CR20190205A - Vectores de citomegalovirus que provocan células t restringidas por moléculas del complejo mayor de histocompatibilidad e - Google Patents

Vectores de citomegalovirus que provocan células t restringidas por moléculas del complejo mayor de histocompatibilidad e

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Publication number
CR20190205A
CR20190205A CR20190205A CR20190205A CR20190205A CR 20190205 A CR20190205 A CR 20190205A CR 20190205 A CR20190205 A CR 20190205A CR 20190205 A CR20190205 A CR 20190205A CR 20190205 A CR20190205 A CR 20190205A
Authority
CR
Costa Rica
Prior art keywords
molecules
major histocompatibility
histocompatibility complex
cells restricted
cytomegalovirus vectors
Prior art date
Application number
CR20190205A
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English (en)
Inventor
Jonah Sacha
Louis Picker
Klaus Frueh
Daniel Malouli
Scott Hansen
Jay Nelson
Meaghan Hancoock
Original Assignee
Univ Oregon Health & Science
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Application filed by Univ Oregon Health & Science filed Critical Univ Oregon Health & Science
Publication of CR20190205A publication Critical patent/CR20190205A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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Abstract

Se revelan vectores de CMV que carecen de proteínas UL128, UL130, UL146 y UL147 activas que también pueden comprender uno o más elementos reguladores de microARN (MRE) que restringen la expresión del CMV. La inmunización con los vectores de CMV revelados permiten la selección de diferentes respuestas de las células T CD8+ - células T CD8+ restringidas por MHC-Ia, MHC-II, o MHC-E.
CR20190205A 2016-10-18 2017-10-18 Vectores de citomegalovirus que provocan células t restringidas por moléculas del complejo mayor de histocompatibilidad e CR20190205A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662409840P 2016-10-18 2016-10-18
PCT/US2017/057106 WO2018075591A1 (en) 2016-10-18 2017-10-18 Cytomegalovirus vectors eliciting t cells restricted by major histocompatibility complex e molecules

Publications (1)

Publication Number Publication Date
CR20190205A true CR20190205A (es) 2020-01-07

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Application Number Title Priority Date Filing Date
CR20190205A CR20190205A (es) 2016-10-18 2017-10-18 Vectores de citomegalovirus que provocan células t restringidas por moléculas del complejo mayor de histocompatibilidad e

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US (2) US10532099B2 (es)
EP (1) EP3529363A4 (es)
JP (2) JP2019531745A (es)
KR (1) KR102604486B1 (es)
CN (1) CN110036112B (es)
AU (1) AU2017346788A1 (es)
BR (1) BR112019007982A2 (es)
CA (1) CA3040303A1 (es)
CL (1) CL2019001054A1 (es)
CO (1) CO2019004102A2 (es)
CR (1) CR20190205A (es)
DO (1) DOP2019000086A (es)
EA (1) EA201990937A1 (es)
EC (1) ECSP19031754A (es)
IL (1) IL266011B2 (es)
MA (1) MA46588A (es)
MX (1) MX2019004518A (es)
PE (1) PE20190840A1 (es)
SG (1) SG11201903340TA (es)
TN (1) TN2019000124A1 (es)
UA (1) UA126860C2 (es)
WO (1) WO2018075591A1 (es)

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CN110036112B (zh) 2016-10-18 2024-05-10 俄勒冈健康与科学大学 引发受主要组织相容性复合体e分子限制的t细胞的巨细胞病毒载体
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JP2022526628A (ja) * 2019-03-21 2022-05-25 ２１シー バイオ 感染時の病原性免疫活性化細胞に対するワクチン
US10632186B1 (en) 2019-03-21 2020-04-28 21C Bio Vaccine to pathogenic immune activation cells during infections
WO2020247859A2 (en) * 2019-06-07 2020-12-10 Oregon Health & Science University Tumor-associated antigen-specific t cell responses
US20220257748A1 (en) * 2019-06-07 2022-08-18 Oregon Health & Science University Hepatitis b virus-specific t cell responses
CN114402080A (zh) * 2019-08-20 2022-04-26 俄勒冈健康与科学大学 人巨细胞病毒的ul18对t细胞应答的调节
JP2023507142A (ja) * 2019-12-16 2023-02-21 オレゴン ヘルス アンド サイエンス ユニバーシティ 多重特異性ｔ細胞受容体
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