JP2019531290A5 - - Google Patents
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- JP2019531290A5 JP2019531290A5 JP2019514814A JP2019514814A JP2019531290A5 JP 2019531290 A5 JP2019531290 A5 JP 2019531290A5 JP 2019514814 A JP2019514814 A JP 2019514814A JP 2019514814 A JP2019514814 A JP 2019514814A JP 2019531290 A5 JP2019531290 A5 JP 2019531290A5
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- 150000001875 compounds Chemical class 0.000 claims description 64
- -1 [1,2,4] triazolo [4,3-a] [1,4] diazepine-6-yl Chemical group 0.000 claims description 18
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 8
- 239000007858 starting material Substances 0.000 claims description 4
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims description 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 2
- 239000003638 chemical reducing agent Substances 0.000 claims description 2
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| EP3454856B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| ES2990061T3 (es) | 2016-05-10 | 2024-11-28 | C4 Therapeutics Inc | Degronímeros espirocíclicos para la degradación de proteínas diana |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| CN110573507B (zh) | 2017-04-14 | 2023-11-14 | 邓迪大学 | 小分子 |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| WO2019043208A1 (en) | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | DIHYDROQUINOLINONES |
| WO2019043217A1 (en) | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | DIHYDROBENZIMIDAZOLONES |
| CN118108706A (zh) | 2017-09-04 | 2024-05-31 | C4医药公司 | 戊二酰亚胺 |
| CN111372585A (zh) | 2017-11-16 | 2020-07-03 | C4医药公司 | 用于靶蛋白降解的降解剂和降解决定子 |
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| EP3781156A4 (en) | 2018-04-16 | 2022-05-18 | C4 Therapeutics, Inc. | SPIROCYCLIC COMPOUNDS |
| EP3578561A1 (en) | 2018-06-04 | 2019-12-11 | F. Hoffmann-La Roche AG | Spiro compounds |
| US20210283139A1 (en) * | 2018-06-13 | 2021-09-16 | Amphista Therapeutics Ltd | Bifunctional molecules for targeting uchl5 |
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| CN110885332B (zh) * | 2019-12-06 | 2022-03-18 | 中国人民解放军第二军医大学 | 一种PDEδ蛋白降解靶向嵌合体及其制备方法和应用 |
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| KR20230106637A (ko) * | 2020-11-11 | 2023-07-13 | 제넨테크, 인크. | 빈혈 및 암 치료용 vhl 억제제로서의 1-(2-(4-시클로프로필-1h-1,2,3-트리아졸-1-일)아세틸)-4-히드록시-n-(벤질)피롤리딘 e-2-카르복사미드 유도체 |
| CN115154419B (zh) * | 2021-04-02 | 2023-11-28 | 中国科学院上海药物研究所 | 一种纳米胶束前体和纳米胶束，其制备方法及应用 |
| CN113651835A (zh) * | 2021-06-04 | 2021-11-16 | 上海大学 | 一种bethdac双靶向protac的制备方法和应用 |
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| CN115109047B (zh) * | 2021-09-08 | 2024-02-20 | 中国科学院化学研究所 | 一种基于protac设计的铁死亡诱导剂 |
| CN114288422B (zh) * | 2022-01-21 | 2023-04-28 | 陕西科技大学 | 一种化学靶向降解目标蛋白的脂质体及其制备方法 |
| CN114907386B (zh) * | 2022-03-11 | 2023-03-31 | 山东大学 | 一种hemtac小分子降解剂及其应用 |
| CN114560908B (zh) * | 2022-03-11 | 2024-10-25 | 国家纳米科学中心 | 一种多肽protac分子及其制备方法和应用 |
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| CN115057909A (zh) * | 2022-07-13 | 2022-09-16 | 浙江工业大学 | 一种基于化合物pacma31的蛋白降解靶向嵌合体及其制备方法与应用 |
| WO2024027792A1 (en) * | 2022-08-05 | 2024-02-08 | Shenzhen Newdel Biotech Co., Ltd. | Protein kinase degrading agent, medicament and use |
| CN115028681B (zh) * | 2022-08-11 | 2022-11-15 | 中国科学院微生物研究所 | 一种降解亲环素a的嵌合体化合物及其制备方法与应用 |
| JP2025538228A (ja) | 2022-11-15 | 2025-11-26 | プレリュード・セラピューティクス・インコーポレイテッド | Ｂｒｍ標的化化合物及び関連する使用方法 |
| WO2024240078A1 (en) * | 2023-05-19 | 2024-11-28 | The Chinese University Of Hong Kong | Compositions and methods related to protein labeling |
| WO2025049555A1 (en) | 2023-08-31 | 2025-03-06 | Oerth Bio Llc | Compositions and methods for targeted inhibition and degradation of proteins in an insect cell |
| CN116855471B (zh) * | 2023-09-04 | 2023-11-28 | 江苏申基生物科技有限公司 | 一种嘌呤核苷磷酸化酶突变体及其应用 |
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| WO2009014730A1 (en) * | 2007-07-26 | 2009-01-29 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors |
| PT2661433T (pt) * | 2011-01-04 | 2017-10-24 | Novartis Ag | Compostos de indole ou seus análogos úteis para o tratamento da degeneração macular relacionada com a idade (amd) |
| WO2013106646A2 (en) * | 2012-01-12 | 2013-07-18 | Yale University | Compounds and methods for the inhibition of vcb e3 ubiquitin ligase |
| KR102668696B1 (ko) | 2012-01-12 | 2024-05-29 | 예일 유니버시티 | E3 유비퀴틴 리가아제에 의한 표적 단백질 및 다른 폴리펩티드의 증진된 분해를 위한 화합물 및 방법 |
| MX2014015738A (es) * | 2012-06-28 | 2015-08-06 | Novartis Ag | Derivados de pirrolidina y su uso como moduladores de la senda del complemento. |
| GB201311891D0 (en) * | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| GB201311888D0 (en) * | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| RU2738833C9 (ru) * | 2014-04-14 | 2022-02-28 | Арвинас, Оперэйшнз, Инк. | Имидные модуляторы протеолиза и способы их применения |
| US10071164B2 (en) * | 2014-08-11 | 2018-09-11 | Yale University | Estrogen-related receptor alpha based protac compounds and associated methods of use |
| JP6817962B2 (ja) * | 2015-01-20 | 2021-01-20 | アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． | ターゲティングされたアンドロゲン受容体分解のための化合物および方法 |
| GB201504314D0 (en) * | 2015-03-13 | 2015-04-29 | Univ Dundee | Small molecules |
| EP3270917A4 (en) | 2015-03-18 | 2018-08-08 | Arvinas, Inc. | Compounds and methods for the enhanced degradation of targeted proteins |
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- 2017-09-14 EP EP17771547.1A patent/EP3512844A1/en not_active Withdrawn
- 2017-09-14 CN CN201780070023.1A patent/CN109952299B/zh active Active
- 2017-09-14 JP JP2019514814A patent/JP7316932B2/ja active Active
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