JP2020023517A5 - - Google Patents

Download PDF

Info

Publication number
JP2020023517A5
JP2020023517A5 JP2019178744A JP2019178744A JP2020023517A5 JP 2020023517 A5 JP2020023517 A5 JP 2020023517A5 JP 2019178744 A JP2019178744 A JP 2019178744A JP 2019178744 A JP2019178744 A JP 2019178744A JP 2020023517 A5 JP2020023517 A5 JP 2020023517A5
Authority
JP
Japan
Prior art keywords
cdr
amino acid
variable
seq
complementarity determining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019178744A
Other languages
English (en)
Japanese (ja)
Other versions
JP7100221B2 (ja
JP2020023517A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2020023517A publication Critical patent/JP2020023517A/ja
Publication of JP2020023517A5 publication Critical patent/JP2020023517A5/ja
Priority to JP2022012715A priority Critical patent/JP7393447B2/ja
Application granted granted Critical
Publication of JP7100221B2 publication Critical patent/JP7100221B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019178744A 2013-08-14 2019-09-30 Ｆｒｉｚｚｌｅｄタンパク質に対する抗体及びその使用方法 Active JP7100221B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022012715A JP7393447B2 (ja) 2013-08-14 2022-01-31 Ｆｒｉｚｚｌｅｄタンパク質に対する抗体及びその使用方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361865668P 2013-08-14 2013-08-14
US61/865,668 2013-08-14

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2016534837A Division JP6617239B2 (ja) 2013-08-14 2014-08-14 Ｆｒｉｚｚｌｅｄタンパク質に対する抗体及びその使用方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022012715A Division JP7393447B2 (ja) 2013-08-14 2022-01-31 Ｆｒｉｚｚｌｅｄタンパク質に対する抗体及びその使用方法

Publications (3)

Publication Number Publication Date
JP2020023517A JP2020023517A (ja) 2020-02-13
JP2020023517A5 true JP2020023517A5 (https=) 2020-09-03
JP7100221B2 JP7100221B2 (ja) 2022-07-13

Family

ID=51398950

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016534837A Active JP6617239B2 (ja) 2013-08-14 2014-08-14 Ｆｒｉｚｚｌｅｄタンパク質に対する抗体及びその使用方法
JP2019178744A Active JP7100221B2 (ja) 2013-08-14 2019-09-30 Ｆｒｉｚｚｌｅｄタンパク質に対する抗体及びその使用方法
JP2022012715A Active JP7393447B2 (ja) 2013-08-14 2022-01-31 Ｆｒｉｚｚｌｅｄタンパク質に対する抗体及びその使用方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2016534837A Active JP6617239B2 (ja) 2013-08-14 2014-08-14 Ｆｒｉｚｚｌｅｄタンパク質に対する抗体及びその使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022012715A Active JP7393447B2 (ja) 2013-08-14 2022-01-31 Ｆｒｉｚｚｌｅｄタンパク質に対する抗体及びその使用方法

Country Status (6)

