JP2020036595A5 - - Google Patents
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- JP2020036595A5 JP2020036595A5 JP2019195331A JP2019195331A JP2020036595A5 JP 2020036595 A5 JP2020036595 A5 JP 2020036595A5 JP 2019195331 A JP2019195331 A JP 2019195331A JP 2019195331 A JP2019195331 A JP 2019195331A JP 2020036595 A5 JP2020036595 A5 JP 2020036595A5
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- JP
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- Prior art keywords
- sequence
- seq
- polypeptide
- cells
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 23
- 229920001184 polypeptide Polymers 0.000 claims 21
- 102000004196 processed proteins & peptides Human genes 0.000 claims 21
- 210000004027 cell Anatomy 0.000 claims 9
- 210000001744 T-lymphocyte Anatomy 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 230000028993 immune response Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 210000004748 cultured cell Anatomy 0.000 claims 3
- 230000001965 increasing effect Effects 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 210000002865 immune cell Anatomy 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 241000282465 Canis Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 241000235058 Komagataella pastoris Species 0.000 claims 1
- 230000001464 adherent effect Effects 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762443281P | 2017-01-06 | 2017-01-06 | |
| US62/443,281 | 2017-01-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019517981A Division JP6609724B1 (ja) | 2017-01-06 | 2018-01-05 | 抗ヒト４−１ｂｂ抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020036595A JP2020036595A (ja) | 2020-03-12 |
| JP2020036595A5 true JP2020036595A5 (enExample) | 2021-07-26 |
| JP7153626B2 JP7153626B2 (ja) | 2022-10-14 |
Family
ID=62791389
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019517981A Active JP6609724B1 (ja) | 2017-01-06 | 2018-01-05 | 抗ヒト４−１ｂｂ抗体およびその使用 |
| JP2019195331A Active JP7153626B2 (ja) | 2017-01-06 | 2019-10-28 | 抗ヒト４－１ｂｂ抗体およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019517981A Active JP6609724B1 (ja) | 2017-01-06 | 2018-01-05 | 抗ヒト４−１ｂｂ抗体およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10174122B2 (enExample) |
| EP (2) | EP4032911A1 (enExample) |
| JP (2) | JP6609724B1 (enExample) |
| KR (2) | KR102089072B1 (enExample) |
| CN (2) | CN112210010B (enExample) |
| AU (3) | AU2018206015B2 (enExample) |
| BR (1) | BR112019007714B1 (enExample) |
| CA (1) | CA3039772C (enExample) |
| ES (1) | ES2905890T3 (enExample) |
| MX (1) | MX374810B (enExample) |
| RU (1) | RU2725811C1 (enExample) |
| SG (2) | SG11201903021WA (enExample) |
| WO (1) | WO2018127787A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101503341B1 (ko) | 2014-03-12 | 2015-03-18 | 국립암센터 | 자가암항원 특이적 cd8+ t 세포의 분리 및 증식방법 |
| US10174122B2 (en) | 2017-01-06 | 2019-01-08 | Eutilex Co., Ltd. | Anti-human 4-1BB antibodies and uses thereof |
| BR112019017241A2 (pt) | 2017-04-13 | 2020-04-14 | Agenus Inc. | anticorpos anti-cd137 e métodos de uso dos mesmos |
| SG10201913147WA (en) | 2017-07-11 | 2020-02-27 | Compass Therapeutics Llc | Agonist antibodies that bind human cd137 and uses thereof |
| CN111511762B (zh) | 2017-08-21 | 2025-05-06 | 天演药业公司 | 抗cd137分子及其用途 |
| US11718679B2 (en) | 2017-10-31 | 2023-08-08 | Compass Therapeutics Llc | CD137 antibodies and PD-1 antagonists and uses thereof |
| EP3713961A2 (en) | 2017-11-20 | 2020-09-30 | Compass Therapeutics LLC | Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof |
| WO2019148445A1 (en) | 2018-02-02 | 2019-08-08 | Adagene Inc. | Precision/context-dependent activatable antibodies, and methods of making and using the same |
| JP7598312B2 (ja) | 2018-07-23 | 2024-12-11 | ハイデルベルク ファーマ リサーチ ゲーエムベーハー | 同種異系の細胞療法における抗－ｃｄ１３７抗体薬物コンジュゲート（ａｄｃ）の使用 |
| MX2021001431A (es) | 2018-08-10 | 2021-05-12 | Chugai Pharmaceutical Co Ltd | Molecula de union al antigeno anti grupo de diferenciacion 137 (cd137) y su uso. |
| CN112739718B (zh) * | 2018-09-12 | 2024-11-26 | 祐和医药科技(北京)有限公司 | 抗tnfrsf9抗体及其用途 |
| WO2020077635A1 (zh) | 2018-10-19 | 2020-04-23 | 苏州丁孚靶点生物技术有限公司 | 抗cd137抗体及其应用 |
| SG11202105152YA (en) | 2018-11-30 | 2021-06-29 | Abl Bio Inc | Anti-pd-l1/anti-4-1bb bispecific antibodies and uses thereof |
| US12227582B2 (en) | 2019-01-02 | 2025-02-18 | Qlsf Biotherapeutics Inc. | CD137 agonist antibodies and uses thereof |
| WO2020216947A1 (en) | 2019-04-24 | 2020-10-29 | Heidelberg Pharma Research Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
