JP2020090517A - Maillard reaction inhibitor - Google Patents
Maillard reaction inhibitor Download PDFInfo
- Publication number
- JP2020090517A JP2020090517A JP2020006457A JP2020006457A JP2020090517A JP 2020090517 A JP2020090517 A JP 2020090517A JP 2020006457 A JP2020006457 A JP 2020006457A JP 2020006457 A JP2020006457 A JP 2020006457A JP 2020090517 A JP2020090517 A JP 2020090517A
- Authority
- JP
- Japan
- Prior art keywords
- present
- genus
- maillard reaction
- inhibitor
- plant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002683 reaction inhibitor Substances 0.000 title claims abstract description 20
- 239000000284 extract Substances 0.000 claims abstract description 12
- 241000521581 Millettia Species 0.000 claims abstract description 8
- 239000004480 active ingredient Substances 0.000 claims abstract description 7
- 241000196324 Embryophyta Species 0.000 claims description 64
- 238000002360 preparation method Methods 0.000 claims description 37
- 235000013305 food Nutrition 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 21
- 208000002249 Diabetes Complications Diseases 0.000 claims description 6
- 206010012655 Diabetic complications Diseases 0.000 claims description 6
- 230000019612 pigmentation Effects 0.000 claims description 3
- 239000000419 plant extract Substances 0.000 abstract description 40
- 239000003112 inhibitor Substances 0.000 description 30
- 238000006243 chemical reaction Methods 0.000 description 24
- 238000000605 extraction Methods 0.000 description 21
- 230000002401 inhibitory effect Effects 0.000 description 17
- 238000007796 conventional method Methods 0.000 description 13
- 239000002904 solvent Substances 0.000 description 13
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 238000002156 mixing Methods 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 230000032683 aging Effects 0.000 description 9
- 240000007228 Mangifera indica Species 0.000 description 8
- 235000014826 Mangifera indica Nutrition 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 235000017048 Garcinia mangostana Nutrition 0.000 description 7
- 240000006053 Garcinia mangostana Species 0.000 description 7
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 7
- 244000274911 Myrica cerifera Species 0.000 description 7
- 235000009134 Myrica cerifera Nutrition 0.000 description 7
- 239000000654 additive Substances 0.000 description 7
- 239000002552 dosage form Substances 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 244000080767 Areca catechu Species 0.000 description 6
- 235000004936 Bromus mango Nutrition 0.000 description 6
- 235000009184 Spondias indica Nutrition 0.000 description 6
- 239000000523 sample Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 244000235603 Acacia catechu Species 0.000 description 5
- 235000006020 Acacia catechu Nutrition 0.000 description 5
- 241000632227 Antenoron Species 0.000 description 5
- 241000209020 Cornus Species 0.000 description 5
- 240000003813 Eugenia uniflora Species 0.000 description 5
- 235000013420 Eugenia uniflora Nutrition 0.000 description 5
- 241000593508 Garcinia Species 0.000 description 5
- 235000000885 Garcinia xanthochymus Nutrition 0.000 description 5
- 241000219433 Myrica Species 0.000 description 5
- 241000881225 Persicaria Species 0.000 description 5
- 235000010889 Rhus javanica Nutrition 0.000 description 5
- 244000097577 Rhus javanica Species 0.000 description 5
- 241001083492 Trapa Species 0.000 description 5
- 241001428357 Trapa japonica Species 0.000 description 5
- 239000001560 acacia catechu Substances 0.000 description 5
- 235000013361 beverage Nutrition 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000006210 lotion Substances 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000012085 test solution Substances 0.000 description 5
- 241000220479 Acacia Species 0.000 description 4
- 108010005094 Advanced Glycation End Products Proteins 0.000 description 4
- 241000546273 Lindera <angiosperm> Species 0.000 description 4
- 241000208225 Rhus Species 0.000 description 4
- 235000014364 Trapa natans Nutrition 0.000 description 4
- 240000001085 Trapa natans Species 0.000 description 4
- 235000008429 bread Nutrition 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- -1 for example Substances 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000013642 negative control Substances 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 241000545417 Aleurites Species 0.000 description 3
- 240000007124 Brassica oleracea Species 0.000 description 3
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 3
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 3
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 3
- 208000002177 Cataract Diseases 0.000 description 3
- 241000871539 Choerospondias Species 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 241000266331 Eugenia Species 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 3
- 240000007472 Leucaena leucocephala Species 0.000 description 3
- 241001093152 Mangifera Species 0.000 description 3
- 240000007594 Oryza sativa Species 0.000 description 3
- 235000007164 Oryza sativa Nutrition 0.000 description 3
- 241000219053 Rumex Species 0.000 description 3
- 241000934878 Sterculia Species 0.000 description 3
- 235000021282 Sterculia Nutrition 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 210000000845 cartilage Anatomy 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 235000014347 soups Nutrition 0.000 description 3
- 229940059107 sterculia Drugs 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 239000006188 syrup Substances 0.000 description 3
- 235000020357 syrup Nutrition 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 235000006491 Acacia senegal Nutrition 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 2
- 235000006667 Aleurites moluccana Nutrition 0.000 description 2
- 244000085278 Aleurites moluccanus Species 0.000 description 2
- 241000533865 Callerya reticulata Species 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 241000759833 Cornus officinalis Species 0.000 description 2
- 244000301850 Cupressus sempervirens Species 0.000 description 2
- 240000008415 Lactuca sativa Species 0.000 description 2
- 235000012857 Lindera obtusiloba Nutrition 0.000 description 2
- 240000006370 Lindera obtusiloba Species 0.000 description 2
- 241000604893 Lindera umbellata Species 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 2
- 241000382362 Persicaria tinctoria Species 0.000 description 2
- 244000184734 Pyrus japonica Species 0.000 description 2
- 235000005291 Rumex acetosa Nutrition 0.000 description 2
- 244000137827 Rumex acetosa Species 0.000 description 2
- 244000207707 Rumex nepalensis Species 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000003518 caustics Substances 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 239000006196 drop Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 235000015220 hamburgers Nutrition 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000007665 sagging Methods 0.000 description 2
- 235000012045 salad Nutrition 0.000 description 2
- 239000003352 sequestering agent Substances 0.000 description 2
- 239000007901 soft capsule Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 235000015961 tonic Nutrition 0.000 description 2
- 230000001256 tonic effect Effects 0.000 description 2
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 1
- 244000131042 Acacia leucophloea Species 0.000 description 1
- 235000016219 Acacia leucophloea Nutrition 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 235000011468 Albizia julibrissin Nutrition 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 235000003840 Amygdalus nana Nutrition 0.000 description 1
- 244000296825 Amygdalus nana Species 0.000 description 1
- 235000006226 Areca catechu Nutrition 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 241000132092 Aster Species 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 241000864415 Cornus controversa Species 0.000 description 1
- 235000017963 Cornus kousa Nutrition 0.000 description 1
- 244000274051 Cornus kousa Species 0.000 description 1
- 235000003363 Cornus mas Nutrition 0.000 description 1
- 240000006766 Cornus mas Species 0.000 description 1
- 235000008375 Decussocarpus nagi Nutrition 0.000 description 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 1
- 206010012689 Diabetic retinopathy Diseases 0.000 description 1
- 239000004278 EU approved seasoning Substances 0.000 description 1
- 241001481760 Erethizon dorsatum Species 0.000 description 1
- 244000087164 Eugenia spicata Species 0.000 description 1
- 235000009419 Fagopyrum esculentum Nutrition 0.000 description 1
- 240000008620 Fagopyrum esculentum Species 0.000 description 1
- 235000001424 Garcinia dulcis Nutrition 0.000 description 1
- 244000287680 Garcinia dulcis Species 0.000 description 1
- 241000173371 Garcinia indica Species 0.000 description 1
- 241001554567 Garcinia subelliptica Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 235000001018 Hibiscus sabdariffa Nutrition 0.000 description 1
- 241000519695 Ilex integra Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 235000004520 Lindera benzoin Nutrition 0.000 description 1
- 244000148992 Lindera benzoin Species 0.000 description 1
- 235000001577 Lindera glauca Nutrition 0.000 description 1
- 244000245109 Lindera glauca Species 0.000 description 1
- 240000005856 Lyophyllum decastes Species 0.000 description 1
- 235000013194 Lyophyllum decastes Nutrition 0.000 description 1
- 235000006791 Mangifera caesia Nutrition 0.000 description 1
- 244000307609 Mangifera caesia Species 0.000 description 1
- 235000001273 Mangifera foetida Nutrition 0.000 description 1
- 244000226150 Mangifera foetida Species 0.000 description 1
- 235000001375 Mangifera odorata Nutrition 0.000 description 1
- 244000063103 Mangifera odorata Species 0.000 description 1
- 240000005852 Mimosa quadrivalvis Species 0.000 description 1
- 235000015429 Mirabilis expansa Nutrition 0.000 description 1
- 244000294411 Mirabilis expansa Species 0.000 description 1
- 244000132436 Myrica rubra Species 0.000 description 1
- 235000014631 Myrica rubra Nutrition 0.000 description 1
- 240000003109 Persicaria chinensis Species 0.000 description 1
- 241000205426 Persicaria filiformis Species 0.000 description 1
- 235000017337 Persicaria hydropiper Nutrition 0.000 description 1
- 240000000275 Persicaria hydropiper Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 235000011432 Prunus Nutrition 0.000 description 1
- 241000208422 Rhododendron Species 0.000 description 1
- 244000262668 Rhus taitensis Species 0.000 description 1
- 241001495449 Robinia pseudoacacia Species 0.000 description 1
- 240000007001 Rumex acetosella Species 0.000 description 1
- 235000015761 Rumex acetosella Nutrition 0.000 description 1
- 235000021501 Rumex crispus Nutrition 0.000 description 1
- 244000207667 Rumex vesicarius Species 0.000 description 1
- 241000124033 Salix Species 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
- 150000004753 Schiff bases Chemical class 0.000 description 1
- 235000003434 Sesamum indicum Nutrition 0.000 description 1
- 244000040738 Sesamum orientale Species 0.000 description 1
- 235000005729 Sterculia foetida Nutrition 0.000 description 1
- 244000240095 Sterculia foetida Species 0.000 description 1
- 241001530029 Syzygium formosanum Species 0.000 description 1
- 241000269841 Thunnus albacares Species 0.000 description 1
- 244000044283 Toxicodendron succedaneum Species 0.000 description 1
- 241000134415 Toxicodendron trichocarpum Species 0.000 description 1
- 244000243786 Trapa incisa Species 0.000 description 1
- 244000153888 Tung Species 0.000 description 1
- 240000001866 Vernicia fordii Species 0.000 description 1
- 240000006917 Vernicia montana Species 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- HAMNKKUPIHEESI-UHFFFAOYSA-N aminoguanidine Chemical compound NNC(N)=N HAMNKKUPIHEESI-UHFFFAOYSA-N 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 235000013527 bean curd Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 235000013736 caramel Nutrition 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 235000019219 chocolate Nutrition 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000014510 cooky Nutrition 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 235000021438 curry Nutrition 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 208000033679 diabetic kidney disease Diseases 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 235000012489 doughnuts Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000002481 ethanol extraction Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 235000019692 hotdogs Nutrition 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000003345 hyperglycaemic effect Effects 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 239000008268 mayonnaise Substances 0.000 description 1
- 235000010746 mayonnaise Nutrition 0.000 description 1
- 235000019690 meat sausages Nutrition 0.000 description 1
- 238000003808 methanol extraction Methods 0.000 description 1
- 239000000401 methanolic extract Substances 0.000 description 1
- 235000020124 milk-based beverage Nutrition 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 235000013536 miso Nutrition 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 235000013557 nattō Nutrition 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 235000014774 prunus Nutrition 0.000 description 1
- 235000011962 puddings Nutrition 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 235000019685 rice crackers Nutrition 0.000 description 1
- 235000014438 salad dressings Nutrition 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 235000011890 sandwich Nutrition 0.000 description 1
- 235000015067 sauces Nutrition 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
- 235000003513 sheep sorrel Nutrition 0.000 description 1
- 235000012046 side dish Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 235000013547 stew Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Abstract
Description
本発明は、植物エキスを有効成分として含有する新規なメイラード反応阻害剤に関する。 The present invention relates to a novel Maillard reaction inhibitor containing a plant extract as an active ingredient.
