JP2020022483A5 - - Google Patents

Download PDF

Info

Publication number
JP2020022483A5
JP2020022483A5 JP2019190648A JP2019190648A JP2020022483A5 JP 2020022483 A5 JP2020022483 A5 JP 2020022483A5 JP 2019190648 A JP2019190648 A JP 2019190648A JP 2019190648 A JP2019190648 A JP 2019190648A JP 2020022483 A5 JP2020022483 A5 JP 2020022483A5
Authority
JP
Japan
Prior art keywords
modified oligonucleotide
pharmaceutical composition
pharmaceutically acceptable
pbs
buffered saline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019190648A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020022483A (ja
JP6924242B2 (ja
Filing date
Publication date
Priority claimed from JP2017546618A external-priority patent/JP6606557B2/ja
Application filed filed Critical
Publication of JP2020022483A publication Critical patent/JP2020022483A/ja
Publication of JP2020022483A5 publication Critical patent/JP2020022483A5/ja
Priority to JP2021124953A priority Critical patent/JP2021184720A/ja
Application granted granted Critical
Publication of JP6924242B2 publication Critical patent/JP6924242B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019190648A 2015-04-16 2019-10-18 C9orf72発現を調節するための組成物 Expired - Fee Related JP6924242B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021124953A JP2021184720A (ja) 2015-04-16 2021-07-30 C9orf72発現を調節するための組成物

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562148691P 2015-04-16 2015-04-16
US62/148,691 2015-04-16
US201562232941P 2015-09-25 2015-09-25
US62/232,941 2015-09-25
US201562239400P 2015-10-09 2015-10-09
US62/239,400 2015-10-09
JP2017546618A JP6606557B2 (ja) 2015-04-16 2016-04-15 C9orf72発現を調節するための組成物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2017546618A Division JP6606557B2 (ja) 2015-04-16 2016-04-15 C9orf72発現を調節するための組成物

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021124953A Division JP2021184720A (ja) 2015-04-16 2021-07-30 C9orf72発現を調節するための組成物

Publications (3)

Publication Number Publication Date
JP2020022483A JP2020022483A (ja) 2020-02-13
JP2020022483A5 true JP2020022483A5 (cg-RX-API-DMAC7.html) 2020-05-14
JP6924242B2 JP6924242B2 (ja) 2021-08-25

Family

ID=57126261

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017546618A Expired - Fee Related JP6606557B2 (ja) 2015-04-16 2016-04-15 C9orf72発現を調節するための組成物
JP2019190648A Expired - Fee Related JP6924242B2 (ja) 2015-04-16 2019-10-18 C9orf72発現を調節するための組成物
JP2021124953A Ceased JP2021184720A (ja) 2015-04-16 2021-07-30 C9orf72発現を調節するための組成物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2017546618A Expired - Fee Related JP6606557B2 (ja) 2015-04-16 2016-04-15 C9orf72発現を調節するための組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021124953A Ceased JP2021184720A (ja) 2015-04-16 2021-07-30 C9orf72発現を調節するための組成物

Country Status (30)

