JP2020196718A5 - - Google Patents
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- JP2020196718A5 JP2020196718A5 JP2020126483A JP2020126483A JP2020196718A5 JP 2020196718 A5 JP2020196718 A5 JP 2020196718A5 JP 2020126483 A JP2020126483 A JP 2020126483A JP 2020126483 A JP2020126483 A JP 2020126483A JP 2020196718 A5 JP2020196718 A5 JP 2020196718A5
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- 239000000203 mixture Substances 0.000 claims 53
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 claims 11
- 229920000153 Povidone-iodine Polymers 0.000 claims 11
- 229960001621 povidone-iodine Drugs 0.000 claims 11
- 150000003431 steroids Chemical class 0.000 claims 10
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 3
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 3
- 230000000845 anti-microbial effect Effects 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000006184 cosolvent Substances 0.000 claims 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 230000000813 microbial effect Effects 0.000 claims 3
- 239000003755 preservative agent Substances 0.000 claims 3
- 230000002335 preservative effect Effects 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 claims 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 2
- 229950000812 dexamethasone palmitate Drugs 0.000 claims 2
- 239000003589 local anesthetic agent Substances 0.000 claims 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims 2
- 235000011152 sodium sulphate Nutrition 0.000 claims 2
- 238000011200 topical administration Methods 0.000 claims 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
- 241000224489 Amoeba Species 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 claims 1
- 206010010984 Corneal abrasion Diseases 0.000 claims 1
- 208000028006 Corneal injury Diseases 0.000 claims 1
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 1
- 229920002057 Pluronic® P 103 Polymers 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- 229920001214 Polysorbate 60 Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229960000686 benzalkonium chloride Drugs 0.000 claims 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 229960004926 chlorobutanol Drugs 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 229960004194 lidocaine Drugs 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 229960002216 methylparaben Drugs 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 239000003961 penetration enhancing agent Substances 0.000 claims 1
- 229940067107 phenylethyl alcohol Drugs 0.000 claims 1
- 229920001983 poloxamer Polymers 0.000 claims 1
- 229920001993 poloxamer 188 Polymers 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims 1
- 229960003415 propylparaben Drugs 0.000 claims 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 235000010199 sorbic acid Nutrition 0.000 claims 1
- 239000004334 sorbic acid Substances 0.000 claims 1
- 229940075582 sorbic acid Drugs 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 229960002372 tetracaine Drugs 0.000 claims 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims 1
- 229940033663 thimerosal Drugs 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78262906P | 2006-03-14 | 2006-03-14 | |
| US60/782,629 | 2006-03-14 | ||
| US84831506P | 2006-09-29 | 2006-09-29 | |
| US60/848,315 | 2006-09-29 | ||
| US11/636,293 US7767217B2 (en) | 2006-03-14 | 2006-12-07 | Ophthalmic compositions comprising povidone-iodine |
| US11/636,293 | 2006-12-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019006930A Division JP6817346B2 (ja) | 2006-03-14 | 2019-01-18 | ポビドンヨードを含む眼用組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020196718A JP2020196718A (ja) | 2020-12-10 |
| JP2020196718A5 true JP2020196718A5 (enExample) | 2021-01-28 |
Family
ID=38509994
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500393A Active JP5415935B2 (ja) | 2006-03-14 | 2007-03-09 | ポビドンヨードを含む眼用組成物 |
| JP2013034815A Active JP5709279B2 (ja) | 2006-03-14 | 2013-02-25 | ポビドンヨードを含む眼用組成物 |
| JP2015021037A Active JP5997303B2 (ja) | 2006-03-14 | 2015-02-05 | ポビドンヨードを含む眼用組成物 |
| JP2016134980A Active JP6389487B2 (ja) | 2006-03-14 | 2016-07-07 | ポビドンヨードを含む眼用組成物 |
| JP2017203363A Active JP6509994B2 (ja) | 2006-03-14 | 2017-10-20 | ポビドンヨードを含む眼用組成物 |
| JP2019006930A Active JP6817346B2 (ja) | 2006-03-14 | 2019-01-18 | ポビドンヨードを含む眼用組成物 |
| JP2020126483A Withdrawn JP2020196718A (ja) | 2006-03-14 | 2020-07-27 | ポビドンヨードを含む眼用組成物 |
Family Applications Before (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500393A Active JP5415935B2 (ja) | 2006-03-14 | 2007-03-09 | ポビドンヨードを含む眼用組成物 |
| JP2013034815A Active JP5709279B2 (ja) | 2006-03-14 | 2013-02-25 | ポビドンヨードを含む眼用組成物 |
| JP2015021037A Active JP5997303B2 (ja) | 2006-03-14 | 2015-02-05 | ポビドンヨードを含む眼用組成物 |
| JP2016134980A Active JP6389487B2 (ja) | 2006-03-14 | 2016-07-07 | ポビドンヨードを含む眼用組成物 |
| JP2017203363A Active JP6509994B2 (ja) | 2006-03-14 | 2017-10-20 | ポビドンヨードを含む眼用組成物 |
| JP2019006930A Active JP6817346B2 (ja) | 2006-03-14 | 2019-01-18 | ポビドンヨードを含む眼用組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (8) | US7767217B2 (enExample) |
| EP (2) | EP2772258B1 (enExample) |
| JP (7) | JP5415935B2 (enExample) |
| KR (7) | KR101538280B1 (enExample) |
| CN (2) | CN103463635B (enExample) |
| AU (1) | AU2007225305B2 (enExample) |
| CA (2) | CA2645765C (enExample) |
| DK (1) | DK1998783T3 (enExample) |
| ES (2) | ES2807552T3 (enExample) |
| MX (3) | MX2008011644A (enExample) |
| NZ (5) | NZ734050A (enExample) |
| PL (1) | PL1998783T3 (enExample) |
| PT (1) | PT1998783E (enExample) |
| SI (1) | SI1998783T1 (enExample) |
| TW (4) | TWI653978B (enExample) |
| WO (1) | WO2007106381A2 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7767217B2 (en) * | 2006-03-14 | 2010-08-03 | Foresight Biotherapeutics | Ophthalmic compositions comprising povidone-iodine |
| KR20170123724A (ko) * | 2006-03-28 | 2017-11-08 | 자블린 파머슈티칼스 인코포레이티드 | 저 투여량의 디클로페낙 및 베타-사이클로덱스트린 제형 |
| EP2003970A4 (en) * | 2006-03-28 | 2012-07-11 | Javelin Pharmaceuticals Inc | FORMULATIONS OF LOW-DOSEED NON-STEROID INFLAMMATORY INHIBITORS AND BETA-CYCLODEXTRIN |
| US8124130B1 (en) * | 2007-05-30 | 2012-02-28 | James Louis Rutkowski | Formulations and methods for recovery from dental surgery |
| US20090263345A1 (en) * | 2008-01-28 | 2009-10-22 | Foresight Biotherapeutics, Inc. | Otic compositions for the treatment of infections of the internal and external ear in mammals |
| WO2009097123A1 (en) * | 2008-01-28 | 2009-08-06 | Foresight Biotherapeutics, Inc. | Device for in-situ generation of povidone-iodine compositions |
| EP2249921B1 (en) | 2008-02-25 | 2020-06-17 | Eyegate Pharmaceuticals, Inc. | Enhanced delivery of dexamethasone phosphate to ocular tissues through iontophoresis |
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