メイラード反応は、還元糖のカルボニル基と蛋白質又はアミノ酸のアミノ基が非酵素的に縮合する反応で、シッフ塩基を経由して、アマドリ転移産物を生成する前期反応と、その後、アマドリ転移産物が分解され、さらに脱水、酸化、縮合、転移等の過程を経て、終末糖化産物群（ＡＧＥ）へと変化する後期反応とに分けられる。食品の加工、貯蔵の際に起こる褐変反応として食品科学の分野では古くからよく知られる現象である。 The Maillard reaction is a non-enzymatic condensation of the carbonyl group of a reducing sugar and the amino group of a protein or amino acid, and a pre-reaction that produces an Amadori transfer product via a Schiff base, followed by decomposition of the Amadori transfer product. And further undergoes processes such as dehydration, oxidation, condensation, transfer, and the like, and is divided into a late-stage reaction that changes into a group of advanced glycation end products (AGE). This phenomenon has long been well known in the field of food science as a browning reaction that occurs during processing and storage of food.
この反応は生体内でも起こっており、ＡＧＥが加齢に依存して種々の生体組織に蓄積すること、また、糖尿病合併症、アルツハイマーや動脈硬化などの加齢関連疾患で、ＡＧＥの蓄積が有意に増加していることが報告されている。さらに、メイラード反応は、加齢に伴って生じる白内障や軟骨の弾力低下、皮膚の老化の原因となり、特に常時高血糖状態である糖尿病患者においてその進行が早いことが報告されている。 This reaction also occurs in vivo, and AGE accumulates in various living tissues depending on aging, and AGE accumulation is significant in age-related diseases such as diabetic complications, Alzheimer's disease and arteriosclerosis. It has been reported to be increasing. Furthermore, it has been reported that the Maillard reaction causes cataract, decreased elasticity of cartilage, and aging of the skin that occur with age, and that the progression thereof is particularly rapid in diabetic patients who are constantly in a hyperglycemic state.
このため、メイラード反応を阻害する物質は、生体内の様々な加齢関連疾患の抑制や糖尿病合併症を抑制し得ると考えられ、そのような物質を求めて種々の研究がされている。 Therefore, substances that inhibit the Maillard reaction are considered to be able to suppress various age-related diseases in vivo and diabetic complications, and various studies have been conducted in search of such substances.
例えば、アミノグアニジンは強力なメイラード反応阻害剤として知られている（例えば、特許文献１参照）。一方でこの化合物は強い副作用を有することが知られている。また、メイラード反応阻害作用を有する植物素材がいくつか知られているが、十分満足のいく効果は得られていない（例えば、特許文献２および特許文献３参照）。 For example, aminoguanidine is known as a potent Maillard reaction inhibitor (see, for example, Patent Document 1). On the other hand, this compound is known to have strong side effects. Further, some plant materials having a Maillard reaction inhibitory action are known, but a sufficiently satisfactory effect has not been obtained (see, for example, Patent Documents 2 and 3).
平均寿命の延びや少子高齢化の進行に伴い、健康を維持しつつ長生きするために、抗加齢いわゆるアンチエイジングへの関心が高まっている中、優れたアンチエイジング効果を有し、かつ安全性の高い機能性食品や化粧品素材等の開発が切望されている。 With increasing life expectancy and declining birthrate and aging population, there is increasing interest in anti-aging, so-called anti-aging, in order to maintain longevity while maintaining good health. Development of highly functional foods and cosmetic materials is highly desired.
本発明は、植物エキスを有効成分として含有する新規なメイラード反応阻害剤を提供することを主な目的とする。また、本発明は、当該メイラード反応阻害剤を含有する経口剤、外用剤および飲食品を提供する。 The main object of the present invention is to provide a novel Maillard reaction inhibitor containing a plant extract as an active ingredient. The present invention also provides an oral preparation, an external preparation, and a food or drink containing the Maillard reaction inhibitor.
本発明者らは、上記課題を解決すべく鋭意検討した結果、特定の植物エキスが優れたメイラード反応阻害作用を有することを見出し、本発明を完成した。 As a result of intensive studies to solve the above problems, the present inventors have found that a specific plant extract has an excellent Maillard reaction inhibitory action, and completed the present invention.
本発明として、例えば下記のものを挙げることができる。
（１）ピンポンノキ属（Ｓｔｅｒｃｕｌｉａ）に属する植物、チャンチンモドキ属（Ｃｈｏｅｒｏｓｐｏｎｄｉａｓ）に属する植物、マンゴー属（Ｍａｎｇｉｆｅｒａ）に属する植物、ウルシ属（Ｒｈｕｓ）に属する植物、フクギ属（Ｇａｒｃｉｎｉａ）に属する植物、クロモジ属（Ｌｉｎｄｅｒａ）に属する植物、イヌタデ属（Ｐｅｒｓｉｃａｒｉａ）に属する植物、ギシギシ属（Ｒｕｍｅｘ）に属する植物、ミズヒキ属（Ａｎｔｅｎｏｒｏｎ）に属する植物、アブラギリ属（Ａｌｅｕｒｉｔｅｓ）に属する植物、アカシア属（Ａｃａｃｉａ）に属する植物、ヒシ属（Ｔｒａｐａ）に属する植物、エウゲニア属（Ｅｕｇｅｎｉａ）に属する植物、ナツフジ属（Ｍｉｌｌｅｔｔｉａ）に属する植物、ミズキ属（Ｃｏｒｎｕｓ）に属する植物、ビンロウ属（Ａｒｅｃａ）に属する植物、ヤマモモ属（Ｍｙｒｉｃａ）に属する植物からなる植物群から選択される１種又は２種以上の植物のエキスを有効成分として含有するメイラード反応阻害剤（以下、「本発明阻害剤」という）。
（２）上記（１）のメイラード反応阻害剤を含有する経口剤（以下、「本発明経口剤」という）。
（３）上記（１）のメイラード反応阻害剤を含有する飲食品（以下、「本発明飲食品」という）。
（４）上記（１）のメイラード反応阻害剤を含有する外用剤（以下、「本発明外用剤」という）。
（５）上記（１）のメイラード反応阻害剤を含有する老化抑制用組成物（以下、「本発明組成物」という）。
（６）上記（１）のメイラード反応阻害剤を含有する、糖尿病合併症の予防又は治療用組成物。
Examples of the present invention include the following.
(1) Plants belonging to the genus Pterponsia (Sterculia), plants belonging to the genus Choerospondias, plants belonging to the genus Mangofer, plants belonging to the genus Rhus, plants belonging to the genus Garcinia; To plants belonging to the genus (Lindera), plants belonging to the genus Persicaria, plants belonging to the genus Rumex, plants belonging to the genus Antenoron, plants belonging to the genus Aleurites, genus Acacia Plants belonging to the genus (Trapa), plants belonging to the genus Eugenia, plants belonging to the genus Milletia, plants belonging to the genus Cornus, plants belonging to the genus Areca, genus Prunus A Maillard reaction inhibitor (hereinafter referred to as "inhibitor of the present invention") containing, as an active ingredient, an extract of one or more plants selected from the group of plants consisting of plants belonging to (Myrica).
(2) An oral preparation containing the Maillard reaction inhibitor of the above (1) (hereinafter referred to as "the oral preparation of the present invention").
(3) A food or drink containing the Maillard reaction inhibitor of the above (1) (hereinafter referred to as "the food or drink of the present invention").
(4) An external preparation containing the Maillard reaction inhibitor of the above (1) (hereinafter referred to as "the external preparation of the present invention").
(5) A composition for suppressing aging containing the Maillard reaction inhibitor of the above (1) (hereinafter, referred to as "the composition of the present invention").
(6) A composition for preventing or treating diabetic complications, comprising the Maillard reaction inhibitor according to (1) above.
本発明阻害剤は、優れたメイラード反応阻害作用を有し、老化に伴って生じる現象、例えば、白内障、軟骨の弾力低下、皮膚の老化（皮膚の弾力低下、しわやたるみの原因となるコラーゲンの架橋形成、肌のくすみの原因となる色素沈着等）の抑制に有用である。また、本発明阻害剤は、食経験があり、副作用が少ない植物のエキスを有効成分として含有し、安全性が高いものである。 The inhibitor of the present invention has an excellent Maillard reaction inhibitory action, and a phenomenon that occurs with aging, for example, cataract, decreased elasticity of cartilage, aging of skin (decreased elasticity of skin, reduction of wrinkles and sagging collagen) It is useful for suppressing cross-linking and pigmentation that causes dull skin. In addition, the inhibitor of the present invention is highly safe because it contains an extract of a plant that has been eaten and has few side effects as an active ingredient.
また、本発明阻害剤は、メイラード反応が関与することが知られている糖尿病合併症の予防又は治療用組成物として用いることもできる。 The inhibitor of the present invention can also be used as a composition for preventing or treating diabetic complications known to be involved in the Maillard reaction.
植物エキス
本発明に係る植物エキスは、ピンポンノキ属（Ｓｔｅｒｃｕｌｉａ）に属する植物、チャンチンモドキ属（Ｃｈｏｅｒｏｓｐｏｎｄｉａｓ）に属する植物、マンゴー属（Ｍａｎｇｉｆｅｒａ）に属する植物、ウルシ属（Ｒｈｕｓ）に属する植物、フクギ属（Ｇａｒｃｉｎｉａ）に属する植物、クロモジ属（Ｌｉｎｄｅｒａ）に属する植物、イヌタデ属（Ｐｅｒｓｉｃａｒｉａ）に属する植物、ギシギシ属（Ｒｕｍｅｘ）に属する植物、ミズヒキ属（Ａｎｔｅｎｏｒｏｎ）に属する植物、アブラギリ属（Ａｌｅｕｒｉｔｅｓ）に属する植物、アカシア属（Ａｃａｃｉａ）に属する植物、ヒシ属（Ｔｒａｐａ）に属する植物、エウゲニア属（Ｅｕｇｅｎｉａ）に属する植物、ナツフジ属（Ｍｉｌｌｅｔｔｉａ）に属する植物、ミズキ属（Ｃｏｒｎｕｓ）に属する植物、ビンロウ属（Ａｒｅｃａ）に属する植物、ヤマモモ属（Ｍｙｒｉｃａ）に属する植物からなる植物群から選択される植物からの抽出エキスである。
Plant Extract The plant extract according to the present invention includes a plant belonging to the genus Pterponsia (Sterculia), a plant belonging to the genus Choerospondias, a plant belonging to the genus Mango (Mangifera), a plant belonging to the genus Rhus, and a genus Aster ( Plants belonging to Garcinia, plants belonging to the genus Lindera, plants belonging to the genus Persicaria, plants belonging to the genus Rumex, plants belonging to the genus Antenoron, plants belonging to the genus Aleurites. , Plants belonging to genus Acacia, plants belonging to genus Trapa, plants belonging to genus Eugenia, plants belonging to genus Milletia, plants belonging to genus Cornus, genus Areca ), a plant selected from the group consisting of plants belonging to the genus Myrica (Myrica).
本発明に係るピンポンノキ属（Ｓｔｅｒｃｕｌｉａ）に属する植物としては、特に限定されないが、例えば、ヤツデアオギリ（Ｓｔｅｒｃｕｌｉａ ｆｏｅｔｉｄａ Ｌ．）、ピンポンノキ（Ｓｔｅｒｃｕｌｉａ ｎｏｂｉｌｉｓ Ｓｍｉｔｈ）、ハンタイカイ（Ｓｔｅｒｃｕｌｉａ ｓｃａｐｈｉｇｅｒａ Ｗａｌｌ．）を挙げることができ、中でもヤツデアオギリ（Ｓｔｅｒｃｕｌｉａ ｆｏｅｔｉｄａ Ｌ．）が好ましい。 The plant belonging to the genus Pterponcia (Sterculia) according to the present invention is not particularly limited, and examples thereof include, but are not limited to, St. Among them, Yatsudeaogiri (Sterculia foetida L.) is preferable.