Country Link
US (4) US9605263B2 (cg-RX-API-DMAC7.html)
EP (2) EP3722424A1 (cg-RX-API-DMAC7.html)
JP (3) JP6606557B2 (cg-RX-API-DMAC7.html)
KR (2) KR102258516B1 (cg-RX-API-DMAC7.html)
CN (2) CN107427532B (cg-RX-API-DMAC7.html)
AU (2) AU2016249002B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017016068A2 (cg-RX-API-DMAC7.html)
CA (1) CA2978103A1 (cg-RX-API-DMAC7.html)
CL (4) CL2017002567A1 (cg-RX-API-DMAC7.html)
CO (1) CO2017007671A2 (cg-RX-API-DMAC7.html)
CY (1) CY1122981T1 (cg-RX-API-DMAC7.html)
DK (1) DK3283080T3 (cg-RX-API-DMAC7.html)
ES (1) ES2791995T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20200843T1 (cg-RX-API-DMAC7.html)
HU (1) HUE049233T2 (cg-RX-API-DMAC7.html)
IL (2) IL253557B (cg-RX-API-DMAC7.html)
LT (1) LT3283080T (cg-RX-API-DMAC7.html)
MX (2) MX366128B (cg-RX-API-DMAC7.html)
MY (1) MY181815A (cg-RX-API-DMAC7.html)
NZ (1) NZ733882A (cg-RX-API-DMAC7.html)
PH (2) PH12017501875B1 (cg-RX-API-DMAC7.html)
PL (1) PL3283080T3 (cg-RX-API-DMAC7.html)
PT (1) PT3283080T (cg-RX-API-DMAC7.html)
RS (1) RS60230B1 (cg-RX-API-DMAC7.html)
RU (1) RU2736574C2 (cg-RX-API-DMAC7.html)
SA (3) SA520412450B1 (cg-RX-API-DMAC7.html)
SG (2) SG10202001856WA (cg-RX-API-DMAC7.html)
SI (1) SI3283080T1 (cg-RX-API-DMAC7.html)
SM (1) SMT202000165T1 (cg-RX-API-DMAC7.html)
WO (1) WO2016168592A2 (cg-RX-API-DMAC7.html)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009323766B2 (en) 2008-12-02 2016-10-06 Wave Life Sciences Ltd. Method for the synthesis of phosphorus atom modified nucleic acids
SG177564A1 (en) 2009-07-06 2012-02-28 Ontorii Inc Novel nucleic acid prodrugs and methods of use thereof
EP2620428B1 (en) 2010-09-24 2019-05-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
JP6268157B2 (ja) 2012-07-13 2018-01-24 株式会社Wave Life Sciences Japan 不斉補助基
WO2014062691A2 (en) 2012-10-15 2014-04-24 Isis Pharmaceuticals, Inc. Compositions for modulating c9orf72 expression
EP2906697A4 (en) 2012-10-15 2016-06-22 Ionis Pharmaceuticals Inc METHOD FOR MONITORING THE C9ORF72 EXPRESSION
DK2906696T4 (da) 2012-10-15 2023-02-27 Ionis Pharmaceuticals Inc Fremgangsmåder til modulering af c9orf72-ekspression
CN112080502A (zh) * 2013-10-11 2020-12-15 Ionis制药公司 用于调节c9orf72表达的组合物
PT3094728T (pt) 2014-01-16 2022-05-19 Wave Life Sciences Ltd Desenho quiral
US11260073B2 (en) 2015-11-02 2022-03-01 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating C90RF72
AU2017248637A1 (en) * 2016-04-13 2018-09-27 Ionis Pharmaceuticals, Inc. Methods for reducing C9ORF72 expression
US11795453B2 (en) * 2016-10-31 2023-10-24 Emendobio, Inc. Compositions for genome editing
US20200362337A1 (en) * 2017-08-08 2020-11-19 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof
US10905707B2 (en) 2017-11-10 2021-02-02 University Of Massachusetts Compositions and methods for the treatment of expanded repeat-associated disorders
US11447775B2 (en) 2018-01-12 2022-09-20 Bristol-Myers Squibb Company Antisense oligonucleotides targeting alpha-synuclein and uses thereof
CN111819283A (zh) 2018-01-12 2020-10-23 百时美施贵宝公司 靶向α-突触核蛋白的反义寡核苷酸及其用途
EP3826650A4 (en) * 2018-07-23 2022-07-27 Enclear Therapies, Inc. METHODS OF TREATMENT OF NEUROLOGICAL DISEASES
WO2020027311A1 (ja) 2018-08-03 2020-02-06 国立大学法人東京医科歯科大学 Tdp-43凝集阻害剤
JP7455831B2 (ja) * 2018-11-21 2024-03-26 アイオーニス ファーマシューティカルズ, インコーポレーテッド プリオン発現を低減するための化合物及び方法
KR20210102294A (ko) 2018-12-06 2021-08-19 바이오젠 엠에이 인코포레이티드 근위축성 측삭 경화증에서 치료요법적 중재를 안내하기 위한 신경필라멘트 단백질
AU2020252020A1 (en) * 2019-03-29 2021-11-11 University Of Massachusetts Oligonucleotide-based modulation of C90RF72
EP3966328A4 (en) * 2019-05-06 2023-10-18 University Of Massachusetts Anti-c9orf72 oligonucleotides and related methods
AU2020363344A1 (en) * 2019-10-06 2022-05-26 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
WO2024036186A2 (en) * 2022-08-09 2024-02-15 The University Of Massachusetts Identification of allele-specific target sequences for c9orf72

