JP2020076766A5 - - Google Patents
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- Publication number
- JP2020076766A5 JP2020076766A5 JP2019193819A JP2019193819A JP2020076766A5 JP 2020076766 A5 JP2020076766 A5 JP 2020076766A5 JP 2019193819 A JP2019193819 A JP 2019193819A JP 2019193819 A JP2019193819 A JP 2019193819A JP 2020076766 A5 JP2020076766 A5 JP 2020076766A5
- Authority
- JP
- Japan
- Prior art keywords
- blood
- drug
- time
- coagulation
- analysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008280 blood Substances 0.000 claims description 91
- 210000004369 blood Anatomy 0.000 claims description 91
- 238000004458 analytical method Methods 0.000 claims description 42
- 229940079593 drug Drugs 0.000 claims description 35
- 239000003814 drug Substances 0.000 claims description 35
- 230000015271 coagulation Effects 0.000 claims description 23
- 238000005345 coagulation Methods 0.000 claims description 23
- 239000003527 fibrinolytic agent Substances 0.000 claims description 20
- 230000003480 fibrinolytic effect Effects 0.000 claims description 20
- 230000036962 time dependent Effects 0.000 claims description 18
- 230000000694 effects Effects 0.000 claims description 11
- 239000003112 inhibitor Substances 0.000 claims description 10
- 230000023555 blood coagulation Effects 0.000 claims description 7
- 102000013566 Plasminogen Human genes 0.000 claims description 6
- 108010051456 Plasminogen Proteins 0.000 claims description 6
- 229940012957 plasmin Drugs 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 5
- 102000008946 Fibrinogen Human genes 0.000 claims description 4
- 108010049003 Fibrinogen Proteins 0.000 claims description 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 4
- 239000012190 activator Substances 0.000 claims description 4
- 229940012952 fibrinogen Drugs 0.000 claims description 4
- 229960002897 heparin Drugs 0.000 claims description 4
- 229920000669 heparin Polymers 0.000 claims description 4
- 230000002123 temporal effect Effects 0.000 claims description 3
- 102000009123 Fibrin Human genes 0.000 claims description 2
- 108010073385 Fibrin Proteins 0.000 claims description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 2
- 230000035602 clotting Effects 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 claims description 2
- 238000011156 evaluation Methods 0.000 claims description 2
- 229950003499 fibrin Drugs 0.000 claims description 2
- 238000005534 hematocrit Methods 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 238000006116 polymerization reaction Methods 0.000 claims description 2
- 238000007711 solidification Methods 0.000 claims 2
- 230000008023 solidification Effects 0.000 claims 2
- 230000020764 fibrinolysis Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014085859 | 2014-04-17 | ||
| JP2014085859 | 2014-04-17 | ||
| JP2016513674A JP6607186B2 (ja) | 2014-04-17 | 2015-03-16 | 血液状態解析装置、血液状態解析システム、血液状態解析方法及びプログラム |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513674A Division JP6607186B2 (ja) | 2014-04-17 | 2015-03-16 | 血液状態解析装置、血液状態解析システム、血液状態解析方法及びプログラム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020076766A JP2020076766A (ja) | 2020-05-21 |
| JP2020076766A5 true JP2020076766A5 (https=) | 2020-11-12 |
| JP6930568B2 JP6930568B2 (ja) | 2021-09-01 |
Family
ID=54323838
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513674A Active JP6607186B2 (ja) | 2014-04-17 | 2015-03-16 | 血液状態解析装置、血液状態解析システム、血液状態解析方法及びプログラム |
| JP2019193819A Active JP6930568B2 (ja) | 2014-04-17 | 2019-10-24 | 血液状態解析装置、血液状態解析システム、血液状態解析方法及びプログラム |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513674A Active JP6607186B2 (ja) | 2014-04-17 | 2015-03-16 | 血液状態解析装置、血液状態解析システム、血液状態解析方法及びプログラム |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20170030891A1 (https=) |
