CN109640951B - 粒度受控的微粒的制备 - Google Patents

粒度受控的微粒的制备 Download PDF

Info

Publication number
CN109640951B
CN109640951B CN201780052322.2A CN201780052322A CN109640951B CN 109640951 B CN109640951 B CN 109640951B CN 201780052322 A CN201780052322 A CN 201780052322A CN 109640951 B CN109640951 B CN 109640951B
Authority
CN
China
Prior art keywords
gas
temperature
suspension
amphiphilic material
perfluorinated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201780052322.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN109640951A (zh
Inventor
T·瑟格斯
P·弗林金
A·拉苏斯
P·布塞
E·高德
S·彻尔考威
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Bracco Suisse SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse SA filed Critical Bracco Suisse SA
Publication of CN109640951A publication Critical patent/CN109640951A/zh
Application granted granted Critical
Publication of CN109640951B publication Critical patent/CN109640951B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201780052322.2A 2016-08-30 2017-08-30 粒度受控的微粒的制备 Active CN109640951B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16186356.8 2016-08-30
EP16186356 2016-08-30
PCT/EP2017/071788 WO2018041906A1 (en) 2016-08-30 2017-08-30 Preparation of size-controlled microparticles

Publications (2)

Publication Number Publication Date
CN109640951A CN109640951A (zh) 2019-04-16
CN109640951B true CN109640951B (zh) 2023-08-25

Family

ID=56842765

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780052322.2A Active CN109640951B (zh) 2016-08-30 2017-08-30 粒度受控的微粒的制备

Country Status (10)

Country Link
US (1) US10918605B2 (https=)
EP (1) EP3506882B1 (https=)
JP (1) JP7197465B2 (https=)
KR (1) KR102474554B1 (https=)
CN (1) CN109640951B (https=)
AU (1) AU2017317646B2 (https=)
DK (1) DK3506882T3 (https=)
ES (1) ES2908708T3 (https=)
IL (1) IL265070B (https=)
WO (1) WO2018041906A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107999155A (zh) * 2017-12-25 2018-05-08 四川蓝光英诺生物科技股份有限公司 微流控芯片及其控制方法、液滴生成装置和微球制备装置
JP7539316B2 (ja) 2018-03-07 2024-08-23 ブラッコ・スイス・ソシエテ・アノニム サイズが制御された微小胞の調製
KR102180629B1 (ko) * 2018-12-24 2020-11-20 서강대학교 산학협력단 세포외 소포 기반의 초음파 조영제용 마이크로버블 및 이의 제조방법
KR102044676B1 (ko) * 2019-03-27 2019-11-14 주식회사 씨트리 생체적합성 고분자 기반 아픽사반 함유 미립구의 제조방법
JP7712877B2 (ja) * 2019-06-25 2025-07-24 ブラッコ・スイス・ソシエテ・アノニム 校正されたガス充填微小胞を調製するための凍結乾燥組成物
EP3990032B1 (en) 2019-06-25 2023-12-06 Bracco Suisse SA Freeze-dried composition for preparing calibrated gas-filled microvesicles
CN116897055A (zh) * 2020-12-27 2023-10-17 索尔斯蒂斯制药有限公司 用于混合旨在用于体内使用的磷脂组合物的筒
JP2024501982A (ja) * 2020-12-27 2024-01-17 ソルスティス ファーマシューティカルズ ビー．ブイ． 体内使用を意図したリン脂質組成物を混合するためのカートリッジ
NL2027237B1 (en) * 2020-12-27 2022-07-21 Solstice Pharmaceuticals B V Process for controlled manufacturing of mono-disperse microbubbles
CN114011478B (zh) * 2021-02-20 2023-06-02 中国海洋石油集团有限公司 一种多功能微流控芯片及其制作方法
KR20240035750A (ko) 2021-07-14 2024-03-18 브라코 스위스 에스.에이. 양이온성 보정된 크기의 기체 충전된 미세소포
WO2025125516A1 (en) 2023-12-13 2025-06-19 Bracco Suisse Sa Calibrated gas-filled microvesicles with ligand
NL2036721B1 (en) * 2023-12-29 2025-07-15 Univ Twente Controlling the stability of microbubbles
WO2025252942A1 (en) 2024-06-06 2025-12-11 Bracco Suisse Sa Anionic gas-filled microvesicles with calibrated sizes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6339810A (ja) * 1986-04-02 1988-02-20 Takeda Chem Ind Ltd リポソ−ムの製造法
WO2012098937A1 (ja) * 2011-01-21 2012-07-26 国立大学法人 神戸大学 リポソームの製造方法
CN102740975A (zh) * 2009-11-24 2012-10-17 欧普科诊断有限责任公司 微流体系统中的流体混合和递送