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118800A (en) 1983-12-20 1992-06-02 California Institute Of Technology Oligonucleotides possessing a primary amino group in the terminal nucleotide
FR2567892B1 (fr) 1984-07-19 1989-02-17 Centre Nat Rech Scient Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
US5185444A (en) 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US5166315A (en) 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5591722A (en) 1989-09-15 1997-01-07 Southern Research Institute 2'-deoxy-4'-thioribonucleosides and their antiviral activity
JPH05504552A (ja) 1989-10-24 1993-07-15 ギリアド サイエンシズ,インコーポレイテッド 2’位が改変されたオリゴヌクレオチド
US5670633A (en) 1990-01-11 1997-09-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
US5646265A (en) 1990-01-11 1997-07-08 Isis Pharmceuticals, Inc. Process for the preparation of 2'-O-alkyl purine phosphoramidites
GB9009980D0 (en) 1990-05-03 1990-06-27 Amersham Int Plc Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides
DK0455905T3 (da) 1990-05-11 1998-12-07 Microprobe Corp Dipsticks til nukleinsyrehybridiseringsassays og fremgangsmåde til kovalent immobilisering af oligonukleotider
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
ES2103918T3 (es) 1991-10-17 1997-10-01 Ciba Geigy Ag Nucleosidos biciclicos, oligonucleotidos, procedimiento para su obtencion y productos intermedios.
US5359044A (en) 1991-12-13 1994-10-25 Isis Pharmaceuticals Cyclobutyl oligonucleotide surrogates
EP0618925B2 (en) 1991-12-24 2012-04-18 Isis Pharmaceuticals, Inc. Antisense oligonucleotides
FR2687679B1 (fr) 1992-02-05 1994-10-28 Centre Nat Rech Scient Oligothionucleotides.
EP0577558A2 (de) 1992-07-01 1994-01-05 Ciba-Geigy Ag Carbocyclische Nukleoside mit bicyclischen Ringen, Oligonukleotide daraus, Verfahren zu deren Herstellung, deren Verwendung und Zwischenproduckte
DK0691968T3 (da) 1993-03-30 1998-02-23 Sanofi Sa Acykliske nukleosid-analoge og oligonukleotidsekvenser indeholdende disse
US5801154A (en) 1993-10-18 1998-09-01 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of multidrug resistance-associated protein
US5446137B1 (en) 1993-12-09 1998-10-06 Behringwerke Ag Oligonucleotides containing 4'-substituted nucleotides
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5627053A (en) 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
US5597909A (en) 1994-08-25 1997-01-28 Chiron Corporation Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
US5681940A (en) * 1994-11-02 1997-10-28 Icn Pharmaceuticals Sugar modified nucleosides and oligonucleotides
US7875733B2 (en) 2003-09-18 2011-01-25 Isis Pharmaceuticals, Inc. Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
JP4236812B2 (ja) 1997-09-12 2009-03-11 エクシコン エ/エス オリゴヌクレオチド類似体
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US20030228597A1 (en) 1998-04-13 2003-12-11 Cowsert Lex M. Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation
US6043352A (en) 1998-08-07 2000-03-28 Isis Pharmaceuticals, Inc. 2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
US5998148A (en) 1999-04-08 1999-12-07 Isis Pharmaceuticals Inc. Antisense modulation of microtubule-associated protein 4 expression
CN102180924A (zh) 1999-05-04 2011-09-14 桑塔里斯制药公司 L-核糖-lna类似物
US6525191B1 (en) 1999-05-11 2003-02-25 Kanda S. Ramasamy Conformationally constrained L-nucleosides
ATE322493T1 (de) 1999-12-30 2006-04-15 Leuven K U Res & Dev Cyclohexennukleinsäuren
USH2191H1 (en) 2000-10-24 2007-06-05 Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
US20050019915A1 (en) 2001-06-21 2005-01-27 Bennett C. Frank Antisense modulation of superoxide dismutase 1, soluble expression
WO2003004602A2 (en) 2001-07-03 2003-01-16 Isis Pharmaceuticals, Inc. Nuclease resistant chimeric oligonucleotides
EP1562971B1 (en) 2002-11-05 2014-02-12 Isis Pharmaceuticals, Inc. Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
