JP2020501513A5 - - Google Patents
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- Publication number
- JP2020501513A5 JP2020501513A5 JP2019517069A JP2019517069A JP2020501513A5 JP 2020501513 A5 JP2020501513 A5 JP 2020501513A5 JP 2019517069 A JP2019517069 A JP 2019517069A JP 2019517069 A JP2019517069 A JP 2019517069A JP 2020501513 A5 JP2020501513 A5 JP 2020501513A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- seq
- construct
- toxin
- peptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662401192P | 2016-09-29 | 2016-09-29 | |
| US201662401195P | 2016-09-29 | 2016-09-29 | |
| US62/401,192 | 2016-09-29 | ||
| US62/401,195 | 2016-09-29 | ||
| PCT/IL2017/051094 WO2018061004A1 (en) | 2016-09-29 | 2017-09-27 | Therapeutic multi-targeting constructs and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020501513A JP2020501513A (ja) | 2020-01-23 |
| JP2020501513A5 true JP2020501513A5 (https=) | 2020-11-12 |
| JP7133225B2 JP7133225B2 (ja) | 2022-09-08 |
Family
ID=61763358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019517069A Active JP7133225B2 (ja) | 2016-09-29 | 2017-09-27 | 治療用多標的コンストラクトおよびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11739163B2 (https=) |
| EP (1) | EP3518953A4 (https=) |
| JP (1) | JP7133225B2 (https=) |
| CN (1) | CN109789183A (https=) |
| AU (2) | AU2017333442A1 (https=) |
| CA (1) | CA3037261A1 (https=) |
| IL (1) | IL265236B2 (https=) |
| WO (1) | WO2018061004A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109789183A (zh) * | 2016-09-29 | 2019-05-21 | Aebi有限公司 | 治疗性多靶向构建体及其用途 |
| US20210198319A1 (en) * | 2017-09-27 | 2021-07-01 | Aebi Ltd. | Cytotoxic peptides and conjugates thereof |
| KR102268983B1 (ko) | 2019-09-11 | 2021-06-24 | 경북대학교 산학협력단 | 엔도테린 수용체 억제제에 의한 엑소좀 분비 억제 또는 pd-l1 발현 억제 용도 |
| CN112252362A (zh) * | 2020-10-10 | 2021-01-22 | 无锡市市政设施建设工程有限公司 | 基于bim实现地铁车站主体结构盘扣支架搭设的方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040058865A1 (en) | 2001-11-26 | 2004-03-25 | Danishefsky Samuel J | Homing peptide multimers, their preparation and uses |
| PT2949658T (pt) | 2003-03-03 | 2018-10-18 | Bracco Suisse Sa | Péptidos que ligam especificamente o recetor de hgf (cmet) e utilizações dos mesmos |
| WO2005090393A2 (en) | 2004-02-09 | 2005-09-29 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services | Multimeric protein toxins to target cells having multiple identifying characteristics |
| US20090305898A1 (en) | 2005-07-21 | 2009-12-10 | Ilan Morad | Methods and Compositions for Identifying a Peptide Having an Intermolecular Interaction With a Target of Interest |
| US20100021473A1 (en) | 2005-12-06 | 2010-01-28 | Domantis Limited | Bispecific Ligands With Binding Specificity to Cell Surface Targets and Methods of Use Therefor |
| WO2007093373A2 (en) | 2006-02-14 | 2007-08-23 | Università Degli Studi Di Siena | Branched multimeric peptides for tumor diagnosis and therapy |
| US20080131428A1 (en) * | 2006-02-24 | 2008-06-05 | Arius Research, Inc. | Cytotoxicity mediation of cells evidencing surface expression of TROP-2 |
