JP2019527239A5 - - Google Patents

Download PDF

Info

Publication number
JP2019527239A5
JP2019527239A5 JP2019519608A JP2019519608A JP2019527239A5 JP 2019527239 A5 JP2019527239 A5 JP 2019527239A5 JP 2019519608 A JP2019519608 A JP 2019519608A JP 2019519608 A JP2019519608 A JP 2019519608A JP 2019527239 A5 JP2019527239 A5 JP 2019527239A5
Authority
JP
Japan
Prior art keywords
cancer
formula
acute
independently
leukemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019519608A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019527239A (ja
JP7013453B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/038697 external-priority patent/WO2017223284A1/en
Publication of JP2019527239A publication Critical patent/JP2019527239A/ja
Publication of JP2019527239A5 publication Critical patent/JP2019527239A5/ja
Priority to JP2022006150A priority Critical patent/JP7372993B2/ja
Application granted granted Critical
Publication of JP7013453B2 publication Critical patent/JP7013453B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019519608A 2016-06-23 2017-06-22 内皮安定化及び抗炎症活性を有する非触媒基質選択的p38α特異的MAPK阻害剤、及びその使用方法 Active JP7013453B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022006150A JP7372993B2 (ja) 2016-06-23 2022-01-19 内皮安定化及び抗炎症活性を有する非触媒基質選択的p38α特異的MAPK阻害剤、及びその使用方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662353856P 2016-06-23 2016-06-23
US62/353,856 2016-06-23
US201762469913P 2017-03-10 2017-03-10
US62/469,913 2017-03-10
PCT/US2017/038697 WO2017223284A1 (en) 2016-06-23 2017-06-22 NON-CATALYTIC SUBSTRATE-SELECTIVE P38α-SPECIFIC MAPK INHIBITORS WITH ENDOTHELIAL-STABILIZING AND ANTI-INFLAMMATORY ACTIVITY, AND METHODS OF USE THEREOF

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022006150A Division JP7372993B2 (ja) 2016-06-23 2022-01-19 内皮安定化及び抗炎症活性を有する非触媒基質選択的p38α特異的MAPK阻害剤、及びその使用方法

Publications (3)

Publication Number Publication Date
JP2019527239A JP2019527239A (ja) 2019-09-26
JP2019527239A5 true JP2019527239A5 (https=) 2020-07-30
JP7013453B2 JP7013453B2 (ja) 2022-01-31

Family

ID=60784745

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019519608A Active JP7013453B2 (ja) 2016-06-23 2017-06-22 内皮安定化及び抗炎症活性を有する非触媒基質選択的p38α特異的MAPK阻害剤、及びその使用方法
JP2022006150A Active JP7372993B2 (ja) 2016-06-23 2022-01-19 内皮安定化及び抗炎症活性を有する非触媒基質選択的p38α特異的MAPK阻害剤、及びその使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022006150A Active JP7372993B2 (ja) 2016-06-23 2022-01-19 内皮安定化及び抗炎症活性を有する非触媒基質選択的p38α特異的MAPK阻害剤、及びその使用方法

Country Status (6)

Country Link
US (5) US20190151324A1 (https=)
EP (1) EP3474835B1 (https=)
JP (2) JP7013453B2 (https=)
CN (2) CN109640970B (https=)
AU (4) AU2017281222B2 (https=)
WO (1) WO2017223284A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017223284A1 (en) * 2016-06-23 2017-12-28 University Of Maryland, Baltimore NON-CATALYTIC SUBSTRATE-SELECTIVE P38α-SPECIFIC MAPK INHIBITORS WITH ENDOTHELIAL-STABILIZING AND ANTI-INFLAMMATORY ACTIVITY, AND METHODS OF USE THEREOF
AU2019392904B9 (en) * 2018-12-07 2022-12-22 University Of Maryland, Baltimore Non-ATP/catalytic site p38 mitogen activated protein kinase inhibitors
EP4153303A1 (en) * 2020-05-18 2023-03-29 GEN1E Lifesciences Inc. P38alpha mitogen-activated protein kinase inhibitors
EP4237415A1 (en) * 2020-10-29 2023-09-06 GEN1E Lifesciences Inc. Crystalline 5-(dimethylamino)-n-(4-(morpholinomethyl)phenyl) naphthalene-1-sulfonamide di-hydrochloride di-hydrate
WO2022204046A1 (en) 2021-03-23 2022-09-29 Gen1E Lifesciences Inc. Substituted naphthyl p38alpha mitogen-activated protein kinase inhibitors
CN113304267B (zh) * 2021-06-11 2022-03-15 河南大学 肺癌的治疗靶点及其应用
US20250093263A1 (en) * 2021-07-22 2025-03-20 The General Hospital Corporation Fret-based assays

