JP2010502767A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010502767A5 JP2010502767A5 JP2009538434A JP2009538434A JP2010502767A5 JP 2010502767 A5 JP2010502767 A5 JP 2010502767A5 JP 2009538434 A JP2009538434 A JP 2009538434A JP 2009538434 A JP2009538434 A JP 2009538434A JP 2010502767 A5 JP2010502767 A5 JP 2010502767A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- compound
- medicament
- compound according
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82516806P | 2006-09-11 | 2006-09-11 | |
| US60/825,168 | 2006-09-11 | ||
| PCT/US2007/078103 WO2008033798A2 (en) | 2006-09-11 | 2007-09-11 | A pyrrolopyrazin as syk-kinase inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010502767A JP2010502767A (ja) | 2010-01-28 |
| JP2010502767A5 true JP2010502767A5 (https=) | 2010-10-07 |
| JP5161237B2 JP5161237B2 (ja) | 2013-03-13 |
Family
ID=39032357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009538434A Expired - Fee Related JP5161237B2 (ja) | 2006-09-11 | 2007-09-11 | Ｓｙｋキナーゼ阻害剤としてのピロロピラジン |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US8658649B2 (https=) |
| EP (1) | EP2094708B1 (https=) |
| JP (1) | JP5161237B2 (https=) |
| KR (1) | KR101443056B1 (https=) |
| CN (2) | CN103804383A (https=) |
| AR (1) | AR062745A1 (https=) |
| AU (1) | AU2007296592B8 (https=) |
| BR (1) | BRPI0716781A2 (https=) |
| CA (1) | CA2663175C (https=) |
| CL (1) | CL2007002617A1 (https=) |
| CO (1) | CO6160236A2 (https=) |
| CR (1) | CR10636A (https=) |
| DK (1) | DK2094708T3 (https=) |
| ES (1) | ES2437318T3 (https=) |
| GT (1) | GT200900055A (https=) |
| HN (1) | HN2009000455A (https=) |
| IL (1) | IL197381A (https=) |
| MA (1) | MA30781B1 (https=) |
| MX (1) | MX2009002616A (https=) |
| MY (1) | MY148107A (https=) |
| NI (1) | NI200900021A (https=) |
| NO (1) | NO20091265L (https=) |
| NZ (1) | NZ575496A (https=) |
| PE (1) | PE20081372A1 (https=) |
| PT (1) | PT2094708E (https=) |
| RU (1) | RU2440352C2 (https=) |
| TN (2) | TN2009000050A1 (https=) |
| TW (1) | TWI399379B (https=) |
| UA (1) | UA94622C2 (https=) |
| UY (1) | UY30584A1 (https=) |
| WO (1) | WO2008033798A2 (https=) |
| ZA (1) | ZA200901073B (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009218609A1 (en) | 2008-02-25 | 2009-09-03 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine kinase inhibitors |
| ATE522534T1 (de) * | 2008-02-25 | 2011-09-15 | Hoffmann La Roche | Pyrrolopyrazin-kinasehemmer |
| CA2716223A1 (en) | 2008-02-25 | 2009-09-03 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine kinase inhibitors |
| ATE522536T1 (de) | 2008-02-25 | 2011-09-15 | Hoffmann La Roche | Pyrrolopyrazin-kinasehemmer |
| JP5368485B2 (ja) | 2008-02-25 | 2013-12-18 | エフ．ホフマン−ラ ロシュ アーゲー | ピロロピラジンキナーゼインヒビター |
| MX2010008308A (es) * | 2008-03-10 | 2010-08-11 | Sanofi Aventis | Tratamiento para trastornos relacionados con los ojos. |
| FR2929851B1 (fr) * | 2008-04-09 | 2012-11-30 | Centre Nat Rech Scient | Molecules inhibant une voie metabolique impliquant la proteine tyrosine kinase syk et procede d'identification de ces molecules |
| PA8851701A1 (es) | 2008-12-03 | 2010-07-27 | Sanofi Aventis | Tratamiento para la glomerulonefritis |
| EP2373655A1 (en) | 2008-12-04 | 2011-10-12 | Sanofi | Crystalline forms |