| EP (1) | EP3133390A4 (https=) |
| JP (2) | JP6607186B2 (https=) |
| WO (1) | WO2015159623A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6442858B2 (ja) | 2014-04-17 | 2018-12-26 | ソニー株式会社 | 血液状態解析装置、血液状態解析システム、血液状態解析方法、および該方法をコンピューターに実現させるための血液状態解析プログラム |
| EP3133395B1 (en) * | 2014-04-17 | 2019-12-25 | Sony Corporation | Blood condition analysis device, blood condition analysis system, blood condition analysis method, and blood condition analysis program for enabling computer to perform said method |
| CN108603888B (zh) * | 2016-02-17 | 2022-06-10 | 索尼公司 | 血小板聚集活性分析设备、分析系统、分析程序和分析方法 |
| WO2017168885A1 (ja) * | 2016-03-28 | 2017-10-05 | ソニー株式会社 | 電気的特性測定装置、電気的特性測定システム、電気的特性測定方法、及びプログラム |
| WO2017169261A1 (ja) * | 2016-03-29 | 2017-10-05 | ソニー株式会社 | 血液凝固系解析システム、血液凝固系解析方法及び血液凝固系解析用プログラム |
| US20190101526A1 (en) * | 2016-03-30 | 2019-04-04 | Sony Corporation | Blood state analysis apparatus, blood state analysis system, blood state analysis method, and program |
| WO2018128002A1 (ja) * | 2017-01-06 | 2018-07-12 | ソニー株式会社 | 血液凝固系解析装置、血液凝固系解析システム、血液凝固系解析方法、及び血液凝固系解析用プログラム、並びに、出血量予測装置、出血量予測システム、出血量予測方法、及び出血量予測用プログラム |
| JP7221490B2 (ja) | 2018-04-26 | 2023-02-14 | シスメックス株式会社 | 血液分析方法、血液分析装置、およびプログラム |
| JP7135620B2 (ja) * | 2018-09-07 | 2022-09-13 | ソニーグループ株式会社 | 血液凝固系解析装置、血液凝固系解析方法及び血液凝固系解析プログラム |
| JP7230429B2 (ja) | 2018-10-25 | 2023-03-01 | ソニーグループ株式会社 | 血小板凝集能解析装置、血小板凝集能解析方法及び血小板凝集能解析システム |
| JP7681270B2 (ja) * | 2020-07-21 | 2025-05-22 | ソニーグループ株式会社 | 血液凝固系解析装置、血液凝固系測定装置、血液凝固系測定システム、血液凝固系解析方法及び血液凝固系測定方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4810090A (en) * | 1987-08-24 | 1989-03-07 | Cobe Laboratories, Inc. | Method and apparatus for monitoring blood components |
| JPH0743388B2 (ja) * | 1990-05-29 | 1995-05-15 | 日立化成工業株式会社 | 血液凝固に伴うゲル化反応の測定法，測定装置及び測定用素子 |
| US6200532B1 (en) * | 1998-11-20 | 2001-03-13 | Akzo Nobel Nv | Devices and method for performing blood coagulation assays by piezoelectric sensing |
| US7179652B2 (en) * | 1999-02-22 | 2007-02-20 | Haemoscope Corporation | Protocol for monitoring platelet inhibition |
| JP4839010B2 (ja) * | 2005-03-29 | 2011-12-14 | シスメックス株式会社 | 分析システム、データ処理装置、及びアプリケーションプログラム |
| WO2006106695A1 (ja) * | 2005-04-01 | 2006-10-12 | Kissei Pharmaceutical Co., Ltd. | 高感度血液学的アッセイ及び試薬 |
| JP2007064916A (ja) * | 2005-09-02 | 2007-03-15 | Tosoh Corp | 抗凝固活性を有する薬剤の評価方法 |
| JP5691168B2 (ja) * | 2009-01-08 | 2015-04-01 | ソニー株式会社 | 血液凝固系解析装置、血液凝固系解析方法及びプログラム |
| AU2011205271B2 (en) * | 2010-01-14 | 2014-01-30 | Baxalta GmbH | Methods and compositions for treating bleeding disorders |
| JP5768422B2 (ja) * | 2011-03-17 | 2015-08-26 | ソニー株式会社 | 血液凝固系解析方法および血液凝固系解析装置 |
| EP2713878B1 (en) * | 2011-05-26 | 2021-07-07 | The General Hospital Corporation | Optical thromboelastography system and method for evaluation of blood coagulation metrics |
| CN109520889B (zh) * | 2012-01-16 | 2022-04-05 | 仪宝科技公司 | 用于测量流体物理性能的方法、装置、和系统 |
| EP2827910A2 (en) * | 2012-03-22 | 2015-01-28 | Baxter International Inc | Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics |
| JP5982976B2 (ja) * | 2012-04-13 | 2016-08-31 | ソニー株式会社 | 血液凝固系解析装置、血液凝固系解析方法及びそのプログラム |
-
2015
- 2015-03-16 WO PCT/JP2015/057647 patent/WO2015159623A1/ja not_active Ceased
- 2015-03-16 US US15/303,059 patent/US20170030891A1/en not_active Abandoned
- 2015-03-16 EP EP15780046.7A patent/EP3133390A4/en not_active Withdrawn
- 2015-03-16 JP JP2016513674A patent/JP6607186B2/ja active Active
-
2019
- 2019-10-24 JP JP2019193819A patent/JP6930568B2/ja active Active
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