|
JP3957765B2
(ja)
|
1997-04-07 |
2007-08-15 |
ジェネンテク・インコーポレイテッド |
抗vegf抗体
|
|
PT1165115E
(pt)
|
1999-03-26 |
2003-10-31 |
Univ California |
Modulacao da permeabilidade vascular por meio dos activadores do receptor tie2
|
|
US6455035B1
(en)
|
1999-03-26 |
2002-09-24 |
Regeneron Pharmaceuticals, Inc. |
Angiopoietins and methods of use thereof
|
|
EP1046715A1
(en)
|
1999-04-23 |
2000-10-25 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Interaction of vascular-endothelial protein-tyrosine phosphatase with the angiopoietin receptor tie-2
|
|
US20020068066A1
(en)
*
|
1999-08-20 |
2002-06-06 |
Wenyuan Shi |
Method for the treatment and prevention of dental caries
|
|
NZ536196A
(en)
|
2000-06-23 |
2006-12-22 |
Schering Ag |
Combinations and compositions which interfere with VEGF/VEGF and angiopoietin/Tie receptor function and their use (II)
|
|
CN1318093C
(zh)
|
2001-09-28 |
2007-05-30 |
参天制药株式会社 |
含与聚乙二醇结合的药物的眼组织注射剂
|
|
US20050260132A1
(en)
|
2001-10-17 |
2005-11-24 |
Daniel Chin |
Monoclonal antibodies directed to receptor protein tyrosine phosphatase zeta
|
|
JP2005511660A
(ja)
|
2001-12-04 |
2005-04-28 |
デヴェロゲン アクチエンゲゼルシャフト フュア エントヴィックルングスビオローギッシェ フォルシュング |
エネルギー恒常性の調節に関与する、PTP10D、Tecタンパク質チロシンキナーゼおよびEDTPの相同性タンパク質
|
|
US20030215899A1
(en)
|
2002-02-13 |
2003-11-20 |
Ceptyr, Inc. |
Reversible oxidation of protein tyrosine phosphatases
|
|
WO2003092611A2
(en)
|
2002-05-03 |
2003-11-13 |
Regeneron Pharmaceuticals, Inc. |
Methods of inducing formation of functional and organized lymphatic vessels
|
|
US7226755B1
(en)
|
2002-09-25 |
2007-06-05 |
The Procter & Gamble Company |
HPTPbeta as a target in treatment of angiogenesis mediated disorders
|
|
US7507568B2
(en)
|
2002-09-25 |
2009-03-24 |
The Proctor & Gamble Company |
Three dimensional coordinates of HPTPbeta
|
|
CA2599606A1
(en)
*
|
2005-02-23 |
2006-08-31 |
Merrimack Pharmaceuticals, Inc. |
Bispecific binding agents for modulating biological activity
|
|
WO2007033216A2
(en)
|
2005-09-12 |
2007-03-22 |
Beth Israel Deaconess Medical Center |
Methods and compositions for the treatment and diagnosis of diseases characterized by vascular leak, hypotension, or a procoagulant state
|
|
JP2009510102A
(ja)
|
2005-09-29 |
2009-03-12 |
ヴァイラル ロジック システムズ テクノロジー コーポレーション |
免疫調節組成物およびその使用
|
|
CA2633211A1
(en)
|
2005-12-15 |
2007-06-21 |
Astrazeneca Ab |
Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or flt1 antagonist for treating cancer
|
|
EP1981520A2
(en)
|
2006-01-30 |
2008-10-22 |
(OSI) Eyetech, Inc. |
Combination therapy for the treatment of neovascular disorders
|
|
MY148763A
(en)
|
2006-03-10 |
2013-05-31 |
Wyeth Corp |
Anti-5t4 antibodies and uses thereof
|
|
CA2647282A1
(en)
|
2006-04-05 |
2007-10-11 |
Pfizer Products Inc. |
Ctla4 antibody combination therapy
|
|
AU2007237096C1
(en)
|
2006-04-07 |
2012-12-13 |
EyePoint, Inc. |
Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof
|
|
US7589212B2
(en)
|
2006-06-27 |
2009-09-15 |
Procter & Gamble Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US7622593B2
(en)
|
2006-06-27 |
2009-11-24 |
The Procter & Gamble Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US8846685B2
(en)
|
2006-06-27 |
2014-09-30 |