| TW201034675A (en) * | 2008-12-18 | 2010-10-01 | Sanofi Aventis | Method for treating macular degeneration |
| US20110112101A1 (en) * | 2009-03-05 | 2011-05-12 | Sanofi-Aventis | Treatment for ocular-related disorders |
| AR075869A1 (es) * | 2009-03-19 | 2011-05-04 | Sanofi Aventis | Sintesis de azaindoles |
| SG181857A1 (en) | 2009-12-23 | 2012-07-30 | Takeda Pharmaceutical | Fused heteroaromatic pyrrolidinones as syk inhibitors |
| US8481541B2 (en) | 2010-03-22 | 2013-07-09 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
| US8518945B2 (en) | 2010-03-22 | 2013-08-27 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
| CA2799904A1 (en) * | 2010-05-20 | 2011-11-24 | F. Hoffmann-La Roche Ag | Pyrrolo [2, 3 - b] pyrazine - 7 - carboxamide derivatives and their use as jak and syk inhibitors |
| CN102906095A (zh) | 2010-05-20 | 2013-01-30 | 弗·哈夫曼-拉罗切有限公司 | 作为syk和jak抑制剂的吡咯并吡嗪衍生物 |
| EP2441755A1 (en) | 2010-09-30 | 2012-04-18 | Almirall, S.A. | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors |
| EP2489663A1 (en) | 2011-02-16 | 2012-08-22 | Almirall, S.A. | Compounds as syk kinase inhibitors |
| JP6026525B2 (ja) | 2011-06-22 | 2016-11-16 | 武田薬品工業株式会社 | 置換６−アザ−イソインドリン−１−オン誘導体 |
| CN104507945B (zh) * | 2012-08-21 | 2018-03-23 | 霍夫曼-拉罗奇有限公司 | 作为syk抑制剂的吡咯并[2,3‑b]吡嗪 |
| NZ715747A (en) | 2013-07-31 | 2017-03-31 | Gilead Sciences Inc | Syk inhibitors |
| US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN116969927B (zh) * | 2023-06-07 | 2024-03-19 | 中南民族大学 | 一种从荜茇中提取分离的化合物及该化合物在制备抗炎药物中的应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1141949A (en) | 1966-02-23 | 1969-02-05 | Sterling Drug Inc | 7-azaindole derivatives |
| US3992392A (en) | 1973-04-27 | 1976-11-16 | The Ohio State University Research Foundation | Synthesis of indoles from anilines and intermediates therein |
| SE9100920D0 (sv) | 1991-03-27 | 1991-03-27 | Astra Ab | New active compounds |
| GB9226855D0 (en) * | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
| JPH10510510A (ja) | 1994-06-09 | 1998-10-13 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体拮抗物質 |
| FR2732969B1 (fr) | 1995-04-14 | 1997-05-16 | Adir | Nouveaux composes pyridiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE69728688T2 (de) | 1996-11-19 | 2004-08-19 | Amgen Inc., Thousand Oaks | Aryl und heteroaryl substituierte kondensierte pyrrole als entzündunghemmende mittel |
| US6312835B1 (en) | 1997-02-13 | 2001-11-06 | Queen's University At Kingston | Luminescent compounds and methods of making and using same |
| DK0970084T3 (da) | 1997-03-19 | 2003-09-29 | Abbott Gmbh & Co Kg | Pyrrolo[2,3-d]pyrimidiner og deres anvendelse som inhibitorer for tyrosinkinase |
| AU7132998A (en) | 1997-04-24 | 1998-11-13 | Ortho-Mcneil Corporation, Inc. | Substituted pyrrolopyridines useful in the treatment of inflammatory diseases |
| ID24300A (id) | 1997-08-05 | 2000-07-13 | Pfizer Prod Inc | 4-AMINOPIROL(3,2-d)PIRIMIDIN SEBAGAI ANTAGONIS-ANTAGONIS RESEPTOR NEUROPEPTIDA Y |
| ES2221213T3 (es) | 1997-10-20 | 2004-12-16 | F. Hoffmann-La Roche Ag | Inhibidores de kinasa biciclicos. |
| WO1999045016A2 (en) | 1998-03-06 | 1999-09-10 | Metabasis Therapeutics, Inc. | Novel prodrugs for phosphorus-containing compounds |