本発明に係るチャンチンモドキ属（Ｃｈｏｅｒｏｓｐｏｎｄｉａｓ）に属する植物としては、特に限定されないが、例えば、チャンチンモドキ（Ｃｈｏｅｒｏｓｐｏｎｄｉａｓ ａｘｉｌｌａｒｉｓ （Ｒｏｘｂ．） Ｂｕｒｔｔ ｅｔ Ｈｉｌｌ）が好ましい。 The plant belonging to the genus Choerospondias according to the present invention is not particularly limited, but, for example, Chanchospodias axillaris (Roxb.) Burtt et Hill) is preferable.
本発明に係るマンゴー属（Ｍａｎｇｉｆｅｒａ）に属する植物としては、特に限定されないが、例えば、マンゴー（Ｍａｎｇｉｆｅｒａ ｉｎｄｉｃａ Ｌ．）、ニオイマンゴー（Ｍａｎｇｉｆｅｒａ ｏｄｏｒａｔａ Ｇｒｉｆｆ．）、ビンジャイマンゴー（Ｍａｎｇｉｆｅｒａ ｃａｅｓｉａ Ｊａｃｋ．）、ウママンゴー（Ｍａｎｇｉｆｅｒａ ｆｏｅｔｉｄａ Ｌｏｕｒ．）を挙げることができ、中でもマンゴー（Ｍａｎｇｉｆｅｒａ ｉｎｄｉｃａ Ｌ．）が好ましい。 The plant belonging to the genus Mangifera according to the present invention is not particularly limited, but examples thereof include mango (Mangifera indica L.), odorant mango (Mangifera odorata Griff.), binjai mango (Mangifera caca. Mengo (Mangifera foetida Lour.) can be mentioned, and among them, mango (Mangifera indica L.) is preferable.
本発明に係るウルシ属（Ｒｈｕｓ）に属する植物としては、特に限定されないが、例えば、ヌルデ（Ｒｈｕｓ ｊａｖａｎｉｃａ Ｌ．）、ハゼノキ（Ｒｈｕｓ ｓｕｃｃｅｄａｎｅａ Ｌ．）、ナンヨウハゼノキ（Ｒｈｕｓｔａｉｔｅｎｓｉｓ Ｇｕｉｌｌ．）、ウルシ（Ｒｈｕｓ ｖｅｒｎｉｃｉｆｌｕａ Ｓｔｏｋｅｓ）、ヤマウルシ（Ｒｈｕｓ ｔｒｉｃｈｏｃａｒｐａ Ｍｉｑ．）を挙げることができ、中でもヌルデ（Ｒｈｕｓ ｊａｖａｎｉｃａ Ｌ．）が好ましい。 The plant belonging to the genus Rhus according to the present invention is not particularly limited, and examples thereof include Rhus javanica L., Rhus succedanea L., Rhustaitensis Guill., and Rhus lucifer. Stokes) and porcupine (Rhus trichocarpa Miq.), among which Nulde (Rhus javanica L.) is preferable.
本発明に係るフクギ属（Ｇａｒｃｉｎｉａ）に属する植物としては、特に限定されないが、例えば、マンゴスチン（Ｇａｒｃｉｎｉａ ｍａｎｇｏｓｔａｎａ Ｌ．）、ゴラカ（Ｇａｒｃｉｎｉａ ｃａｍｂｏｇｉａ Ｄｅｓｒ．）、ムムンジン（Ｇａｒｃｉｎｉａ ｄｉｏｉｃａ Ｂｌｕｍｅ）、グルグル（Ｇａｒｃｉｎｉａ ａｔｒｏｖｉｒｉｄｉｓ Ｇｒｉｆｆ． ｅｘ Ｔ． Ａｎｄｅｒｓｏｎ）、オオバノマンゴスチン（Ｇａｒｃｉｎｉａ ｄｕｌｃｉｓ （Ｒｏｘｂ．） Ｋｕｒｚ）、インドマンゴスチン（Ｇａｒｃｉｎｉａ ｉｎｄｉｃａ Ｃｈｏｉｓｙ）、フクギ（Ｇａｒｃｉｎｉａ ｓｕｂｅｌｌｉｐｔｉｃａ Ｍｅｒｒ．）、タマゴノキ（Ｇａｒｃｉｎｉａ ｘａｎｔｈｏｃｈｙｍｕｓ Ｈｏｏｋ． ｆ． ｅｘ Ｔ． Ａｎｄｅｒｓ．）を挙げることができ、中でもマンゴスチン（Ｇａｒｃｉｎｉａ ｍａｎｇｏｓｔａｎａ Ｌ．）が好ましい。 The plant belonging to the genus Garcinia according to the present invention is not particularly limited, but examples thereof include mangosteen (Garcinia mangostana L.), goraka (Garcinia cambogia gludia der.), and mumundine (Garcinia glucia diar). Ex T. Anderson), Obana mangosteen (Garcinia dulcis (Roxb. Kurz), Indian mangosteen (Garcinia indica Choisy) A. guinea chrysanthemum (Garcinia subelliptica) G. Among them, mangosteen (Garcinia mangostana L.) is preferable.
本発明に係るクロモジ属（Ｌｉｎｄｅｒａ）に属する植物としては、特に限定されないが、例えば、クロモジ（Ｌｉｎｄｅｒａ ｕｍｂｅｌｌａｔａ Ｔｈｕｎｂ．）、アメリカクロモジ（Ｌｉｎｄｅｒａ ｂｅｎｚｏｉｎ （Ｌ．）Ｂｌｕｍｅ）、テンダイウヤク（Ｌｉｎｄｅｒａ ｓｔｒｙｃｈｎｉｆｏｌｉａ （Ｓｉｅｂ． ｅｔ Ｚｕｃｃ．） Ｆ． Ｖｉｌｌ．）、ヤマコウバシ（Ｌｉｎｄｅｒａ ｇｌａｕｃａ Ｂｌｕｍｅ）、ダンコウバイ（Ｌｉｎｄｅｒａ ｏｂｔｕｓｉｌｏｂａ Ｂｌｕｍｅ）、シロモジ（Ｌｉｎｄｅｒａ ｔｒｉｌｏｂａ （Ｓｉｅｂ．ｅｔ Ｚｕｃｃ．）Ｂｌｕｍｅ）を挙げることができ、中でもクロモジ（Ｌｉｎｄｅｒａ ｕｍｂｅｌｌａｔａ Ｔｈｕｎｂ．）が好ましい。 The plant belonging to the genus Lindera according to the present invention is not particularly limited, but examples thereof include Lindera umbellata Thunb., American black locust (Lindera benzoin (L.) Blume), and Linda strychnif. Zucc.) F. Vill.), Yamabushi (Lindera glauca Blume), Dankobai (Lindera obtusiloba Blume), Shiromoji (Lindera tribala moth) (Sieb. et Zunda moth) can be mentioned. Is preferred.
本発明に係るイヌタデ属（Ｐｅｒｓｉｃａｒｉａ）に属する植物としては、特に限定されないが、例えば、アイ（Ｐｅｒｓｉｃａｒｉａ ｔｉｎｃｔｏｒｉａ （Ｌｏｕｒ．） Ｈ． Ｇｒｏｓｓ）、ヤナギタデ（Ｐｅｒｓｉｃａｒｉａ ｈｙｄｒｏｐｉｐｅｒ （Ｌ．） Ｓｐａｃｈ）、オオイヌタデ（Ｐｅｒｓｉｃａｒｉａ ｌａｐａｔｈｉｆｏｌｉａ （Ｌ．） Ｓ． Ｆ． Ｇｒａｙ）、オオケタデ（Ｐｅｒｓｉｃａｒｉａ ｏｒｉｅｎｔａｌｉｓ （Ｌ．） Ａｓｓｅｎｏｖ）、ツルソバ（Ｐｅｒｓｉｃａｒｉａ ｃｈｉｎｅｎｓｉｓ （Ｌ．） Ｎａｋａｉ）、ミゾソバ（Ｐｅｒｓｉｃａｒｉａ ｔｈｕｎｂｅｒｇｉｉ （Ｓｉｅｂ． ｅｔ Ｚｕｃｃ．） Ｈ． Ｇｒｏｓｓ）を挙げることができ、中でもアイ（Ｐｅｒｓｉｃａｒｉａ ｔｉｎｃｔｏｒｉａ （Ｌｏｕｒ．） Ｈ． Ｇｒｏｓｓ）が好ましい。 The plant belonging to the genus Persicaria according to the present invention is not particularly limited, and examples thereof include eye (Persicaria tinctoria (Lour.) H. Gross), willow tree (Persicaria hydropiper (L.) spatia (P.) sapach), and O. (L.) SF Gray, Persimmonia orientalis (L.) Assenov, Persicaria chinensis (L.) Nakai, and Persicaria thunberge.. Persicaria thunbergi. Among them, eye (Persicaria tinctoria (Lour.) H. Gross) is preferable.
本発明に係るギシギシ属（Ｒｕｍｅｘ）に属する植物としては、特に限定されないが、例えば、キブネダイオウ（Ｒｕｍｅｘ ｎｅｐａｌｅｎｓｉｓ Ｓｐｒｅｎｇ．）、スイバ（Ｒｕｍｅｘ ａｃｅｔｏｓａ Ｌ．）、ヒメスイバ（Ｒｕｍｅｘ ａｃｅｔｏｓｅｌｌａ Ｌ．）、ギシギシ（Ｒｕｍｅｘ ｊａｐｏｎｉｃｕｓ Ｈｏｕｔｔ．）、ナガバギシギシ（Ｒｕｍｅｘ ｃｒｉｓｐｕｓ Ｌ．）を挙げることができ、中でもキブネダイオウ（Ｒｕｍｅｘ ｎｅｐａｌｅｎｓｉｓ Ｓｐｒｅｎｇ．）が好ましい。 The plant belonging to the genus Rumex according to the present invention is not particularly limited, but examples thereof include Rumex nepalensis Spreng., Sorrel (Rumex acetosa L.), Rumex acetosella Lp. Houtt.) and Rumex crispus L.), and among them, Rumex nepalensis Spreng.) is preferable.
本発明に係るミズヒキ属（Ａｎｔｅｎｏｒｏｎ）に属する植物としては、特に限定されないが、例えば、ミズヒキ（Ａｎｔｅｎｏｒｏｎ ｆｉｌｉｆｏｒｍｅ （Ｔｈｕｎｂ．） Ｒｏｂｅｒｔｙ ｅｔ Ｖａｕｔｉｅｒ）、シンミズヒキ（Ａｎｔｅｎｏｒｏｎ ｎｅｏｆｉｌｉｆｏｒｍｅ （Ｎａｋａｉ） Ｈａｒａ）を挙げることができ、中でもミズヒキ（Ａｎｔｅｎｏｒｏｎ ｆｉｌｉｆｏｒｍｅ （Ｔｈｕｎｂ．） Ｒｏｂｅｒｔｙ ｅｔ Ｖａｕｔｉｅｒ）が好ましい。 Examples of plants belonging to the genus Antenoron according to the present invention include, but are not limited to, citrus albacore (Antenoron filiforme (Thunb.) Roberty et Vautier) and cinnamon cypress (Antenoron neofiliforme (Nakai)). Of these, Mizunohiki (Antenoron filiform (Thunb.) Roberty et Vautier) is preferable.
