JP2019531763A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019531763A5 JP2019531763A5 JP2019533313A JP2019533313A JP2019531763A5 JP 2019531763 A5 JP2019531763 A5 JP 2019531763A5 JP 2019533313 A JP2019533313 A JP 2019533313A JP 2019533313 A JP2019533313 A JP 2019533313A JP 2019531763 A5 JP2019531763 A5 JP 2019531763A5
- Authority
- JP
- Japan
- Prior art keywords
- item
- sequence
- site
- anchor sequence
- specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023113050A JP2023119040A (ja) | 2016-09-07 | 2023-07-10 | 遺伝子発現をモジュレートするための方法および組成物 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662384603P | 2016-09-07 | 2016-09-07 | |
| US62/384,603 | 2016-09-07 | ||
| US201662416501P | 2016-11-02 | 2016-11-02 | |
| US62/416,501 | 2016-11-02 | ||
| US201662439327P | 2016-12-27 | 2016-12-27 | |
| US62/439,327 | 2016-12-27 | ||
| US201762542703P | 2017-08-08 | 2017-08-08 | |
| US62/542,703 | 2017-08-08 | ||
| PCT/US2017/050553 WO2018049073A1 (en) | 2016-09-07 | 2017-09-07 | Methods and compositions for modulating gene expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023113050A Division JP2023119040A (ja) | 2016-09-07 | 2023-07-10 | 遺伝子発現をモジュレートするための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019531763A JP2019531763A (ja) | 2019-11-07 |
| JP2019531763A5 true JP2019531763A5 (https=) | 2020-10-22 |
| JP7682604B2 JP7682604B2 (ja) | 2025-05-26 |
Family
ID=61562240
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019533313A Active JP7682604B2 (ja) | 2016-09-07 | 2017-09-07 | 遺伝子発現をモジュレートするための方法および組成物 |
| JP2023113050A Pending JP2023119040A (ja) | 2016-09-07 | 2023-07-10 | 遺伝子発現をモジュレートするための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023113050A Pending JP2023119040A (ja) | 2016-09-07 | 2023-07-10 | 遺伝子発現をモジュレートするための方法および組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US20190255106A1 (https=) |
| EP (1) | EP3510152A4 (https=) |
| JP (2) | JP7682604B2 (https=) |
| CN (1) | CN109890962A (https=) |
| AU (2) | AU2017324550B2 (https=) |
| CA (1) | CA3035910A1 (https=) |
| WO (4) | WO2018049079A1 (https=) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| AU2015330699B2 (en) | 2014-10-10 | 2021-12-02 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| EP4464338A3 (en) | 2014-11-07 | 2025-02-12 | Editas Medicine, Inc. | Systems for improving crispr/cas-mediated genome-editing |
| CA2986310A1 (en) | 2015-05-11 | 2016-11-17 | Editas Medicine, Inc. | Optimized crispr/cas9 systems and methods for gene editing in stem cells |
| CN108026526B (zh) | 2015-06-09 | 2023-05-12 | 爱迪塔斯医药公司 | 用于改善移植的crispr/cas相关方法和组合物 |
| EP3353296B1 (en) | 2015-09-24 | 2020-11-04 | Editas Medicine, Inc. | Use of exonucleases to improve crispr/cas-mediated genome editing |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| US11597924B2 (en) | 2016-03-25 | 2023-03-07 | Editas Medicine, Inc. | Genome editing systems comprising repair-modulating enzyme molecules and methods of their use |
| US11236313B2 (en) | 2016-04-13 | 2022-02-01 | Editas Medicine, Inc. | Cas9 fusion molecules, gene editing systems, and methods of use thereof |
| CN109843914B (zh) | 2016-07-06 | 2024-03-15 | 沃泰克斯药物股份有限公司 | 用于治疗疼痛相关病症的材料和方法 |
| JP7305534B2 (ja) | 2016-07-06 | 2023-07-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | 疼痛関連障害を処置するための物質及び方法 |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| CA3034369A1 (en) | 2016-08-19 | 2018-02-22 | Whitehead Institute For Biomedical Research | Methods of editing dna methylation |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| US20190255106A1 (en) | 2016-09-07 | 2019-08-22 | Flagship Pioneering Inc. | Methods and compositions for modulating gene expression |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| US20200149039A1 (en) | 2016-12-12 | 2020-05-14 | Whitehead Institute For Biomedical Research | Regulation of transcription through ctcf loop anchors |
