DK3506882T3 - Fremstilling af størrelseskontrollerede mikropartikler - Google Patents
Fremstilling af størrelseskontrollerede mikropartikler Download PDFInfo
- Publication number
- DK3506882T3 DK3506882T3 DK17758869.6T DK17758869T DK3506882T3 DK 3506882 T3 DK3506882 T3 DK 3506882T3 DK 17758869 T DK17758869 T DK 17758869T DK 3506882 T3 DK3506882 T3 DK 3506882T3
- Authority
- DK
- Denmark
- Prior art keywords
- manufacture
- size
- controlled microparticles
- microparticles
- controlled
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasonic imaging preparations
- A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasonic imaging preparations
- A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16186356 | 2016-08-30 | ||
| PCT/EP2017/071788 WO2018041906A1 (en) | 2016-08-30 | 2017-08-30 | Preparation of size-controlled microparticles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3506882T3 true DK3506882T3 (da) | 2022-03-21 |
Family
ID=56842765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17758869.6T DK3506882T3 (da) | 2016-08-30 | 2017-08-30 | Fremstilling af størrelseskontrollerede mikropartikler |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10918605B2 (https=) |
| EP (1) | EP3506882B1 (https=) |
| JP (1) | JP7197465B2 (https=) |
| KR (1) | KR102474554B1 (https=) |
| CN (1) | CN109640951B (https=) |
| AU (1) | AU2017317646B2 (https=) |
| DK (1) | DK3506882T3 (https=) |
| ES (1) | ES2908708T3 (https=) |
| IL (1) | IL265070B (https=) |
| WO (1) | WO2018041906A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107999155A (zh) * | 2017-12-25 | 2018-05-08 | 四川蓝光英诺生物科技股份有限公司 | 微流控芯片及其控制方法、液滴生成装置和微球制备装置 |
| CA3091952A1 (en) | 2018-03-07 | 2019-09-12 | Bracco Suisse Sa | Preparation of size-controlled microvesicles |
| KR102180629B1 (ko) * | 2018-12-24 | 2020-11-20 | 서강대학교 산학협력단 | 세포외 소포 기반의 초음파 조영제용 마이크로버블 및 이의 제조방법 |
| KR102044676B1 (ko) * | 2019-03-27 | 2019-11-14 | 주식회사 씨트리 | 생체적합성 고분자 기반 아픽사반 함유 미립구의 제조방법 |
| US20220409749A1 (en) * | 2019-06-25 | 2022-12-29 | Bracco Suisse Sa | Freeze-dried composition for preparing calibrated gas-filled microvesicles |
| DK3990032T3 (da) * | 2019-06-25 | 2023-12-18 | Bracco Suisse Sa | Frysetørret sammensætning til fremstilling af kalibrerede gasfyldte mikrovesikler |
| CN116897055A (zh) * | 2020-12-27 | 2023-10-17 | 索尔斯蒂斯制药有限公司 | 用于混合旨在用于体内使用的磷脂组合物的筒 |
| EP4267203A1 (en) * | 2020-12-27 | 2023-11-01 | Solstice Pharmaceuticals B.V. | A cartridge for mixing a phospholipid composition intended for intracorporeal use |
| NL2027237B1 (en) * | 2020-12-27 | 2022-07-21 | Solstice Pharmaceuticals B V | Process for controlled manufacturing of mono-disperse microbubbles |
| CN114011478B (zh) * | 2021-02-20 | 2023-06-02 | 中国海洋石油集团有限公司 | 一种多功能微流控芯片及其制作方法 |
| US12233131B2 (en) | 2021-07-14 | 2025-02-25 | Bracco Suisse Sa | Cationic calibrated-size gas-filled microvesicles |
| WO2025125516A1 (en) | 2023-12-13 | 2025-06-19 | Bracco Suisse Sa | Calibrated gas-filled microvesicles with ligand |
| NL2036721B1 (en) * | 2023-12-29 | 2025-07-15 | Univ Twente | Controlling the stability of microbubbles |
| WO2025252942A1 (en) | 2024-06-06 | 2025-12-11 | Bracco Suisse Sa | Anionic gas-filled microvesicles with calibrated sizes |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0751496B2 (ja) * | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | リポソ−ムの製造法 |
| US7083572B2 (en) | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
| CN1068229C (zh) | 1993-12-15 | 2001-07-11 | 勃勒柯研究有限公司 | 超声对比介质、含该介质的对比剂及方法 |
| US20020159951A1 (en) * | 1997-05-06 | 2002-10-31 | Unger Evan C. | Novel targeted compositions for diagnostic and therapeutic use |
| JP4670083B2 (ja) | 2003-02-04 | 2011-04-13 | ブラッコ・シュイス・ソシエテ・アノニム | 超音波造影剤およびその製造方法 |
| CA2543296A1 (en) * | 2003-10-31 | 2005-05-12 | Point Biomedical Corporation | Reconstitutable microsphere compositions useful as ultrasonic contrast agents |
| ES2859481T3 (es) * | 2009-11-24 | 2021-10-04 | Opko Diagnostics Llc | Mezcla y suministro de fluidos en sistemas microfluídicos |
| WO2012098937A1 (ja) * | 2011-01-21 | 2012-07-26 | 国立大学法人 神戸大学 | リポソームの製造方法 |
| GB201111082D0 (en) * | 2011-06-29 | 2011-08-10 | Univ Leeds | Bubble generation |
| EP2827979A1 (en) | 2012-03-22 | 2015-01-28 | Universiteit Twente | Apparatus and method for mass producing a monodisperse microbubble agent |
-
2017
- 2017-08-30 US US16/327,519 patent/US10918605B2/en active Active
- 2017-08-30 IL IL265070A patent/IL265070B/en unknown
- 2017-08-30 CN CN201780052322.2A patent/CN109640951B/zh active Active
- 2017-08-30 JP JP2019508185A patent/JP7197465B2/ja active Active
- 2017-08-30 DK DK17758869.6T patent/DK3506882T3/da active
- 2017-08-30 ES ES17758869T patent/ES2908708T3/es active Active
- 2017-08-30 EP EP17758869.6A patent/EP3506882B1/en active Active
- 2017-08-30 AU AU2017317646A patent/AU2017317646B2/en active Active
- 2017-08-30 KR KR1020197008825A patent/KR102474554B1/ko active Active
- 2017-08-30 WO PCT/EP2017/071788 patent/WO2018041906A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019526551A (ja) | 2019-09-19 |
| CN109640951A (zh) | 2019-04-16 |
| IL265070B (en) | 2022-09-01 |
| ES2908708T3 (es) | 2022-05-03 |
| JP7197465B2 (ja) | 2022-12-27 |
| AU2017317646B2 (en) | 2023-07-06 |
| US10918605B2 (en) | 2021-02-16 |
| IL265070A (https=) | 2019-04-30 |
| CN109640951B (zh) | 2023-08-25 |
| KR102474554B1 (ko) | 2022-12-06 |
| US20190175516A1 (en) | 2019-06-13 |
| WO2018041906A1 (en) | 2018-03-08 |
| CA3032062A1 (en) | 2018-03-08 |
| EP3506882A1 (en) | 2019-07-10 |
| KR20190042681A (ko) | 2019-04-24 |
| AU2017317646A1 (en) | 2019-02-21 |
| EP3506882B1 (en) | 2022-01-12 |
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