本発明に係るアブラギリ属（Ａｌｅｕｒｉｔｅｓ）に属する植物としては、特に限定されないが、例えば、ククイノキ（Ａｌｅｕｒｉｔｅｓ ｍｏｌｕｃｃａｎａ （Ｌ．） Ｗｉｌｌｄ．）、アブラギリ（Ａｌｅｕｒｉｔｅｓ ｃｏｒｄａｔａ （Ｔｈｕｎｂ） Ｒ．Ｂｒ． ｅｘ Ｓｔｅｕｄ．）、シナアブラギリ（Ａｌｅｕｒｉｔｅｓ ｆｏｒｄｉｉ Ｈｅｍｓｌ．）、カントンアブラギリ（Ａｌｅｕｒｉｔｅｓ ｍｏｎｔａｎａ （Ｌｏｕｒ．） Ｗｉｌｓ．）を挙げることができ、中でもククイノキ（Ａｌｅｕｒｉｔｅｓ ｍｏｌｕｃｃａｎａ （Ｌ．） Ｗｉｌｌｄ．）が好ましい。 The plant belonging to the genus Aleurites according to the present invention is not particularly limited, and examples thereof include, for example, Kukuoki (Aleurites moluccana (L.) Wild.), Abragitiri (Aleurites cordata (Thunb) R. Br. ex Steed.), There can be mentioned Chinese abragiri (Aleurites fordii Hemsl.) and canton abragili (Aleurites montana (Lour.) Wils.), and among them, Kukuinooki (Aleurites moluccana (L.) Wild.) is preferable.
本発明に係るアカシア属（Ａｃａｃｉａ）に属する植物としては、特に限定されないが、例えば、アセンヤクノキ（Ａｃａｃｉａ ｃａｔｅｃｈｕ Ｗｉｌｌｄ．）、リウコフロエアアカシア（Ａｃａｃｉａ ｌｅｕｃｏｐｈｌｏｅａ Ｗｉｌｌｄ．）、ミモサアカシア（Ａｃａｃｉａ ｄｅｃｕｒｒｅｎｓ Ｗｉｌｌｄ．）、モリシマアカシア（Ａｃａｃｉａ ｍｅａｒｎｓｉｉ Ｄｅ Ｗｉｌｄ．）、アラビアゴムノキ（Ａｃａｃｉａ ｓｅｎｅｇａｌ （Ｌ．） Ｗｉｌｌｄ．）を挙げることができ、中でもアセンヤクノキ（Ａｃａｃｉａ ｃａｔｅｃｈｕ Ｗｉｌｌｄ．）、リウコフロエアアカシア（Ａｃａｃｉａ ｌｅｕｃｏｐｈｌｏｅａ Ｗｉｌｌｄ．）が好ましい。 The plant belonging to the genus Acacia according to the present invention is not particularly limited, but examples thereof include Acacia catechu Wild., Acacia leucophloea Wild., and Mimosa Acacia dec. , Acacia marnsii De Wild., and Gum acacia (Acacia senegal (L.) Willd.), and among them, Acacia catechu Willd. and Riuco floea acacia. preferable.
本発明に係るヒシ属（Ｔｒａｐａ）に属する植物としては、特に限定されないが、例えば、ツノナシビシ（Ｔｒａｐａ ａｃｏｒｎｉｓ Ｎａｋａｎｏ）、ヒメビシ（Ｔｒａｐａ ｉｎｃｉｓａ Ｓｉｅｂ. ｅｔ Ｚｕｃ.）、ヒシ（Ｔｒａｐａ ｊａｐｏｎｉｃａ Ｆｌｅｒｏｖ）、トウビシ（Ｔｒａｐａ ｂｉｓｐｉｎｏｓａ Ｒｏｘｂ．）、トラパ・ナタンス（Ｔｒａｐａ ｎａｔａｎｓ Ｌ．）、オニビシ（Ｔｒａｐａ ｎａｔａｎｓ Ｌ．ｖａｒ．ｊａｐｏｎｉｃａ Ｎａｋａｉ ）を挙げることができ、中でもヒシ（Ｔｒａｐａ ｊａｐｏｎｉｃａ Ｆｌｅｒｏｖ）、トウビシ（Ｔｒａｐａ ｂｉｓｐｉｎｏｓａ Ｒｏｘｂ．）、オニビシ（Ｔｒａｐａ ｎａｔａｎｓ Ｌ．ｖａｒ．ｊａｐｏｎｉｃａ Ｎａｋａｉ ）が好ましい。 The plant belonging to the genus (Trapa) according to the present invention is not particularly limited, and examples thereof include Trapa aconis Nakano, Trapa incisa Sieb. et Zuc., Trapa japonica Trova, Levi. bispinosa Roxb.), Trapa natans L., and Onibishi (Trapa natans L. var. japonica Nakai). Among them, Trapa japonica flesh (Trapa japonica flesh), Trapa japonica fleb. Trapa natans L. var. japonica Nakai) is preferred.
本発明に係るエウゲニア属（Ｅｕｇｅｎｉａ）に属する植物としては、特に限定されないが、例えば、ピタンガ（Ｅｕｇｅｎｉａ ｕｎｉｆｌｏｒａ Ｌ．）、タイワンアデク（Ｅｕｇｅｎｉａ ｆｏｒｍｏｓａｎａ Ｈａｙａｔａ），セイロンアデク（Ｅｕｇｅｎｉａ ｓｐｉｃａｔａ Ｌａｍ．）を挙げることができ、中でもピタンガ（Ｅｕｇｅｎｉａ ｕｎｉｆｌｏｒａ Ｌ．）が好ましい。 The plant belonging to the genus Eugenia according to the present invention is not particularly limited, but examples thereof include Pitanga (Eugenia uniflora L.), Taiwan Adekku (Eugenia formosana Hayata), and Ceylon Adekaku (Eugenia spicata). Of these, pitanga (Eugenia uniflora L.) is preferable.
本発明に係るナツフジ属（Ｍｉｌｌｅｔｔｉａ）に属する植物としては、特に限定されないが、例えば、ムラサキナツフジ（Ｍｉｌｌｅｔｔｉａ ｒｅｔｉｃｕｌａｔａ Ｂｅｎｔｈ．）、ミレッティア・ニティダ（Ｍｉｌｌｅｔｔｉａ ｎｉｔｉｄａ Ｂｅｎｔｈ．）を挙げることができ、中でもムラサキナツフジ（Ｍｉｌｌｅｔｔｉａ ｒｅｔｉｃｕｌａｔａ Ｂｅｎｔｈ．）が好ましい。 The plant belonging to the genus Milletia according to the present invention is not particularly limited, and examples thereof include purple azalea (Millettia reticulata Benth.) and Milletia nitida Benth. Fuji (Millettia reticulata Benth.) is preferred.
本発明に係るミズキ属（Ｃｏｒｎｕｓ）に属する植物としては、特に限定されないが、例えば、サンシュユ（Ｃｏｒｎｕｓ ｏｆｆｉｃｉｎａｌｉｓ Ｓｉｅｂ． ｅｔ Ｚｕｃｃ．）、セイヨウサンシュユ（Ｃｏｒｎｕｓ ｍａｓ Ｌ．）、ヤマボウシ（Ｃｏｒｎｕｓｋｏｕｓａ Ｂｕｅｒｇ． ｅｘ Ｈａｎｃｅ）、ミズキ（Ｃｏｒｎｕｓｃｏｎｔｒｏｖｅｒｓａ Ｈｅｍｓｌ．）を挙げることができ、中でもサンシュユ（Ｃｏｒｎｕｓ ｏｆｆｉｃｉｎａｌｉｓ Ｓｉｅｂ． ｅｔ Ｚｕｃｃ．）が好ましい。 The plant belonging to the genus Cornus according to the present invention is not particularly limited, but examples thereof include Sanshuyu (Cornus officinalis Sieb. et Zuccc.), Cornus masyu (Cornus mas L.), Cornus kousa burg. , Cornus (Cornus controversa Hemsl.), among which Sanshuyu (Cornus officinalis Sieb. et Zuccc.) is preferable.
本発明に係るビンロウ属（Ａｒｅｃａ）に属する植物としては、特に限定されないが、例えば、ビンロウジュ（Ａｒｅｃａ ｃａｔｅｃｈｕ Ｌ．）が好ましい。 The plant belonging to the genus Areca (Areca) according to the present invention is not particularly limited, but for example, areca catechu L. is preferred.
本発明に係るヤマモモ属（Ｍｙｒｉｃａ）に属する植物としては、特に限定されないが、例えば、シロコヤマモモ（Ｍｙｒｉｃａ ｃｅｒｉｆｅｒａ Ｌ．）、ヤマモモ（Ｍｙｒｉｃａ ｒｕｂｒａ Ｓｉｅｂ． ｅｔ Ｚｕｃｃ．）、カロライナヤマモモ（Ｍｙｒｉｃａ ｃａｒｏｌｉｎｅｎｓｉｓ Ｍｉｌｌ．）を挙げることができ、中でもシロコヤマモモ（Ｍｙｒｉｃａ ｃｅｒｉｆｅｒａ Ｌ．）が好ましい。 The plant belonging to the genus Myrica (Myrica) according to the present invention is not particularly limited, but for example, white bayberry (Myrica cerifera L.), bayberry (Myrica rubra Sieb. et Zucc.), carolina bayberry is cis (Mariric). Among them, Shiroko bayberry (Myrica cerifera L.) is preferable.
上記の植物の中で、ヤツデアオギリ、チャンチンモドキ、マンゴー、ヌルデ、マンゴスチン、クロモジ、アイ、キブネダイオウ、ミズヒキ、ククイノキ、アセンヤクノキ、リウコフロエアアカシア、ヒシ、ピタンガ、ムラサキナツフジ、サンシュユ、ビンロウジュ、シロコヤマモモからなる植物群から選ばれる植物からの抽出エキスが特に好ましい。
植物エキスの製造方法
本発明に係る植物エキスの製造には、上記植物の各部位、例えば、花、花穂、果皮、果実、果肉、茎、葉、枝、枝葉、幹、樹皮、根茎、根皮、根、種子、虫えい、心材、地上部、地下部又は全草を用いることができる。
Among the above-mentioned plants, yatudeaogiri, chanchinoki, mango, nurude, mangosteen, kuromoji, ai, kibunedaiou, mizuhiki, kukuinoki, acacia cypress, ryukofuroea acacia, hishi, pitanga, murasakinathuji, sanshyu, areca, shiroko Extracted extracts from plants selected from the group consisting of bayberry are particularly preferred.
Method for producing plant extract For producing the plant extract according to the present invention, each part of the above plant, for example, flower, spike, pericarp, fruit, pulp, stem, leaf, branch, branch, stem, bark, Rhizome, root bark, roots, seeds, insects, heartwood, aboveground parts, belowground parts or whole plants can be used.
本発明に係る植物エキスの製造方法は、特に限定されず、例えば、通常用いられる方法により製造することができる。具体的には、植物の各部位をそのまま又は適当な大きさに切断し、搾汁又は溶媒で抽出することにより製造することができる。抽出溶媒としては、例えば、水、各種有機溶媒、あるいはそれらの混合溶媒を用いることができる。抽出のための有機溶媒としては、例えば、低級アルコール（例えば、メタノール、エタノール）、クロロホルム、酢酸エチル、ｎ−ヘキサンを挙げることができる。抽出溶媒の中で、特に水、メタノール、エタノールが好ましい。また、これらの溶媒を一種又は二種以上混合して用いることもできる。 The method for producing the plant extract according to the present invention is not particularly limited, and for example, it can be produced by a commonly used method. Specifically, it can be produced by cutting each part of the plant as it is or cutting it into an appropriate size and extracting it with juice or a solvent. As the extraction solvent, for example, water, various organic solvents, or a mixed solvent thereof can be used. Examples of the organic solvent for extraction include lower alcohols (eg, methanol, ethanol), chloroform, ethyl acetate, n-hexane. Among the extraction solvents, water, methanol and ethanol are particularly preferable. Further, these solvents may be used alone or in combination of two or more.
