JP2019529575A5 - - Google Patents
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- Publication number
- JP2019529575A5 JP2019529575A5 JP2019538721A JP2019538721A JP2019529575A5 JP 2019529575 A5 JP2019529575 A5 JP 2019529575A5 JP 2019538721 A JP2019538721 A JP 2019538721A JP 2019538721 A JP2019538721 A JP 2019538721A JP 2019529575 A5 JP2019529575 A5 JP 2019529575A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- use according
- treatment
- compounds
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000002193 Pain Diseases 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims description 12
- 206010046798 Uterine leiomyoma Diseases 0.000 claims description 12
- 229960005309 estradiol Drugs 0.000 claims description 12
- 229930182833 estradiol Natural products 0.000 claims description 12
- 201000010260 leiomyoma Diseases 0.000 claims description 12
- 201000009273 Endometriosis Diseases 0.000 claims description 7
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims description 7
- 239000000583 progesterone congener Substances 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 125000006508 2,6-difluorobenzyl group Chemical group [H]C1=C([H])C(F)=C(C(F)=C1[H])C([H])([H])* 0.000 claims description 4
- 201000009274 endometriosis of uterus Diseases 0.000 claims description 4
- 208000007106 menorrhagia Diseases 0.000 claims description 4
- 125000004943 pyrimidin-6-yl group Chemical group N1=CN=CC=C1* 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims 30
- 208000005641 Adenomyosis Diseases 0.000 claims 3
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 claims 3
- 208000000450 Pelvic Pain Diseases 0.000 claims 3
- 229960001652 norethindrone acetate Drugs 0.000 claims 3
- 235000012054 meals Nutrition 0.000 claims 2
- 230000027939 micturition Effects 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010010774 Constipation Diseases 0.000 claims 1
- 208000005171 Dysmenorrhea Diseases 0.000 claims 1
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 1
- 206010057671 Female sexual dysfunction Diseases 0.000 claims 1
- 206010021639 Incontinence Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000037093 Menstruation Disturbances Diseases 0.000 claims 1
- 206010027339 Menstruation irregular Diseases 0.000 claims 1
- 206010046555 Urinary retention Diseases 0.000 claims 1
- 208000016599 Uterine disease Diseases 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 230000013872 defecation Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 206010016256 fatigue Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000017708 myomatous neoplasm Diseases 0.000 claims 1
- 210000000754 myometrium Anatomy 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 201000004059 subependymal giant cell astrocytoma Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- -1 (1- (2,6-difluorobenzyl) -5-((dimethylamino) methyl) -3- (6-methoxy-3-pyridazinyl) -2,4-dioxo-1,2,3,4-tetrahydrothieno [2,3-d] Pyrimidine-6-yl) phenyl Chemical group 0.000 description 4