Aerpio Therapeutics Inc. |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US20130023542A1
(en)
|
2006-06-27 |
2013-01-24 |
Aerpio Therapeutics Inc. |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US7795444B2
(en)
|
2006-06-27 |
2010-09-14 |
Warner Chilcott Company |
Human protein tyrosine phosphatase inhibitors and methods of use
|
|
US10259860B2
(en)
|
2007-02-27 |
2019-04-16 |
Aprogen Inc. |
Fusion proteins binding to VEGF and angiopoietin
|
|
US8642067B2
(en)
|
2007-04-02 |
2014-02-04 |
Allergen, Inc. |
Methods and compositions for intraocular administration to treat ocular conditions
|
|
EP2170402B1
(en)
|
2007-06-26 |
2015-03-25 |
Children's Medical Center Corporation |
Metap-2 inhibitor polymersomes for therapeutic administration
|
|
US20100260668A1
(en)
*
|
2008-04-29 |
2010-10-14 |
Abbott Laboratories |
Dual Variable Domain Immunoglobulins and Uses Thereof
|
|
US8410251B2
(en)
|
2008-06-20 |
2013-04-02 |
National University Corporation Okayama University |
Antibody against calcified globule and use of the same
|
|
US8268314B2
(en)
|
2008-10-08 |
2012-09-18 |
Hoffmann-La Roche Inc. |
Bispecific anti-VEGF/anti-ANG-2 antibodies
|
|
EP3785735A1
(en)
|
2008-11-03 |
2021-03-03 |
Molecular Partners AG |
Binding proteins inhibiting the vegf-a receptor interaction
|
|
US9096555B2
(en)
|
2009-01-12 |
2015-08-04 |
Aerpio Therapeutics, Inc. |
Methods for treating vascular leak syndrome
|
|
SG10201702247SA
(en)
|
2009-01-12 |
2017-04-27 |
Aerpio Therapeutics Inc |
Methods for treating vascular leak syndrome
|
|
WO2010097800A1
(en)
|
2009-02-26 |
2010-09-02 |
Muhammad Abdulrazik |
Synergistic combination of bioactive compounds for lowering of intraocular pressure
|
|
EP2411412B1
(en)
*
|
2009-03-24 |
2015-05-27 |
Teva Biopharmaceuticals USA, Inc. |
Humanized antibodies against light and uses thereof
|
|
US8883832B2
(en)
|
2009-07-06 |
2014-11-11 |
Aerpio Therapeutics Inc. |
Compounds, compositions, and methods for preventing metastasis of cancer cells
|
|
MY160399A
(en)
|
2009-07-06 |
2017-03-15 |
Aerpio Therapeutics Inc |
Compounds, compositions, and methods for preventing metastasis of cancer cells
|
|
CA2782333C
(en)
*
|
2009-12-02 |
2019-06-04 |
Imaginab, Inc. |
J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use
|
|
TWI510246B
(zh)
|
2010-04-30 |
2015-12-01 |
Molecular Partners Ag |
抑制vegf-a受體交互作用的經修飾結合性蛋白質
|
|
US20180092883A1
(en)
|
2010-10-07 |
2018-04-05 |
Aerpio Therapeutics, Inc. |
Phosphatase inhibitors for treating ocular diseases
|
|
US20120129847A1
(en)
|
2010-10-07 |
2012-05-24 |
Kevin Gene Peters |
Compositions and methods for treating ocular edema, neovascularization and related diseases
|
|
CN103402582A
(zh)
|
2011-02-11 |
2013-11-20 |
普西维达公司 |
使用抗水肿疗法治疗黄斑水肿的方法
|
|
WO2012158818A2
(en)
*
|
2011-05-16 |
2012-11-22 |
Fabion Pharmaceuticals, Inc. |
Multi-specific fab fusion proteins and methods of use
|
|
EP3501536B1
(en)
|
2011-10-13 |
2025-12-24 |
EyePoint Pharmaceuticals, Inc. |
Treatment of ocular disease
|
|
AU2012323856B2
(en)
|
2011-10-13 |
2017-05-25 |
EyePoint, Inc. |
Methods for treating Vascular Leak Syndrome and cancer
|
|
LT3495387T
(lt)
|
2012-07-13 |
2021-11-25 |
Roche Glycart Ag |
Bispecifiniai anti-vegf / anti-ang-2 antikūnai ir jų panaudojimas akių kraujagyslių ligoms gydyti
