JP2020028300A5 - - Google Patents
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- Publication number
- JP2020028300A5 JP2020028300A5 JP2019201128A JP2019201128A JP2020028300A5 JP 2020028300 A5 JP2020028300 A5 JP 2020028300A5 JP 2019201128 A JP2019201128 A JP 2019201128A JP 2019201128 A JP2019201128 A JP 2019201128A JP 2020028300 A5 JP2020028300 A5 JP 2020028300A5
- Authority
- JP
- Japan
- Prior art keywords
- mutation
- pik3ca
- sequence
- polynucleotide
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54888604P | 2004-03-02 | 2004-03-02 | |
| US60/548,886 | 2004-03-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018090580A Division JP6695381B2 (ja) | 2004-03-02 | 2018-05-09 | ヒトの癌におけるpik3ca遺伝子の変異 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020038337A Division JP7169315B2 (ja) | 2004-03-02 | 2020-03-06 | ヒトの癌におけるpik3ca遺伝子の変異 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020028300A JP2020028300A (ja) | 2020-02-27 |
| JP2020028300A5 true JP2020028300A5 (https=) | 2020-04-16 |
| JP6694543B2 JP6694543B2 (ja) | 2020-05-13 |
Family
ID=35056655
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007501815A Withdrawn JP2007530017A (ja) | 2004-03-02 | 2005-02-18 | ヒトの癌におけるpik3ca遺伝子の変異 |
| JP2012052427A Expired - Lifetime JP5336620B2 (ja) | 2004-03-02 | 2012-03-09 | ヒトの癌におけるpik3ca遺伝子の変異 |
| JP2013100073A Expired - Lifetime JP5894110B2 (ja) | 2004-03-02 | 2013-05-10 | ヒトの癌におけるpik3ca遺伝子の変異 |
| JP2015245769A Expired - Lifetime JP6250017B2 (ja) | 2004-03-02 | 2015-12-17 | ヒトの癌におけるpik3ca遺伝子の変異 |
| JP2017202265A Expired - Lifetime JP6395917B2 (ja) | 2004-03-02 | 2017-10-19 | ヒトの癌におけるpik3ca遺伝子の変異 |
| JP2018090580A Expired - Lifetime JP6695381B2 (ja) | 2004-03-02 | 2018-05-09 | ヒトの癌におけるpik3ca遺伝子の変異 |
| JP2019201128A Expired - Lifetime JP6694543B2 (ja) | 2004-03-02 | 2019-11-06 | ヒトの癌におけるpik3ca遺伝子の変異 |
| JP2020038337A Expired - Lifetime JP7169315B2 (ja) | 2004-03-02 | 2020-03-06 | ヒトの癌におけるpik3ca遺伝子の変異 |
| JP2020078786A Expired - Lifetime JP7001735B2 (ja) | 2004-03-02 | 2020-04-28 | ヒトの癌におけるpik3ca遺伝子の変異 |
| JP2022022542A Expired - Lifetime JP7304987B2 (ja) | 2004-03-02 | 2022-02-17 | ヒトの癌におけるpik3ca遺伝子の変異 |
Family Applications Before (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007501815A Withdrawn JP2007530017A (ja) | 2004-03-02 | 2005-02-18 | ヒトの癌におけるpik3ca遺伝子の変異 |
| JP2012052427A Expired - Lifetime JP5336620B2 (ja) | 2004-03-02 | 2012-03-09 | ヒトの癌におけるpik3ca遺伝子の変異 |
| JP2013100073A Expired - Lifetime JP5894110B2 (ja) | 2004-03-02 | 2013-05-10 | ヒトの癌におけるpik3ca遺伝子の変異 |
| JP2015245769A Expired - Lifetime JP6250017B2 (ja) | 2004-03-02 | 2015-12-17 | ヒトの癌におけるpik3ca遺伝子の変異 |
| JP2017202265A Expired - Lifetime JP6395917B2 (ja) | 2004-03-02 | 2017-10-19 | ヒトの癌におけるpik3ca遺伝子の変異 |
| JP2018090580A Expired - Lifetime JP6695381B2 (ja) | 2004-03-02 | 2018-05-09 | ヒトの癌におけるpik3ca遺伝子の変異 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020038337A Expired - Lifetime JP7169315B2 (ja) | 2004-03-02 | 2020-03-06 | ヒトの癌におけるpik3ca遺伝子の変異 |