- 208000010579 uterine corpus leiomyoma Diseases 0.000 description 4
- 201000007954 uterine fibroid Diseases 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 206010000210 abortion Diseases 0.000 description 1
- 231100000176 abortion Toxicity 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662402150P | 2016-09-30 | 2016-09-30 | |
| US201662402034P | 2016-09-30 | 2016-09-30 | |
| US201662402055P | 2016-09-30 | 2016-09-30 | |
| US62/402,055 | 2016-09-30 | ||
| US62/402,150 | 2016-09-30 | ||
| US62/402,034 | 2016-09-30 | ||
| US201762492839P | 2017-05-01 | 2017-05-01 | |
| US62/492,839 | 2017-05-01 | ||
| US201762528409P | 2017-07-03 | 2017-07-03 | |
| US62/528,409 | 2017-07-03 | ||
| PCT/EP2017/074907 WO2018060501A2 (en) | 2016-09-30 | 2017-09-29 | Methods of treating uterine fibroids and endometriosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019529575A JP2019529575A (ja) | 2019-10-17 |
| JP2019529575A5 true JP2019529575A5 (OSRAM) | 2020-11-12 |
| JP7043503B2 JP7043503B2 (ja) | 2022-03-29 |
Family
ID=60915460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019538721A Active JP7043503B2 (ja) | 2016-09-30 | 2017-09-29 | 子宮筋腫及び子宮内膜症を治療する方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US11033551B2 (OSRAM) |
| EP (2) | EP4094766B1 (OSRAM) |
| JP (1) | JP7043503B2 (OSRAM) |
| CN (1) | CN110312512B (OSRAM) |
| AU (2) | AU2017336363B2 (OSRAM) |
| BR (1) | BR112019006227A2 (OSRAM) |
| CA (1) | CA3038879A1 (OSRAM) |
| CY (1) | CY1125254T1 (OSRAM) |
| DK (1) | DK3518933T4 (OSRAM) |
| ES (2) | ES3018413T3 (OSRAM) |
| FI (1) | FI3518933T4 (OSRAM) |
| HR (1) | HRP20220708T4 (OSRAM) |
| HU (2) | HUE072130T2 (OSRAM) |
| IL (2) | IL265700B2 (OSRAM) |
| LT (1) | LT3518933T (OSRAM) |
| MD (1) | MD3518933T4 (OSRAM) |
| MX (1) | MX2019003726A (OSRAM) |
| NZ (1) | NZ752916A (OSRAM) |
| PL (2) | PL3518933T5 (OSRAM) |
| PT (1) | PT3518933T (OSRAM) |
| RS (1) | RS63300B2 (OSRAM) |
| SI (1) | SI3518933T2 (OSRAM) |
| SM (1) | SMT202200254T1 (OSRAM) |
| WO (1) | WO2018060501A2 (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3518933T2 (sl) | 2016-09-30 | 2025-05-30 | Sumitomo Pharma Switzerland Gmbh | Metode zdravljenja materničnih miom in endometrioze |
| WO2018060463A2 (en) | 2016-09-30 | 2018-04-05 | Myovant Sciences Gmbh | Treatment of prostate cancer |
| JP7292566B2 (ja) | 2017-06-05 | 2023-06-19 | キッセイ薬品工業株式会社 | 子宮筋腫を治療し、月経失血を低下させるゴナドトロピン放出ホルモンアンタゴニスト投与計画 |
| MA49256A (fr) | 2017-06-05 | 2021-05-26 | ObsEva SA | Schémas posologiques comprenant un antagoniste de l'hormone de libération des gonadotrophines pour le traitement de l'endométriose |
| BR112020021276A2 (pt) * | 2018-04-19 | 2021-01-26 | Abbvie Inc. | métodos de tratamento de sangramento menstrual intenso |
| MA54058A (fr) | 2018-10-29 | 2021-09-08 | ObsEva SA | Compositions et méthodes de traitement de l'endométriose interne et de l'endométriose rectovaginale |
| RU2711658C1 (ru) * | 2019-04-16 | 2020-01-20 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта" | Способ лечения наружного генитального эндометриоза |