Country Link
US (2) US10077304B2 (https=)
EP (2) EP3033356B1 (https=)
JP (3) JP6617239B2 (https=)
AU (2) AU2014306564B2 (https=)
CA (1) CA2921398C (https=)
WO (1) WO2015023851A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10077304B2 (en) 2013-08-14 2018-09-18 The Governing Council Of The University Of Toronto Antibodies against frizzled receptor
WO2016205566A1 (en) * 2015-06-16 2016-12-22 The Regents Of The University Of California Fzd7 specific antibodies and vaccines to treat cancer and control stem cell function
WO2017127933A1 (en) 2016-01-29 2017-08-03 The Governing Council Of The University Of Toronto Frizzled protein-binding agents and methods of use thereof
EP3509616A1 (en) * 2016-09-09 2019-07-17 H. Hoffnabb-La Roche Ag Selective peptide inhibitors of frizzled
US11773171B2 (en) 2017-12-19 2023-10-03 Surrozen Operating, Inc. WNT surrogate molecules and uses thereof
CN111699003B (zh) 2017-12-19 2024-05-03 瑟罗泽恩奥普瑞汀公司 抗lrp5/6抗体和使用方法
CN117946267A (zh) * 2017-12-19 2024-04-30 瑟罗泽恩奥普瑞汀公司 抗卷曲蛋白抗体和使用方法
JP7550647B2 (ja) * 2018-02-14 2024-09-20 アントレラ セラピューティクス インコーポレイテッド Ｗｎｔシグナル伝達を活性化する多価結合分子およびその使用
US20210292422A1 (en) 2018-07-05 2021-09-23 Surrozen, Inc. Multi-specific wnt surrogate molecules and uses thereof
JP7377288B2 (ja) * 2019-06-11 2023-11-09 アントレラ セラピューティクス インコーポレイテッド 多価ｆｚｄおよびｗｎｔ結合分子とその使用
AU2020328475A1 (en) * 2019-08-12 2022-03-31 Antlera Therapeutics Inc. Frizzled receptor antibodies and uses thereof
CN111138539B (zh) * 2019-11-06 2020-12-01 上海健康医学院 一种靶向Frizzled7人源化抗体及其制备方法与应用
CA3204321A1 (en) 2020-12-18 2022-06-23 Antlera Therapeutics Inc. Tetravalent fzd and wnt co-receptor binding antibody molecules and uses thereof
WO2023250402A2 (en) 2022-06-22 2023-12-28 Antlera Therapeutics Inc. Tetravalent fzd and wnt co-receptor binding antibody molecules and uses thereof
CN119053624A (zh) * 2022-02-18 2024-11-29 芝加哥大学 生长激素受体靶向多肽
WO2026055308A1 (en) 2024-09-06 2026-03-12 Merck Sharp & Dohme Llc Multivalent fzd4, wnt co-receptor, and vegf receptor molecules and uses thereof
US20260092125A1 (en) 2024-09-06 2026-04-02 Eyebiotech Limited Multivalent fzd4, wnt co-receptor, and vegf binding molecules and uses thereof