|
|
EP2916827B1
(en)
|
2012-11-08 |
2020-06-10 |
Clearside Biomedical Inc. |
Methods for the treatment of ocular disease in human subjects
|
|
AU2014233363B2
(en)
|
2013-03-15 |
2017-06-29 |
EyePoint, Inc. |
Compositions, formulations and methods for treating ocular diseases
|
|
US20150050277A1
(en)
|
2013-03-15 |
2015-02-19 |
Aerpio Therapeutics Inc. |
Compositions and methods for treating ocular diseases
|
|
JP2016522249A
(ja)
|
2013-06-20 |
2016-07-28 |
ノバルティス アーゲー |
脈絡膜血管新生の治療におけるvegfアンタゴニストの使用
|
|
WO2014203183A1
(en)
|
2013-06-20 |
2014-12-24 |
Novartis Ag |
Use of a vegf antagonist in treating macular edema
|
|
EP3019527A2
(en)
|
2013-07-11 |
2016-05-18 |
Novartis AG |
Use of a vegf antagonist in treating retinopathy of prematurity
|
|
KR20160029794A
(ko)
|
2013-07-11 |
2016-03-15 |
노파르티스 아게 |
소아 환자의 맥락망막 신생혈관성 및 투과성 장애의 치료에 있어서 vegf 길항제의 용도
|
|
US10617755B2
(en)
|
2013-08-30 |
2020-04-14 |
Genentech, Inc. |
Combination therapy for the treatment of glioblastoma
|
|
WO2015058048A1
(en)
|
2013-10-18 |
2015-04-23 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions comprising a combination of a vegf antagonist and an anti-ctla-4 antibody
|
|
SG11201605580RA
(en)
|
2014-01-10 |
2016-10-28 |
Anaptysbio Inc |
Antibodies directed against interleukin-33 (il-33)
|
|
CN105026433B
(zh)
|
2014-01-24 |
2018-10-19 |
上海恒瑞医药有限公司 |
VEGF与PDGFRβ双特异性融合蛋白及其用途
|
|
EP3116503A4
(en)
|
2014-03-14 |
2017-08-23 |
Aerpio Therapeutics, Inc. |
Hptp-beta inhibitors
|
|
US9719135B2
(en)
|
2014-07-03 |
2017-08-01 |
Mannin Research Inc. |
Conditional angiopoietin-1/angiopoietin-2 double knock-out mice with defective ocular drainage system
|
|
WO2016022813A1
(en)
|
2014-08-07 |
2016-02-11 |
Aerpio Therapeutics, Inc. |
Combination of immunotherapies with activators of tie-2
|
|
WO2016044436A2
(en)
|
2014-09-16 |
2016-03-24 |
Ovascience, Inc. |
Anti-vasa antibodies, and methods of production and use thereof
|
|
WO2016049183A1
(en)
*
|
2014-09-24 |
2016-03-31 |
Aerpio Therapeutics, Inc. |
Ve-ptp extracellular domain antibodies delivered by a gene therapy vector
|
|
TWI738632B
(zh)
|
2014-11-07 |
2021-09-11 |
瑞士商諾華公司 |
穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
|
|
US20160144025A1
(en)
|
2014-11-25 |
2016-05-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and formulations for treating vascular eye diseases
|
|
AU2016240220B2
(en)
|
2015-04-02 |
2019-11-21 |
Molecular Partners Ag |
Designed ankyrin repeat domains with binding specificity for serum albumin
|
|
WO2017035430A2
(en)
|
2015-08-27 |
2017-03-02 |
Kolltan Pharmaceuticals, Inc. |
Anti-alk antibodies and methods for use thereof
|
|
RU2763916C2
(ru)
|
2015-09-23 |
2022-01-11 |
Дженентек, Инк. |
Оптимизированные варианты анти-vegf антител
|
|
ES2981607T3
(es)
|
2015-09-23 |
2024-10-09 |
Eyepoint Pharmaceuticals Inc |
Activadores de Tie-2 para uso en el tratamiento de la presión intraocular
|
|
CN109069638B
(zh)
|
2016-03-24 |
2022-03-29 |
璟尚生物制药公司 |
用于癌症治疗的三特异性抑制剂
|
|
AU2017299581B2
(en)
|
2016-07-20 |
2024-05-23 |
EyePoint, Inc. |
Humanized monoclonal antibodies that target ve-ptp (hptp-β)
|
|
CN120058958A
(zh)
|
2018-09-24 |
2025-05-30 |
视点制药公司 |
靶向HPTP-β(VE-PTP)和VEGF的多特异性抗体
|