| CN110194776B (zh) * | 2019-06-27 | 2021-05-28 | 四川伊诺达博医药科技有限公司 | 一种瑞卢戈利的合成方法 |
| WO2021023877A2 (en) * | 2019-08-08 | 2021-02-11 | ObsEva S.A. | Compositions and methods for the treatment of estrogen-dependent disorders |
| JP2022551316A (ja) * | 2019-10-10 | 2022-12-08 | ミオバント サイエンシズ ゲーエムベーハー | Ｎ－（４－（１－（２，６－ジフルオロベンジル）－５－（（ジメチルアミノ）メチル）－３－（６－メトキシ－３－ピリダジニル）－２，４－ジオキソ－１，２，３，４－テトラヒドロチエノ［２，３－ｄ］ピリミジン－６－イル）フェニル）－Ｎ’－メトキシ尿素の結晶形 |
| CN115175912B (zh) * | 2019-10-10 | 2025-04-11 | 住友制药瑞士有限公司 | N-(4-(1-(2,6-二氟苄基)-5-((二甲基氨基)甲基)-3-(6-甲氧基-3-哒嗪基)-2,4-二氧代-1,2,3,4-四氢噻吩并[2,3-d]嘧啶-6-基)苯基)-n′-甲氧基脲的结晶溶剂化形式 |
| CA3172074A1 (en) * | 2020-02-19 | 2021-08-26 | Aspira Women's Health Inc. | Compositions for endometriosis assessment having improved specificity |
| CN113384581B (zh) * | 2020-03-12 | 2023-11-14 | 成都倍特药业股份有限公司 | 一种包含促性腺激素释放激素拮抗剂的药物组合物 |
| MX2022015003A (es) | 2020-05-29 | 2023-03-03 | Myovant Sciences Gmbh | Formas de dosificacion oral solidas de combinacion de antagonistas de la hormona liberadora de gonadotropina. |
| JP2023549196A (ja) | 2020-11-11 | 2023-11-22 | ミオバント サイエンシズ ゲーエムベーハー | レルゴリクスの投与方法 |
| WO2023066941A1 (en) | 2021-10-18 | 2023-04-27 | Myovant Sciences Gmbh | Crystalline form of an ethanol solvate of n-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'-methoxyurea |
| CN117069735A (zh) * | 2022-05-10 | 2023-11-17 | 北京海美源医药科技有限公司 | 一种高效合成瑞卢戈利的方法和其应用 |
| WO2024015934A2 (en) * | 2022-07-13 | 2024-01-18 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods of diagnostic screening and early detection of adenomyosis |
| TW202428262A (zh) * | 2022-11-09 | 2024-07-16 | 美商坦帕斯醫療公司 | 三唑酮化合物及其用途 |
| WO2025106820A1 (en) * | 2023-11-16 | 2025-05-22 | University Of South Florida | Method of preventing progesterone contraceptive-induced abnormal uterine bleeding (aub) |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US492839A (en) | 1893-03-07 | Key for brake-shoes | ||
| US402034A (en) | 1889-04-23 | Dumping-wagon | ||
| US528409A (en) | 1894-10-30 | Denis ahern | ||
| US402055A (en) | 1889-04-23 | Water-motor | ||
| US402150A (en) | 1889-04-30 | Broadcast seed-sower | ||
| FR2512732A1 (fr) | 1981-09-14 | 1983-03-18 | Raffinage Cie Francaise | Procede de fabrication d'objets composes d'un materiau rigide expanse a base de polychlorure de vinyle, objets obtenus par ce procede et leurs applications |
| US5340585A (en) | 1991-04-12 | 1994-08-23 | University Of Southern California | Method and formulations for use in treating benign gynecological disorders |
| ECSP961635A (es) | 1996-01-11 | 1997-06-27 | Desprendimiento controlado de esteroides del recubrimiento de azucar | |
| ECSP971998A (es) | 1997-01-15 | 1998-04-07 | Desprendimiento controlado de esteroides del recubrimiento de azucar | |
| DE19815060A1 (de) | 1998-04-03 | 1999-10-14 | Jenapharm Gmbh | Pharmazeutische Präparate zur Therapie von Nebenwirkungen während und/oder nach einer GnRHa-Therapie |