US8604183B2 (en) 2002-11-05 2013-12-10 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
EP2314691A3 (en) 2002-11-14 2012-01-18 Dharmacon, Inc. Fuctional and hyperfunctional siRNA
US7250496B2 (en) 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
US7217807B2 (en) 2002-11-26 2007-05-15 Rosetta Genomics Ltd Bioinformatically detectable group of novel HIV regulatory genes and uses thereof
WO2004106356A1 (en) 2003-05-27 2004-12-09 Syddansk Universitet Functionalized nucleotide derivatives
US7427672B2 (en) 2003-08-28 2008-09-23 Takeshi Imanishi Artificial nucleic acids of n-o bond crosslinkage type
US20050261233A1 (en) 2004-04-21 2005-11-24 Sanjay Bhanot Modulation of glucose-6-phosphatase translocase expression
CN101052717A (zh) 2004-05-11 2007-10-10 α基因株式会社 诱发rna干扰的多核苷酸以及使用该多核苷酸的基因表达抑制方法
JP2008501335A (ja) 2004-06-03 2008-01-24 アイシス ファーマシューティカルズ、インク. キメラギャップ化オリゴマー組成物
EP1766071A4 (en) 2004-06-03 2009-11-11 Isis Pharmaceuticals Inc DOUBLE-STRONG COMPOSITIONS WITH DIFFERENTLY MODIFIED STRANDS FOR USE IN GENE MODULATION
US20080261905A1 (en) 2004-11-08 2008-10-23 K.U. Leuven Research And Development Modified Nucleosides for Rna Interference
PT2161038E (pt) 2006-01-26 2014-03-10 Isis Pharmaceuticals Inc Composições e suas utilizações dirigidas à huntingtina
CN102908630B (zh) 2006-01-27 2014-11-19 Isis制药公司 6-修饰的双环核酸类似物
EP2015758B1 (en) 2006-05-05 2014-04-02 Isis Pharmaceuticals, Inc. Compounds and methods for modulating expression apob
EP2066684B1 (en) 2006-05-11 2012-07-18 Isis Pharmaceuticals, Inc. 5'-modified bicyclic nucleic acid analogs
EP2076597A2 (en) 2006-10-09 2009-07-08 Santaris Pharma A/S Rna antagonist compounds for the modulation of pcsk9
CN101563458A (zh) 2006-12-14 2009-10-21 诺瓦提斯公司 治疗肌肉和心血管病症的组合物和方法
EP2125852B1 (en) 2007-02-15 2016-04-06 Ionis Pharmaceuticals, Inc. 5'-substituted-2'-f modified nucleosides and oligomeric compounds prepared therefrom
ES2388590T3 (es) 2007-05-30 2012-10-16 Isis Pharmaceuticals, Inc. Análogos de ácidos nucleicos bicíclicos con puente aminometileno N-sustituido.
WO2008154401A2 (en) 2007-06-08 2008-12-18 Isis Pharmaceuticals, Inc. Carbocyclic bicyclic nucleic acid analogs
ATE462787T1 (de) 2007-06-18 2010-04-15 Commissariat Energie Atomique Reversibles sirna-silencing eines mutierten und endogenen huntington-wildtypgens und dessen anwendung zur behandlung von morbus huntington
WO2009006478A2 (en) 2007-07-05 2009-01-08 Isis Pharmaceuticals, Inc. 6-disubstituted bicyclic nucleic acid analogs
US20090123928A1 (en) 2007-10-11 2009-05-14 The Johns Hopkins University Genomic Landscapes of Human Breast and Colorectal Cancers
CA2704560A1 (en) * 2007-11-05 2009-05-14 Baltic Technology Development, Ltd. Use of oligonucleotides with modified bases in hybridization of nucleic acids
WO2009067647A1 (en) 2007-11-21 2009-05-28 Isis Pharmaceuticals, Inc. Carbocyclic alpha-l-bicyclic nucleic acid analogs
US8530640B2 (en) 2008-02-07 2013-09-10 Isis Pharmaceuticals, Inc. Bicyclic cyclohexitol nucleic acid analogs
US8501805B2 (en) 2008-09-24 2013-08-06 Isis Pharmaceuticals, Inc. Substituted alpha-L-bicyclic nucleosides
US8604192B2 (en) 2008-09-24 2013-12-10 Isis Pharmaceuticals, Inc. Cyclohexenyl nucleic acids analogs
WO2010120820A1 (en) 2009-04-13 2010-10-21 Isis Pharmaceuticals, Inc. Compositions and methods for modulation of smn2 splicing
BRPI1015236A2 (pt) * 2009-04-15 2019-09-24 Isis Pharmaceuticals Inc métodos para modular uma resposta inflamatória, apra melhorar uma doença, distúrbio ou condição inflamatórios em um animal, para tratar um animal em risco para uma doença, distúrbio ou condição inflamatórios, para inibir a expressão de fator xi em um animal, para reduzir o risco de doença, distúrbio ou condição inflamatórios, em um animal, para tratar um animal em risco para uma doença inflamatória, e para tratar um animal tendo uma doença inflamatória, e, uso de um composto marcado para fator xi
