096A (ja) 2020-02-06
MY205553A (en) 2024-10-25
IL267216B2 (en) 2025-04-01
US20200208142A1 (en) 2020-07-02
AU2017378078B2 (en) 2024-06-13
EP3551755A1 (en) 2019-10-16
KR102612226B1 (ko) 2023-12-12
PH12019501302A1 (en) 2019-10-28
EA201991446A1 (ru) 2020-03-03
JP7418210B2 (ja) 2024-01-19
BR112019012012A2 (pt) 2019-10-29
MX2019006825A (es) 2019-10-30
WO2018111745A1 (en) 2018-06-21
AU2017378078A1 (en) 2019-07-25
KR20190100227A (ko) 2019-08-28
IL267216A (en) 2019-08-29
CA3056218A1 (en) 2018-06-21
IL267216B1 (en) 2024-12-01
US20220170009A1 (en) 2022-06-02

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