JP2007530017A - ヒトの癌におけるｐｉｋ３ｃａ遺伝子の変異 - Google Patents
ヒトの癌におけるｐｉｋ３ｃａ遺伝子の変異 Download PDFInfo
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| DE102021126650A1 (de) | 2021-10-14 | 2023-04-20 | Rheinische Friedrich-Wilhelms-Universität Bonn, Körperschaft des öffentlichen Rechts | Verfahren zur bestimmung der ansprechwahrscheinlichkeit einer malignen erkrankung auf eine behandlung mit einem pharmazeutischen hemmwirkstoff |
| CN116219015A (zh) * | 2023-02-06 | 2023-06-06 | 中日友好医院(中日友好临床医学研究所) | 基于pcr的dna中pik3ca基因突变检测试剂盒及检测方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5248671A (en) * | 1989-02-15 | 1993-09-28 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oligonucleotides |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5846824A (en) * | 1994-02-07 | 1998-12-08 | Ludwig Institute For Cancer Research | Polypeptides having kinase activity, their preparation and use |
| US6274327B1 (en) | 1992-04-13 | 2001-08-14 | Ludwig Institute For Cancer Research | Polypeptides having kinase activity, their preparation and use |
| GB9208135D0 (en) | 1992-04-13 | 1992-05-27 | Ludwig Inst Cancer Res | Polypeptides having kinase activity,their preparation and use |
| US5846624A (en) * | 1996-12-06 | 1998-12-08 | The Standard Register Company | Dual face pressure sensitive label |
| US6277563B1 (en) | 1997-01-16 | 2001-08-21 | The Regents Of The University Of California | Genetic alterations associated with cancer |
| US7670767B1 (en) | 1997-01-16 | 2010-03-02 | The Regents Of The University Of California | Genetic alterations associated with cancer |
| US6558903B1 (en) | 1999-06-30 | 2003-05-06 | Millennium Pharmaceuticals, Inc. | Kinases and uses thereof |
| WO2001016306A2 (en) | 1999-08-27 | 2001-03-08 | Chiron Corporation | Chimeric antisense oligonucleotides and cell transfecting formulations thereof |
| CA2395872A1 (en) * | 2000-01-31 | 2001-08-02 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
| WO2002027028A1 (en) * | 2000-09-28 | 2002-04-04 | Atairgin Technologies, Inc. | A method of determining tumor characteristics by determining abnormal copy number or expression level of lipid-associated genes |
| US20020142305A1 (en) | 2001-03-27 | 2002-10-03 | Koei Chin | Methods for diagnosing and monitoring ovarian cancer by screening gene copy numbers |
| US20030135033A1 (en) * | 2002-01-04 | 2003-07-17 | Anke Klippel-Giese | Compounds and methods for the identification and/ or validation of a target |
| WO2004010900A1 (en) | 2002-07-25 | 2004-02-05 | Avantec Vascular Corporation | Devices delivering therapeutic agents and methods regarding the same |
| KR20070087266A (ko) * | 2003-04-03 | 2007-08-28 | 세마포르 파머슈티컬즈, 아이엔씨. | 피아이-3 키나아제 억제제 프로드러그 |
| SI3296407T1 (sl) | 2004-03-02 | 2019-09-30 | The Johns Hopkins University | Mutacije gena PIK3CA pri rakih pri ljudeh |
-
2005
- 2005-02-18 SI SI200532262T patent/SI3296407T1/sl unknown
- 2005-02-18 ES ES19175606T patent/ES2869167T3/es not_active Expired - Lifetime
- 2005-02-18 DK DK17197306.8T patent/DK3296407T3/da active
- 2005-02-18 PT PT57232779T patent/PT1730303E/pt unknown
- 2005-02-18 ES ES17197306T patent/ES2743125T3/es not_active Expired - Lifetime
- 2005-02-18 DK DK19175606.3T patent/DK3556866T3/da active
- 2005-02-18 SI SI200531792T patent/SI1730303T1/sl unknown
- 2005-02-18 JP JP2007501815A patent/JP2007530017A/ja not_active Withdrawn
- 2005-02-18 EP EP12164819.0A patent/EP2497836B1/en not_active Expired - Lifetime
- 2005-02-18 AU AU2005227148A patent/AU2005227148B2/en not_active Expired
- 2005-02-18 EP EP15150891.8A patent/EP2896703B1/en not_active Expired - Lifetime
- 2005-02-18 CA CA2560696A patent/CA2560696C/en not_active Expired - Lifetime