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4681581A (en) 1983-12-05 1987-07-21 Coates Fredrica V Adjustable size diaper and folding method therefor
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5776093A (en) 1985-07-05 1998-07-07 Immunomedics, Inc. Method for imaging and treating organs and tissues
US4735210A (en) 1985-07-05 1988-04-05 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US5101827A (en) 1985-07-05 1992-04-07 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5203778A (en) 1986-02-18 1993-04-20 Boehringer Laboratories Process and apparatus for removal of insoluble fat from blood of a patient
EP0279862B1 (en) 1986-08-28 1993-11-03 Teijin Limited Cytocidal antibody complex and process for its preparation
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5648471A (en) 1987-12-03 1997-07-15 Centocor, Inc. One vial method for labeling antibodies with Technetium-99m
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
ES2096590T3 (es) 1989-06-29 1997-03-16 Medarex Inc Reactivos biespecificos para la terapia del sida.
DK0486622T3 (da) 1989-08-09 1999-07-19 Rhomed Inc Direkte radiomærkning af antistoffer og andre proteiner med technetium eller rhenium
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
DE69120146T2 (de) 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5151510A (en) 1990-04-20 1992-09-29 Applied Biosystems, Inc. Method of synethesizing sulfurized oligonucleotide analogs
WO1992000373A1 (en) 1990-06-29 1992-01-09 Biosource Genetics Corporation Melanin production by transformed microorganisms
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
ATE158021T1 (de) 1990-08-29 1997-09-15 Genpharm Int Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
WO1993012227A1 (en) 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
DE69133557D1 (de) 1990-08-29 2007-03-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5194594A (en) 1990-09-07 1993-03-16 Techniclone, Inc. Modified antibodies
WO1992020373A1 (en) 1991-05-14 1992-11-26 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
WO1992022670A1 (en) 1991-06-12 1992-12-23 Genpharm International, Inc. Early detection of transgenic embryos
WO1992022645A1 (en) 1991-06-14 1992-12-23 Genpharm International, Inc. Transgenic immunodeficient non-human animals
WO1993004169A1 (en) 1991-08-20 1993-03-04 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
PT1024191E (pt) 1991-12-02 2008-12-22 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
US5777085A (en) 1991-12-20 1998-07-07 Protein Design Labs, Inc. Humanized antibodies reactive with GPIIB/IIIA
ATE208374T1 (de) 1992-02-18 2001-11-15 Otsuka Kagaku Kk Beta-laktam und cepham verbindungen und ihre herstellung
US5233409A (en) 1992-02-25 1993-08-03 Schwab Karl W Color analysis of organic constituents in sedimentary rocks for thermal maturity
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
AU4541093A (en) 1992-06-18 1994-01-24 Genpharm International, Inc. Methods for producing transgenic non-human animals harboring a yeast artificial chromosome
ES2301158T3 (es) 1992-07-24 2008-06-16 Amgen Fremont Inc. Produccion de anticuerpos xenogenicos.
DK0752248T3 (da) 1992-11-13 2000-11-13 Idec Pharma Corp Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig
JPH08509612A (ja) 1993-04-26 1996-10-15 ジェンファーム インターナショナル インコーポレイテッド 異種抗体を産生することができるトランスジェニック非ヒト動物
CA2164288A1 (en) 1993-06-04 1994-12-22 Barbara Ensoli Method for treating kaposi's sarcoma with antisense oligonucleotides
US5625825A (en) 1993-10-21 1997-04-29 Lsi Logic Corporation Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network
EP0745134A1 (en) 1994-02-22 1996-12-04 Danafarber Cancer Institute Nucleic acid delivery system, method of synthesis and uses thereof
US5643763A (en) 1994-11-04 1997-07-01 Genpharm International, Inc. Method for making recombinant yeast artificial chromosomes by minimizing diploid doubling during mating
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5703057A (en) 1995-04-07 1997-12-30 Board Of Regents The University Of Texas System Expression library immunization
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
KR100308764B1 (ko) 1995-08-29 2001-12-17 마나배게이사꾸 키메라동물및그의제작법
US6025130A (en) 1996-04-04 2000-02-15 Mercator Genetics, Inc. Hereditary hemochromatosis gene
CA2722378C (en) 1996-12-03 2015-02-03 Amgen Fremont Inc. Human antibodies that bind tnf.alpha.
US6833268B1 (en) 1999-06-10 2004-12-21 Abgenix, Inc. Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
SG190568A1 (en) * 2008-09-26 2013-06-28 Oncomed Pharm Inc Frizzled-binding agents and uses thereof
CA2794674A1 (en) 2010-04-01 2011-10-06 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
EP3281640A1 (en) * 2011-06-17 2018-02-14 President and Fellows of Harvard College Frizzled 2 as a target for therapeutic antibodies in the treatment of cancer
WO2013080055A2 (en) * 2011-09-27 2013-06-06 The Governing Council Of The University Of Toronto Molecular display method
US9111624B2 (en) 2013-03-22 2015-08-18 Katsuyuki Fujita Semiconductor memory device
US10077304B2 (en) 2013-08-14 2018-09-18 The Governing Council Of The University Of Toronto Antibodies against frizzled receptor

Similar Documents

Publication Publication Date Title
JP2020023517A5 (https=)
JP2022105495A5 (https=)
IL321750A (en) Anti-ctla4 antibodies, antibody fragments, immunoconjugates thereof and their uses
JP2021530223A5 (https=)
JP2020114210A5 (https=)
JP2023123502A5 (https=)
RU2015131718A (ru) Мет-связывающие агенты и их применения
JP2020063262A5 (https=)
JP2020122013A5 (https=)
JP2021534762A5 (https=)
JP2020524174A5 (https=)
JP2011514149A5 (https=)
JP2022527635A5 (https=)
JP2018523493A5 (https=)
JP2019536430A5 (https=)
JP2022513384A5 (https=)
JP2013527762A5 (https=)
RU2019128134A (ru) Антитело против gprc5d и молекула, содержащая антитело
JP2013515508A5 (https=)
CN117106099A (zh) 一种抗dll3嵌合抗原受体及其用途
JP2017531427A5 (https=)
JP2020510659A5 (https=)
JP2011505146A5 (https=)
JP2019506841A5 (https=)
CN108025064A (zh) 抗磷脂酰肌醇蛋白聚糖-3抗体和其用于诊断与治疗癌症的用途