NZ597504A (en) 2009-06-15 2013-10-25 Alnylam Pharmaceuticals Inc Lipid formulated dsrna targeting the pcsk9 gene
CA2767231A1 (en) 2009-07-06 2011-01-13 Alnylam Pharmaceuticals, Inc. Cell-based bioprocessing
WO2011005860A2 (en) 2009-07-07 2011-01-13 Alnylam Pharmaceuticals, Inc. 5' phosphate mimics
EP2462153B1 (en) 2009-08-06 2015-07-29 Isis Pharmaceuticals, Inc. Bicyclic cyclohexose nucleic acid analogs
EP2563921B1 (en) 2010-04-30 2016-11-23 Cellectis Method for modulating double-strand break-induced homologous recombination
WO2012005898A2 (en) 2010-06-15 2012-01-12 Alnylam Pharmaceuticals, Inc. Chinese hamster ovary (cho) cell transcriptome, corresponding sirnas and uses thereof
KR101900770B1 (ko) * 2010-07-19 2018-09-20 아이오니스 파마수티컬즈, 인코포레이티드 근육긴장성 이영양증-단백질 키나제(dmpk) 발현의 조절 방법
WO2012087983A1 (en) 2010-12-20 2012-06-28 The General Hospital Corporation Polycomb-associated non-coding rnas
WO2012068405A2 (en) * 2010-11-17 2012-05-24 Isis Pharmaceuticals, Inc. Modulation of alpha synuclein expression
US20140050778A1 (en) 2010-12-28 2014-02-20 University Of Rochester Nucleic acid binding compounds, methods of making, and use thereof
BR112013024768B1 (pt) 2011-04-01 2022-02-08 Ionis Pharmaceuticals, Inc Composto para inibição da expressão de mrna e proteína stat3, uso do composto e composição farmacêutica
UA118951C2 (uk) * 2011-04-21 2019-04-10 Айоніс Фармасьютікалз, Інк. Модулювання експресії вірусу гепатиту b (hbv)
DK2751284T3 (en) * 2011-08-31 2017-03-27 Univ Manchester PROCEDURE FOR DIAGNOSTICING A NEURODEGENERATIVE DISEASE
WO2013036833A1 (en) 2011-09-09 2013-03-14 Mayo Foundation For Medical Education And Research Detecting frontotemporal dementia and amyotrophic lateral sclerosis
RU2014119787A (ru) * 2011-10-25 2015-12-10 Айсис Фармасьютикалс, Инк. Антисмысловая регуляция экспрессии gccr
AU2012340118A1 (en) * 2011-11-17 2014-04-24 Rheonix, Inc. System and methods for selective molecular analysis
US10066228B2 (en) 2011-11-30 2018-09-04 Sarepta Therapeutics, Inc. Oligonucleotides for treating expanded repeat diseases
CA2858576A1 (en) 2011-12-06 2013-06-13 Research Institute At Nationwide Children's Hospital Non-ionic, low osmolar contrast agents for delivery of antisense oligonucleotides and treatment of disease
HUE033431T2 (en) 2012-04-23 2017-11-28 Biomarin Tech Bv RNA modulating oligonucleotides with improved characteristics in the treatment of neuromuscular disorders
NZ631071A (en) * 2012-05-24 2017-02-24 Ionis Pharmaceuticals Inc Methods and compositions for modulating apolipoprotein(a) expression
WO2014062691A2 (en) 2012-10-15 2014-04-24 Isis Pharmaceuticals, Inc. Compositions for modulating c9orf72 expression
DK2906696T4 (da) * 2012-10-15 2023-02-27 Ionis Pharmaceuticals Inc Fremgangsmåder til modulering af c9orf72-ekspression
EP2906697A4 (en) * 2012-10-15 2016-06-22 Ionis Pharmaceuticals Inc METHOD FOR MONITORING THE C9ORF72 EXPRESSION
ES2744804T3 (es) * 2013-01-22 2020-02-26 Deutsches Zentrum Fuer Neurodegenerative Erkrankungen E V Proteínas de repetición de dipéptidos como objetivo terapéutico en enfermedades neurodegenerativas con expansión de repetición de hexanucleótidos
CN112080502A (zh) * 2013-10-11 2020-12-15 Ionis制药公司 用于调节c9orf72表达的组合物
WO2016024205A1 (en) * 2014-08-15 2016-02-18 Pfizer Inc. Oligomers targeting hexanucleotide repeat expansion in human c9orf72 gene
WO2016060919A1 (en) 2014-10-14 2016-04-21 The Board Of Regents Of The University Of Texas System Allele selective inhibition of mutant c9orf72 foci expression by duplex rnas targeting the expanded hexanucleotide repeat
US11260073B2 (en) 2015-11-02 2022-03-01 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating C90RF72
AU2017248637A1 (en) 2016-04-13 2018-09-27 Ionis Pharmaceuticals, Inc. Methods for reducing C9ORF72 expression
US10399845B2 (en) 2017-09-22 2019-09-03 Emco Wheaton Retail Corporation Testable overfill prevention valve for a liquid storage container