| JP2020078786A Expired - Lifetime JP7001735B2 (ja) | 2004-03-02 | 2020-04-28 | ヒトの癌におけるpik3ca遺伝子の変異 |
| JP2022022542A Expired - Lifetime JP7304987B2 (ja) | 2004-03-02 | 2022-02-17 | ヒトの癌におけるpik3ca遺伝子の変異 |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US8026053B2 (https=) |
| EP (5) | EP2497836B1 (https=) |
| JP (10) | JP2007530017A (https=) |
| AU (2) | AU2005227148B2 (https=) |
| CA (1) | CA2560696C (https=) |
| CY (1) | CY1121975T1 (https=) |
| DK (3) | DK3296407T3 (https=) |
| ES (5) | ES2869167T3 (https=) |
| HU (1) | HUE045690T2 (https=) |
| LT (1) | LT3296407T (https=) |
| PL (2) | PL1730303T3 (https=) |
| PT (3) | PT1730303E (https=) |
| SI (2) | SI3296407T1 (https=) |
| WO (1) | WO2005091849A2 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3296407T1 (sl) | 2004-03-02 | 2019-09-30 | The Johns Hopkins University | Mutacije gena PIK3CA pri rakih pri ljudeh |
| EP1849877A1 (en) * | 2006-04-24 | 2007-10-31 | Erasmus University Medical Center Rotterdam | Replicative history of T-and B-cell subsets |
| WO2008109375A2 (en) * | 2007-03-02 | 2008-09-12 | Mdrna, Inc. | Nucleic acid compounds for inhibiting pik3c gene expression and uses thereof |
| GB2453173A (en) * | 2007-09-28 | 2009-04-01 | Dxs Ltd | Polynucleotide primers |
| US7863437B2 (en) | 2007-12-03 | 2011-01-04 | Enzon Pharmaceuticals, Inc. | RNA antagonist compounds for the modulation of PIK3CA expression |
| WO2009152346A2 (en) * | 2008-06-11 | 2009-12-17 | Intradigm Corporation | Compositions comprising phosphoinositide 3-kinase sirna and methods of use thereof |
| CN101445832B (zh) * | 2008-12-23 | 2011-09-14 | 广州益善生物技术有限公司 | Pik3ca基因突变的检测探针、液相芯片及其检测方法 |
| US20110236916A1 (en) * | 2010-03-26 | 2011-09-29 | Mayo Foundation For Medical Education And Research | Methods and materials for detecting colorectal neoplasm |
| AU2011329180A1 (en) * | 2010-11-15 | 2013-05-02 | Enzon Pharmaceuticals, Inc. | Methods of treating cancers with HER3 and PIK3CA antisense oligonucleotides |
| JP2013545756A (ja) * | 2010-11-16 | 2013-12-26 | グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー2、リミテッド | 投与および治療方法 |
| US9157125B2 (en) | 2011-02-02 | 2015-10-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | GRIN2A mutations and use thereof for the diagnosis of melanoma |
| US9295673B2 (en) | 2011-02-23 | 2016-03-29 | Intellikine Llc | Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof |
| ES2625288T3 (es) | 2011-04-15 | 2017-07-19 | The Johns Hopkins University | Sistema de secuenciación segura |
| RU2014107713A (ru) * | 2011-07-28 | 2015-09-10 | Дженентек, Инк | Модель рака молочной железы у животных, кроме человека, с активируемым pik3ca h1047r |
| US9376715B2 (en) | 2011-12-09 | 2016-06-28 | Roche Molecular Systems, Inc | Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene |
| WO2013177386A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Biotherapeutics Inc. | Biomarkers for predicting response to tweak receptor (tweakr) agonist therapy |
| CN102816839A (zh) * | 2012-07-06 | 2012-12-12 | 杭州艾迪康医学检验中心有限公司 | 用于检测结直肠癌pik3ca基因热点突变位点的试剂盒 |
| AU2013338393C1 (en) | 2012-10-29 | 2024-07-25 | The Johns Hopkins University | Papanicolaou test for ovarian and endometrial cancers |
| CN108130373A (zh) * | 2013-03-13 | 2018-06-08 | 豪夫迈·罗氏有限公司 | 在人pi3kca (pik3ca)基因中检测突变的方法和组合物 |
| ES2859645T3 (es) | 2013-03-14 | 2021-10-04 | Mayo Found Medical Education & Res | Detección de neoplasia |
| KR101501826B1 (ko) * | 2013-04-05 | 2015-03-13 | 연세대학교 산학협력단 | 위암에 대한 예후 예측 모형의 제조방법 |
| EP3027654B1 (en) * | 2013-07-30 | 2019-09-25 | Blueprint Medicines Corporation | Pik3c2g fusions |
| EP4234722A3 (en) | 2014-03-31 | 2023-09-20 | Mayo Foundation for Medical Education and Research | Detecting colorectal neoplasm |
| RS59710B1 (sr) | 2014-08-07 | 2020-01-31 | Pharmassist Ltd | Metod određivanja mutacionog statusa pik3ca u uzorku |
| US12391985B2 (en) | 2014-08-07 | 2025-08-19 | Pharmassist Ltd | Method of determining PIK3CA mutational status in a sample |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| CN104531854B (zh) * | 2014-11-10 | 2017-01-18 | 中国人民解放军第三〇七医院 | 检测西妥昔单抗治疗转移性结直肠癌耐药的试剂盒 |
| US10030272B2 (en) | 2015-02-27 | 2018-07-24 | Mayo Foundation For Medical Education And Research | Detecting gastrointestinal neoplasms |
| CN107532124B (zh) | 2015-03-27 | 2022-08-09 | 精密科学公司 | 检测食管疾病 |
| EP4435112A3 (en) * | 2015-05-27 | 2025-02-26 | Quest Diagnostics Investments Incorporated | Compositions and methods for screening solid tumors |
| US11286531B2 (en) | 2015-08-11 | 2022-03-29 | The Johns Hopkins University | Assaying ovarian cyst fluid |
| CN108138235B (zh) | 2015-08-31 | 2022-04-15 | 梅约医药教育及研究基金会 | 检测胃肿瘤 |
| JP2018535997A (ja) | 2015-12-03 | 2018-12-06 | ノバルティス アーゲー | ctDNAにPIK3CA変異を有するために事前選択された患者におけるPI3K阻害剤を用いた癌の処置 |
| RU2608960C1 (ru) * | 2016-03-18 | 2017-01-27 | Федеральное государственное бюджетное учреждение "Российский онкологический научный центр имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "РОНЦ им. Н.Н. Блохина" Минздрава России) | Клеточная линия crov Cel муцинозного рака яичников человека, предназначенная для разработки лечения таргетными препаратами |
| US10370726B2 (en) | 2016-04-14 | 2019-08-06 | Mayo Foundation For Medical Education And Research | Detecting colorectal neoplasia |
| CA3020628A1 (en) | 2016-04-14 | 2017-10-19 | Mayo Foundation For Medical Education And Research | Detecting pancreatic high-grade dysplasia |
| CN110431241B (zh) | 2017-02-28 | 2024-04-19 | 梅约医学教育与研究基金会 | 检测前列腺癌 |
| JP7224645B2 (ja) * | 2017-03-30 | 2023-02-20 | 国立大学法人 東京大学 | 異なる複数の目的遺伝子の評価方法 |
| IL319255A (en) | 2017-08-07 | 2025-04-01 | Univ Johns Hopkins | Methods and materials for cancer assessment and treatment |
| JP7067896B2 (ja) | 2017-10-27 | 2022-05-16 | シスメックス株式会社 | 品質評価方法、品質評価装置、プログラム、および記録媒体 |
| US10975443B2 (en) | 2017-11-30 | 2021-04-13 | Mayo Foundation For Medical Education And Research | Detecting breast cancer |
| JP2023513606A (ja) | 2020-02-14 | 2023-03-31 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 核酸を評価するための方法および材料 |
| CN111363827A (zh) * | 2020-04-30 | 2020-07-03 | 北京和合医学诊断技术股份有限公司 | 用于检测pik3ca基因突变的引物组及其应用方法 |
| DE102021126650A1 (de) | 2021-10-14 | 2023-04-20 | Rheinische Friedrich-Wilhelms-Universität Bonn, Körperschaft des öffentlichen Rechts | Verfahren zur bestimmung der ansprechwahrscheinlichkeit einer malignen erkrankung auf eine behandlung mit einem pharmazeutischen hemmwirkstoff |
| CN116219015A (zh) * | 2023-02-06 | 2023-06-06 | 中日友好医院(中日友好临床医学研究所) | 基于pcr的dna中pik3ca基因突变检测试剂盒及检测方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5248671A (en) * | 1989-02-15 | 1993-09-28 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oligonucleotides |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5846824A (en) * | 1994-02-07 | 1998-12-08 | Ludwig Institute For Cancer Research | Polypeptides having kinase activity, their preparation and use |
| US6274327B1 (en) | 1992-04-13 | 2001-08-14 | Ludwig Institute For Cancer Research | Polypeptides having kinase activity, their preparation and use |
| GB9208135D0 (en) | 1992-04-13 | 1992-05-27 | Ludwig Inst Cancer Res | Polypeptides having kinase activity,their preparation and use |
| US5846624A (en) * | 1996-12-06 | 1998-12-08 | The Standard Register Company | Dual face pressure sensitive label |
| US6277563B1 (en) | 1997-01-16 | 2001-08-21 | The Regents Of The University Of California | Genetic alterations associated with cancer |
| US7670767B1 (en) | 1997-01-16 | 2010-03-02 | The Regents Of The University Of California | Genetic alterations associated with cancer |
| US6558903B1 (en) | 1999-06-30 | 2003-05-06 | Millennium Pharmaceuticals, Inc. | Kinases and uses thereof |
| WO2001016306A2 (en) | 1999-08-27 | 2001-03-08 | Chiron Corporation | Chimeric antisense oligonucleotides and cell transfecting formulations thereof |
| CA2395872A1 (en) * | 2000-01-31 | 2001-08-02 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
| WO2002027028A1 (en) * | 2000-09-28 | 2002-04-04 | Atairgin Technologies, Inc. | A method of determining tumor characteristics by determining abnormal copy number or expression level of lipid-associated genes |
| US20020142305A1 (en) | 2001-03-27 | 2002-10-03 | Koei Chin | Methods for diagnosing and monitoring ovarian cancer by screening gene copy numbers |
| US20030135033A1 (en) * | 2002-01-04 | 2003-07-17 | Anke Klippel-Giese | Compounds and methods for the identification and/ or validation of a target |
| WO2004010900A1 (en) | 2002-07-25 | 2004-02-05 | Avantec Vascular Corporation | Devices delivering therapeutic agents and methods regarding the same |
| KR20070087266A (ko) * | 2003-04-03 | 2007-08-28 | 세마포르 파머슈티컬즈, 아이엔씨. | 피아이-3 키나아제 억제제 프로드러그 |
| SI3296407T1 (sl) | 2004-03-02 | 2019-09-30 | The Johns Hopkins University | Mutacije gena PIK3CA pri rakih pri ljudeh |
-
2005
- 2005-02-18 SI SI200532262T patent/SI3296407T1/sl unknown
- 2005-02-18 ES ES19175606T patent/ES2869167T3/es not_active Expired - Lifetime
- 2005-02-18 DK DK17197306.8T patent/DK3296407T3/da active
- 2005-02-18 PT PT57232779T patent/PT1730303E/pt unknown