| EP3555297A1 (en) | 2016-12-19 | 2019-10-23 | Editas Medicine, Inc. | Assessing nuclease cleavage |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| JP7229923B2 (ja) | 2017-01-06 | 2023-02-28 | エディタス・メディシン、インコーポレイテッド | ヌクレアーゼ切断を評価する方法 |
| DK3565891T3 (da) | 2017-01-09 | 2023-07-24 | Whitehead Inst Biomedical Res | Fremgangsmåder til ændring af genekspression ved forstyrrelse af transkriptionsfaktor-multimere, der strukturerer regulatoriske sløjfer |
| US11730828B2 (en) | 2017-02-07 | 2023-08-22 | The Regents Of The University Of California | Gene therapy for haploinsufficiency |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11499151B2 (en) | 2017-04-28 | 2022-11-15 | Editas Medicine, Inc. | Methods and systems for analyzing guide RNA molecules |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| MX2019014640A (es) | 2017-06-09 | 2020-10-05 | Editas Medicine Inc | Nucleasas de repeticiones palíndromicas agrupadas y regularmente interespaciadas de proteina asociada 9 (cas9) genomanipuladas. |
| US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| EP3717505A4 (en) | 2017-12-01 | 2021-12-01 | Encoded Therapeutics, Inc. | GENENICALLY MODIFIED DNA-BINDING PROTEINS |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3790980A4 (en) * | 2018-05-06 | 2022-03-23 | Emendobio Inc. | DIFFERENTIAL KNOCKOUT OF AN ALLEL OF A HETEROZYGOUS ELAN GENE |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| EP3823633A4 (en) | 2018-06-29 | 2023-05-03 | Editas Medicine, Inc. | SYNTHETIC LEAD MOLECULES, COMPOSITIONS AND METHODS RELATED THERETO |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| AU2019326408A1 (en) * | 2018-08-23 | 2021-03-11 | Sangamo Therapeutics, Inc. | Engineered target specific base editors |
| CN119264211A (zh) | 2018-08-27 | 2025-01-07 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| US20220380760A1 (en) * | 2018-10-15 | 2022-12-01 | Flagship Pioneering Innovations V, Inc. | Disrupting genomic complex assembly in fusion genes |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| JP2022513159A (ja) * | 2018-11-29 | 2022-02-07 | フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド | Ｒｎａを調節する方法 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| JP7624728B2 (ja) | 2019-02-25 | 2025-01-31 | ユニバーシティ オブ マサチューセッツ | Ｄｎａ結合ドメイントランスアクチベーター及びその使用 |
| WO2020176553A1 (en) * | 2019-02-25 | 2020-09-03 | Sense Therapeutics Inc. | Intracellular mutation targeting therapy |
| KR20210140819A (ko) * | 2019-03-18 | 2021-11-23 | 사운드 애그리컬쳐 컴퍼니 | 식물에서 유전자 발현의 프로그래밍가능한 후성적 제어 |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| PL3976798T3 (pl) * | 2019-05-29 | 2026-04-07 | Encoded Therapeutics, Inc. | Kompozycje i sposoby selektywnej regulacji genów |
| CA3154759A1 (en) * | 2019-09-23 | 2021-04-01 | Flagship Pioneering Innovations V, Inc. | Modulating genomic complexes |
| EP4048807A1 (en) * | 2019-09-23 | 2022-08-31 | Omega Therapeutics, Inc. | Compositions and methods for modulating apolipoprotein b (apob) gene expression |
| CN114729376A (zh) | 2019-09-23 | 2022-07-08 | 欧米茄治疗公司 | 用于调节肝细胞核因子4α(HNF4α)基因表达的组合物和方法 |
| WO2021061640A1 (en) * | 2019-09-23 | 2021-04-01 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for modulating genomic complex integrity index |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| US12435334B2 (en) | 2019-11-06 | 2025-10-07 | Emendobio Inc. | Differential knockout of an allele of a heterozygous ELANE gene-II |
