|
US3710795A
(en)
|
1970-09-29 |
1973-01-16 |
Alza Corp |
Drug-delivery device with stretched, rate-controlling membrane
|
|
GB1429184A
(en)
|
1972-04-20 |
1976-03-24 |
Allen & Hanburys Ltd |
Physically anti-inflammatory steroids for use in aerosols
|
|
US4044126A
(en)
|
1972-04-20 |
1977-08-23 |
Allen & Hanburys Limited |
Steroidal aerosol compositions and process for the preparation thereof
|
|
USRE28819E
(en)
|
1972-12-08 |
1976-05-18 |
Syntex (U.S.A.) Inc. |
Dialkylated glycol compositions and medicament preparations containing same
|
|
GB2013703B
(en)
*
|
1978-01-25 |
1982-06-03 |
Bayer Ag |
Heterocyclic dyestuffs
|
|
US4328245A
(en)
|
1981-02-13 |
1982-05-04 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4410545A
(en)
|
1981-02-13 |
1983-10-18 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4358603A
(en)
|
1981-04-16 |
1982-11-09 |
Syntex (U.S.A.) Inc. |
Acetal stabilized prostaglandin compositions
|
|
US4409239A
(en)
|
1982-01-21 |
1983-10-11 |
Syntex (U.S.A.) Inc. |
Propylene glycol diester solutions of PGE-type compounds
|
|
GB9222253D0
(en)
*
|
1992-10-23 |
1992-12-09 |
Celltech Ltd |
Chemical compounds
|
|
GB9304920D0
(en)
*
|
1993-03-10 |
1993-04-28 |
Celltech Ltd |
Chemical compounds
|
|
US6716575B2
(en)
*
|
1995-12-18 |
2004-04-06 |
Sugen, Inc. |
Diagnosis and treatment of AUR1 and/or AUR2 related disorders
|
|
GB9625184D0
(en)
*
|
1996-12-04 |
1997-01-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
ATE342971T1
(de)
*
|
1997-08-15 |
2006-11-15 |
Univ Hiroshima |
Den zellzyklus regulierende proteine
|
|
US7462605B2
(en)
*
|
1998-01-23 |
2008-12-09 |
Celmed Oncology (Usa), Inc. |
Phosphoramidate compounds and methods of use
|
|
US6706491B1
(en)
*
|
1999-04-09 |
2004-03-16 |
The Board Of Trustees Of The University Of Illinois |
Reagents and methods for identifying and modulating expression of genes regulated by p21
|
|
US20050113460A1
(en)
*
|
1999-04-30 |
2005-05-26 |
The Regents Of The University Of Michigan |
Compositions and methods relating to novel compounds and targets thereof
|
|
US6982265B1
(en)
*
|
1999-05-21 |
2006-01-03 |
Bristol Myers Squibb Company |
Pyrrolotriazine inhibitors of kinases
|
|
WO2001047922A2
(en)
*
|
1999-12-24 |
2001-07-05 |
Aventis Pharma Limited |
Azaindoles
|
|
WO2001055116A2
(en)
*
|
2000-01-28 |
2001-08-02 |
Astrazeneca Ab |
Quinoline derivatives and their use as aurora 2 kinase inhibitors
|
|
JP4739632B2
(ja)
*
|
2000-02-05 |
2011-08-03 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Ｅｒｋのインヒビターとして有用なピラゾール組成物
|
|
KR20010111298A
(ko)
*
|
2000-02-05 |
2001-12-17 |
버텍스 파마슈티칼스 인코포레이티드 |
Ｅｒｋ의 억제제로서 유용한 피라졸 조성물
|
|
JP2001302667A
(ja)
*
|
2000-04-28 |
2001-10-31 |
Bayer Ag |
イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体
|
|
US6555329B2
(en)
*
|
2000-06-09 |
2003-04-29 |
Boehringer Ingelheim International Gmbh |
Method for identifying compounds altering higher-order chromatin-dependent chromosome stability
|
|
US20050009876A1
(en)
*
|
2000-07-31 |
2005-01-13 |
Bhagwat Shripad S. |
Indazole compounds, compositions thereof and methods of treatment therewith
|
|
US6352858B1
(en)
*
|
2000-09-11 |
2002-03-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of BTAK expression
|
|
US6660731B2
