JP2019531745A5 - - Google Patents
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- JP2019531745A5 JP2019531745A5 JP2019520801A JP2019520801A JP2019531745A5 JP 2019531745 A5 JP2019531745 A5 JP 2019531745A5 JP 2019520801 A JP2019520801 A JP 2019520801A JP 2019520801 A JP2019520801 A JP 2019520801A JP 2019531745 A5 JP2019531745 A5 JP 2019531745A5
- Authority
- JP
- Japan
- Prior art keywords
- cmv
- mir
- vector
- nucleic acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 241000701022 Cytomegalovirus Species 0.000 claims 34
- 239000013598 vector Substances 0.000 claims 30
- 239000000427 antigen Substances 0.000 claims 19
- 102000036639 antigens Human genes 0.000 claims 17
- 108091007433 antigens Proteins 0.000 claims 16
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 12
- 150000007523 nucleic acids Chemical group 0.000 claims 12
- 108091008874 T cell receptors Proteins 0.000 claims 8
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 108700011259 MicroRNAs Proteins 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 239000002679 microRNA Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 108091023084 miR-126 stem-loop Proteins 0.000 claims 3
- 108091065272 miR-126-1 stem-loop Proteins 0.000 claims 3
- 108091081187 miR-126-2 stem-loop Proteins 0.000 claims 3
- 108091030790 miR-126-3 stem-loop Proteins 0.000 claims 3
- 108091092317 miR-126-4 stem-loop Proteins 0.000 claims 3
- 230000001717 pathogenic effect Effects 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 241000701024 Human betaherpesvirus 5 Species 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- 101150088910 UL82 gene Proteins 0.000 claims 2
- 101150085955 US11 gene Proteins 0.000 claims 2
- 210000003038 endothelium Anatomy 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- -1 miR-130a Proteins 0.000 claims 2
- 108091079658 miR-142-1 stem-loop Proteins 0.000 claims 2
- 108091071830 miR-142-2 stem-loop Proteins 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 108091008875 B cell receptors Proteins 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 241000282693 Cercopithecidae Species 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000021309 Germ cell tumor Diseases 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 1
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims 1
- 241000725303 Human immunodeficiency virus Species 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- 241000282560 Macaca mulatta Species 0.000 claims 1
- 108091028080 MiR-132 Proteins 0.000 claims 1
- 108091033773 MiR-155 Proteins 0.000 claims 1
- 108091036422 MiR-296 Proteins 0.000 claims 1
- 108091028049 Mir-221 microRNA Proteins 0.000 claims 1
- 108091062140 Mir-223 Proteins 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 241001631646 Papillomaviridae Species 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 101150016730 UL79 gene Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 210000002798 bone marrow cell Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 230000007813 immunodeficiency Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 108091064282 miR-125 stem-loop Proteins 0.000 claims 1
- 108091037066 miR-125-1 stem-loop Proteins 0.000 claims 1
- 108091062107 miR-125-2 stem-loop Proteins 0.000 claims 1
- 108091079767 miR-125-3 stem-loop Proteins 0.000 claims 1
- 108091032320 miR-146 stem-loop Proteins 0.000 claims 1
- 108091024530 miR-146a stem-loop Proteins 0.000 claims 1
- 108091062762 miR-21 stem-loop Proteins 0.000 claims 1
- 108091041631 miR-21-1 stem-loop Proteins 0.000 claims 1
- 108091044442 miR-21-2 stem-loop Proteins 0.000 claims 1
- 108091048308 miR-210 stem-loop Proteins 0.000 claims 1
- 108091061917 miR-221 stem-loop Proteins 0.000 claims 1