抽出溶媒の使用量は、用いる植物原料や抽出溶媒等により異なるが、重量比で、１：２〜１：３０（植物原料：抽出溶媒）の範囲内が適当であり、１：３〜１：２０の範囲内が好ましく、１：５〜１：１０の範囲内がより好ましい。抽出時間は、1時間〜１５日の範囲内が適当である。抽出温度は、５〜１００℃の範囲内が適当である。抽出方法については特に制限されず、バッチ抽出、カラムを用いた連続抽出等、任意の方法を適用することができる。 The amount of the extraction solvent used varies depending on the plant raw material used, the extraction solvent, etc., but the weight ratio is preferably within the range of 1:2 to 1:30 (plant raw material: extraction solvent), and 1:3 to 1:1. The range of 20 is preferable, and the range of 1:5 to 1:10 is more preferable. The extraction time is appropriately within the range of 1 hour to 15 days. The extraction temperature is appropriately in the range of 5 to 100°C. The extraction method is not particularly limited, and any method such as batch extraction or continuous extraction using a column can be applied.
得られた植物エキスは、そのままの状態で用いることもできるが、必要に応じ、その活性に影響のない範囲内で更に精製処理を加えてもよい。このような精製処理は、通常の方法によって行えばよく、例えば、植物エキスを常法によりろ過することにより行うことができる。その後、得られたろ液を減圧濃縮、凍結乾燥して、本発明に係る植物エキスとすることができる。
本発明阻害剤、本発明組成物
本発明阻害剤は、上記のようにして得られた植物エキスを1種又は2種以上含有するものである。本発明阻害剤は、例えば、上記のようにして得られた植物エキスを、そのまま又は担体として使用することのできる素材と混合し、次いで、常法により粉末状、塊状、液状などの各種形態に加工することにより製造することができる。
The obtained plant extract can be used as it is, but may be further purified if necessary within a range that does not affect its activity. Such a purification treatment may be carried out by an ordinary method, for example, by filtering the plant extract by an ordinary method. Then, the obtained filtrate can be concentrated under reduced pressure and freeze-dried to obtain the plant extract according to the present invention.
Inhibitor of the present invention, composition of the present invention The inhibitor of the present invention contains one kind or two or more kinds of the plant extract obtained as described above. The inhibitor of the present invention is, for example, a plant extract obtained as described above, mixed with a material that can be used as it is or as a carrier, and then, in various forms such as a powder, a lump, and a liquid by a conventional method. It can be manufactured by processing.
本発明組成物は、本発明阻害剤を含有するものである。本発明組成物は、例えば、本発明阻害剤をそのまま用いることもできるし、又は、本発明阻害剤と、担体として使用することのできる素材とを混合し、次いで、常法により粉末状、塊状、液状などの各種形態に加工することにより製造することができる。 The composition of the present invention contains the inhibitor of the present invention. In the composition of the present invention, for example, the inhibitor of the present invention can be used as it is, or the inhibitor of the present invention can be mixed with a material that can be used as a carrier, and then powdered or lumped by a conventional method. It can be manufactured by processing into various forms such as liquid form.
本発明阻害剤及び本発明組成物には、任意に医薬上又は食品上許容される添加物を配合することができる。かかる添加剤としては、例えば、結合剤、崩壊剤、滑沢剤、分散剤、懸濁剤、乳化剤、緩衝剤、酸化防止剤、賦形剤、界面活性剤、紫外線防止剤、金属イオン封鎖剤、増粘剤、防腐剤、抗菌剤、保湿剤、色素を挙げることができ、これらの１種又は２種以上を適当量使用することができる。 The inhibitor of the present invention and the composition of the present invention may optionally contain pharmaceutically or food-acceptable additives. Examples of such additives include binders, disintegrants, lubricants, dispersants, suspending agents, emulsifiers, buffers, antioxidants, excipients, surfactants, UV inhibitors, sequestering agents. , Thickeners, antiseptics, antibacterial agents, moisturizers, and dyes, and one or more of these can be used in an appropriate amount.
本発明阻害剤及び本発明組成物における植物エキスの配合量は、特に限定されず、０．０１重量％（以下、単に「％」という）以上、好ましくは、０．０５〜５０％である。
本発明阻害剤及び本発明組成物は、常法により、錠剤、散剤、顆粒剤、カプセル剤、液剤、シロップ剤、ドロップ錠、トニック、ローション、軟膏、クリーム等の剤型に適宜調製することができる。
The content of the plant extract in the inhibitor of the present invention and the composition of the present invention is not particularly limited and is 0.01% by weight (hereinafter, simply referred to as “%”) or more, preferably 0.05 to 50%.
The inhibitor of the present invention and the composition of the present invention can be appropriately prepared into a dosage form such as tablets, powders, granules, capsules, solutions, syrups, drops, tonics, lotions, ointments and creams by a conventional method. it can.
本発明阻害剤及び本発明組成物の摂取量は、含有されている植物エキスの種類、剤型、投与対象者の年齢、体重等により異なるが、通常、成人１日当り、植物エキスの重量として、０．１〜１００ｇの範囲内とするのが適当であり、１〜６０ｇの範囲内とするのが好ましいが、必ずしもこの範囲に限られるものではない。かかる１日当りの摂取量は、１回で摂取してもよく、また、２〜４回に分割して摂取してもよい。 The intake amount of the inhibitor of the present invention and the composition of the present invention varies depending on the type of the plant extract contained, the dosage form, the age, weight and the like of the administration subject, but usually, as the weight of the plant extract per adult day, The amount is suitably in the range of 0.1 to 100 g, preferably 1 to 60 g, but not necessarily limited to this range. The daily intake amount may be one time or may be divided into 2 to 4 times and may be ingested.
本発明阻害剤及び本発明組成物は、優れたメイラード反応阻害作用を有するため、老化に伴って生じる現象、例えば、白内障、軟骨の弾力低下、皮膚の老化（皮膚の弾力低下、しわやたるみの原因となるコラーゲンの架橋形成、肌のくすみの原因となる色素沈着等）の抑制に用いることができる。また、本発明阻害剤は、メイラード反応が関与することが知られている、糖尿病合併症（例えば、心筋梗塞、糖尿病性腎症、糖尿病性網膜症、糖尿病性神経症）の予防又は治療に用いることもできる。
経口剤
本発明経口剤は、本発明阻害剤を含有する、経口摂取が可能な組成物を意味する。本発明経口剤は、本発明阻害剤をそのまま又は必要に応じて、経口剤を製造する際に用いられる医薬上又は食品上許容される添加剤とを適量配合したものを、常法により製剤化することにより得ることができる。かかる添加剤としては、賦形剤、充填剤、増量剤、結合剤、崩壊剤、界面活性剤、調味料、香料、滑沢剤等を挙げることができる。
Since the inhibitor of the present invention and the composition of the present invention have an excellent Maillard reaction inhibitory action, a phenomenon that occurs with aging, for example, cataract, a decrease in elasticity of cartilage, aging of skin (a decrease in elasticity of skin, wrinkles and sagging It can be used for suppressing the formation of cross-linkage of collagen, which is a cause, and the pigmentation that causes dullness of skin). Further, the inhibitor of the present invention is used for the prevention or treatment of diabetic complications (for example, myocardial infarction, diabetic nephropathy, diabetic retinopathy, diabetic neuropathy), which are known to involve Maillard reaction. You can also
Oral agent The oral agent of the present invention means a composition containing the inhibitor of the present invention and capable of being taken orally. The oral preparation of the present invention is obtained by formulating an appropriate amount of the inhibitor of the present invention as it is or, if necessary, with a pharmaceutically or food-acceptable additive used in the production of an oral preparation by a conventional method. Can be obtained by Examples of such additives include excipients, fillers, fillers, binders, disintegrants, surfactants, seasonings, fragrances, lubricants and the like.
本発明経口剤の製剤化に際して、他の生理機能を有する素材を配合することもできる。本発明経口剤の剤型は特に限定されず、例えば、錠剤、散剤、顆粒剤、カプセル剤、液剤、シロップ剤、ドロップ剤を挙げることができる。 When formulating the oral preparation of the present invention, other materials having physiological functions can be blended. The dosage form of the oral preparation of the present invention is not particularly limited, and examples thereof include tablets, powders, granules, capsules, solutions, syrups, and drops.
本発明経口剤における本発明阻害剤の含有量としては、含有されている本発明に係る植物エキスの種類、剤型等に合わせて適宜調製すればよいが、例えば、製剤全量中、本発明阻害剤を固形分換算で、０．５〜６０％、好ましくは３〜５０％、特に好ましくは５〜１０％の範囲内で配合すれば良い。 The content of the inhibitor of the present invention in the oral preparation of the present invention may be appropriately adjusted according to the type of the plant extract according to the present invention contained, the dosage form, and the like. The agent may be added in a range of 0.5 to 60%, preferably 3 to 50%, and particularly preferably 5 to 10% in terms of solid content.
本発明経口剤の摂取量は、含有されている本発明に係る植物エキスの種類、剤型、投与対象者の年齢、体重等により異なるが、通常、成人１日当り、本発明に係る植物エキスの重量として、０．１〜１００ｇの範囲内とするのが適当であり、１〜６０ｇの範囲内とするのが好ましいが、必ずしもこの範囲に限られるものではない。かかる１日当りの摂取量は、１回で摂取してもよく、また、２〜４回に分割して摂取してもよい。
外用剤
本発明外用剤は、本発明阻害剤を含有する、外用で使用することが可能な組成物を意味する。
The intake amount of the oral preparation of the present invention varies depending on the type, dosage form, age, body weight, etc. of the contained plant extract according to the present invention, but usually the adult plant extract of the present invention per day The weight is appropriately in the range of 0.1 to 100 g, preferably in the range of 1 to 60 g, but not necessarily limited to this range. The daily intake amount may be one time or may be divided into 2 to 4 times and may be ingested.
External preparation The external preparation of the present invention means a composition containing the inhibitor of the present invention, which can be used externally.
本発明外用剤は、本発明阻害剤をそのまま又は必要に応じて、外用剤を製造する際に用いられる医薬上、化粧上又は食品上許容される添加剤とを適量配合したものを常法により製剤化することにより得ることができる。かかる添加剤としては、軟膏用基材、アルコール、多価アルコール、水溶性高分子、酸化防止剤、ｐH調整剤、紫外線防止剤、金属イオン封鎖剤、増粘剤、界面活性剤、精製水、防腐剤、抗菌剤、油剤、高級脂肪酸、脂肪酸エステル、保湿剤、色素、ビタミン類、アミノ酸類等を挙げることができる。 The external preparation of the present invention, the inhibitor of the present invention as it is or, if necessary, a mixture of an appropriate amount of a pharmaceutically, cosmetically or food-acceptable additive used in the preparation of an external preparation is prepared by a conventional method. It can be obtained by formulating. Examples of such additives include bases for ointments, alcohols, polyhydric alcohols, water-soluble polymers, antioxidants, pH adjusters, UV inhibitors, sequestering agents, thickeners, surfactants, purified water, Preservatives, antibacterial agents, oils, higher fatty acids, fatty acid esters, humectants, pigments, vitamins, amino acids and the like can be mentioned.
さらに、本発明阻害剤を、公知の医薬部外品、化粧品に配合して本発明外用剤として用いることもできる。 Furthermore, the inhibitor of the present invention can be used as the external preparation of the present invention by blending it with known quasi drugs and cosmetics.
本発明外用剤には、本発明阻害剤のほか、老化抑制効果を高めるための成分を更に配合したり、他の生理機能を有する素材を配合することもできる。かかる成分としては、例えば、紫外線防止剤、酸化防止剤、保湿剤、細胞賦活剤、血流促進剤を挙げることができる。これらの1種又は２種以上を適当量使用することができる。 In addition to the inhibitor of the present invention, the external preparation of the present invention can be further blended with a component for enhancing the effect of suppressing aging, or can be blended with another material having a physiological function. Examples of such components include a UV inhibitor, an antioxidant, a moisturizer, a cell activator, and a blood flow promoter. One or more of these can be used in an appropriate amount.