| US6265393B1 (en) * | 1998-08-07 | 2001-07-24 | Heinrichs William Leroy | Prevention of endometriosis signs or symptons |
| TWI225863B (en) | 1999-03-24 | 2005-01-01 | Takeda Chemical Industries Ltd | Thienopyrimidine compounds, their production and use |
| US6297379B1 (en) | 1999-03-24 | 2001-10-02 | Takeda Chemical Industries, Ltd. | Thienopyrimidine compounds, their production and use |
| US6849738B2 (en) | 2000-02-29 | 2005-02-01 | Takeda Chemical Industries, Ltd. | Processes for the production of thienopyrimidine derivatives |
| US7569570B2 (en) | 2002-01-30 | 2009-08-04 | Takeda Pharmaceutical Company Limited | Thienopyrimidines, process for preparing the same and use thereof |
| CN101153042A (zh) | 2003-01-29 | 2008-04-02 | 武田药品工业株式会社 | 噻吩并嘧啶化合物及其用途 |
| ES2314448T3 (es) | 2003-07-07 | 2009-03-16 | Neurocrine Biosciences, Inc. | Derivados de pirimidina-2,4-diona como antagonistas del receptor de la hormona de liberacion de la gonadotropina. |
| MY151322A (en) | 2004-04-30 | 2014-05-15 | Bayer Ip Gmbh | Management of breakthrough bleeding in extended hormonal contraceptive regimens |
| US20090048273A1 (en) | 2005-07-22 | 2009-02-19 | Takeda Pharmaceutical Company Limited | Premature ovulation preventive agent |
| TWI386417B (zh) | 2005-12-22 | 2013-02-21 | Takeda Pharmaceutical | 轉移抑素衍生物及其用途 |
| EA017029B1 (ru) | 2007-04-06 | 2012-09-28 | Ньюрокрайн Байосайенсиз, Инк. | Антагонисты рецептора гонадотропин-рилизинг-фактора и способы их применения |
| US8765948B2 (en) | 2007-11-07 | 2014-07-01 | Neurocrine Biosciences, Inc. | Processes for the preparation of uracil derivatives |
| JPWO2010026993A1 (ja) | 2008-09-03 | 2012-02-02 | 武田薬品工業株式会社 | 製剤における吸収性改善方法および吸収性が改善された製剤 |
| US9427418B2 (en) | 2009-02-23 | 2016-08-30 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
| US9624161B2 (en) | 2009-02-23 | 2017-04-18 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
| SG186333A1 (en) | 2010-06-16 | 2013-01-30 | Endorech Inc | Methods of treating or preventing estrogen-related diseases |
| JP2012077020A (ja) | 2010-09-30 | 2012-04-19 | Mochida Pharmaceut Co Ltd | ゲスターゲンとＧｎＲＨアンタゴニストとの組合せ医薬 |
| RS58703B1 (sr) | 2012-09-28 | 2019-06-28 | Takeda Pharmaceuticals Co | Metoda proizvodnje derivata tienopirimidina |
| IL241595B2 (en) * | 2013-03-15 | 2025-10-01 | Abbvie Inc | Composition for use in methods of treating heavy menstrual bleeding associated with uterine fibroids |
| JP6730978B2 (ja) | 2015-02-26 | 2020-07-29 | 武田薬品工業株式会社 | 固形製剤 |
| HK1258062A1 (zh) | 2015-09-01 | 2019-11-01 | Abbvie Inc. | 给予恶拉戈利的方法 |
| SI3518933T2 (sl) | 2016-09-30 | 2025-05-30 | Sumitomo Pharma Switzerland Gmbh | Metode zdravljenja materničnih miom in endometrioze |
| WO2018060463A2 (en) | 2016-09-30 | 2018-04-05 | Myovant Sciences Gmbh | Treatment of prostate cancer |
| MA49256A (fr) | 2017-06-05 | 2021-05-26 | ObsEva SA | Schémas posologiques comprenant un antagoniste de l'hormone de libération des gonadotrophines pour le traitement de l'endométriose |