| WO1999051233A1 (en) | 1998-04-02 | 1999-10-14 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| EP1070064A1 (en) | 1998-04-02 | 2001-01-24 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| ATE482945T1 (de) | 1998-05-26 | 2010-10-15 | Chugai Pharmaceutical Co Ltd | Heterozyklische indolderivate und mono- oder diazaindol-derivate |
| CA2344262A1 (en) | 1998-09-18 | 2000-03-30 | Basf Aktiengesellschaft | 4-aminopyrrolopyrimidines as kinase inhibitors |
| PE20010306A1 (es) | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| GB9930698D0 (en) * | 1999-12-24 | 2000-02-16 | Rhone Poulenc Rorer Ltd | Chemical compounds |
| OA12514A (en) | 1999-12-24 | 2006-05-29 | Aventis Pharma Ltd | Azaindoles. |
| US6770666B2 (en) | 1999-12-27 | 2004-08-03 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs |
| YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
| DE10009000A1 (de) | 2000-02-25 | 2001-08-30 | Basf Ag | Verfahren zur Herstellung substituierter Indole |
| AU2001247589A1 (en) | 2000-03-20 | 2001-10-03 | Axys Pharmaceuticals, Inc. | Non-amidine containing protease inhibitors |
| JP2001302667A (ja) * | 2000-04-28 | 2001-10-31 | Bayer Ag | イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体 |
| US6673923B2 (en) | 2000-05-03 | 2004-01-06 | Tularik Inc. | Pyrazole antimicrobial agents |
| JP2004503553A (ja) | 2000-06-14 | 2004-02-05 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | ６，５−縮合二環式複素環 |
| CA2424222A1 (en) | 2000-10-02 | 2002-04-11 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| WO2003000690A1 (en) | 2001-06-25 | 2003-01-03 | Aventis Pharmaceuticals Inc. | Synthesis of heterocyclic compounds employing microwave technology |
| AR035543A1 (es) | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
| JP5039268B2 (ja) | 2001-10-26 | 2012-10-03 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | ベンゾイミダゾールおよび類縁体および蛋白キナーゼ阻害剤としてのその使用 |
| US20040082365A1 (en) * | 2002-07-18 | 2004-04-29 | Celerica Ltd | Digitization and transmitting cellular RF signals by several light wavelengths |
| EP1388541A1 (en) | 2002-08-09 | 2004-02-11 | Centre National De La Recherche Scientifique (Cnrs) | Pyrrolopyrazines as kinase inhibitors |
| WO2005014543A1 (ja) | 2003-08-06 | 2005-02-17 | Japan Tobacco Inc. | 縮合環化合物及びそのｈｃｖポリメラーゼ阻害剤としての利用 |
| MX2007001126A (es) * | 2004-07-27 | 2007-09-25 | Sgx Pharmaceuticals Inc | Moduladores de heterociclo cinasa de anillo fusionado. |
| GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| FR2876582B1 (fr) | 2004-10-15 | 2007-01-05 | Centre Nat Rech Scient Cnrse | Utilisation de derives de pyrrolo-pyrazines pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules |
| AU2005304952B2 (en) | 2004-11-08 | 2013-04-04 | Baxter Healthcare S.A. | Nanoparticulate compositions of tubulin inhibitors |
| EP1814883A1 (en) * | 2004-11-22 | 2007-08-08 | Vertex Pharmaceuticals Incorporated | Bicyclic inhibitors or rho kinase |
| US20110112101A1 (en) | 2009-03-05 | 2011-05-12 | Sanofi-Aventis | Treatment for ocular-related disorders |
-
2007
- 2007-09-10 CL CL200702617A patent/CL2007002617A1/es unknown
- 2007-09-11 CN CN201310652393.XA patent/CN103804383A/zh active Pending
- 2007-09-11 CN CNA2007800336608A patent/CN101511838A/zh active Pending
- 2007-09-11 MY MYPI20090720A patent/MY148107A/en unknown
- 2007-09-11 AU AU2007296592A patent/AU2007296592B8/en not_active Ceased