Similar Documents

Publication Publication Date Title
JP2020022483A5 (cg-RX-API-DMAC7.html)
JP2020058368A5 (cg-RX-API-DMAC7.html)
JP2016116520A5 (cg-RX-API-DMAC7.html)
JP2017513469A5 (cg-RX-API-DMAC7.html)
JP2018199700A5 (cg-RX-API-DMAC7.html)
RU2017139121A (ru) Композиции для модулирования экспрессии c9orf72
JP2012505660A5 (cg-RX-API-DMAC7.html)
JP2019088329A5 (cg-RX-API-DMAC7.html)
JP2019512498A5 (cg-RX-API-DMAC7.html)
JP2021074021A5 (cg-RX-API-DMAC7.html)
JP2017536366A5 (cg-RX-API-DMAC7.html)
JP2021072840A5 (cg-RX-API-DMAC7.html)
JP2017505623A5 (cg-RX-API-DMAC7.html)
JP2017536119A5 (cg-RX-API-DMAC7.html)
JP2019062913A5 (cg-RX-API-DMAC7.html)
JP2014521310A5 (cg-RX-API-DMAC7.html)
JP2018530560A5 (cg-RX-API-DMAC7.html)
JP2016513976A5 (cg-RX-API-DMAC7.html)
JP2019141097A5 (cg-RX-API-DMAC7.html)
JP2007504830A5 (cg-RX-API-DMAC7.html)
JP2016502858A5 (cg-RX-API-DMAC7.html)
RU2016116849A (ru) Композиции для модуляции экспрессии c90rf72
JP2012050438A5 (cg-RX-API-DMAC7.html)
JP2020522244A5 (cg-RX-API-DMAC7.html)
JP2018509143A5 (cg-RX-API-DMAC7.html)