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
PT682530E (pt) 1993-12-15 2003-06-30 Bracco Research Sa Misturas de gases uteis como meios de contraste para ultrassons
US20020159951A1 (en) * 1997-05-06 2002-10-31 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
DE602004029010D1 (de) 2003-02-04 2010-10-21 Bracco Suisse Sa Ultraschall kontrastmittel und verfahren zur erstellung
JP2007509989A (ja) * 2003-10-31 2007-04-19 ポイント バイオメディカル コーポレイション 超音波造影剤として有用な再構成可能なミクロスフィア組成物
GB201111082D0 (en) * 2011-06-29 2011-08-10 Univ Leeds Bubble generation
US9782733B2 (en) 2012-03-22 2017-10-10 Universiteit Twente Apparatus and method for mass producing a monodisperse microbubble agent

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6339810A (ja) * 1986-04-02 1988-02-20 Takeda Chem Ind Ltd リポソ−ムの製造法
CN102740975A (zh) * 2009-11-24 2012-10-17 欧普科诊断有限责任公司 微流体系统中的流体混合和递送
WO2012098937A1 (ja) * 2011-01-21 2012-07-26 国立大学法人 神戸大学 リポソームの製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Production of microbubbles from axisymmetric flow focusing in the jetting regime for moderate Reynolds numbers;E. J. Vega 等;《PHYSICAL REVIEW E》;20140623(第89期);全文 *

Also Published As

Publication number Publication date
US20190175516A1 (en) 2019-06-13
AU2017317646B2 (en) 2023-07-06
ES2908708T3 (es) 2022-05-03
KR20190042681A (ko) 2019-04-24
EP3506882A1 (en) 2019-07-10
IL265070A (https=) 2019-04-30
CA3032062A1 (en) 2018-03-08
DK3506882T3 (da) 2022-03-21
JP2019526551A (ja) 2019-09-19
EP3506882B1 (en) 2022-01-12
CN109640951A (zh) 2019-04-16
IL265070B (en) 2022-09-01
AU2017317646A1 (en) 2019-02-21
KR102474554B1 (ko) 2022-12-06
JP7197465B2 (ja) 2022-12-27
WO2018041906A1 (en) 2018-03-08
US10918605B2 (en) 2021-02-16

Similar Documents

Publication Publication Date Title
CN109640951B (zh) 粒度受控的微粒的制备
JP2019526551A5 (https=)
KR102888001B1 (ko) 크기-제어 미세소포의 제조
AU696056B2 (en) Novel therapeutic delivery systems
JP4916969B2 (ja) ガス状のフッ化化合物充填脂微小球
CN101528268B (zh) 具有聚合物修饰的脂质的充气微囊泡
CN114007656A (zh) 用于制备标准化充气微泡的冻干组合物
JP7712878B2 (ja) 校正されたガス充填微小胞を調製するための凍結乾燥組成物
CA3032062C (en) Preparation of size-controlled microparticles
Jeng Synthesis of multifunctional microbubbles through precursor microfluidic droplet generation

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant