JP7316932B2 - プロテオリシス標的化キメラの調製に有用なフルオロヒドロキシプロリン誘導体 - Google Patents

プロテオリシス標的化キメラの調製に有用なフルオロヒドロキシプロリン誘導体 Download PDF

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JP7316932B2
JP7316932B2 JP2019514814A JP2019514814A JP7316932B2 JP 7316932 B2 JP7316932 B2 JP 7316932B2 JP 2019514814 A JP2019514814 A JP 2019514814A JP 2019514814 A JP2019514814 A JP 2019514814A JP 7316932 B2 JP7316932 B2 JP 7316932B2
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JP2019531290A (ja
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アレッシオ チュッリ，
アンドレア テスタ，
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University of Dundee
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2019514814A 2016-09-14 2017-09-14 プロテオリシス標的化キメラの調製に有用なフルオロヒドロキシプロリン誘導体 Active JP7316932B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1615617.6 2016-09-14
GB1615617.6A GB2554071A (en) 2016-09-14 2016-09-14 Small molecules
PCT/GB2017/052726 WO2018051107A1 (en) 2016-09-14 2017-09-14 Fluorohydroxyproline derivatives useful in the preparation of proteolysis targeted chimeras

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JP2019531290A JP2019531290A (ja) 2019-10-31
JP2019531290A5 JP2019531290A5 (https=) 2020-10-22
JP7316932B2 true JP7316932B2 (ja) 2023-07-28

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US (1) US11234988B2 (https=)
EP (1) EP3512844A1 (https=)
JP (1) JP7316932B2 (https=)
CN (1) CN109952299B (https=)
GB (1) GB2554071A (https=)
WO (1) WO2018051107A1 (https=)

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