JP2019526551A5 - - Google Patents
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- JP2019526551A5 JP2019526551A5 JP2019508185A JP2019508185A JP2019526551A5 JP 2019526551 A5 JP2019526551 A5 JP 2019526551A5 JP 2019508185 A JP2019508185 A JP 2019508185A JP 2019508185 A JP2019508185 A JP 2019508185A JP 2019526551 A5 JP2019526551 A5 JP 2019526551A5
- Authority
- JP
- Japan
- Prior art keywords
- temperature
- gas
- microvesicles
- suspension
- amphipathic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000463 material Substances 0.000 claims description 77
- 239000007789 gas Substances 0.000 claims description 71
- 238000000034 method Methods 0.000 claims description 54
- 239000000725 suspension Substances 0.000 claims description 48
- -1 fatty acid diesters Chemical class 0.000 claims description 47
- 239000007788 liquid Substances 0.000 claims description 41
- 239000000203 mixture Substances 0.000 claims description 37
- 150000003904 phospholipids Chemical class 0.000 claims description 37
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- 238000001816 cooling Methods 0.000 claims description 25
- 239000012530 fluid Substances 0.000 claims description 23
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- 235000014113 dietary fatty acids Nutrition 0.000 claims description 20
- 239000000194 fatty acid Substances 0.000 claims description 20
- 229930195729 fatty acid Natural products 0.000 claims description 20
- 230000015572 biosynthetic process Effects 0.000 claims description 16
- 229910052757 nitrogen Inorganic materials 0.000 claims description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 10
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims description 7
- 239000003570 air Substances 0.000 claims description 6
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- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 5
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims description 5
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims description 4
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- 229910052760 oxygen Inorganic materials 0.000 claims description 4
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- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 3
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- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims description 2
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- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 18
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- 230000000087 stabilizing effect Effects 0.000 description 10
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
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- 238000010438 heat treatment Methods 0.000 description 6
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- 239000002243 precursor Substances 0.000 description 6
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- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
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- FQZQXPXKJFOAGE-KICCZPNWSA-N [(2r)-3-[hydroxy-[(5r)-2,3,4,5,6-pentahydroxycyclohexyl]oxyphosphoryl]oxy-2-octadecanoyloxypropyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCCCC)COP(O)(=O)OC1C(O)C(O)C(O)[C@@H](O)C1O FQZQXPXKJFOAGE-KICCZPNWSA-N 0.000 description 4
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| CN107999155A (zh) * | 2017-12-25 | 2018-05-08 | 四川蓝光英诺生物科技股份有限公司 | 微流控芯片及其控制方法、液滴生成装置和微球制备装置 |
| JP7539316B2 (ja) | 2018-03-07 | 2024-08-23 | ブラッコ・スイス・ソシエテ・アノニム | サイズが制御された微小胞の調製 |
| KR102180629B1 (ko) * | 2018-12-24 | 2020-11-20 | 서강대학교 산학협력단 | 세포외 소포 기반의 초음파 조영제용 마이크로버블 및 이의 제조방법 |
| KR102044676B1 (ko) * | 2019-03-27 | 2019-11-14 | 주식회사 씨트리 | 생체적합성 고분자 기반 아픽사반 함유 미립구의 제조방법 |
| JP7712877B2 (ja) * | 2019-06-25 | 2025-07-24 | ブラッコ・スイス・ソシエテ・アノニム | 校正されたガス充填微小胞を調製するための凍結乾燥組成物 |
| EP3990032B1 (en) | 2019-06-25 | 2023-12-06 | Bracco Suisse SA | Freeze-dried composition for preparing calibrated gas-filled microvesicles |
| CN116897055A (zh) * | 2020-12-27 | 2023-10-17 | 索尔斯蒂斯制药有限公司 | 用于混合旨在用于体内使用的磷脂组合物的筒 |
| JP2024501982A (ja) * | 2020-12-27 | 2024-01-17 | ソルスティス ファーマシューティカルズ ビー．ブイ． | 体内使用を意図したリン脂質組成物を混合するためのカートリッジ |
| NL2027237B1 (en) * | 2020-12-27 | 2022-07-21 | Solstice Pharmaceuticals B V | Process for controlled manufacturing of mono-disperse microbubbles |
| CN114011478B (zh) * | 2021-02-20 | 2023-06-02 | 中国海洋石油集团有限公司 | 一种多功能微流控芯片及其制作方法 |
| KR20240035750A (ko) | 2021-07-14 | 2024-03-18 | 브라코 스위스 에스.에이. | 양이온성 보정된 크기의 기체 충전된 미세소포 |
| WO2025125516A1 (en) | 2023-12-13 | 2025-06-19 | Bracco Suisse Sa | Calibrated gas-filled microvesicles with ligand |
| NL2036721B1 (en) * | 2023-12-29 | 2025-07-15 | Univ Twente | Controlling the stability of microbubbles |
| WO2025252942A1 (en) | 2024-06-06 | 2025-12-11 | Bracco Suisse Sa | Anionic gas-filled microvesicles with calibrated sizes |
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| JPH0751496B2 (ja) * | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | リポソ−ムの製造法 |
| US7083572B2 (en) | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
| PT682530E (pt) | 1993-12-15 | 2003-06-30 | Bracco Research Sa | Misturas de gases uteis como meios de contraste para ultrassons |
| US20020159951A1 (en) * | 1997-05-06 | 2002-10-31 | Unger Evan C. | Novel targeted compositions for diagnostic and therapeutic use |
| DE602004029010D1 (de) | 2003-02-04 | 2010-10-21 | Bracco Suisse Sa | Ultraschall kontrastmittel und verfahren zur erstellung |
| JP2007509989A (ja) * | 2003-10-31 | 2007-04-19 | ポイント バイオメディカル コーポレイション | 超音波造影剤として有用な再構成可能なミクロスフィア組成物 |
| EA024999B1 (ru) * | 2009-11-24 | 2016-11-30 | Опкоу Дайагностикс, Ллк. | Смешивание и доставка текучих сред в микрофлюидных системах |
| WO2012098937A1 (ja) * | 2011-01-21 | 2012-07-26 | 国立大学法人 神戸大学 | リポソームの製造方法 |
| GB201111082D0 (en) * | 2011-06-29 | 2011-08-10 | Univ Leeds | Bubble generation |
| US9782733B2 (en) | 2012-03-22 | 2017-10-10 | Universiteit Twente | Apparatus and method for mass producing a monodisperse microbubble agent |
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