| US12258599B2 (en) | 2019-11-06 | 2025-03-25 | Emendobio Inc. | Method to inactivate a mutant allele of an ELANE gene |
| US20220387515A1 (en) * | 2019-11-06 | 2022-12-08 | Emendobio Inc. | Differential knockout of an allele of a heterozygous elane gene using guides 21-30 nucleotides in length |
| EP4061968A4 (en) * | 2019-11-22 | 2023-12-27 | National University of Singapore | Method and system for identifying and validating shared candidate antigens and shared antigen-specific t lymphocyte pairs |
| CN114981424A (zh) * | 2020-01-17 | 2022-08-30 | 尼祖姆贝公司 | 在染色质靶点处dna链断裂的诱导 |
| JPWO2021171688A1 (https=) * | 2020-02-26 | 2021-09-02 | ||
| CN116209756A (zh) | 2020-03-04 | 2023-06-02 | 旗舰先锋创新Vi有限责任公司 | 调控基因组的方法和组合物 |
| CA3173528A1 (en) | 2020-03-11 | 2021-09-16 | Omega Therapeutics, Inc. | Compositions and methods for modulating forkhead box p3 (foxp3) gene expression |
| WO2021216457A1 (en) * | 2020-04-24 | 2021-10-28 | Spinalcyte, Llc | Treatment of frontotemporal dementia using fibroblasts and products thereof |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| KR20230079181A (ko) * | 2020-09-29 | 2023-06-05 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 다중 유전자의 발현을 억제하는 조성물 및 방법 |
| CN112301020B (zh) * | 2020-10-19 | 2024-04-12 | 复旦大学附属肿瘤医院 | Iii类脱氧核酶突变体及其制备方法与应用 |
| CN114621959B (zh) * | 2020-12-08 | 2023-05-26 | 中国科学院海洋研究所 | 一种编码牙鲆igf2可溶性蛋白的基因及蛋白重组表达方法与应用 |
| KR20240011120A (ko) * | 2020-12-22 | 2024-01-25 | 크로마 메디슨, 인크. | 후성유전학적 편집을 위한 조성물 및 방법 |
| EP4308153A4 (en) * | 2021-03-16 | 2025-12-17 | Massachusetts Gen Hospital | Compositions and methods for treating diseases associated with nucleoside repeat expansion |
| EP4367242A2 (en) | 2021-07-07 | 2024-05-15 | Omega Therapeutics, Inc. | Compositions and methods for modulating secreted frizzled receptor protein 1 (sfrp1) gene expression |
| US20230116385A1 (en) * | 2021-08-30 | 2023-04-13 | Sachi Bioworks Inc. | Composition of a therapeutic oligomer |
| AU2022343268A1 (en) | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| GB2625500B (en) | 2021-09-21 | 2026-04-01 | Scribe Therapeutics Inc | Engineered CasX repressor systems |
| WO2023225349A2 (en) * | 2022-05-20 | 2023-11-23 | Helex Inc. | Tissue specific methods and compositions for gene editing |
| WO2023250429A2 (en) * | 2022-06-22 | 2023-12-28 | Flagship Pioneering Innovations V, Inc. | Combination therapies comprising myc modulation |
| AU2023286673A1 (en) * | 2022-06-22 | 2024-12-12 | Acuitas Therapeutics, Inc. | Formulations for modulating myc expression |
| AU2024270764A1 (en) | 2023-05-15 | 2025-12-04 | Nchroma Bio, Inc. | Compositions and methods for epigenetic regulation of hbv gene expression |
| WO2024238723A1 (en) | 2023-05-16 | 2024-11-21 | Omega Therapeutics, Inc. | Methods and compositions for modulating pcsk9 expression |
| EP4713027A1 (en) | 2023-05-16 | 2026-03-25 | Omega Therapeutics, Inc. | Methods and compositions for modulating methylation of a target gene |
| EP4716741A2 (en) | 2023-05-23 | 2026-04-01 | Flagship Labs 114, Inc. | Compositions and methods for reducing cxcl9, cxcl10, and cxcl11 gene expression |
| WO2025019742A1 (en) | 2023-07-19 | 2025-01-23 | Omega Therapeutics, Inc. | Methods and compositions for modulating ctnnb1 expression |
| WO2025085423A1 (en) * | 2023-10-19 | 2025-04-24 | The Broad Institute, Inc. | Method of multi-locus crispri targeting with a single truncated guide |
