CN109640951B - 粒度受控的微粒的制备 - Google Patents

粒度受控的微粒的制备 Download PDF

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Publication number
CN109640951B
CN109640951B CN201780052322.2A CN201780052322A CN109640951B CN 109640951 B CN109640951 B CN 109640951B CN 201780052322 A CN201780052322 A CN 201780052322A CN 109640951 B CN109640951 B CN 109640951B
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China
Prior art keywords
gas
temperature
suspension
amphiphilic material
perfluorinated
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CN201780052322.2A
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English (en)
Chinese (zh)
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CN109640951A (zh
Inventor
T·瑟格斯
P·弗林金
A·拉苏斯
P·布塞
E·高德
S·彻尔考威
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Bracco Suisse SA
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Bracco Suisse SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201780052322.2A 2016-08-30 2017-08-30 粒度受控的微粒的制备 Active CN109640951B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16186356 2016-08-30
EP16186356.8 2016-08-30
PCT/EP2017/071788 WO2018041906A1 (en) 2016-08-30 2017-08-30 Preparation of size-controlled microparticles

Publications (2)

Publication Number Publication Date
CN109640951A CN109640951A (zh) 2019-04-16
CN109640951B true CN109640951B (zh) 2023-08-25

Family

ID=56842765

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780052322.2A Active CN109640951B (zh) 2016-08-30 2017-08-30 粒度受控的微粒的制备

Country Status (10)

Country Link
US (1) US10918605B2 (https=)
EP (1) EP3506882B1 (https=)
JP (1) JP7197465B2 (https=)
KR (1) KR102474554B1 (https=)
CN (1) CN109640951B (https=)
AU (1) AU2017317646B2 (https=)
DK (1) DK3506882T3 (https=)
ES (1) ES2908708T3 (https=)
IL (1) IL265070B (https=)
WO (1) WO2018041906A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107999155A (zh) * 2017-12-25 2018-05-08 四川蓝光英诺生物科技股份有限公司 微流控芯片及其控制方法、液滴生成装置和微球制备装置
CA3091952A1 (en) 2018-03-07 2019-09-12 Bracco Suisse Sa Preparation of size-controlled microvesicles
KR102180629B1 (ko) * 2018-12-24 2020-11-20 서강대학교 산학협력단 세포외 소포 기반의 초음파 조영제용 마이크로버블 및 이의 제조방법
KR102044676B1 (ko) * 2019-03-27 2019-11-14 주식회사 씨트리 생체적합성 고분자 기반 아픽사반 함유 미립구의 제조방법
US20220409749A1 (en) * 2019-06-25 2022-12-29 Bracco Suisse Sa Freeze-dried composition for preparing calibrated gas-filled microvesicles
DK3990032T3 (da) * 2019-06-25 2023-12-18 Bracco Suisse Sa Frysetørret sammensætning til fremstilling af kalibrerede gasfyldte mikrovesikler
CN116897055A (zh) * 2020-12-27 2023-10-17 索尔斯蒂斯制药有限公司 用于混合旨在用于体内使用的磷脂组合物的筒
EP4267203A1 (en) * 2020-12-27 2023-11-01 Solstice Pharmaceuticals B.V. A cartridge for mixing a phospholipid composition intended for intracorporeal use
NL2027237B1 (en) * 2020-12-27 2022-07-21 Solstice Pharmaceuticals B V Process for controlled manufacturing of mono-disperse microbubbles
CN114011478B (zh) * 2021-02-20 2023-06-02 中国海洋石油集团有限公司 一种多功能微流控芯片及其制作方法
US12233131B2 (en) 2021-07-14 2025-02-25 Bracco Suisse Sa Cationic calibrated-size gas-filled microvesicles
WO2025125516A1 (en) 2023-12-13 2025-06-19 Bracco Suisse Sa Calibrated gas-filled microvesicles with ligand
NL2036721B1 (en) * 2023-12-29 2025-07-15 Univ Twente Controlling the stability of microbubbles
WO2025252942A1 (en) 2024-06-06 2025-12-11 Bracco Suisse Sa Anionic gas-filled microvesicles with calibrated sizes

Citations (3)

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Publication number Priority date Publication date Assignee Title
JPS6339810A (ja) * 1986-04-02 1988-02-20 Takeda Chem Ind Ltd リポソ−ムの製造法
WO2012098937A1 (ja) * 2011-01-21 2012-07-26 国立大学法人 神戸大学 リポソームの製造方法
CN102740975A (zh) * 2009-11-24 2012-10-17 欧普科诊断有限责任公司 微流体系统中的流体混合和递送

Family Cites Families (7)

* Cited by examiner, † Cited by third party
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US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
CN1068229C (zh) 1993-12-15 2001-07-11 勃勒柯研究有限公司 超声对比介质、含该介质的对比剂及方法
US20020159951A1 (en) * 1997-05-06 2002-10-31 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
JP4670083B2 (ja) 2003-02-04 2011-04-13 ブラッコ・シュイス・ソシエテ・アノニム 超音波造影剤およびその製造方法
CA2543296A1 (en) * 2003-10-31 2005-05-12 Point Biomedical Corporation Reconstitutable microsphere compositions useful as ultrasonic contrast agents
GB201111082D0 (en) * 2011-06-29 2011-08-10 Univ Leeds Bubble generation
EP2827979A1 (en) 2012-03-22 2015-01-28 Universiteit Twente Apparatus and method for mass producing a monodisperse microbubble agent

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6339810A (ja) * 1986-04-02 1988-02-20 Takeda Chem Ind Ltd リポソ−ムの製造法
CN102740975A (zh) * 2009-11-24 2012-10-17 欧普科诊断有限责任公司 微流体系统中的流体混合和递送
WO2012098937A1 (ja) * 2011-01-21 2012-07-26 国立大学法人 神戸大学 リポソームの製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Production of microbubbles from axisymmetric flow focusing in the jetting regime for moderate Reynolds numbers;E. J. Vega 等;《PHYSICAL REVIEW E》;20140623(第89期);全文 *

Also Published As

Publication number Publication date
JP2019526551A (ja) 2019-09-19
CN109640951A (zh) 2019-04-16
IL265070B (en) 2022-09-01
ES2908708T3 (es) 2022-05-03
JP7197465B2 (ja) 2022-12-27
AU2017317646B2 (en) 2023-07-06
US10918605B2 (en) 2021-02-16
DK3506882T3 (da) 2022-03-21
IL265070A (https=) 2019-04-30
KR102474554B1 (ko) 2022-12-06
US20190175516A1 (en) 2019-06-13
WO2018041906A1 (en) 2018-03-08
CA3032062A1 (en) 2018-03-08
EP3506882A1 (en) 2019-07-10
KR20190042681A (ko) 2019-04-24
AU2017317646A1 (en) 2019-02-21
EP3506882B1 (en) 2022-01-12

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