JP2019535671A5 - - Google Patents
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- Publication number
- JP2019535671A5 JP2019535671A5 JP2019521064A JP2019521064A JP2019535671A5 JP 2019535671 A5 JP2019535671 A5 JP 2019535671A5 JP 2019521064 A JP2019521064 A JP 2019521064A JP 2019521064 A JP2019521064 A JP 2019521064A JP 2019535671 A5 JP2019535671 A5 JP 2019535671A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- polymer
- cyclopropylmethoxy
- methylsulfonylphenyl
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 27
- 229920000642 polymer Polymers 0.000 claims 19
- UWZAJPITKGWMFJ-UHFFFAOYSA-N 4-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-2-methylisoquinolin-1-one Chemical compound Cn1cc(-c2cc(ccc2OCC2CC2)S(C)(=O)=O)c2ccccc2c1=O UWZAJPITKGWMFJ-UHFFFAOYSA-N 0.000 claims 11
- 239000011159 matrix material Substances 0.000 claims 9
- 239000007787 solid Substances 0.000 claims 9
- 239000001913 cellulose Substances 0.000 claims 8
- 229920002678 cellulose Polymers 0.000 claims 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- -1 cyclopropylmethoxy Chemical group 0.000 claims 5
- 238000010922 spray-dried dispersion Methods 0.000 claims 5
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 2
- 238000001694 spray drying Methods 0.000 claims 2
- QAOMZDFCQJQQQS-UHFFFAOYSA-N 3-methyl-2h-isoquinolin-1-one Chemical compound C1=CC=C2C(=O)NC(C)=CC2=C1 QAOMZDFCQJQQQS-UHFFFAOYSA-N 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 102000011931 Nucleoproteins Human genes 0.000 claims 1
- 108010061100 Nucleoproteins Proteins 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- SPTSIOTYTJZTOG-UHFFFAOYSA-N acetic acid;octadecanoic acid Chemical compound CC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O SPTSIOTYTJZTOG-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000001046 rapid expansion of supercritical solution Methods 0.000 claims 1
- 230000002381 testicular Effects 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022066855A JP2022095897A (ja) | 2016-10-20 | 2022-04-14 | ブロモドメイン阻害剤 |
| JP2024021416A JP2024056905A (ja) | 2016-10-20 | 2024-02-15 | ブロモドメイン阻害剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662410756P | 2016-10-20 | 2016-10-20 | |
| US62/410,756 | 2016-10-20 | ||
| PCT/US2017/057439 WO2018075796A1 (en) | 2016-10-20 | 2017-10-19 | Bromodomain inhibitor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022066855A Division JP2022095897A (ja) | 2016-10-20 | 2022-04-14 | ブロモドメイン阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535671A JP2019535671A (ja) | 2019-12-12 |
| JP2019535671A5 true JP2019535671A5 (https=) | 2020-10-22 |
| JP7129973B2 JP7129973B2 (ja) | 2022-09-02 |
Family
ID=62019669
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019521064A Active JP7129973B2 (ja) | 2016-10-20 | 2017-10-19 | ブロモドメイン阻害剤 |
| JP2022066855A Pending JP2022095897A (ja) | 2016-10-20 | 2022-04-14 | ブロモドメイン阻害剤 |
| JP2024021416A Pending JP2024056905A (ja) | 2016-10-20 | 2024-02-15 | ブロモドメイン阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022066855A Pending JP2022095897A (ja) | 2016-10-20 | 2022-04-14 | ブロモドメイン阻害剤 |
| JP2024021416A Pending JP2024056905A (ja) | 2016-10-20 | 2024-02-15 | ブロモドメイン阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP3528810A4 (https=) |
| JP (3) | JP7129973B2 (https=) |
| CN (1) | CN110099685A (https=) |
| AR (1) | AR109859A1 (https=) |
| AU (1) | AU2017345468B2 (https=) |
| TW (1) | TW201821062A (https=) |
| WO (1) | WO2018075796A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201642860A (zh) * | 2015-04-22 | 2016-12-16 | 塞爾基因定量細胞研究公司 | 布羅莫結構域抑制劑 |
| US10702517B2 (en) | 2015-04-22 | 2020-07-07 | Celgene Quanticel Research, Inc. | Bromodomain inhibitor |
| JP7434274B2 (ja) * | 2018-07-23 | 2024-02-20 | セルジーン・クオンティセル・リサーチ・インコーポレイテッド | ブロモドメイン阻害剤の合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1248869A2 (en) * | 2000-01-07 | 2002-10-16 | Transform Pharmaceuticals, Inc. | High-throughput formation, identification, and analysis of diverse solid-forms |
| GB0919434D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| JP2016529246A (ja) | 2013-08-06 | 2016-09-23 | オンコエシックス ゲーエムベーハー | Ｂｅｔブロモドメイン阻害剤を用いるびまん性大細胞型ｂ細胞性リンパ腫（ｄｌｂｃｌ）の治療方法 |
| WO2015031824A1 (en) * | 2013-08-30 | 2015-03-05 | Icahn School Of Medicine At Mount Sinai | Cyclic vinylogous amides as bromodomain inhibitors |
| SG10201804471PA (en) * | 2013-10-18 | 2018-07-30 | Celgene Quanticel Research Inc | Bromodomain inhibitors |
| CN105960239A (zh) * | 2013-11-27 | 2016-09-21 | 翁科埃斯克斯有限公司 | 利用含有噻吩并三唑并二氮杂*化合物的药物制剂治疗白血病的方法 |
| TW201642860A (zh) * | 2015-04-22 | 2016-12-16 | 塞爾基因定量細胞研究公司 | 布羅莫結構域抑制劑 |
| CN105732624B (zh) * | 2016-01-28 | 2019-08-02 | 中国药科大学 | 吡咯[4,3,2-de]喹啉-2(1H)-酮类BRD4蛋白抑制剂的制备方法及其用途 |
-
2017
- 2017-10-19 EP EP17862619.8A patent/EP3528810A4/en not_active Withdrawn
- 2017-10-19 WO PCT/US2017/057439 patent/WO2018075796A1/en not_active Ceased
- 2017-10-19 AU AU2017345468A patent/AU2017345468B2/en active Active
- 2017-10-19 CN CN201780076154.0A patent/CN110099685A/zh active Pending
- 2017-10-19 JP JP2019521064A patent/JP7129973B2/ja active Active
- 2017-10-20 TW TW106136093A patent/TW201821062A/zh unknown
- 2017-10-20 AR ARP170102935A patent/AR109859A1/es unknown
-
2022
- 2022-04-14 JP JP2022066855A patent/JP2022095897A/ja active Pending
-
2024
- 2024-02-15 JP JP2024021416A patent/JP2024056905A/ja active Pending
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