| CN118773200B (zh) * | 2024-07-18 | 2025-06-10 | 华中科技大学同济医学院附属同济医院 | 一种ttc21b基因突变位点及其应用 |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1622569B1 (en) | 2003-04-24 | 2015-12-02 | Incyte Corporation | Aza spiro alkane derivatives as inhibitors of metallproteases |
| WO2009146033A2 (en) | 2008-03-31 | 2009-12-03 | Sma Foundation | Compositions and methods for modulating smn activity |
| KR101728655B1 (ko) | 2008-12-18 | 2017-04-19 | 다이서나 파마수이티컬, 인크. | 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법 |
| EP2414524B1 (en) | 2009-04-03 | 2017-08-23 | Centre National De La Recherche Scientifique | Gene transfer vectors comprising genetic insulator elements and methods to identify genetic insulator elements |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2694686B2 (en) * | 2011-04-06 | 2023-07-19 | The University of Chicago | COMPOSITION AND METHODS RELATED TO MODIFICATION OF 5-METHYLCYTOSINE (5mC) |
| US9234213B2 (en) * | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
| CN112301024A (zh) * | 2013-03-15 | 2021-02-02 | 通用医疗公司 | 使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性 |
| US20160186208A1 (en) | 2013-04-16 | 2016-06-30 | Whitehead Institute For Biomedical Research | Methods of Mutating, Modifying or Modulating Nucleic Acid in a Cell or Nonhuman Mammal |
| EP3636750A1 (en) | 2013-09-04 | 2020-04-15 | Csir | Site-specific nuclease single-cell assay targeting gene regulatory elements to silence gene expression |
| US9526784B2 (en) * | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| WO2015038892A1 (en) | 2013-09-13 | 2015-03-19 | Moderna Therapeutics, Inc. | Polynucleotide compositions containing amino acids |
| WO2015191780A2 (en) * | 2014-06-10 | 2015-12-17 | The General Hospital Corporation | Ccctc-binding factor (ctcf) rna interactome |
| WO2015196128A2 (en) | 2014-06-19 | 2015-12-23 | Moderna Therapeutics, Inc. | Alternative nucleic acid molecules and uses thereof |
| WO2016014794A1 (en) * | 2014-07-25 | 2016-01-28 | Sangamo Biosciences, Inc. | Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells |
| US10077453B2 (en) * | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| GB201418965D0 (https=) | 2014-10-24 | 2014-12-10 | Ospedale San Raffaele And Fond Telethon | |
| TWI716367B (zh) * | 2014-10-31 | 2021-01-21 | 麻省理工學院 | 用於常間回文重複序列叢集（ｃｒｉｓｐｒ）之大量平行組合性基因學 |
| EP4464338A3 (en) * | 2014-11-07 | 2025-02-12 | Editas Medicine, Inc. | Systems for improving crispr/cas-mediated genome-editing |
| EP3221813A4 (en) * | 2014-11-20 | 2018-04-18 | Children's Medical Center Corporation | Methods relating to the detection of recurrent and non-specific double strand breaks in the genome |
| WO2016089920A1 (en) | 2014-12-01 | 2016-06-09 | The Broad Institute, Inc. | Method for in situ determination of nucleic acid proximity |
| EP3237017A4 (en) | 2014-12-24 | 2018-08-01 | Dana-Farber Cancer Institute, Inc. | Systems and methods for genome modification and regulation |
| CN107429263A (zh) * | 2015-01-15 | 2017-12-01 | 斯坦福大学托管董事会 | 调控基因组编辑的方法 |
| US10023922B2 (en) | 2015-03-23 | 2018-07-17 | Whitehead Institute For Biomedical Research | Reporter of genomic methylation and uses thereof |
| KR102888521B1 (ko) | 2015-04-06 | 2025-11-19 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna |
| EP3087974A1 (en) * | 2015-04-29 | 2016-11-02 | Rodos BioTarget GmbH | Targeted nanocarriers for targeted drug delivery of gene therapeutics |
| US20170014449A1 (en) * | 2015-07-13 | 2017-01-19 | Elwha LLC, a limited liability company of the State of Delaware | Site-specific epigenetic editing |