本発明外用剤の具体的な使用態様としては、特に限定されず、例えば、化粧水、乳液、クリーム、軟膏、ローション、オイル、パックを挙げることができる。 A specific use mode of the external preparation of the present invention is not particularly limited, and examples thereof include lotion, emulsion, cream, ointment, lotion, oil, and pack.
本発明外用剤における本発明阻害剤の含有量としては、含有されている本発明に係る植物エキスの種類、剤型等に合わせて適宜調製すればよいが、例えば、製剤全量中、固形分換算で、０．０００１〜３０％、好ましくは０．００１〜２５％、特に好ましくは０．５〜２０％の範囲で配合すればよい。 The content of the inhibitor of the present invention in the external preparation of the present invention may be appropriately adjusted according to the type of the plant extract according to the present invention contained, the dosage form, etc., for example, in the total amount of the preparation, in terms of solid content. Then, it may be added in an amount of 0.0001 to 30%, preferably 0.001 to 25%, and particularly preferably 0.5 to 20%.
本発明外用剤の使用量は、含有されている本発明に係る植物エキスの種類、剤型、投与対象者の年齢、体重等により異なるが、通常、成人１日当り、植物エキスの重量として、０．１〜１００ｇの範囲内とするのが適当であり、１〜６０ｇの範囲内とするのが好ましいが、必ずしもこの範囲に限られるものではない。かかる１日当りの使用量は、１回で使用してもよく、また、２〜４回に分割して使用してもよい。
飲食品
本発明飲食品は、本発明阻害剤と公知の食材又は飲食品とを混合して、常法により、食品に加工することにより得ることができる。
The amount of the external preparation of the present invention to be used varies depending on the type of the plant extract contained in the present invention, the dosage form, the age and weight of the administration subject, etc. It is suitable to be in the range of 1 to 100 g, preferably in the range of 1 to 60 g, but it is not necessarily limited to this range. The amount used per day may be used once, or may be divided into 2 to 4 times and used.
Food and Beverage The food and drink of the present invention can be obtained by mixing the inhibitor of the present invention with a known food material or food and drink and processing it into food by a conventional method.
本発明飲食品の形態は特に限定されず、例えば、粉末状、塊状、液状、シロップ状、ゼリー状を挙げることができる。 The form of the food or drink of the present invention is not particularly limited, and examples thereof include powder, mass, liquid, syrup, and jelly.
本発明飲食品には、食品上許容される他の成分を配合することができる。かかる成分としては、例えば、栄養素、賦形剤、増量剤、甘味料、香味剤、着色剤、防腐剤、乳化剤、可溶化剤、多価アルコール、有機酸、無機酸、水溶性高分子を挙げることができる。これらの1種又は2種以上を適当量使用することができる。 The food or drink of the present invention may be mixed with other food-acceptable components. Examples of such components include nutrients, excipients, bulking agents, sweeteners, flavoring agents, coloring agents, preservatives, emulsifiers, solubilizers, polyhydric alcohols, organic acids, inorganic acids, water-soluble polymers. be able to. One or more of these can be used in an appropriate amount.
本発明飲食品の種類としては、例えば、飲料（清涼飲料、乳飲料、ジュース、茶類等）、粉末飲料（粉末ジュース、粉末スープ等）、練製品（畜肉ソーセージ、魚肉ソーセージ、かまぼこ、竹輪等）、惣菜（オムレツ、卵焼、ハンバーグ、コロッケ、ミーとボール、酢の物、酢豚、サラダ、餃子、しゅうまい、ロールキャベツ、豆腐、筑前煮、煮豆、ひじき煮、唐揚、天ぷら、フライ、茶碗蒸、胡麻和え、サラダ、カレー、シチュー、スープ、チャーハン、おにぎり、餅、ふりかけ、味噌汁等）、麺類（うどん、そうめん、そば、スパゲッティ、マカロニ、ラーメン等）、調理パン（ハンバーガー、ホットドッグ、サンドイッチ等）、パン（食パン、フランスパン等）、菓子（ケーキ、クッキー、ウエハース、クレープ、ヨーグルト、プリン、キャンディー、ガム、アイスクリーム、キャラメル、チョコレート、ドーナツ、せんべい、ようかん、ういろう、もなか、まんじゅう、大福餅、おはぎ、団子、甘納豆、中華まん等）を挙げることができる。この他、マヨネーズ、サラダドレッシング等も挙げることができる。 The types of food and drink of the present invention include, for example, beverages (soft drinks, milk drinks, juices, teas, etc.), powdered drinks (powdered juice, powdered soup, etc.), paste products (live meat sausage, fish sausage, kamaboko, bamboo rings, etc. ), side dish (omelet, omelet, hamburger, croquette, me and balls, vinegared food, vinegared pork, salad, dumplings, shimai, roll cabbage, tofu, boiled chikuzen, boiled beans, hijiki boiled, fried chicken, tempura, fry, chawanmushi, sesame sauce. , Salad, curry, stew, soup, fried rice, rice ball, rice cake, sprinkle, miso soup), noodles (udon, somen, soba, spaghetti, macaroni, ramen, etc.), cooked bread (hamburger, hot dog, sandwich, etc.), bread (Bread, French bread, etc.), confectionery (cake, cookie, wafer, crepe, yogurt, pudding, candy, gum, ice cream, caramel, chocolate, donut, rice cracker, yokan, uiro, monaka, manju, daifuku mochi, ohagi, Examples include dumplings, natto, Chinese buns, etc.). In addition, mayonnaise, salad dressing, etc. can be mentioned.
本発明飲食品への本発明阻害剤の添加量は、添加剤の有無や食品の種類等により異なるが、含有されている本発明に係る植物エキスの固形分換算で０．０１〜５０％の範囲内とするのが適当であり、０．１〜３０％の範囲内とするのが好ましいが、必ずしもこの範囲に限られるものではない。 The amount of the inhibitor of the present invention added to the food or drink of the present invention varies depending on the presence or absence of the additive, the type of food, etc., but is 0.01 to 50% in terms of the solid content of the contained plant extract of the present invention. It is suitable to be within the range, preferably 0.1 to 30%, but not necessarily limited to this range.
本発明飲食品の摂取量は、摂取者の性別、年齢、体重等によって異なる。かかる摂取量は、成人１日当り、本発明に係る植物エキスの重量として、０．１〜１００ｇの範囲内とするのが適当であり、１〜６０ｇの範囲内とするのが好ましいが、必ずしもこの範囲に限られるものではない。かかる１日当りの使用量は、１回で使用してもよく、また、２〜４回に分割して使用してもよい。 The intake amount of the food or drink of the present invention varies depending on the sex, age, weight, etc. of the recipient. Such an amount of intake is appropriately in the range of 0.1 to 100 g, preferably in the range of 1 to 60 g, as the weight of the plant extract according to the present invention per day for an adult, but this is not always necessary. It is not limited to the range. The amount used per day may be used once, or may be divided into 2 to 4 times and used.
以下に参考例、抽出例、試験例、実施例を掲げて本発明をさらに詳述する。但し、本発明が下記実施例に限定されないことは言うまでもない。
参考例１ ケイシエキス（５０％エタノール抽出）の製造
ケイシ粉末（前忠株式会社製）５ｇを５０％エタノール１００mLに浸漬し、常温で５日間静置した後、濃縮、凍結乾燥し、ケイシエキスを得た。
抽出例１ 各植物エキス（メタノール抽出）の製造
表１に記載の番号１〜１９の各植物を風乾後、６０℃で一晩乾燥させた。ブレンダーにて粉砕後、得られた粉砕物 １００ｇをメタノール５００ｍLに浸漬し、常温で一週間静置した。得られた抽出液をろ過して得られたろ液はロータリーエバポレーターでメタノールを留去して乾固し、番号１〜１９の各植物エキスを得た。
Hereinafter, the present invention will be described in more detail with reference to Reference Examples, Extraction Examples, Test Examples, and Examples. However, it goes without saying that the present invention is not limited to the following examples.
Reference Example 1 Production of cabbage extract (50% ethanol extraction) 5 g of cabbage powder (manufactured by Maeda Corporation) was immersed in 100 mL of 50% ethanol, allowed to stand at room temperature for 5 days, then concentrated and freeze-dried to obtain a caustic extract. ..
Extraction Example 1 Production of Plant Extracts (Methanol Extraction) The plants of Nos. 1 to 19 shown in Table 1 were air-dried and then dried at 60° C. overnight. After pulverizing with a blender, 100 g of the obtained pulverized product was immersed in 500 mL of methanol and allowed to stand at room temperature for 1 week. The filtrate obtained by filtering the obtained extract was evaporated to dryness by removing the methanol with a rotary evaporator to obtain each plant extract of Nos. 1 to 19.
試験例１ メイラード反応阻害活性の測定
参考例１、抽出例１で得られた各植物エキスはジメチルスルホキシド（ＤＭＳＯ）に３０ｍｇ／ｍＬとなるように溶解した。なお、参考例１のケイシエキスを陽性対照として用いた。また、陰性対照には、検体の代わりにＤＭＳＯを用いた。
Test Example 1 Measurement of Maillard Reaction Inhibitory Activity Each plant extract obtained in Reference Example 1 and Extraction Example 1 was dissolved in dimethyl sulfoxide (DMSO) at 30 mg/mL. In addition, the caustic extract of Reference Example 1 was used as a positive control. Further, DMSO was used as a negative control instead of the sample.
各検体はＤＭＳＯで、試験溶液中の植物エキスの最終濃度が１０、５、２．５、１．２５、０．６２５μｇ／ｍＬとなるように調製した。各検体２０μＬ、１００ｍＭリン酸バッファー５００μＬ、蒸留水１８０μＬ、２Ｍグルコース溶液１００μＬ、４ｍｇ／ｍＬ ＢＳＡ溶液２００μＬを１．５ｍLマイクロテストチューブ（アズワン社製）に入れて混合し、試験溶液とした。その後、試験溶液及び陰性対照を６０℃下３０時間インキュベートした。 Each sample was prepared with DMSO so that the final concentration of the plant extract in the test solution was 10, 5, 2.5, 1.25, 0.625 μg/mL. 20 μL of each sample, 500 μL of 100 mM phosphate buffer, 180 μL of distilled water, 100 μL of 2M glucose solution, 200 μL of 4 mg/mL BSA solution were placed in a 1.5 mL microtest tube (manufactured by AS ONE) and mixed to prepare a test solution. Then, the test solution and the negative control were incubated at 60°C for 30 hours.
次に、この反応液１ｍＬへトリクロロ酢酸（ＴＣＡ）１００ｍＬを添加し、４℃下、１５０００ｒｐｍで４分間遠心分離した。上清を除去後、残った沈殿物を０．２５Ｎ 水酸化ナトリウム−ＰＢＳ溶液１ｍＬにて溶解した。得られた試験溶液を、蛍光プレートリーダー（インフィニットＭ２００ＦＡＬ、５５２−８２６３１、ＴＥＣＡＮ社製）を用いて、励起波長３６０ｎｍ、蛍光波長４４０ｎｍにて蛍光測定した。 Next, 100 mL of trichloroacetic acid (TCA) was added to 1 mL of this reaction liquid, and the mixture was centrifuged at 15000 rpm for 4 minutes at 4°C. After removing the supernatant, the remaining precipitate was dissolved in 1 mL of a 0.25N sodium hydroxide-PBS solution. The obtained test solution was subjected to fluorescence measurement at an excitation wavelength of 360 nm and a fluorescence wavelength of 440 nm using a fluorescence plate reader (Infinite M200FAL, 552-82631, manufactured by TECAN).
ブランク１として、陰性対照と同組成の溶液であって、インキュベートしていないものを用いた。また、試験溶液と同組成の溶液であって、インキュベートしていないものをブランク２とした。 As blank 1, a solution having the same composition as the negative control but not incubated was used. Further, a solution having the same composition as the test solution and not incubated was designated as blank 2.