| EP3986933A1 (en) * | 2019-06-21 | 2022-04-27 | Regeneron Pharmaceuticals, Inc. | Use of bispecific antigen-binding molecules that bind psma and cd3 in combination with 4-1bb co-stimulation |
| CN114829405B (zh) | 2019-12-10 | 2025-07-18 | 爱必乐生物公司 | 抗bcma/抗4-1bb双特异性抗体及其用途 |
| WO2021132746A1 (en) * | 2019-12-24 | 2021-07-01 | Abl Bio, Inc. | Anti-bcma/anti-4-1bb bispecific antibodies and uses thereof |
| CN113045657B (zh) | 2019-12-26 | 2022-06-07 | 杭州济元基因科技有限公司 | 一种人源化抗人bcma单克隆抗体及其car-t细胞 |
| IL295382B1 (en) * | 2020-02-12 | 2026-08-01 | Chugai Seiyaku Kk | Anti-CD137 antigen-binding molecule for use in cancer treatment |
| JP7715722B2 (ja) * | 2020-02-28 | 2025-07-30 | 上海復宏漢霖生物技術股▲フン▼有限公司 | 抗ｃｄ１３７コンストラクト及びその使用 |
| EP4118117A1 (en) * | 2020-03-13 | 2023-01-18 | Julius-Maximilians-Universität Würzburg | Affinity matured and humanized binding domains targeting ror2 |
| JP2023504675A (ja) | 2020-05-19 | 2023-02-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ガンの処置のための結合分子 |
| EP4163301B1 (en) * | 2020-06-11 | 2025-10-01 | Iwate Medical University | Humanized anti-gpc-1 antibody |
| WO2022029496A1 (en) * | 2020-08-07 | 2022-02-10 | Eutilex Co., Ltd. | Anti-her2 / anti-4-1bb bispecific antibodies and uses thereof |
| CN114075287B (zh) | 2020-08-18 | 2023-07-21 | 湖南远泰生物技术有限公司 | 人源化bcma抗体和bcma-car-t细胞 |
| WO2022053864A1 (en) * | 2020-09-08 | 2022-03-17 | Kwon Byoung S | Pd-1 polypeptide variants |
| CN114195894B (zh) * | 2020-09-17 | 2025-02-25 | 普米斯生物技术(珠海)有限公司 | 一种靶向4-1bb的抗体及其应用 |
| KR20230129484A (ko) * | 2021-01-08 | 2023-09-08 | 베이징 한미 파마슈티컬 컴퍼니 리미티드 | 4-1bb와 특이적으로 결합하는 항체 및 그 항원 결합단편 |
| WO2022148410A1 (zh) * | 2021-01-08 | 2022-07-14 | 北京韩美药品有限公司 | 抗pd-l1/抗4-1bb天然抗体结构样异源二聚体形式双特异抗体及其制备 |
| CN117321079A (zh) * | 2021-01-11 | 2023-12-29 | 优特力克斯有限公司 | 包含抗4-1bb抗体及pd-1蛋白或其片段的双特异性表位结合蛋白及其用途 |
| JP2024530325A (ja) | 2021-08-31 | 2024-08-16 | ラノバ メディシンズ リミテッド | 抗４－１ｂｂナノボディ |
| WO2024040195A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| EP4719352A1 (en) | 2023-05-31 | 2026-04-08 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| US20250127728A1 (en) | 2023-10-05 | 2025-04-24 | Capstan Therapeutics, Inc. | Constrained Ionizable Cationic Lipids and Lipid Nanoparticles |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| WO2025106539A1 (en) * | 2023-11-14 | 2025-05-22 | Mayo Foundation For Medical Education And Research | Materials and methods for treating cancer |
| US20250302763A1 (en) | 2024-02-22 | 2025-10-02 | Capstan Therapeutics, Inc. | Immune engineering amplification |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
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-
2018
- 2018-01-05 US US15/863,526 patent/US10174122B2/en active Active
- 2018-01-05 CA CA3039772A patent/CA3039772C/en active Active
- 2018-01-05 JP JP2019517981A patent/JP6609724B1/ja active Active
- 2018-01-05 CN CN202011039658.5A patent/CN112210010B/zh active Active
- 2018-01-05 EP EP21211128.0A patent/EP4032911A1/en active Pending
- 2018-01-05 KR KR1020197015730A patent/KR102089072B1/ko active Active
- 2018-01-05 BR BR112019007714-6A patent/BR112019007714B1/pt active IP Right Grant
- 2018-01-05 KR KR1020207006944A patent/KR102427192B1/ko active Active
- 2018-01-05 MX MX2019004692A patent/MX374810B/es active IP Right Grant
- 2018-01-05 EP EP18736336.1A patent/EP3523332B1/en active Active
- 2018-01-05 ES ES18736336T patent/ES2905890T3/es active Active
- 2018-01-05 AU AU2018206015A patent/AU2018206015B2/en active Active
- 2018-01-05 CN CN201880005123.0A patent/CN110392696B/zh active Active
- 2018-01-05 WO PCT/IB2018/000043 patent/WO2018127787A1/en not_active Ceased
- 2018-01-05 SG SG11201903021WA patent/SG11201903021WA/en unknown
- 2018-01-05 RU RU2019116731A patent/RU2725811C1/ru active
- 2018-01-05 SG SG10201914064QA patent/SG10201914064QA/en unknown
- 2018-11-14 US US16/191,381 patent/US10919972B2/en active Active
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2019
- 2019-07-05 AU AU2019204847A patent/AU2019204847B2/en active Active
- 2019-10-28 JP JP2019195331A patent/JP7153626B2/ja active Active
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2020
- 2020-02-13 US US16/790,299 patent/US10774151B2/en active Active
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2021
- 2021-01-26 US US17/158,474 patent/US11859004B2/en active Active
- 2021-04-22 AU AU2021202474A patent/AU2021202474A1/en not_active Abandoned
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