(en)
*
|
2000-09-15 |
2003-12-09 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6613776B2
(en)
*
|
2000-09-15 |
2003-09-02 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
WO2002022605A1
(en)
*
|
2000-09-15 |
2002-03-21 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US7473691B2
(en)
*
|
2000-09-15 |
2009-01-06 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6610677B2
(en)
*
|
2000-09-15 |
2003-08-26 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
AU2002215053A1
(en)
*
|
2000-11-27 |
2002-06-24 |
Pharmacia Italia S.P.A. |
Phenylacetamido- pyrazole derivatives and their use as antitumor agents
|
|
US6659911B2
(en)
*
|
2000-11-28 |
2003-12-09 |
Yamaha Marine Kabushiki Kaisha |
Shift assist system for an outboard motor
|
|
EP1345941A1
(fr)
*
|
2000-12-20 |
2003-09-24 |
Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) |
Inhibiteurs de kinases dependantes des cylines (cdk) et de la glycogene synthase kinase-3 (gsk-3)
|
|
US6989385B2
(en)
*
|
2000-12-21 |
2006-01-24 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
MY130778A
(en)
*
|
2001-02-09 |
2007-07-31 |
Vertex Pharma |
Heterocyclic inhibitiors of erk2 and uses thereof
|
|
WO2002087758A1
(en)
*
|
2001-04-28 |
2002-11-07 |
China Petroleum & Chemical Corporation |
A rare earth zeolite y and the preparation process thereof
|
|
GEP20053712B
(en)
*
|
2001-05-14 |
2005-12-26 |
Pfizer Prod Inc |
Tartrate Salts of 5,8,14-Triazatetracyclo {10.3.1.0²,11.04,9}-Hexadeca-2(11),3,5,7,9-Pentaene and Pharmaceutical Compositions Thereof
|
|
WO2002094809A1
(fr)
*
|
2001-05-24 |
2002-11-28 |
Yamanouchi Pharmaceutical Co., Ltd. |
Derives de 3-quinoleine-2-(1h)-ylideneindoline-2-one
|
|
MXPA03010961A
(es)
*
|
2001-05-31 |
2004-02-27 |
Vertex Pharma |
Compuestos de tiazol utiles como inhibidores de proteinas cinasas.
|
|
ES2274035T3
(es)
*
|
2001-06-01 |
2007-05-16 |
Vertex Pharmaceuticals Incorporated |
Compuestos de tiazol utiles como inhibidores de proteina quinasas.
|
|
GB0115109D0
(en)
*
|
2001-06-21 |
2001-08-15 |
Aventis Pharma Ltd |
Chemical compounds
|
|
AU2002322775A1
(en)
*
|
2001-07-27 |
2003-02-17 |
The Regents Of The University Of California |
Stk15 (stk6) gene polymorphism and methods of determining cancer risk
|
|
WO2003011287A1
(en)
*
|
2001-08-03 |
2003-02-13 |
Vertex Pharmaceuticals Incorporated |
Pyrazolon derivatives as inhibitors of gsk-3
|
|
AU2002342607B2
(en)
*
|
2001-08-06 |
2006-10-19 |
Pharmacia Italia S.P.A. |
Aminoisoxazole derivatives active as kinase inhibitors
|
|
US20030073692A1
(en)
*
|
2001-08-07 |
2003-04-17 |
Pharmacia & Upjohn S.P.A. |
Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them
|
|
US6806272B2
(en)
*
|
2001-09-04 |
2004-10-19 |
Boehringer Ingelheim Pharma Kg |
Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
|
|
BR0212613A
(pt)
*
|
2001-09-19 |
2004-08-31 |
Pharmacia Corp |
Compostos de indazol substituìdos para o tratamento de inflamação
|
|
EP1444207A2
(en)
*
|
2001-09-19 |
2004-08-11 |
Pharmacia Corporation |
Substituted pyrazolyl-compounds for the treatment of inflammation
|
|
ATE363473T1
(de)
*
|
2001-09-19 |
2007-06-15 |
Pharmacia Corp |
Substituierte pyrazoloverbindungen zur behandlung von entzündungen
|
|
CN1316634C
(zh)
*
|