| CN115175912B (zh) | 2019-10-10 | 2025-04-11 | 住友制药瑞士有限公司 | N-(4-(1-(2,6-二氟苄基)-5-((二甲基氨基)甲基)-3-(6-甲氧基-3-哒嗪基)-2,4-二氧代-1,2,3,4-四氢噻吩并[2,3-d]嘧啶-6-基)苯基)-n′-甲氧基脲的结晶溶剂化形式 |
| JP2022551316A (ja) | 2019-10-10 | 2022-12-08 | ミオバント サイエンシズ ゲーエムベーハー | Ｎ－（４－（１－（２，６－ジフルオロベンジル）－５－（（ジメチルアミノ）メチル）－３－（６－メトキシ－３－ピリダジニル）－２，４－ジオキソ－１，２，３，４－テトラヒドロチエノ［２，３－ｄ］ピリミジン－６－イル）フェニル）－Ｎ’－メトキシ尿素の結晶形 |
| MX2022015003A (es) | 2020-05-29 | 2023-03-03 | Myovant Sciences Gmbh | Formas de dosificacion oral solidas de combinacion de antagonistas de la hormona liberadora de gonadotropina. |
| JP2023549196A (ja) | 2020-11-11 | 2023-11-22 | ミオバント サイエンシズ ゲーエムベーハー | レルゴリクスの投与方法 |
| WO2023066941A1 (en) | 2021-10-18 | 2023-04-27 | Myovant Sciences Gmbh | Crystalline form of an ethanol solvate of n-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'-methoxyurea |
-
2017
- 2017-09-29 SI SI201731123T patent/SI3518933T2/sl unknown
- 2017-09-29 PL PL17823018.1T patent/PL3518933T5/pl unknown
- 2017-09-29 HU HUE22162349A patent/HUE072130T2/hu unknown
- 2017-09-29 HU HUE17823018A patent/HUE059101T2/hu unknown
- 2017-09-29 MD MDE20190880T patent/MD3518933T4/ro unknown
- 2017-09-29 MX MX2019003726A patent/MX2019003726A/es unknown
- 2017-09-29 JP JP2019538721A patent/JP7043503B2/ja active Active
- 2017-09-29 CN CN201780072987.XA patent/CN110312512B/zh active Active
- 2017-09-29 AU AU2017336363A patent/AU2017336363B2/en active Active
- 2017-09-29 PT PT178230181T patent/PT3518933T/pt unknown
- 2017-09-29 ES ES22162349T patent/ES3018413T3/es active Active
- 2017-09-29 EP EP22162349.9A patent/EP4094766B1/en active Active
- 2017-09-29 NZ NZ752916A patent/NZ752916A/en unknown
- 2017-09-29 SM SM20220254T patent/SMT202200254T1/it unknown
- 2017-09-29 LT LTEPPCT/EP2017/074907T patent/LT3518933T/lt unknown
- 2017-09-29 CA CA3038879A patent/CA3038879A1/en active Pending
- 2017-09-29 DK DK17823018.1T patent/DK3518933T4/da active
- 2017-09-29 WO PCT/EP2017/074907 patent/WO2018060501A2/en not_active Ceased
- 2017-09-29 EP EP17823018.1A patent/EP3518933B2/en active Active
- 2017-09-29 HR HRP20220708TT patent/HRP20220708T4/hr unknown
- 2017-09-29 ES ES17823018T patent/ES2912929T5/es active Active
- 2017-09-29 PL PL22162349.9T patent/PL4094766T3/pl unknown
- 2017-09-29 BR BR112019006227-0A patent/BR112019006227A2/pt unknown
- 2017-09-29 FI FIEP17823018.1T patent/FI3518933T4/fi active
- 2017-09-29 RS RS20220565A patent/RS63300B2/sr unknown
-
2019
- 2019-03-28 IL IL265700A patent/IL265700B2/en unknown
- 2019-03-29 US US16/370,299 patent/US11033551B2/en active Active
-
2021
- 2021-05-11 US US17/317,769 patent/US11793812B2/en active Active
-
2022
- 2022-06-02 CY CY20221100390T patent/CY1125254T1/el unknown
- 2022-07-15 US US17/866,201 patent/US11957684B2/en active Active
- 2022-09-30 AU AU2022241582A patent/AU2022241582C1/en active Active
-
2023
- 2023-02-12 IL IL300580A patent/IL300580B2/en unknown
-
2024
- 2024-01-30 US US18/427,579 patent/US20240165118A1/en active Pending
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