| WO2017011710A2 (en) | 2015-07-14 | 2017-01-19 | Whitehead Institute For Biomedical Research | Chromosome neighborhood structures and methods relating thereto |
| WO2017031370A1 (en) * | 2015-08-18 | 2017-02-23 | The Broad Institute, Inc. | Methods and compositions for altering function and structure of chromatin loops and/or domains |
| WO2017040793A1 (en) | 2015-09-01 | 2017-03-09 | Dana-Farber Cancer Institute Inc. | Systems and methods for selection of grna targeting strands for cas9 localization |
| US20190048340A1 (en) * | 2015-09-24 | 2019-02-14 | Crispr Therapeutics Ag | Novel family of rna-programmable endonucleases and their uses in genome editing and other applications |
| US20170130247A1 (en) | 2015-09-30 | 2017-05-11 | Whitehead Institute For Biomedical Research | Compositions and methods for altering gene expression |
| US20190062752A1 (en) | 2015-10-29 | 2019-02-28 | Whitehead Institute For Biomedical Research | Transcription Factor Trapping by RNA in Gene Regulatory Elements |
| US11339442B2 (en) | 2015-12-14 | 2022-05-24 | The General Hospital Corporation | Methods of detecting insulator dysfunction and oncogene activation for screening, diagnosis and treatment of patients in need thereof |
| JP2019508037A (ja) * | 2016-02-16 | 2019-03-28 | イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔ | 標的化遺伝子編集を増強するための組成物およびその使用方法 |
| GB201608000D0 (en) | 2016-05-06 | 2016-06-22 | Oxford Biodynamics Ltd | Chromosome detection |
| CA3034369A1 (en) * | 2016-08-19 | 2018-02-22 | Whitehead Institute For Biomedical Research | Methods of editing dna methylation |
| US20190255106A1 (en) | 2016-09-07 | 2019-08-22 | Flagship Pioneering Inc. | Methods and compositions for modulating gene expression |
| WO2018085460A2 (en) | 2016-11-02 | 2018-05-11 | Flagship Pioneering, Inc. | Compositions and methods for cell delivery |
| US20200149039A1 (en) | 2016-12-12 | 2020-05-14 | Whitehead Institute For Biomedical Research | Regulation of transcription through ctcf loop anchors |
| DK3565891T3 (da) | 2017-01-09 | 2023-07-24 | Whitehead Inst Biomedical Res | Fremgangsmåder til ændring af genekspression ved forstyrrelse af transkriptionsfaktor-multimere, der strukturerer regulatoriske sløjfer |
| US20210322577A1 (en) | 2017-03-03 | 2021-10-21 | Flagship Pioneering Innovations V, Inc. | Methods and systems for modifying dna |
| WO2018204764A1 (en) | 2017-05-05 | 2018-11-08 | Camp4 Therapeutics Corporation | Identification and targeted modulation of gene signaling networks |
| WO2019036430A1 (en) | 2017-08-14 | 2019-02-21 | Camp4 Therapeutics Corporation | METHODS OF TREATING HEPATIC DISEASES |
| WO2019071054A1 (en) | 2017-10-04 | 2019-04-11 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS FOR MODIFYING THE FUNCTION AND STRUCTURE OF BUCKLES AND / OR CHROMATIN DOMAINS |
| EP3587516B1 (en) | 2018-06-27 | 2024-05-22 | Ricoh Company, Ltd. | Ink, method of manufacturing acrylic resin particle, printing method, ink accommodating unit, and inkjet printing device |
| US20220380760A1 (en) | 2018-10-15 | 2022-12-01 | Flagship Pioneering Innovations V, Inc. | Disrupting genomic complex assembly in fusion genes |
| JP2022513159A (ja) | 2018-11-29 | 2022-02-07 | フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド | Ｒｎａを調節する方法 |
| WO2021061640A1 (en) | 2019-09-23 | 2021-04-01 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for modulating genomic complex integrity index |
| CA3154759A1 (en) | 2019-09-23 | 2021-04-01 | Flagship Pioneering Innovations V, Inc. | Modulating genomic complexes |
| US20220348893A1 (en) | 2019-09-23 | 2022-11-03 | Omega Therapeutics, Inc | Methods and compositions for modulating frataxin expression and treating friedrich's ataxia |
