JP2019528272A5 - - Google Patents

Info

Publication number

JP2019528272A5

JP2019528272A5 JP2019508847A JP2019508847A JP2019528272A5 JP 2019528272 A5 JP2019528272 A5 JP 2019528272A5 JP 2019508847 A JP2019508847 A JP 2019508847A JP 2019508847 A JP2019508847 A JP 2019508847A JP 2019528272 A5 JP2019528272 A5 JP 2019528272A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

oral

oral pharmaceutical

composition according

patient

Prior art date

2017-08-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000008203 oral pharmaceutical composition Substances 0.000 claims 48
• 229940124624 oral corticosteroid Drugs 0.000 claims 18
• 239000000203 mixture Substances 0.000 claims 5
• 150000003431 steroids Chemical class 0.000 claims 4
• 208000019505 Deglutition disease Diseases 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 239000000243 solution Substances 0.000 claims 3
• 239000000725 suspension Substances 0.000 claims 3
• 206010020751 Hypersensitivity Diseases 0.000 claims 2
• 208000026935 allergic disease Diseases 0.000 claims 2
• 230000007815 allergy Effects 0.000 claims 2
• 210000003979 eosinophil Anatomy 0.000 claims 2
• 201000000708 eosinophilic esophagitis Diseases 0.000 claims 2
• 210000003238 esophagus Anatomy 0.000 claims 2
• 229960002714 fluticasone Drugs 0.000 claims 2
• MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 2
• 229960000289 fluticasone propionate Drugs 0.000 claims 2
• WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 2
• 239000007788 liquid Substances 0.000 claims 2
• 230000036470 plasma concentration Effects 0.000 claims 2
• 230000000291 postprandial effect Effects 0.000 claims 2
• 239000008247 solid mixture Substances 0.000 claims 2
• 239000003826 tablet Substances 0.000 claims 2
• VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 1
• LUKZNWIVRBCLON-GXOBDPJESA-N Ciclesonide Chemical compound C1([C@H]2O[C@@]3([C@H](O2)C[C@@H]2[C@@]3(C[C@H](O)[C@@H]3[C@@]4(C)C=CC(=O)C=C4CC[C@H]32)C)C(=O)COC(=O)C(C)C)CCCCC1 LUKZNWIVRBCLON-GXOBDPJESA-N 0.000 claims 1
• 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
• XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 1
• 229920002472 Starch Polymers 0.000 claims 1
• 229940092705 beclomethasone Drugs 0.000 claims 1
• NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 claims 1
• 239000000090 biomarker Substances 0.000 claims 1
• 229960004436 budesonide Drugs 0.000 claims 1
• 229960003728 ciclesonide Drugs 0.000 claims 1
• 239000003246 corticosteroid Substances 0.000 claims 1
• 229960001334 corticosteroids Drugs 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000007938 effervescent tablet Substances 0.000 claims 1
• 238000001839 endoscopy Methods 0.000 claims 1
• 150000002148 esters Chemical class 0.000 claims 1
• 238000011156 evaluation Methods 0.000 claims 1
• 239000004503 fine granule Substances 0.000 claims 1
• 229960000676 flunisolide Drugs 0.000 claims 1
• 235000013305 food Nutrition 0.000 claims 1
• 239000008187 granular material Substances 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 239000008101 lactose Substances 0.000 claims 1
• 235000011475 lollipops Nutrition 0.000 claims 1
• 239000007937 lozenge Substances 0.000 claims 1
• 239000011159 matrix material Substances 0.000 claims 1
• 235000012054 meals Nutrition 0.000 claims 1
• 229960001664 mometasone Drugs 0.000 claims 1
• QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 claims 1
• 239000006191 orally-disintegrating tablet Substances 0.000 claims 1
• 230000007170 pathology Effects 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000843 powder Substances 0.000 claims 1
• 239000000651 prodrug Substances 0.000 claims 1
• 229940002612 prodrug Drugs 0.000 claims 1
• MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 claims 1
• 230000002940 repellent Effects 0.000 claims 1
• 239000005871 repellent Substances 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000002002 slurry Substances 0.000 claims 1
• 239000012453 solvate Substances 0.000 claims 1
• 239000008107 starch Substances 0.000 claims 1
• 235000019698 starch Nutrition 0.000 claims 1
• 230000009885 systemic effect Effects 0.000 claims 1
• 230000000007 visual effect Effects 0.000 claims 1