メイラード反応阻害活性（％）は、以下の数式に従い算出した。 The Maillard reaction inhibitory activity (%) was calculated according to the following mathematical formula.
横軸に試料の濃度（ｍｇ／ｍＬ）、縦軸にメイラード反応阻害活性（％）をとった対数グラフを作成し、５０％阻害活性を示す濃度（ＩＣ50）を算出した。その結果を表２に示す。 A logarithmic graph in which the horizontal axis represents the sample concentration (mg/mL) and the vertical axis represents the Maillard reaction inhibitory activity (%) was prepared, and the concentration showing 50% inhibitory activity (IC 50 ) was calculated. The results are shown in Table 2.
表２に示したとおり、本発明に係る植物エキスは、強力なメイラード反応阻害作用が報告されているケイシのＩＣ50と同等またはそれ以上の阻害活性を示し、優れたメイラード反応阻害作用を有することが示された。 As shown in Table 2, the plant extract according to the present invention exhibits an inhibitory activity equal to or higher than the IC 50 of Keishi, which has been reported to have a strong inhibitory effect on Maillard reaction, and has an excellent inhibitory effect on Maillard reaction. It has been shown.
抽出例２ アセンヤクノキおよびヌルデの植物エキスの製造
表１および２に記載の番号４（ヌルデ、虫えい）および番号１２（アセンヤクノキ、心材）について、各植物を風乾後、６０℃で一晩乾燥させ、ブレンダーにて粉砕した。得られた粉砕物 ２ｇおよび３０ｍLの各抽出溶媒（９９．５％エタノール、７０％含水エタノールまたは水）を５０ｍL容のスクリューキャップ付試験管に入れて攪拌した後、８０℃で３０分間静置した。得られた抽出液をろ過して得られたろ液はロータリーエバポレーターで濃縮乾固し、表３に記載の番号２０〜２５の各植物エキスを得た。
試験例２ メイラード反応阻害活性の測定
抽出例２で得られた各植物エキスは、試験例１の方法に従って、メイラード反応阻害活性を測定した。ただし、各植物エキスはＤＭＳＯの代わりに各抽出溶媒に溶解し、検体調製には、ＤＭＳＯの代わりに各抽出溶媒を用いた。試料溶液中の植物エキスの最終濃度は１０、５、２、０.２、０.１μｇ／ｍＬとなるよう調製した。また、陽性対照として、アセンヤクノキ（心材）およびヌルデ（虫えい）のメタノール抽出エキスを用い、陰性対照として、検体の代わりに抽出溶媒を用いた。
Extraction Example 2 Production of plant extract of Acacia catechu and Nurude With respect to No. 4 (Nurude, insect gall) and No. 12 (Acacia catechu, heartwood) described in Tables 1 and 2, each plant was air-dried and then dried at 60° C. overnight. It was crushed with a blender. 2 g of the obtained pulverized product and 30 mL of each extraction solvent (99.5% ethanol, 70% water-containing ethanol or water) were put into a test tube with a screw cap of 50 mL and stirred, and then allowed to stand at 80° C. for 30 minutes. .. The filtrate obtained by filtering the obtained extract was concentrated to dryness with a rotary evaporator to obtain each plant extract of Nos. 20 to 25 shown in Table 3.
Test Example 2 Measurement of Maillard reaction inhibitory activity For each plant extract obtained in Extraction Example 2, Maillard reaction inhibitory activity was measured according to the method of Test Example 1. However, each plant extract was dissolved in each extraction solvent instead of DMSO, and each sample extraction solvent was used instead of DMSO. The final concentration of the plant extract in the sample solution was adjusted to be 10, 5, 2, 0.2, 0.1 μg/mL. As a positive control, a methanol extract of Acacia catechu (heartwood) and nullde (insect worm) was used, and as a negative control, an extraction solvent was used instead of the sample.
その結果を表３に示す。 The results are shown in Table 3.
表３に示したとおり、本発明に係る植物エキスは、試験例２で用いたいずれの溶媒で抽出したエキスであっても、優れたメイラード反応阻害作用を有することが示された。 As shown in Table 3, it was shown that the plant extract according to the present invention had an excellent Maillard reaction inhibitory action regardless of the extract extracted with any of the solvents used in Test Example 2.
抽出例３ ヒシ属の植物エキスの製造
ヒシ（Ｔｒａｐａ ｊａｐｏｎｉｃａ Ｆｌｅｒｏｖ）の果実、トウビシ（Ｔｒａｐａ ｂｉｓｐｉｎｏｓａ Ｒｏｘｂ．）の果実および果皮、オニビシ（Ｔｒａｐａ ｎａｔａｎｓ Ｌ．ｖａｒ．ｊａｐｏｎｉｃａ Ｎａｋａｉ ）の果実および果皮について、抽出例２と同様の方法に従って植物エキスの製造を行い、各植物エキスを得た。
試験例３ メイラード反応阻害活性の測定
試験例２と同様の方法に従って、表４に記載の番号２６〜３７の各植物エキスについてメイラード反応阻害活性の測定を行った。ただし、陽性対照として、ヒシ（果実）のメタノール抽出エキスを用いた。
Extraction Example 3 Production of a plant extract of the genus Rhizome The fruit of Trapa (Trapa japonica Flerov), the fruit and pericarp of Trapa bispinosa Roxb. A plant extract was produced in the same manner as in 2 to obtain each plant extract.
Test Example 3 Measurement of Maillard reaction inhibitory activity According to the same method as in Test Example 2, the Maillard reaction inhibitory activity was measured for each plant extract of Nos. 26 to 37 shown in Table 4. However, as a positive control, a methanol-extracted extract of Hishi (fruit) was used.
その結果を表４に示す。 The results are shown in Table 4.
表４に示したとおり、本発明に係る植物エキスは、優れたメイラード反応阻害作用を有することが示された。 As shown in Table 4, it was shown that the plant extract according to the present invention has an excellent Maillard reaction inhibitory action.
次に、本発明阻害剤を含有する経口剤、外用剤、飲食品の実施例を示す。
実施例１ 経口剤（錠剤）の調製
以下の配合割合に従い、各成分を混合して、常法に従って錠剤を製造する。
Next, examples of oral preparations, external preparations and foods and drinks containing the inhibitor of the present invention will be shown.
Example 1 Preparation of oral preparation (tablet) The components are mixed according to the following compounding ratio to produce tablets according to a conventional method.
実施例２ 経口剤（顆粒剤）の調製
以下の配合割合に従い、各成分を混合して、常法に従って顆粒剤を製造する。
Example 2 Preparation of Oral Agent (Granule) Granules are manufactured according to a conventional method by mixing the components in the following mixing ratio.
実施例３ 経口剤（ソフトカプセル剤）の調製
以下の配合割合に従い、各成分を混合して、常法に従ってソフトカプセル剤を製造する。
Example 3 Preparation of Oral Formulation (Soft Capsule) Each component is mixed according to the following blending ratio to produce a soft capsule according to a conventional method.
実施例４ 外用剤（クリーム）の調製
以下の配合割合に従い、各成分を混合して、常法に従ってクリームを製造する。
Example 4 Preparation of external preparation (cream) The ingredients are mixed in the following mixing ratio to produce a cream according to a conventional method.
実施例５ 外用剤（化粧水）の調製
以下の配合割合に従い、各成分を混合して、常法に従って化粧水を製造する。
Example 5 Preparation of external preparation (lotion) Tonic lotion is produced according to a conventional method by mixing the components in the following blending ratio.
実施例６ 飲食品（飲料）の調製
以下の配合割合に従い、各成分を混合して、常法に従って飲料を製造する。
Example 6 Preparation of Food and Beverage (Beverage) Beverages are manufactured according to a conventional method by mixing the components according to the following blending ratios.
実施例７ 飲食品（キャンデー）の調製
以下の配合割合に従い、各成分を混合して、常法に従ってキャンディーを製造する。
Example 7 Preparation of food and drink (candy) According to the following blending ratio, the respective components are mixed to produce a candy according to a conventional method.
Claims (7)
A composition for preventing or treating diabetic complications, comprising the Maillard reaction inhibitor according to claim 1 or 2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008220606 | 2008-08-29 | ||
| JP2008220606 | 2008-08-29 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018191338A Division JP6674001B2 (en) | 2008-08-29 | 2018-10-10 | Maillard reaction inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2020090517A true JP2020090517A (en) | 2020-06-11 |
Family
ID=42207982
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009198057A Pending JP2010077123A (en) | 2008-08-29 | 2009-08-28 | Maillard reaction inhibitor |
| JP2014011143A Active JP5805226B2 (en) | 2008-08-29 | 2014-01-24 | Maillard reaction inhibitor |
| JP2015164539A Active JP6131993B2 (en) | 2008-08-29 | 2015-08-24 | Maillard reaction inhibitor |
| JP2017000885A Active JP6420376B2 (en) | 2008-08-29 | 2017-01-06 | Maillard reaction inhibitor |
| JP2018191338A Expired - Fee Related JP6674001B2 (en) | 2008-08-29 | 2018-10-10 | Maillard reaction inhibitor |
| JP2020006457A Pending JP2020090517A (en) | 2008-08-29 | 2020-01-20 | Maillard reaction inhibitor |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009198057A Pending JP2010077123A (en) | 2008-08-29 | 2009-08-28 | Maillard reaction inhibitor |
| JP2014011143A Active JP5805226B2 (en) | 2008-08-29 | 2014-01-24 | Maillard reaction inhibitor |
| JP2015164539A Active JP6131993B2 (en) | 2008-08-29 | 2015-08-24 | Maillard reaction inhibitor |
| JP2017000885A Active JP6420376B2 (en) | 2008-08-29 | 2017-01-06 | Maillard reaction inhibitor |
| JP2018191338A Expired - Fee Related JP6674001B2 (en) | 2008-08-29 | 2018-10-10 | Maillard reaction inhibitor |
Country Status (1)
| Country | Link |
|---|---|
| JP (6) | JP2010077123A (en) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5361431B2 (en) * | 2009-02-12 | 2013-12-04 | 丸善製薬株式会社 | Antioxidant |
| DE102011102824A1 (en) * | 2011-05-30 | 2012-12-06 | Merck Patent Gmbh | Extracts from Eugenia uniflora |
| KR101416572B1 (en) | 2011-06-29 | 2014-07-07 | 한국생명공학연구원 | Composition for antiaging comprising extract or fractions of Mastixia arborea C.B.Clarke as an active ingredient |
| WO2013002522A2 (en) * | 2011-06-29 | 2013-01-03 | 한국생명공학연구원 | Anti-aging composition containing a mastixia arborea c.b.clarke extract or a fraction thereof as an active ingredient |
| JP6197278B2 (en) * | 2011-10-28 | 2017-09-20 | 日本新薬株式会社 | Mangosteen extract |
| JP5403638B2 (en) * | 2011-12-26 | 2014-01-29 | 敏 新川 | Composition exhibiting collagen producing action |
| WO2013180490A1 (en) * | 2012-05-30 | 2013-12-05 | 한국생명공학연구원 | Pharmaceutical composition for preventing and alleviating skin aging, containing aleurites fordii extract, fraction thereof or diterpene compound isolated therefrom as active ingredient |
| JP2014037399A (en) * | 2012-07-18 | 2014-02-27 | Up Well:Kk | Anti-glycation agent and method for producing the same |
| JP6201598B2 (en) * | 2012-10-02 | 2017-09-27 | 日本新薬株式会社 | Maillard reaction inhibitor |
| EP2957289A4 (en) * | 2013-02-18 | 2016-12-21 | Arkray Inc | Oxidized protein hydrolase activity enhancing agent |
| WO2016121892A1 (en) * | 2015-01-29 | 2016-08-04 | 正雄 神野 | Infertility ameliorating agent compound |
| JP6077045B2 (en) * | 2015-01-29 | 2017-02-08 | 正雄 神野 | Infertility improver composition |
| CN105249099B (en) * | 2015-10-20 | 2018-07-27 | 南昌大学 | A kind of production method of Spondias axillaris functional lactobacillus beverages |
| JP6148780B1 (en) * | 2016-02-05 | 2017-06-14 | 参天製薬株式会社 | A composition containing xanthophyll and a processed plant of the genus Hishi |