| AU2021350024A1 (en) | 2020-09-24 | 2023-05-04 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for inhibiting gene expression |
| KR20230079181A (ko) | 2020-09-29 | 2023-06-05 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 다중 유전자의 발현을 억제하는 조성물 및 방법 |
| CA3205133A1 (en) | 2020-12-15 | 2022-06-23 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for modulating myc expression |
-
2017
- 2017-09-07 US US16/330,999 patent/US20190255106A1/en not_active Abandoned
- 2017-09-07 CN CN201780066156.1A patent/CN109890962A/zh active Pending
- 2017-09-07 WO PCT/US2017/050561 patent/WO2018049079A1/en not_active Ceased
- 2017-09-07 JP JP2019533313A patent/JP7682604B2/ja active Active
- 2017-09-07 WO PCT/US2017/050556 patent/WO2018049075A1/en not_active Ceased
- 2017-09-07 EP EP17849560.2A patent/EP3510152A4/en active Pending
- 2017-09-07 WO PCT/US2017/050558 patent/WO2018049077A1/en not_active Ceased
- 2017-09-07 AU AU2017324550A patent/AU2017324550B2/en active Active
- 2017-09-07 WO PCT/US2017/050553 patent/WO2018049073A1/en not_active Ceased
- 2017-09-07 CA CA3035910A patent/CA3035910A1/en active Pending
- 2017-11-22 US US15/821,632 patent/US11312955B2/en active Active
-
2018
- 2018-10-09 US US16/155,688 patent/US11624065B2/en active Active
-
2022
- 2022-03-18 US US17/698,917 patent/US12522823B2/en active Active
- 2022-03-18 US US17/698,912 patent/US12509683B2/en active Active
-
2023
- 2023-07-10 JP JP2023113050A patent/JP2023119040A/ja active Pending
-
2024
- 2024-06-11 AU AU2024203956A patent/AU2024203956A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019531763A5 (https=) | ||
| TWI880645B (zh) | 抑制lpa之基因表現之組合物及方法 | |
| US11136597B2 (en) | Compositions for enhancing targeted gene editing and methods of use thereof | |
| US9828601B2 (en) | Compositions for inhibiting checkpoint gene expression and uses thereof | |
| US20210322577A1 (en) | Methods and systems for modifying dna | |
| JP2016513976A5 (https=) | ||
| US20200308590A1 (en) | Compositions and methods for treatment of cystic fibrosis | |
| TW201920227A (zh) | 用於抑制脂蛋白元C-III (APOC3)表現之RNAi試劑及組合物 | |
| CA3035910A1 (en) | Methods and compositions for modulating gene expression | |
| US20180312839A1 (en) | Methods and compositions for increasing smn expression | |
| EP3573618B1 (en) | Compositions and methods for hemoglobin production | |
| JP2010515707A5 (https=) | ||
| CN104769112A (zh) | 用于在细胞中表达蛋白质的方法和产品 | |
| EP4041894A1 (en) | COMPOSITIONS AND METHODS FOR MODULATING HEPATOCYTE NUCLEAR FACTOR 4-ALPHA (HNF4a) GENE EXPRESSION | |
| ES2291536T3 (es) | Control de la expresion de gen usando un complejo de un oligonucleotido y un peptido regulatorio. | |
| JP2022512739A (ja) | 操作された長鎖散在反復エレメント（ｌｉｎｅ）トランスポゾンおよびそれらの使用方法 | |
| WO2021183720A1 (en) | Compositions and methods for modulating forkhead box p3 (foxp3) gene expression | |
| CA3097914A1 (en) | Methods of gene therapy | |
| Summerton | Intracellular inactivation of specific nucleotide sequences: a general approach to the treatment of viral diseases and virally-mediated cancers | |
| US20240279687A1 (en) | Peptide nucleic acids for spatiotemporal control of crispr-cas binding | |
| JP2020521491A5 (https=) | ||
| JP2024530169A (ja) | 方法 | |
| US20220243211A1 (en) | Peptide nucleic acid compositions with modified hoogsteen binding segments and methods of use thereof | |
| US20220372474A1 (en) | Hydroxymethyl-modified gamma-pna compositions and methods of use thereof | |
| CN115317610A (zh) | 基于vps9d1-as1靶点的aso药物在肿瘤治疗中的应用 |