- 2007-09-11 JP JP2009538434A patent/JP5161237B2/ja not_active Expired - Fee Related
- 2007-09-11 BR BRPI0716781-4A2A patent/BRPI0716781A2/pt not_active IP Right Cessation
- 2007-09-11 NZ NZ575496A patent/NZ575496A/en not_active IP Right Cessation
- 2007-09-11 KR KR1020097005040A patent/KR101443056B1/ko not_active Expired - Fee Related
- 2007-09-11 TW TW096133786A patent/TWI399379B/zh not_active IP Right Cessation
- 2007-09-11 ES ES07842207.8T patent/ES2437318T3/es active Active
- 2007-09-11 WO PCT/US2007/078103 patent/WO2008033798A2/en not_active Ceased
- 2007-09-11 MX MX2009002616A patent/MX2009002616A/es active IP Right Grant
- 2007-09-11 PT PT78422078T patent/PT2094708E/pt unknown
- 2007-09-11 EP EP07842207.8A patent/EP2094708B1/en active Active
- 2007-09-11 UY UY30584A patent/UY30584A1/es not_active Application Discontinuation
- 2007-09-11 PE PE2007001220A patent/PE20081372A1/es not_active Application Discontinuation
- 2007-09-11 RU RU2009113615/04A patent/RU2440352C2/ru not_active IP Right Cessation
- 2007-09-11 CA CA2663175A patent/CA2663175C/en not_active Expired - Fee Related
- 2007-09-11 AR ARP070104013A patent/AR062745A1/es not_active Application Discontinuation
- 2007-09-11 DK DK07842207.8T patent/DK2094708T3/da active
- 2007-11-09 UA UAA200903417A patent/UA94622C2/ru unknown
-
2009
- 2009-02-16 ZA ZA2009/01073A patent/ZA200901073B/en unknown
- 2009-02-17 TN TN2009000050A patent/TN2009000050A1/fr unknown
- 2009-02-17 TN TN2009000049A patent/TN2009000049A1/fr unknown
- 2009-02-17 NI NI200900021A patent/NI200900021A/es unknown
- 2009-02-25 CR CR10636A patent/CR10636A/es not_active Application Discontinuation
- 2009-03-03 IL IL197381A patent/IL197381A/en not_active IP Right Cessation
- 2009-03-10 US US12/401,254 patent/US8658649B2/en not_active Expired - Fee Related
- 2009-03-10 HN HN2009000455A patent/HN2009000455A/es unknown
- 2009-03-10 GT GT200900055A patent/GT200900055A/es unknown
- 2009-03-11 CO CO09025278A patent/CO6160236A2/es unknown
- 2009-03-26 NO NO20091265A patent/NO20091265L/no not_active Application Discontinuation
- 2009-04-06 MA MA31765A patent/MA30781B1/fr unknown
-
2014
- 2014-01-28 US US14/166,396 patent/US20140142110A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010502767A5 (https=) | ||
| CA2663175A1 (en) | Kinase inhibitor | |
| JP6194389B2 (ja) | キナーゼ調節のための化合物および方法、ならびにその適応 | |
| KR101663339B1 (ko) | Ｒａｆ 키나제의 억제를 위한 피롤로［２,３-ｂ］피리딘 유도체 | |
| CN102480966B (zh) | 融合的杂环化合物及其用途 | |
| JP2010526814A5 (https=) | ||
| JP2010515715A5 (https=) | ||
| JP2009516653A5 (https=) | ||
| JP2009502743A5 (https=) | ||
| JP7633178B2 (ja) | ピロールアミド系化合物及びその用途 | |
| JP2010509356A5 (https=) | ||
| TW201706262A (zh) | Ｄｎａ烷化劑 | |
| JP2016503779A5 (https=) | ||
| JP2012526766A5 (https=) | ||
| JP2014065696A5 (https=) | ||
| JP2008518904A5 (https=) | ||
| TW201022281A (en) | Imidazolothiazole compounds and methods of use thereof | |
| JP2008513498A5 (https=) | ||
| JP2006514012A5 (https=) | ||
| TW201443043A (zh) | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 | |
| JP2009543843A (ja) | 直接トロンビン阻害剤に関する新規適応 | |
| JP2009506014A5 (https=) | ||
| JP2010505961A5 (https=) | ||
| EA015103B1 (ru) | Производные n-фенил-2-пиримидинамина и способ их получения | |
| JP2012509265A5 (https=) |