- 108091063489 miR-221-1 stem-loop Proteins 0.000 claims 1
- 108091055391 miR-221-2 stem-loop Proteins 0.000 claims 1
- 108091031076 miR-221-3 stem-loop Proteins 0.000 claims 1
- 108091029997 miR-328 stem-loop Proteins 0.000 claims 1
- 108091027983 miR-378-1 stem-loop Proteins 0.000 claims 1
- 108091089716 miR-378-2 stem-loop Proteins 0.000 claims 1
- 108091050734 miR-652 stem-loop Proteins 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022169043A JP7478794B2 (ja) | 2016-10-18 | 2022-10-21 | 主要組織適合遺伝子複合体ｅ分子によって拘束されるｔ細胞を誘発するサイトメガロウイルスベクター及びｈｃｍｖベクターを含む組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662409840P | 2016-10-18 | 2016-10-18 | |
| US62/409,840 | 2016-10-18 | ||
| PCT/US2017/057106 WO2018075591A1 (en) | 2016-10-18 | 2017-10-18 | Cytomegalovirus vectors eliciting t cells restricted by major histocompatibility complex e molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022169043A Division JP7478794B2 (ja) | 2016-10-18 | 2022-10-21 | 主要組織適合遺伝子複合体ｅ分子によって拘束されるｔ細胞を誘発するサイトメガロウイルスベクター及びｈｃｍｖベクターを含む組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019531745A JP2019531745A (ja) | 2019-11-07 |
| JP2019531745A5 true JP2019531745A5 (https=) | 2020-11-26 |
Family
ID=62018862
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019520801A Pending JP2019531745A (ja) | 2016-10-18 | 2017-10-18 | 主要組織適合遺伝子複合体ｅ分子によって拘束されるｔ細胞を誘発するサイトメガロウイルスベクター |
| JP2022169043A Active JP7478794B2 (ja) | 2016-10-18 | 2022-10-21 | 主要組織適合遺伝子複合体ｅ分子によって拘束されるｔ細胞を誘発するサイトメガロウイルスベクター及びｈｃｍｖベクターを含む組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022169043A Active JP7478794B2 (ja) | 2016-10-18 | 2022-10-21 | 主要組織適合遺伝子複合体ｅ分子によって拘束されるｔ細胞を誘発するサイトメガロウイルスベクター及びｈｃｍｖベクターを含む組成物 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10532099B2 (https=) |
| EP (1) | EP3529363B1 (https=) |
| JP (2) | JP2019531745A (https=) |
| KR (1) | KR102604486B1 (https=) |
| CN (1) | CN110036112B (https=) |
| AU (1) | AU2017346788A1 (https=) |
| BR (1) | BR112019007982A2 (https=) |
| CA (1) | CA3040303A1 (https=) |
| CL (1) | CL2019001054A1 (https=) |
| CO (1) | CO2019004102A2 (https=) |
| CR (1) | CR20190205A (https=) |
| DO (1) | DOP2019000086A (https=) |
| EA (1) | EA201990937A1 (https=) |
| EC (1) | ECSP19031754A (https=) |
| IL (1) | IL266011B2 (https=) |
| MA (1) | MA46588A (https=) |
| MX (1) | MX2019004518A (https=) |
| PE (1) | PE20190840A1 (https=) |
| SG (1) | SG11201903340TA (https=) |
| TN (1) | TN2019000124A1 (https=) |
| UA (1) | UA126860C2 (https=) |
| WO (1) | WO2018075591A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3351636T (pt) | 2010-05-14 | 2020-09-24 | Univ Oregon Health & Science | Vectores de hcmv e rhcmv recombinantes codificadores de um antigénio heterólogo isolado a partir de um vírus paramyxoviridae e seus usos |
| CA2832109C (en) | 2011-06-10 | 2021-07-06 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| JP6483033B2 (ja) | 2013-03-05 | 2019-03-13 | オレゴン・ヘルス・アンド・サイエンス・ユニバーシティＯｒｅｇｏｎ Ｈｅａｌｔｈ ＆ Ｓｃｉｅｎｃｅ Ｕｎｉｖｅｒｓｉｔｙ | Ｔ細胞ターゲティングを調節することができるサイトメガロウイルスベクター |
| KR102403547B1 (ko) | 2014-07-16 | 2022-05-30 | 오레곤 헬스 앤드 사이언스 유니버시티 | 외인성 항원을 포함하는 인간 시토메갈로바이러스 |
| JP6816031B2 (ja) | 2015-02-10 | 2021-01-20 | オレゴン ヘルス アンド サイエンス ユニバーシティ | 非標準的なｃｄ８＋ｔ細胞応答を生成するのに有用な方法および組成物 |
| AU2016355468B2 (en) | 2015-11-20 | 2022-12-15 | Oregon Health & Science University | CMV vectors comprising microRNA recognition elements |
| CN110036112B (zh) | 2016-10-18 | 2024-05-10 | 俄勒冈健康与科学大学 | 引发受主要组织相容性复合体e分子限制的t细胞的巨细胞病毒载体 |
| US10632186B1 (en) | 2019-03-21 | 2020-04-28 | 21C Bio | Vaccine to pathogenic immune activation cells during infections |
| WO2020188111A1 (en) | 2019-03-21 | 2020-09-24 | 21C Bio | Vaccine to pathogenic immune activation cells during infections |
