CN109311893A - 含有取代环戊基的吡咯并嘧啶化合物 - Google Patents
含有取代环戊基的吡咯并嘧啶化合物 Download PDFInfo
- Publication number
- CN109311893A CN109311893A CN201780037341.8A CN201780037341A CN109311893A CN 109311893 A CN109311893 A CN 109311893A CN 201780037341 A CN201780037341 A CN 201780037341A CN 109311893 A CN109311893 A CN 109311893A
- Authority
- CN
- China
- Prior art keywords
- compound
- acid
- pyrrolo
- pyrimidine
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims (9)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2016104279501 | 2016-06-16 | ||
CN201610427950.1A CN107513067A (zh) | 2016-06-16 | 2016-06-16 | 含有取代环戊基的吡咯并嘧啶化合物 |
PCT/CN2017/088424 WO2017215628A1 (zh) | 2016-06-16 | 2017-06-15 | 含有取代环戊基的吡咯并嘧啶化合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109311893A true CN109311893A (zh) | 2019-02-05 |
CN109311893B CN109311893B (zh) | 2020-09-04 |
Family
ID=60664307
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610427950.1A Pending CN107513067A (zh) | 2016-06-16 | 2016-06-16 | 含有取代环戊基的吡咯并嘧啶化合物 |
CN201780037341.8A Active CN109311893B (zh) | 2016-06-16 | 2017-06-15 | 含有取代环戊基的吡咯并嘧啶化合物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610427950.1A Pending CN107513067A (zh) | 2016-06-16 | 2016-06-16 | 含有取代环戊基的吡咯并嘧啶化合物 |
Country Status (3)
Country | Link |
---|---|
US (1) | US10617692B2 (zh) |
CN (2) | CN107513067A (zh) |
WO (1) | WO2017215628A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107513067A (zh) * | 2016-06-16 | 2017-12-26 | 北京赛林泰医药技术有限公司 | 含有取代环戊基的吡咯并嘧啶化合物 |
WO2020135401A1 (zh) * | 2018-12-24 | 2020-07-02 | 正大天晴药业集团股份有限公司 | 吡咯并嘧啶化合物的治疗用途及其固体药物组合物 |
WO2021180093A1 (zh) * | 2020-03-09 | 2021-09-16 | 正大天晴药业集团股份有限公司 | 吡咯并嘧啶化合物的治疗噬血细胞综合征的用途 |
CN114085224A (zh) * | 2020-08-25 | 2022-02-25 | 北京普祺医药科技有限公司 | 一种吡咯并嘧啶化合物的制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101448826A (zh) * | 2005-12-13 | 2009-06-03 | 因塞特公司 | 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡咯和吡咯并[2,3-b]嘧啶 |
CN101815717A (zh) * | 2007-06-13 | 2010-08-25 | 因塞特公司 | JANUS激酶抑制剂(R)-3-(4-(7H-吡咯并[2,3-d]嘧啶-4-基)-1H-吡唑-1-基)-3-环戊基丙腈的代谢产物 |
CN102596960A (zh) * | 2009-10-09 | 2012-07-18 | 因西特公司 | 3-(4-(7H-吡咯并[2,3-d]嘧啶-4-基)-1H-吡唑-1-基)-3-环戊基丙腈的羟基衍生物、酮基衍生物和葡糖苷酸衍生物 |
CN107513067A (zh) * | 2016-06-16 | 2017-12-26 | 北京赛林泰医药技术有限公司 | 含有取代环戊基的吡咯并嘧啶化合物 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0102366A2 (hu) | 1998-06-04 | 2001-11-28 | Abbott Laboratories | Sejttapadást gátló, gyulladáscsökkentő hatású vegyületek |
PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
MXPA02005675A (es) | 1999-12-10 | 2002-09-02 | Pfizer Prod Inc | Compuestos de pirrolo(2,3-d)pirimidina. |
JP2006518381A (ja) | 2003-02-07 | 2006-08-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なヘテロアリール置換ピロール |
SE0301373D0 (sv) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Novel compounds |
SE0301372D0 (sv) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Novel compounds |
CN105777754B (zh) | 2014-12-16 | 2019-07-26 | 北京赛林泰医药技术有限公司 | 吡咯并嘧啶化合物 |
-
2016
- 2016-06-16 CN CN201610427950.1A patent/CN107513067A/zh active Pending
-
2017
- 2017-06-15 WO PCT/CN2017/088424 patent/WO2017215628A1/zh active Application Filing
- 2017-06-15 US US16/310,221 patent/US10617692B2/en active Active
- 2017-06-15 CN CN201780037341.8A patent/CN109311893B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101448826A (zh) * | 2005-12-13 | 2009-06-03 | 因塞特公司 | 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡咯和吡咯并[2,3-b]嘧啶 |
CN101815717A (zh) * | 2007-06-13 | 2010-08-25 | 因塞特公司 | JANUS激酶抑制剂(R)-3-(4-(7H-吡咯并[2,3-d]嘧啶-4-基)-1H-吡唑-1-基)-3-环戊基丙腈的代谢产物 |
CN102596960A (zh) * | 2009-10-09 | 2012-07-18 | 因西特公司 | 3-(4-(7H-吡咯并[2,3-d]嘧啶-4-基)-1H-吡唑-1-基)-3-环戊基丙腈的羟基衍生物、酮基衍生物和葡糖苷酸衍生物 |
CN107513067A (zh) * | 2016-06-16 | 2017-12-26 | 北京赛林泰医药技术有限公司 | 含有取代环戊基的吡咯并嘧啶化合物 |
Also Published As
Publication number | Publication date |
---|---|
US20190183899A1 (en) | 2019-06-20 |
CN107513067A (zh) | 2017-12-26 |
WO2017215628A1 (zh) | 2017-12-21 |
US10617692B2 (en) | 2020-04-14 |
CN109311893B (zh) | 2020-09-04 |
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PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20190530 Address after: No. 369, Yuzhou South Road, Lianyungang, Jiangsu Province Applicant after: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Applicant after: Capital Pharmaceutical Holdings (Beijing) Co., Ltd. Applicant after: Lianyungang Runzhong Pharmaceutical Co.,Ltd. Address before: No. 369, Yuzhou South Road, Lianyungang, Jiangsu Province Applicant before: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Applicant before: Beijing Centaurus Biopharma Technology Co., Ltd. Applicant before: Lianyungang Runzhong Pharmaceutical Co.,Ltd. |
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GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: No. 369, Yuzhou South Road, Lianyungang, Jiangsu Province Patentee after: CHIA TAI TIANQING PHARMACEUTICAL GROUP Co.,Ltd. Patentee after: Capital Pharmaceutical Holdings (Beijing) Co.,Ltd. Patentee after: LIANYUNGANG RUNZHONG PHARMACEUTICAL Co.,Ltd. Address before: No. 369, Yuzhou South Road, Lianyungang, Jiangsu Province Patentee before: CHIA TAI TIANQING PHARMACEUTICAL GROUP Co.,Ltd. Patentee before: Shouyao holding (Beijing) Co.,Ltd. Patentee before: LIANYUNGANG RUNZHONG PHARMACEUTICAL Co.,Ltd. |