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR96352E (fr) 1967-12-29 1972-06-16 Science Union & Cie Nouveaux dérives du spiro (4,5) decane et leur procédé de préparation.
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US4992445A (en) 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
US5001139A (en) 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
DE19801646A1 (de) 1998-01-17 1999-07-22 Bayer Ag Substituierte alpha,beta-annellierte Butyrolactone
JPH11269146A (ja) 1998-03-24 1999-10-05 Mitsui Chem Inc 分化誘導剤
PT1537116E (pt) 2002-09-04 2010-09-03 Schering Corp Pirazolopirimidinas adequadas para o tratamento de doenças cancerosas
TW200503994A (en) 2003-01-24 2005-02-01 Novartis Ag Organic compounds
WO2004072077A1 (de) 2003-02-13 2004-08-26 Aventis Pharma Deutshland Gmbh STICKSTOFF SUBSTITUIERTE HEXAHYDRO-PYRAZINO[1,2-a]PYRIMIDIN-4,7-DIONDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL
JP2007532615A (ja) 2004-04-13 2007-11-15 アステックス、セラピューティックス、リミテッド 医薬化合物
US7297817B2 (en) 2004-04-13 2007-11-20 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
WO2006105237A2 (en) * 2005-03-29 2006-10-05 The University Of Maryland, Baltimore Inhibitors for extracellular signal-regulated kinase docking domains and uses therefor
TW200904421A (en) * 2007-05-03 2009-02-01 Astellas Pharma Inc New compounds
US8778953B2 (en) 2008-02-29 2014-07-15 Chroma Therapeutics Ltd. Inhibitors of P38 map kinase
US20120172375A1 (en) 2008-11-07 2012-07-05 Bruce Trapp Compounds and methods of promoting oligodendrocyte precursor differentiation
WO2010082912A1 (en) * 2009-01-15 2010-07-22 Avalon Pharmaceuticals Derivatives of multi-ring aromatic compounds and uses as anti-tumor agents
WO2010094977A1 (en) * 2009-02-23 2010-08-26 Arrow Therapeutics Limited Novel biphenyl compounds useful for the treatment of hepatitis c
WO2014111130A1 (en) 2013-01-15 2014-07-24 Müller Karl Alex Rapid solid-state reaction of oxides with ultraviolet radiation
EP3004087B1 (en) * 2013-06-06 2017-08-09 CHIESI FARMACEUTICI S.p.A. Derivatives of [1,2,4]triazolo[4,3-a]pyridine as p38-map kinase inhibitors
US9025712B2 (en) 2013-07-30 2015-05-05 Pixart Imaging Inc. Sensor, clock frequency adjusting system and method thereof
ES2677595T3 (es) * 2014-02-14 2018-08-03 Respivert Limited Compuestos heterocíclicos aromáticos como compuestos antiinflamatorios
GB201417168D0 (en) 2014-09-29 2014-11-12 Univ Hertfordshire Higher Education Corp Compounds
WO2016073633A1 (en) * 2014-11-05 2016-05-12 University Of Kansas SMALL MOLECULE INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE (mtPTP)
WO2017223284A1 (en) * 2016-06-23 2017-12-28 University Of Maryland, Baltimore NON-CATALYTIC SUBSTRATE-SELECTIVE P38α-SPECIFIC MAPK INHIBITORS WITH ENDOTHELIAL-STABILIZING AND ANTI-INFLAMMATORY ACTIVITY, AND METHODS OF USE THEREOF
TW201829381A (zh) 2016-12-22 2018-08-16 美商拜奧馬林製藥公司 組蛋白脫乙醯基酶抑制劑
AU2019392904B9 (en) 2018-12-07 2022-12-22 University Of Maryland, Baltimore Non-ATP/catalytic site p38 mitogen activated protein kinase inhibitors
WO2021183970A1 (en) 2020-03-13 2021-09-16 University Of Maryland, Baltimore Non-atp/catalytic site p38 mitogen activated protein kinase inhibitors
EP4153303A1 (en) 2020-05-18 2023-03-29 GEN1E Lifesciences Inc. P38alpha mitogen-activated protein kinase inhibitors

Similar Documents

Publication Publication Date Title
JP2019527239A5 (https=)
AU2015335391B2 (en) Uses of duloxetine HCL medicament in preparing pharmaceutical composition for treatment of cancer
RU2468016C2 (ru) СОЕДИНЕНИЯ И СПОСОБЫ ИНГИБИРОВАНИЯ ВЗАИМОДЕЙСТВИЯ БЕЛКОВ Bcl СО СВЯЗЫВАЮЩИМИ ПАРТНЕРАМИ
JP7058345B2 (ja) Bcl-2阻害剤及びMDM2阻害剤の組合せ製品並びに疾患の予防及び/又治療におけるその使用
JP2013507415A5 (https=)
JP2010510214A5 (https=)
JP2008521928A5 (https=)
JP2016536283A5 (https=)
AU2017200232A1 (en) Combination therapy
JP2017510641A5 (https=)
TWI726362B (zh) Bcl-2抑制劑與利妥昔單抗和/或苯達莫司汀或Bcl-2抑制劑與CHOP聯合用藥的協同抗腫瘤作用
JP2020515571A5 (https=)
JP2016506916A5 (https=)
JP2021519308A5 (https=)
JP2015509540A5 (https=)
HRP20192101T1 (hr) Inhibitori ezh2
JP2016513704A5 (https=)
RU2016122731A (ru) Функционализированные и замещенные индолы в качестве противораковых агентов
EP3716978B1 (en) N-(phenyl)-n'-(6-quinoxalinyl)-urea derivatives as ikkb inhibitors for the treatment of cancer
RU2016147654A (ru) Соединения для лечения рака
JP2010506919A5 (https=)
JP2017507151A5 (https=)
CN116113416A (zh) 四环类衍生物、其制备方法和其医药上的用途
CN109689652A (zh) 稠杂环类衍生物、其制备方法及其在医学上的应用
WO2013170758A1 (zh) 含稠环结构的苯甲酰胺类化合物及其作为抗肿瘤药物应用