| US11077185B2 (en) | 2019-03-21 | 2021-08-03 | 21C Bio | Vaccine to pathogenic immune activation cells during infections |
| US12599658B2 (en) | 2019-06-07 | 2026-04-14 | Oregon Health & Science University | Hepatitis B virus-specific T cell responses |
| JP2022536122A (ja) * | 2019-06-07 | 2022-08-12 | オレゴン ヘルス アンド サイエンス ユニバーシティ | 腫瘍関連抗原特異的ｔ細胞応答 |
| AU2020334061A1 (en) * | 2019-08-20 | 2022-03-10 | Oregon Health & Science University | Modulation of T cell responses by UL18 of human cytomegalovirus |
| EP4021923A1 (en) * | 2019-08-29 | 2022-07-06 | VIR Biotechnology, Inc. | Hepatitis b virus vaccines |
| JP2023507142A (ja) * | 2019-12-16 | 2023-02-21 | オレゴン ヘルス アンド サイエンス ユニバーシティ | 多重特異性ｔ細胞受容体 |
| WO2023034783A1 (en) | 2021-08-31 | 2023-03-09 | Vir Biotechnology, Inc. | Tuberculosis vaccines |
| CA3226699A1 (en) | 2021-08-31 | 2023-03-09 | Vir Biotechnology, Inc. | Recombinant hcmv vectors and uses thereof |
| WO2024121424A1 (en) | 2022-12-09 | 2024-06-13 | Daniel Zagury | Composite aids vaccine generating anti-hiv specific neutralizing antibodies and/or anti-hiv cytotoxic t cells |
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| WO1988010311A1 (en) | 1987-06-26 | 1988-12-29 | Syntro Corporation | Recombinant human cytomegalovirus containing foreign gene and use thereof |
| US5273876A (en) | 1987-06-26 | 1993-12-28 | Syntro Corporation | Recombinant human cytomegalovirus containing foreign gene |
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| KR102403547B1 (ko) | 2014-07-16 | 2022-05-30 | 오레곤 헬스 앤드 사이언스 유니버시티 | 외인성 항원을 포함하는 인간 시토메갈로바이러스 |
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| AU2016355468B2 (en) | 2015-11-20 | 2022-12-15 | Oregon Health & Science University | CMV vectors comprising microRNA recognition elements |
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| CN110036112B (zh) | 2016-10-18 | 2024-05-10 | 俄勒冈健康与科学大学 | 引发受主要组织相容性复合体e分子限制的t细胞的巨细胞病毒载体 |
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2017
- 2017-10-18 CN CN201780064422.7A patent/CN110036112B/zh active Active
- 2017-10-18 CA CA3040303A patent/CA3040303A1/en active Pending
- 2017-10-18 WO PCT/US2017/057106 patent/WO2018075591A1/en not_active Ceased
- 2017-10-18 JP JP2019520801A patent/JP2019531745A/ja active Pending
- 2017-10-18 SG SG11201903340TA patent/SG11201903340TA/en unknown
- 2017-10-18 US US15/786,847 patent/US10532099B2/en active Active
- 2017-10-18 CR CR20190205A patent/CR20190205A/es unknown
- 2017-10-18 EP EP17862978.8A patent/EP3529363B1/en active Active
- 2017-10-18 UA UAA201904893A patent/UA126860C2/uk unknown
- 2017-10-18 EA EA201990937A patent/EA201990937A1/ru unknown
- 2017-10-18 MA MA046588A patent/MA46588A/fr unknown
- 2017-10-18 MX MX2019004518A patent/MX2019004518A/es unknown
- 2017-10-18 AU AU2017346788A patent/AU2017346788A1/en not_active Abandoned
- 2017-10-18 KR KR1020197013148A patent/KR102604486B1/ko active Active
- 2017-10-18 IL IL266011A patent/IL266011B2/en unknown
- 2017-10-18 PE PE2019000824A patent/PE20190840A1/es unknown
- 2017-10-18 BR BR112019007982A patent/BR112019007982A2/pt not_active Application Discontinuation
- 2017-10-18 TN TNP/2019/000124A patent/TN2019000124A1/en unknown
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2019
- 2019-04-08 DO DO2019000086A patent/DOP2019000086A/es unknown
- 2019-04-17 CL CL2019001054A patent/CL2019001054A1/es unknown
- 2019-04-24 CO CONC2019/0004102A patent/CO2019004102A2/es unknown
- 2019-05-07 EC ECSENADI201931754A patent/ECSP19031754A/es unknown
- 2019-11-26 US US16/696,403 patent/US11305015B2/en active Active
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2022
- 2022-10-21 JP JP2022169043A patent/JP7478794B2/ja active Active
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