JP2007530017A - ヒトの癌におけるpik3ca遺伝子の変異 - Google Patents

ヒトの癌におけるpik3ca遺伝子の変異 Download PDF

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Publication number
JP2007530017A
JP2007530017A JP2007501815A JP2007501815A JP2007530017A JP 2007530017 A JP2007530017 A JP 2007530017A JP 2007501815 A JP2007501815 A JP 2007501815A JP 2007501815 A JP2007501815 A JP 2007501815A JP 2007530017 A JP2007530017 A JP 2007530017A
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pik3ca
seq
mutation
body sample
mutations
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ヤーデナ サミュエルス
ビクター ベルクレスク
ケネス ダブリュー. キンズラー
バート ボゲルステイン
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Johns Hopkins University
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Veterinary Medicine (AREA)
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  • General Engineering & Computer Science (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
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JP2007501815A 2004-03-02 2005-02-18 ヒトの癌におけるpik3ca遺伝子の変異 Withdrawn JP2007530017A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54888604P 2004-03-02 2004-03-02
PCT/US2005/005193 WO2005091849A2 (en) 2004-03-02 2005-02-18 Mutations of the pik3ca gene in human cancers

Related Child Applications (1)

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JP2012052427A Division JP5336620B2 (ja) 2004-03-02 2012-03-09 ヒトの癌におけるpik3ca遺伝子の変異

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JP2007530017A true JP2007530017A (ja) 2007-11-01

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Family Applications (10)

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JP2007501815A Withdrawn JP2007530017A (ja) 2004-03-02 2005-02-18 ヒトの癌におけるpik3ca遺伝子の変異
JP2012052427A Expired - Lifetime JP5336620B2 (ja) 2004-03-02 2012-03-09 ヒトの癌におけるpik3ca遺伝子の変異
JP2013100073A Expired - Lifetime JP5894110B2 (ja) 2004-03-02 2013-05-10 ヒトの癌におけるpik3ca遺伝子の変異
JP2015245769A Expired - Lifetime JP6250017B2 (ja) 2004-03-02 2015-12-17 ヒトの癌におけるpik3ca遺伝子の変異
JP2017202265A Expired - Lifetime JP6395917B2 (ja) 2004-03-02 2017-10-19 ヒトの癌におけるpik3ca遺伝子の変異
JP2018090580A Expired - Lifetime JP6695381B2 (ja) 2004-03-02 2018-05-09 ヒトの癌におけるpik3ca遺伝子の変異
JP2019201128A Expired - Lifetime JP6694543B2 (ja) 2004-03-02 2019-11-06 ヒトの癌におけるpik3ca遺伝子の変異
JP2020038337A Expired - Lifetime JP7169315B2 (ja) 2004-03-02 2020-03-06 ヒトの癌におけるpik3ca遺伝子の変異
JP2020078786A Expired - Lifetime JP7001735B2 (ja) 2004-03-02 2020-04-28 ヒトの癌におけるpik3ca遺伝子の変異
JP2022022542A Expired - Lifetime JP7304987B2 (ja) 2004-03-02 2022-02-17 ヒトの癌におけるpik3ca遺伝子の変異

Family Applications After (9)

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JP2012052427A Expired - Lifetime JP5336620B2 (ja) 2004-03-02 2012-03-09 ヒトの癌におけるpik3ca遺伝子の変異
JP2013100073A Expired - Lifetime JP5894110B2 (ja) 2004-03-02 2013-05-10 ヒトの癌におけるpik3ca遺伝子の変異
JP2015245769A Expired - Lifetime JP6250017B2 (ja) 2004-03-02 2015-12-17 ヒトの癌におけるpik3ca遺伝子の変異
JP2017202265A Expired - Lifetime JP6395917B2 (ja) 2004-03-02 2017-10-19 ヒトの癌におけるpik3ca遺伝子の変異
JP2018090580A Expired - Lifetime JP6695381B2 (ja) 2004-03-02 2018-05-09 ヒトの癌におけるpik3ca遺伝子の変異
JP2019201128A Expired - Lifetime JP6694543B2 (ja) 2004-03-02 2019-11-06 ヒトの癌におけるpik3ca遺伝子の変異
JP2020038337A Expired - Lifetime JP7169315B2 (ja) 2004-03-02 2020-03-06 ヒトの癌におけるpik3ca遺伝子の変異
JP2020078786A Expired - Lifetime JP7001735B2 (ja) 2004-03-02 2020-04-28 ヒトの癌におけるpik3ca遺伝子の変異
JP2022022542A Expired - Lifetime JP7304987B2 (ja) 2004-03-02 2022-02-17 ヒトの癌におけるpik3ca遺伝子の変異

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US (6) US8026053B2 (https=)
EP (5) EP2497836B1 (https=)
JP (10) JP2007530017A (https=)
AU (2) AU2005227148B2 (https=)
CA (1) CA2560696C (https=)
CY (1) CY1121975T1 (https=)
DK (3) DK3556866T3 (https=)
ES (5) ES2437590T3 (https=)
HU (1) HUE045690T2 (https=)
LT (1) LT3296407T (https=)
PL (2) PL3296407T3 (https=)
PT (3) PT1730303E (https=)
SI (2) SI3296407T1 (https=)
WO (1) WO2005091849A2 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011505124A (ja) * 2007-12-03 2011-02-24 エンゾン ファーマシューティカルズ,インコーポレーテッド Pik3ca発現をモジュレーションするためのrnaアンタゴニスト化合物
CN102816839A (zh) * 2012-07-06 2012-12-12 杭州艾迪康医学检验中心有限公司 用于检测结直肠癌pik3ca基因热点突变位点的试剂盒
JP2016510982A (ja) * 2013-03-13 2016-04-14 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft ヒトpi3kca(pik3ca)遺伝子変異検出のための方法及び組成物
JP2016515390A (ja) * 2013-04-05 2016-05-30 ユニバーシティ−インダストリー・ファンデーション・ヨンセイ・ユニバーシティ 胃癌に対する予後予測模型の製造方法
WO2018181863A1 (ja) * 2017-03-30 2018-10-04 国立大学法人東京大学 異なる複数の目的遺伝子の評価方法

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JP2007530017A (ja) 2004-03-02 2007-11-01 ザ ジョンズ ホプキンス ユニバーシティ ヒトの癌におけるpik3ca遺伝子の変異
EP1849877A1 (en) * 2006-04-24 2007-10-31 Erasmus University Medical Center Rotterdam Replicative history of T-and B-cell subsets
WO2008109375A2 (en) * 2007-03-02 2008-09-12 Mdrna, Inc. Nucleic acid compounds for inhibiting pik3c gene expression and uses thereof
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CN101445832B (zh) * 2008-12-23 2011-09-14 广州益善生物技术有限公司 Pik3ca基因突变的检测探针、液相芯片及其检测方法
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JP2013545756A (ja) * 2010-11-16 2013-12-26 グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー2、リミテッド 投与および治療方法
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US9376715B2 (en) 2011-12-09 2016-06-28 Roche Molecular Systems, Inc Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene
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CA2902916C (en) 2013-03-14 2018-08-28 Mayo Foundation For Medical Education And Research Detecting neoplasm
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CN120700143A (zh) 2014-03-31 2025-09-26 梅奥医学教育和研究基金会 检测结直肠赘生物
DK3198026T3 (da) * 2014-08-07 2020-01-20 Pharmassist Ltd Fremgangsmåde til bestemmelse af pik3ca-mutationsstatus i en prøve
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US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
CN104531854B (zh) * 2014-11-10 2017-01-18 中国人民解放军第三〇七医院 检测西妥昔单抗治疗转移性结直肠癌耐药的试剂盒
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JP7481804B2 (ja) 2016-04-14 2024-05-13 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 高度膵異形成の検出
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JP7067896B2 (ja) 2017-10-27 2022-05-16 シスメックス株式会社 品質評価方法、品質評価装置、プログラム、および記録媒体
JP7277460B2 (ja) 2017-11-30 2023-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 乳癌の検出
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CN111363827A (zh) * 2020-04-30 2020-07-03 北京和合医学诊断技术股份有限公司 用于检测pik3ca基因突变的引物组及其应用方法
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011505124A (ja) * 2007-12-03 2011-02-24 エンゾン ファーマシューティカルズ,インコーポレーテッド Pik3ca発現をモジュレーションするためのrnaアンタゴニスト化合物
CN102816839A (zh) * 2012-07-06 2012-12-12 杭州艾迪康医学检验中心有限公司 用于检测结直肠癌pik3ca基因热点突变位点的试剂盒
JP2016510982A (ja) * 2013-03-13 2016-04-14 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft ヒトpi3kca(pik3ca)遺伝子変異検出のための方法及び組成物
JP2016515390A (ja) * 2013-04-05 2016-05-30 ユニバーシティ−インダストリー・ファンデーション・ヨンセイ・ユニバーシティ 胃癌に対する予後予測模型の製造方法
WO2018181863A1 (ja) * 2017-03-30 2018-10-04 国立大学法人東京大学 異なる複数の目的遺伝子の評価方法

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AU2005227148B2 (en) 2010-11-11
WO2005091849A3 (en) 2009-04-16
US8026053B2 (en) 2011-09-27
US20150079593A1 (en) 2015-03-19
US10704105B2 (en) 2020-07-07
EP3556866B1 (en) 2021-04-07
DK3296407T3 (da) 2019-08-19
EP3296407B1 (en) 2019-05-22
SI3296407T1 (sl) 2019-09-30
CY1121975T1 (el) 2020-10-14
JP2013226141A (ja) 2013-11-07
SI1730303T1 (sl) 2013-12-31
PL1730303T3 (pl) 2014-04-30
PT3296407T (pt) 2019-08-23
EP3296407A1 (en) 2018-03-21
JP2012183065A (ja) 2012-09-27
DK1730303T3 (da) 2013-11-04
ES2869167T3 (es) 2021-10-25
US10787713B2 (en) 2020-09-29
EP1730303A2 (en) 2006-12-13
AU2011200600B2 (en) 2012-02-23
JP2020092711A (ja) 2020-06-18
ES2537633T3 (es) 2015-06-10
JP2020115891A (ja) 2020-08-06
CA2560696C (en) 2019-06-25
EP3556866A1 (en) 2019-10-23
US20090208505A1 (en) 2009-08-20
ES2663248T3 (es) 2018-04-11
JP5336620B2 (ja) 2013-11-06
EP1730303A4 (en) 2009-09-09
JP2022059046A (ja) 2022-04-12
JP2018153189A (ja) 2018-10-04
JP5894110B2 (ja) 2016-03-23
JP7304987B2 (ja) 2023-07-07
JP6695381B2 (ja) 2020-05-20
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