- 2005-02-18 US US10/591,347 patent/US8026053B2/en active Active
- 2005-02-18 ES ES15150891.8T patent/ES2663248T3/es not_active Expired - Lifetime
- 2005-02-18 PT PT17197306T patent/PT3296407T/pt unknown
- 2005-02-18 DK DK05723277.9T patent/DK1730303T3/da active
- 2005-02-18 PL PL05723277T patent/PL1730303T3/pl unknown
- 2005-02-18 HU HUE17197306A patent/HUE045690T2/hu unknown
- 2005-02-18 ES ES12164819.0T patent/ES2537633T3/es not_active Expired - Lifetime
- 2005-02-18 EP EP17197306.8A patent/EP3296407B1/en not_active Expired - Lifetime
- 2005-02-18 PL PL17197306T patent/PL3296407T3/pl unknown
- 2005-02-18 ES ES05723277.9T patent/ES2437590T3/es not_active Expired - Lifetime
- 2005-02-18 LT LTEP17197306.8T patent/LT3296407T/lt unknown
- 2005-02-18 WO PCT/US2005/005193 patent/WO2005091849A2/en not_active Ceased
- 2005-02-18 EP EP19175606.3A patent/EP3556866B1/en not_active Expired - Lifetime
- 2005-02-18 PT PT191756063T patent/PT3556866T/pt unknown
- 2005-02-18 EP EP05723277.9A patent/EP1730303B1/en not_active Expired - Lifetime
-
2011
- 2011-02-11 AU AU2011200600A patent/AU2011200600B2/en not_active Expired
- 2011-08-16 US US13/210,736 patent/US20110319477A1/en not_active Abandoned
-
2012
- 2012-03-09 JP JP2012052427A patent/JP5336620B2/ja not_active Expired - Lifetime
-
2013
- 2013-05-10 JP JP2013100073A patent/JP5894110B2/ja not_active Expired - Lifetime
-
2014
- 2014-10-31 US US14/529,351 patent/US10422006B2/en not_active Expired - Lifetime
-
2015
- 2015-12-17 JP JP2015245769A patent/JP6250017B2/ja not_active Expired - Lifetime
-
2017
- 2017-10-19 JP JP2017202265A patent/JP6395917B2/ja not_active Expired - Lifetime
- 2017-12-08 US US15/836,366 patent/US10704105B2/en not_active Expired - Lifetime
-
2018
- 2018-05-09 JP JP2018090580A patent/JP6695381B2/ja not_active Expired - Lifetime
-
2019
- 2019-08-21 CY CY20191100895T patent/CY1121975T1/el unknown
- 2019-10-07 US US16/595,055 patent/US11549150B2/en not_active Expired - Lifetime
- 2019-11-06 JP JP2019201128A patent/JP6694543B2/ja not_active Expired - Lifetime
-
2020
- 2020-03-06 JP JP2020038337A patent/JP7169315B2/ja not_active Expired - Lifetime
- 2020-04-20 US US16/853,230 patent/US10787713B2/en not_active Expired - Lifetime
- 2020-04-28 JP JP2020078786A patent/JP7001735B2/ja not_active Expired - Lifetime
-
2022
- 2022-02-17 JP JP2022022542A patent/JP7304987B2/ja not_active Expired - Lifetime
Non-Patent Citations (5)
| Title |
|---|
| JPN6010056030, "Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ", ２００３， Ｖｏｌ．６３， ｐｐ．４２２５−４２３１ * |
| JPN6010056031, "Ｏｎｃｏｇｅｎｅ", ２０００， Ｖｏｌ．１９， ｐｐ．２７３９−２７４４ * |
| JPN6010056032, "Ｎａｔｕｒｅ Ｇｅｎｅｔｉｃｓ", １９９９， Ｖｏｌ．２１， ｐｐ．９９−１０２ * |
| JPN6010056033, "Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｌｏｇｉｃａｌ Ｃｈｅｍｉｓｔｒｙ", ２０００， Ｖｏｌ．２７５， Ｎｏ．６， ｐｐ．３７４１−３７４４ * |
| JPN6010056035, "Ｐｒｏｃｅｅｄｉｎｇｓ． Ａｎｎｕａｌ Ｍｅｅｔｉｎｇ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ａｓｓｏｃｉａｔｉｏｎ ｆｏｒ Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ", ２００２， Ｖｏｌ．４３， ｐ．６０２ * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011505124A (ja) * | 2007-12-03 | 2011-02-24 | エンゾン ファーマシューティカルズ，インコーポレーテッド | Ｐｉｋ３ｃａ発現をモジュレーションするためのｒｎａアンタゴニスト化合物 |
| CN102816839A (zh) * | 2012-07-06 | 2012-12-12 | 杭州艾迪康医学检验中心有限公司 | 用于检测结直肠癌pik3ca基因热点突变位点的试剂盒 |
| JP2016510982A (ja) * | 2013-03-13 | 2016-04-14 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ヒトｐｉ３ｋｃａ（ｐｉｋ３ｃａ）遺伝子変異検出のための方法及び組成物 |
| JP2016515390A (ja) * | 2013-04-05 | 2016-05-30 | ユニバーシティ−インダストリー・ファンデーション・ヨンセイ・ユニバーシティ | 胃癌に対する予後予測模型の製造方法 |
| WO2018181863A1 (ja) * | 2017-03-30 | 2018-10-04 | 国立大学法人東京大学 | 異なる複数の目的遺伝子の評価方法 |
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