AU2014306564B2 - Antibodies against frizzled proteins and methods of use thereof - Google Patents

Antibodies against frizzled proteins and methods of use thereof Download PDF

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Publication number
AU2014306564B2
AU2014306564B2 AU2014306564A AU2014306564A AU2014306564B2 AU 2014306564 B2 AU2014306564 B2 AU 2014306564B2 AU 2014306564 A AU2014306564 A AU 2014306564A AU 2014306564 A AU2014306564 A AU 2014306564A AU 2014306564 B2 AU2014306564 B2 AU 2014306564B2
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Australia
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region
cdr
amino acid
acid sequence
seq
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AU2014306564A
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AU2014306564A1 (en
Inventor
Stephane ANGERS
Amandeep GAKHAL
Jason MOFFAT
Guohua Pan
Melanie ROBITAILLE
Sachdev Sidhu
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Antlera Therapeutics Inc
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Antlera Therapeutics Inc
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Priority to AU2019264562A priority Critical patent/AU2019264562B2/en
Assigned to SIDHU, SACHDEV, MOFFAT, Jason, ANGERS, Stephane, ROBITAILLE, Melanie reassignment SIDHU, SACHDEV Request for Assignment Assignors: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
Assigned to MODMAB THERAPEUTICS CORPORATION reassignment MODMAB THERAPEUTICS CORPORATION Request for Assignment Assignors: ANGERS, Stephane, MOFFAT, Jason, ROBITAILLE, Melanie, SIDHU, SACHDEV
Assigned to ANTLERA THERAPEUTICS INC. reassignment ANTLERA THERAPEUTICS INC. Request for Assignment Assignors: MODMAB THERAPEUTICS CORPORATION
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2014306564A 2013-08-14 2014-08-14 Antibodies against frizzled proteins and methods of use thereof Active AU2014306564B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2019264562A AU2019264562B2 (en) 2013-08-14 2019-11-12 Antibodies against frizzled proteins and methods of use thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361865668P 2013-08-14 2013-08-14
US61/865,668 2013-08-14
PCT/US2014/051070 WO2015023851A1 (en) 2013-08-14 2014-08-14 Antibodies against frizzled proteins and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2019264562A Division AU2019264562B2 (en) 2013-08-14 2019-11-12 Antibodies against frizzled proteins and methods of use thereof

Publications (2)

Publication Number Publication Date
AU2014306564A1 AU2014306564A1 (en) 2016-03-03
AU2014306564B2 true AU2014306564B2 (en) 2019-10-17

Family

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AU2014306564A Active AU2014306564B2 (en) 2013-08-14 2014-08-14 Antibodies against frizzled proteins and methods of use thereof
AU2019264562A Active AU2019264562B2 (en) 2013-08-14 2019-11-12 Antibodies against frizzled proteins and methods of use thereof

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Country Status (6)

Country Link
US (2) US10077304B2 (https=)
EP (2) EP3033356B1 (https=)
JP (3) JP6617239B2 (https=)
AU (2) AU2014306564B2 (https=)
CA (1) CA2921398C (https=)
WO (1) WO2015023851A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3033356B1 (en) 2013-08-14 2020-01-15 Sachdev Sidhu Antibodies against frizzled proteins and methods of use thereof
WO2016205566A1 (en) * 2015-06-16 2016-12-22 The Regents Of The University Of California Fzd7 specific antibodies and vaccines to treat cancer and control stem cell function
US10919968B2 (en) 2016-01-29 2021-02-16 Modmab Therapeutics Corporation Frizzled5 protein-binding agents
EP3509616A1 (en) * 2016-09-09 2019-07-17 H. Hoffnabb-La Roche Ag Selective peptide inhibitors of frizzled
EP3732201A4 (en) 2017-12-19 2022-04-20 Surrozen Operating, Inc. WNT SURROGATES AND THEIR USES
CN111655729B (zh) * 2017-12-19 2023-10-20 瑟罗泽恩奥普瑞汀公司 抗卷曲蛋白抗体和使用方法
CN111699003B (zh) 2017-12-19 2024-05-03 瑟罗泽恩奥普瑞汀公司 抗lrp5/6抗体和使用方法
US20210032352A1 (en) 2018-02-14 2021-02-04 Antera Therapeutics Inc. Multivalent Binding Molecules Activating WNT Signaling and Uses Thereof
CA3104526A1 (en) 2018-07-05 2020-01-09 Surrozen, Inc. Multi-specific wnt surrogate molecules and uses thereof
CN120025448A (zh) * 2019-06-11 2025-05-23 安托拉诊疗公司 多价fzd和wnt结合分子及其用途
CN120647760A (zh) * 2019-08-12 2025-09-16 安托拉诊疗公司 卷曲受体抗体及其用途
CN112159474B (zh) * 2019-11-06 2021-11-19 上海健康医学院 一种靶向Frizzled7人源化抗体及其制备方法与应用
WO2022130342A1 (en) 2020-12-18 2022-06-23 Antlera Therapeutics Inc. Tetravalent fzd and wnt co-receptor binding antibody molecules and uses thereof
WO2023250402A2 (en) 2022-06-22 2023-12-28 Antlera Therapeutics Inc. Tetravalent fzd and wnt co-receptor binding antibody molecules and uses thereof
KR20250005069A (ko) * 2022-02-18 2025-01-17 더 유니버서티 오브 시카고 성장호르몬 수용체 표적 폴리펩티드
US20260092125A1 (en) 2024-09-06 2026-04-02 Eyebiotech Limited Multivalent fzd4, wnt co-receptor, and vegf binding molecules and uses thereof
WO2026055312A1 (en) 2024-09-06 2026-03-12 Merck Sharp & Dohme Llc Multivalent fzd4, wnt co-receptor, and vegf receptor molecules and uses thereof

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WO2010037041A2 (en) * 2008-09-26 2010-04-01 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof

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Also Published As

Publication number Publication date
JP7393447B2 (ja) 2023-12-06
JP2016528256A (ja) 2016-09-15
CA2921398A1 (en) 2015-02-19
AU2014306564A1 (en) 2016-03-03
CA2921398C (en) 2021-12-14
AU2019264562A1 (en) 2019-12-05
JP2020023517A (ja) 2020-02-13
EP3033356B1 (en) 2020-01-15
US20190202909A1 (en) 2019-07-04
JP6617239B2 (ja) 2019-12-11
US20160194394A1 (en) 2016-07-07
AU2019264562B2 (en) 2022-01-13
US10689442B2 (en) 2020-06-23
EP3705494A2 (en) 2020-09-09
JP2022105495A (ja) 2022-07-14
WO2015023851A1 (en) 2015-02-19
EP3033356A1 (en) 2016-06-22
JP7100221B2 (ja) 2022-07-13
US10077304B2 (en) 2018-09-18
EP3705494A3 (en) 2020-12-09

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