| PE20081140A1 (es) | 2006-10-25 | 2008-09-22 | Amgen Inc | Agentes terapeuticos a base de peptidos derivados de toxinas |
| US8536113B2 (en) * | 2006-12-21 | 2013-09-17 | Janssen Biotech, Inc. | EGFR binding peptides and uses thereof |
| CA2697922A1 (en) | 2007-08-28 | 2009-03-12 | Biogen Idec Ma Inc. | Compositions that bind multiple epitopes of igf-1r |
| CN102007145A (zh) | 2008-02-14 | 2011-04-06 | 百时美施贵宝公司 | 基于结合egfr的工程化蛋白质的靶向治疗剂 |
| EP2352522A4 (en) | 2008-11-06 | 2014-03-05 | Univ Washington | BISPECIFIC AUXILIARIES FOR INTRA-CELLULAR RELEASE |
| JP2010154842A (ja) | 2008-12-03 | 2010-07-15 | Koji Kawakami | Ｅｇｆｒを標的にした新規抗がんキメラペプチド |
| WO2010083495A2 (en) | 2009-01-18 | 2010-07-22 | The Board Of Trustees Of The Leland Stanford Junior University | Polypeptides targeting vascular endothelial growth factor receptor-2 and alpha v beta 3 integrin |
| WO2011047135A2 (en) | 2009-10-14 | 2011-04-21 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for treating bladder cancer |
| AU2011227714B2 (en) | 2010-03-19 | 2014-09-04 | Takeda Pharmaceutical Company Limited | TFPI inhibitors and methods of use |
| EP2714738B1 (en) * | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| EP2817341A4 (en) * | 2012-02-23 | 2015-12-02 | Harvard College | MICROBIAL MODIFIED TOXIN RECEPTOR FOR THE DISTRIBUTION OF AGENTS IN CELLS |
| CN110563850A (zh) * | 2012-04-30 | 2019-12-13 | 比奥孔有限公司 | 靶向/免疫调节性融合蛋白及其制造方法 |
| JP6103832B2 (ja) | 2012-06-25 | 2017-03-29 | Hoya株式会社 | Ｅｇｆｒ結合性ペプチド |
| CA3081073C (en) | 2013-03-12 | 2023-09-12 | Biocon Ltd. | Fusion immunomodulatory proteins and methods for making same |
| WO2015010094A1 (en) | 2013-07-18 | 2015-01-22 | Eutropics Pharmaceuticals, Inc. | Differential bh3 mitochondrial profiling |
| WO2015023979A1 (en) | 2013-08-16 | 2015-02-19 | Equip, Llc | Discrete peg constructs |
| WO2015195721A1 (en) * | 2014-06-16 | 2015-12-23 | Purdue Research Foundation | Compositions and methods for treating cancer |
| CN109789183A (zh) * | 2016-09-29 | 2019-05-21 | Aebi有限公司 | 治疗性多靶向构建体及其用途 |
| US20210198319A1 (en) | 2017-09-27 | 2021-07-01 | Aebi Ltd. | Cytotoxic peptides and conjugates thereof |
| US20200339629A1 (en) | 2019-04-24 | 2020-10-29 | Aebi Ltd. | Therapeutic constructs comprising cmet binding peptides |
-
2017
- 2017-09-27 CN CN201780060289.8A patent/CN109789183A/zh active Pending
- 2017-09-27 EP EP17855166.9A patent/EP3518953A4/en active Pending
- 2017-09-27 CA CA3037261A patent/CA3037261A1/en active Pending
- 2017-09-27 US US16/337,163 patent/US11739163B2/en active Active
- 2017-09-27 IL IL265236A patent/IL265236B2/en unknown
- 2017-09-27 JP JP2019517069A patent/JP7133225B2/ja active Active
- 2017-09-27 WO PCT/IL2017/051094 patent/WO2018061004A1/en not_active Ceased
- 2017-09-27 AU AU2017333442A patent/AU2017333442A1/en not_active Abandoned
-
2022
- 2022-08-24 AU AU2022221434A patent/AU2022221434A1/en not_active Abandoned
-
2023
- 2023-07-06 US US18/348,229 patent/US20240002547A1/en active Pending
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