- 2005-02-18 ES ES17197306T patent/ES2743125T3/es not_active Expired - Lifetime
- 2005-02-18 DK DK19175606.3T patent/DK3556866T3/da active
- 2005-02-18 SI SI200531792T patent/SI1730303T1/sl unknown
- 2005-02-18 JP JP2007501815A patent/JP2007530017A/ja not_active Withdrawn
- 2005-02-18 EP EP12164819.0A patent/EP2497836B1/en not_active Expired - Lifetime
- 2005-02-18 AU AU2005227148A patent/AU2005227148B2/en not_active Expired
- 2005-02-18 EP EP15150891.8A patent/EP2896703B1/en not_active Expired - Lifetime
- 2005-02-18 CA CA2560696A patent/CA2560696C/en not_active Expired - Lifetime
- 2005-02-18 US US10/591,347 patent/US8026053B2/en active Active
- 2005-02-18 ES ES15150891.8T patent/ES2663248T3/es not_active Expired - Lifetime
- 2005-02-18 PT PT17197306T patent/PT3296407T/pt unknown
- 2005-02-18 DK DK05723277.9T patent/DK1730303T3/da active
- 2005-02-18 PL PL05723277T patent/PL1730303T3/pl unknown
- 2005-02-18 HU HUE17197306A patent/HUE045690T2/hu unknown
- 2005-02-18 ES ES12164819.0T patent/ES2537633T3/es not_active Expired - Lifetime
- 2005-02-18 EP EP17197306.8A patent/EP3296407B1/en not_active Expired - Lifetime
- 2005-02-18 PL PL17197306T patent/PL3296407T3/pl unknown
- 2005-02-18 ES ES05723277.9T patent/ES2437590T3/es not_active Expired - Lifetime
- 2005-02-18 LT LTEP17197306.8T patent/LT3296407T/lt unknown
- 2005-02-18 WO PCT/US2005/005193 patent/WO2005091849A2/en not_active Ceased
- 2005-02-18 EP EP19175606.3A patent/EP3556866B1/en not_active Expired - Lifetime
- 2005-02-18 PT PT191756063T patent/PT3556866T/pt unknown
- 2005-02-18 EP EP05723277.9A patent/EP1730303B1/en not_active Expired - Lifetime
-
2011
- 2011-02-11 AU AU2011200600A patent/AU2011200600B2/en not_active Expired
- 2011-08-16 US US13/210,736 patent/US20110319477A1/en not_active Abandoned
-
2012
- 2012-03-09 JP JP2012052427A patent/JP5336620B2/ja not_active Expired - Lifetime
-
2013
- 2013-05-10 JP JP2013100073A patent/JP5894110B2/ja not_active Expired - Lifetime
-
2014
- 2014-10-31 US US14/529,351 patent/US10422006B2/en not_active Expired - Lifetime
-
2015
- 2015-12-17 JP JP2015245769A patent/JP6250017B2/ja not_active Expired - Lifetime
-
2017
- 2017-10-19 JP JP2017202265A patent/JP6395917B2/ja not_active Expired - Lifetime
- 2017-12-08 US US15/836,366 patent/US10704105B2/en not_active Expired - Lifetime
-
2018
- 2018-05-09 JP JP2018090580A patent/JP6695381B2/ja not_active Expired - Lifetime
-
2019
- 2019-08-21 CY CY20191100895T patent/CY1121975T1/el unknown
- 2019-10-07 US US16/595,055 patent/US11549150B2/en not_active Expired - Lifetime
- 2019-11-06 JP JP2019201128A patent/JP6694543B2/ja not_active Expired - Lifetime
-
2020
- 2020-03-06 JP JP2020038337A patent/JP7169315B2/ja not_active Expired - Lifetime
- 2020-04-20 US US16/853,230 patent/US10787713B2/en not_active Expired - Lifetime
- 2020-04-28 JP JP2020078786A patent/JP7001735B2/ja not_active Expired - Lifetime
-
2022
- 2022-02-17 JP JP2022022542A patent/JP7304987B2/ja not_active Expired - Lifetime
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