2001-10-03 |
2007-05-16 |
株式会社东芝 |
X光平面检测器
|
|
US20040010027A1
(en)
*
|
2001-12-17 |
2004-01-15 |
Pharmacia & Upjohn Spa |
Hydroxphenyl-pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical comositions comprising them
|
|
WO2003055491A1
(en)
*
|
2001-12-24 |
2003-07-10 |
Astrazeneca Ab |
Substituted quinazoline derivatives as inhibitors of aurora kinases
|
|
FR2836914B1
(fr)
*
|
2002-03-11 |
2008-03-14 |
Aventis Pharma Sa |
Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
|
|
DE60332433D1
(de)
*
|
2002-03-15 |
2010-06-17 |
Vertex Pharma |
Azolylaminoazine als proteinkinasehemmer
|
|
US20040009981A1
(en)
*
|
2002-03-15 |
2004-01-15 |
David Bebbington |
Compositions useful as inhibitors of protein kinases
|
|
US6846928B2
(en)
*
|
2002-03-15 |
2005-01-25 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of protein kinases
|
|
EP1485381B8
(en)
*
|
2002-03-15 |
2010-05-12 |
Vertex Pharmaceuticals Incorporated |
Azolylaminoazine as inhibitors of protein kinases
|
|
US7304061B2
(en)
*
|
2002-04-26 |
2007-12-04 |
Vertex Pharmaceuticals Incorporated |
Heterocyclic inhibitors of ERK2 and uses thereof
|
|
US6989451B2
(en)
*
|
2002-06-04 |
2006-01-24 |
Valeant Research & Development |
Heterocyclic compounds and uses thereof
|
|
MY141867A
(en)
*
|
2002-06-20 |
2010-07-16 |
Vertex Pharma |
Substituted pyrimidines useful as protein kinase inhibitors
|
|
US7361665B2
(en)
*
|
2002-07-09 |
2008-04-22 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
|
|
AU2003262642B2
(en)
*
|
2002-08-14 |
2010-06-17 |
Vertex Pharmaceuticals Incorporated |
Protein kinase inhibitors and uses thereof
|
|
NZ538685A
(en)
*
|
2002-09-23 |
2008-02-29 |
Schering Corp |
Imidazopyrazines as cyclin dependent kinase inhibitors
|
|
JP2006513170A
(ja)
*
|
2002-11-18 |
2006-04-20 |
トーラス エイチエスエイ エルエルシー |
酸および塩基から溶液を連続的に自動混合する方法
|
|
US20040242613A1
(en)
*
|
2003-01-30 |
2004-12-02 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Pyrimidine derivatives useful as inhibitors of PKC-theta
|
|
US6861422B2
(en)
*
|
2003-02-26 |
2005-03-01 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
|
|
EP2385041B1
(en)
*
|
2003-05-01 |
2013-09-18 |
Bristol-Myers Squibb Company |
Pyrazole-amine compounds useful as kinase inhibitors
|
|
US20050125852A1
(en)
*
|
2003-05-09 |
2005-06-09 |
Sugen, Inc. |
Novel kinases
|
|
CN1809563A
(zh)
*
|
2003-06-20 |
2006-07-26 |
希龙公司 |
吡啶并[1,2－a]嘧啶－4－酮化合物用作抗癌药
|
|
US20050065171A1
(en)
*
|
2003-06-25 |
2005-03-24 |
Shakespeare William C. |
Substituted purine derivatives
|
|
US20050032869A1
(en)
*
|
2003-07-08 |
2005-02-10 |
Pharmacia Italia S.P.A. |
Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
|
|
US7141568B2
(en)
*
|
2003-07-09 |
2006-11-28 |
Pfizer Italia S.R.L. |
Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
|
|
US20050026984A1
(en)
*
|
2003-07-29 |
2005-02-03 |
Aventis Pharma S.A. |
Substituted thieno [2,3-c] pyrazoles and their use as medicinal products
|
|
US7094791B2
(en)
*
|
2003-07-31 |
2006-08-22 |
Avalon Pharmaceuticals, Inc. |
Derivatives of 3-hydroxy-pyrrole-2,4-dicarboxylic acid and uses thereof
|
|
US7279575B2
(en)
*
|
2003-08-08 |
2007-10-09 |
Pfizer Italia S.R.L. |
Pyrimidylpyrrole derivatives active as kinase inhibitors
|
|