| WO2017135466A1 (en) * | 2016-02-05 | 2017-08-10 | 参天製薬株式会社 | Composition containing xanthophyll and processed product of trapa genus plant |
| JP6122200B1 (en) * | 2016-10-20 | 2017-04-26 | 養命酒製造株式会社 | Anti-glycation composition |
| KR20200011442A (en) | 2017-06-01 | 2020-02-03 | 산텐 세이야꾸 가부시키가이샤 | A composition for the prevention and / or improvement of brain dysfunction, which contains lutein or its salts and processed products of rhododendron plants |
| JP6980419B2 (en) * | 2017-06-13 | 2021-12-15 | 学校法人近畿大学 | AGEs production inhibitor |
| KR102128978B1 (en) * | 2018-05-09 | 2020-07-01 | 재단법인 경기도경제과학진흥원 | Composition for Skin-lightening and Improving Wrinkle Using an Extract of Amblygonum orientale |
| CN109431846B (en) * | 2018-11-28 | 2021-09-07 | 邯郸学院 | A skin care product containing bioactive components |
| JP7142296B2 (en) * | 2019-07-02 | 2022-09-27 | 株式会社アカシアの樹 | elastase inhibitor |
| KR102305237B1 (en) * | 2019-07-29 | 2021-09-29 | 재단법인 경기도경제과학진흥원 | Compositions for Improving Skin Wrinkles and Skin Whitening Using an Extract of Persicaria filiforme |
| CN110622652A (en) * | 2019-10-25 | 2019-12-31 | 广西南亚热带农业科学研究所 | Method for inhibiting sprouting of sterculia nobilis seeds |
| JP2022080275A (en) * | 2020-11-17 | 2022-05-27 | 株式会社ニコリオ | Composition |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0597649A (en) * | 1991-08-07 | 1993-04-20 | Tsuneo Nanba | Cosmetic |
| JP2000143488A (en) * | 1998-11-16 | 2000-05-23 | Ichimaru Pharcos Co Ltd | Cosmetic composition containing humectant plant extract |
| JP2003212770A (en) * | 2002-01-22 | 2003-07-30 | Ichimaru Pharcos Co Ltd | Maillard reaction inhibitor |
| JP2005008572A (en) * | 2003-06-19 | 2005-01-13 | Yakult Honsha Co Ltd | Lipase inhibitor |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0813833B2 (en) * | 1987-02-20 | 1996-02-14 | 株式会社太田胃散 | Novel flavonoid glycoside and method for producing the same |
| JP3558349B2 (en) * | 1992-04-24 | 2004-08-25 | 御木本製薬株式会社 | Whitening cosmetics |
| JPH07109215A (en) * | 1993-10-08 | 1995-04-25 | Momotani Jiyuntenkan:Kk | Maillard reaction inhibitor for make-up and skin cosmetic for suppressing maillard reaction |
| JPH07112938A (en) * | 1993-10-15 | 1995-05-02 | Nkk Corp | Aldose reductase inhibitor |
| JP3464038B2 (en) * | 1994-05-23 | 2003-11-05 | 御木本製薬株式会社 | Collagen synthesis promoter |
| JPH08333270A (en) * | 1995-06-06 | 1996-12-17 | Mikimoto Pharmaceut Co Ltd | Cell activator |
| JPH0920636A (en) * | 1995-07-04 | 1997-01-21 | Shiseido Co Ltd | Skin preparation for external use |
| JPH1036257A (en) * | 1996-05-22 | 1998-02-10 | Kikkoman Corp | Maillard reaction inhibitor |
| JPH11106371A (en) * | 1997-07-04 | 1999-04-20 | Nisshin Flour Milling Co Ltd | Acylhydrazone derivative |
| JP2001316221A (en) * | 2000-05-10 | 2001-11-13 | Naris Cosmetics Co Ltd | Antiaging agent and cosmetic |
| JP2001316239A (en) * | 2000-05-10 | 2001-11-13 | Mikimoto Pharmaceut Co Ltd | Skin care preparation |
| JP2003063976A (en) * | 2001-08-28 | 2003-03-05 | Ichimaru Pharcos Co Ltd | Water chestnut extract-containing cosmetic composition |
| JP4577868B2 (en) * | 2001-10-23 | 2010-11-10 | 株式会社資生堂 | Matrix metalloprotease activity inhibitor |
| KR100777554B1 (en) * | 2001-11-08 | 2007-11-16 | 주식회사 엘지생활건강 | Composition for skin whitening containing Sitosterol |
| JP2003261435A (en) * | 2002-03-11 | 2003-09-16 | Ichimaru Pharcos Co Ltd | Energy modifying agent |
| JP2004189663A (en) * | 2002-12-11 | 2004-07-08 | Ichimaru Pharcos Co Ltd | Maillard reaction inhibitor |
| JP4979181B2 (en) * | 2003-01-31 | 2012-07-18 | 株式会社ヤクルト本社 | Glycation inhibitors and uses thereof |
| JP4195840B2 (en) * | 2003-07-18 | 2008-12-17 | アークレイ株式会社 | Maillard reaction inhibitor |
| JP2005225763A (en) * | 2004-02-10 | 2005-08-25 | Ichimaru Pharcos Co Ltd | New compound and cosmetic composition or food composition comprising the same |
| JP2005314286A (en) * | 2004-04-28 | 2005-11-10 | Zenzaburo Hara | Bleaching cosmetic |
| JP5023317B2 (en) * | 2005-03-03 | 2012-09-12 | 国立大学法人弘前大学 | Type IV allergic reaction inhibitor |
| JP5020475B2 (en) * | 2005-03-14 | 2012-09-05 | 共栄化学工業株式会社 | Fibroblast activator and skin external preparation containing the same |
| JP2006298813A (en) * | 2005-04-20 | 2006-11-02 | Mikimoto Pharmaceut Co Ltd | Wrinkle and sag inhibitor and hyaluronidase activity inhibitor |
| US20090263339A1 (en) * | 2005-05-27 | 2009-10-22 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenky | Agent for external application to the skin |
| JP2007119373A (en) * | 2005-10-26 | 2007-05-17 | Arkray Inc | Maillard reaction product-decomposing agent and drink or food using the same |
| JP2007186457A (en) * | 2006-01-13 | 2007-07-26 | Ichimaru Pharcos Co Ltd | Tryptase activity inhibitor and its utilization |
| JP5635226B2 (en) * | 2006-01-24 | 2014-12-03 | 株式会社林原 | Hair papilla cell growth promoter |
| JP5313436B2 (en) * | 2006-03-23 | 2013-10-09 | 株式会社ナリス化粧品 | Maillard reaction inhibitor, external preparation for skin containing the same, and food and drink |
| JP5063947B2 (en) * | 2006-07-18 | 2012-10-31 | 株式会社ナリス化粧品 | Acrolein adduct formation inhibitor, and skin anti-aging external preparation and anti-aging food and drink containing the same |
| CN101229181A (en) * | 2006-09-12 | 2008-07-30 | 徐广爱 | Medicine compounds for curing diabetes and complications thereof |
| US20100034757A1 (en) * | 2006-11-24 | 2010-02-11 | Mitsukiyo Fujii | Extract powder of indigo plant, and its preparation and uses |
| FR2918570B1 (en) * | 2007-07-09 | 2012-10-05 | Engelhard Lyon | DIGLYCATION OF AGEs. |
| US9072717B2 (en) * | 2007-09-18 | 2015-07-07 | Elc Management Llc | Cosmetic compositions containing alpha glucosidase inhibitors and methods of use |
-
2009
- 2009-08-28 JP JP2009198057A patent/JP2010077123A/en active Pending
-
2014
- 2014-01-24 JP JP2014011143A patent/JP5805226B2/en active Active
-
2015
- 2015-08-24 JP JP2015164539A patent/JP6131993B2/en active Active
-
2017
- 2017-01-06 JP JP2017000885A patent/JP6420376B2/en active Active
-
2018
- 2018-10-10 JP JP2018191338A patent/JP6674001B2/en not_active Expired - Fee Related
-
2020
- 2020-01-20 JP JP2020006457A patent/JP2020090517A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0597649A (en) * | 1991-08-07 | 1993-04-20 | Tsuneo Nanba | Cosmetic |
| JP2000143488A (en) * | 1998-11-16 | 2000-05-23 | Ichimaru Pharcos Co Ltd | Cosmetic composition containing humectant plant extract |
| JP2003212770A (en) * | 2002-01-22 | 2003-07-30 | Ichimaru Pharcos Co Ltd | Maillard reaction inhibitor |
| JP2005008572A (en) * | 2003-06-19 | 2005-01-13 | Yakult Honsha Co Ltd | Lipase inhibitor |
Non-Patent Citations (1)
| Title |
|---|
| NATURAL MEDICINES, vol. 51(1), JPN6020050238, 1997, pages 4 - 17, ISSN: 0004552824 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5805226B2 (en) | 2015-11-04 |
| JP6674001B2 (en) | 2020-04-01 |
| JP2014094964A (en) | 2014-05-22 |
| JP6420376B2 (en) | 2018-11-07 |
| JP2017095492A (en) | 2017-06-01 |
| JP2010077123A (en) | 2010-04-08 |
| JP2015232025A (en) | 2015-12-24 |
| JP6131993B2 (en) | 2017-05-24 |
| JP2019023215A (en) | 2019-02-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6674001B2 (en) | Maillard reaction inhibitor | |
| WO2013100105A1 (en) | Maillard reaction inhibitor | |
| JP2010178736A (en) | Skin beauty-ameliorating agent, antioxidant, skin beauty-ameliorating composition, or cosmetic food/drink | |
| JP2022001589A (en) | Anti-obesity agent, cosmetic product, and food and drink products | |
| JP5597828B2 (en) | Hair restorer | |
| JP2017160255A (en) | Mangosteen extract | |
| JP2003055244A (en) | Agent promoting hyaluronic acid production, cosmetics, food and beverage including the hyaluronic acid production-promoting agent | |
| JP4585070B2 (en) | Cyclic AMP phosphodiesterase inhibitor and antiallergic / antiinflammatory agent | |
| JP2013184974A (en) | Maillard reaction inhibitor and use thereof | |
| JP5832714B2 (en) | Tyrosinase activity inhibitor and melanin production inhibitor | |
| JP7296611B2 (en) | Nitric oxide production accelerator | |
| KR101988909B1 (en) | Composition for skin cell regeneration, anti-wrinkle, antioxidant, anti-imflamation, and skin whitening | |
| JP2017165686A (en) | Liver function improver | |
| JP5422137B2 (en) | Whitening agent, tyrosinase activity inhibitor, melanin production inhibitor, and skin external preparation for whitening | |
| JP6326611B2 (en) | CMA production inhibitor | |
| JP4464082B2 (en) | Muscle cell sugar transport enhancing composition containing mugwort as an active ingredient | |
| JP6201598B2 (en) | Maillard reaction inhibitor | |
| JP7320270B2 (en) | Liver function improver | |
| KR101661423B1 (en) | anti-oxidant and anti-inflammation composition extracted from Isodon excisus, and its extracting method | |
| KR101909740B1 (en) | Composition for skin cell regeneration, anti-wrinkle, antioxidant and skin whitening comprising Monotropein | |
| JP2010013416A (en) | Algae extract having hair-growing effect | |
| JP2018090639A (en) | Cma production inhibiting agent | |
| JP2024061935A (en) | Plaque formation inhibitors | |
| TWI626950B (en) | Fibroblast proliferation promoter and Mena reaction inhibitor | |
| JP2023073564A (en) | Bone strengthening agent and bone strengthening composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200122 |
|
| RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20200129 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20200130 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210119 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20210810 |