US20050043346A1
(en)
*
|
2003-08-08 |
2005-02-24 |
Pharmacia Italia S.P.A. |
Pyridylpyrrole derivatives active as kinase inhibitors
|
|
CA2536253A1
(en)
*
|
2003-08-20 |
2005-03-03 |
Vertex Pharmaceuticals Incorporated |
Aminofurazan compounds useful as protein kinase inhibitors
|
|
US20050085531A1
(en)
*
|
2003-10-03 |
2005-04-21 |
Hodge Carl N. |
Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
|
|
US20050107386A1
(en)
*
|
2003-11-19 |
2005-05-19 |
Rama Krishna Narla |
Methods of treating diseases and disorders by targeting multiple kinases
|
|
FR2865934B1
(fr)
*
|
2004-02-05 |
2006-05-05 |
Sanofi Synthelabo |
Utilisation de derives d'indolizine 1,2,3 substitues, inhibiteurs des fgfs, pour la preparation de medicaments utiles pour le traitement de maladies liees a une angiogenese pathologique choroidienne
|
|
AR047969A1
(es)
*
|
2004-02-25 |
2006-03-15 |
Schering Corp |
Pirazolotriazinas como inhibidores de quinasa
|
|
FR2868421B1
(fr)
*
|
2004-04-01 |
2008-08-01 |
Aventis Pharma Sa |
Nouveaux benzothiazoles et leur utilisation comme medicaments
|
|
FR2871158A1
(fr)
*
|
2004-06-04 |
2005-12-09 |
Aventis Pharma Sa |
Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
|
|
DE102004029784A1
(de)
*
|
2004-06-21 |
2006-01-05 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
|
|
DE102004034623A1
(de)
*
|
2004-07-16 |
2006-02-02 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 6-Formyl-tetrahydropteridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
|
US7521457B2
(en)
*
|
2004-08-20 |
2009-04-21 |
Boehringer Ingelheim International Gmbh |
Pyrimidines as PLK inhibitors
|
|
EP1786817A1
(de)
*
|
2004-08-26 |
2007-05-23 |
Boehringer Ingelheim International GmbH |
Pteridinone als plk (polo like kinase) inhibitoren
|
|
WO2006021548A1
(de)
*
|
2004-08-27 |
2006-03-02 |
Boehringer Ingelheim International Gmbh |
Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel
|
|
FR2876377B1
(fr)
*
|
2004-10-11 |
2007-03-16 |
Univ Claude Bernard Lyon |
Nouveaux derives de 9h-pyrido[2,3-b]indole, leur procede de preparation, ainsi que les compositions pharmaceutiques contenant de tels composes
|
|
BRPI0516093A
(pt)
*
|
2004-10-12 |
2008-08-19 |
Astrazeneca Ab |
derivado de quinazolina, processo para a preparação do mesmo, composição farmacêutica, uso de um derivado de quinazolina, e, método para tratamento de distúrbios proliferativos celulares em um animal de sanque quente
|
|
FR2882751B1
(fr)
*
|
2005-03-04 |
2007-09-14 |
Aventis Pharma Sa |
Hydrazinocarbonyl-thieno[2,3-c]pyrazoles, procede de preparation, compositions les contenant et utilisation
|
|
FR2884821B1
(fr)
*
|
2005-04-26 |
2007-07-06 |
Aventis Pharma Sa |
Pyrrolopyridines substitues, compositions les contenant, procede de fabrication et utilisation
|
|
EP1896472A1
(de)
*
|
2005-06-09 |
2008-03-12 |
Boehringer Ingelheim International GmbH |
Alpha-carboline als cdk-1 inhibitoren
|
|
US8119655B2
(en)
*
|
2005-10-07 |
2012-02-21 |
Takeda Pharmaceutical Company Limited |
Kinase inhibitors
|
|
CA2666138A1
(en)
*
|
2006-10-09 |
2008-05-08 |
Takeda Pharmaceutical Company Limited |
Kinase inhibitors
|
|
WO2009129401A1
(en)
*
|
2008-04-16 |
2009-10-22 |
Takeda Pharmaceutical Company Limited |
Kinase inhibitors
|