JP2019526550A5 - - Google Patents
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- Publication number
- JP2019526550A5 JP2019526550A5 JP2019508173A JP2019508173A JP2019526550A5 JP 2019526550 A5 JP2019526550 A5 JP 2019526550A5 JP 2019508173 A JP2019508173 A JP 2019508173A JP 2019508173 A JP2019508173 A JP 2019508173A JP 2019526550 A5 JP2019526550 A5 JP 2019526550A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- pyridin
- amino
- pyrimidin
- benzamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(*)c1nc(*)c2nc(C)[n](C(CI)I)c2n1 Chemical compound CC(*)c1nc(*)c2nc(C)[n](C(CI)I)c2n1 0.000 description 4
- IYXKCVLIKNINEL-UHFFFAOYSA-N CC#CC(N(CCC1)C1NC)=O Chemical compound CC#CC(N(CCC1)C1NC)=O IYXKCVLIKNINEL-UHFFFAOYSA-N 0.000 description 1
- ACVJPEOEZZBOHY-UHFFFAOYSA-N CC(C=CC=C1)(C=C1NC)NC(C=C)=O Chemical compound CC(C=CC=C1)(C=C1NC)NC(C=C)=O ACVJPEOEZZBOHY-UHFFFAOYSA-N 0.000 description 1
- JCXOKBUYQHZSEY-UHFFFAOYSA-N CN(C)C(CCC1)CN1C(C=C)=O Chemical compound CN(C)C(CCC1)CN1C(C=C)=O JCXOKBUYQHZSEY-UHFFFAOYSA-N 0.000 description 1
- FPHMTFSROQUUQU-UHFFFAOYSA-N CNC(C#CI)=O Chemical compound CNC(C#CI)=O FPHMTFSROQUUQU-UHFFFAOYSA-N 0.000 description 1
- BEQQDUWUAIDHNZ-UHFFFAOYSA-N CNC(CCC1)N1C(C=C)=O Chemical compound CNC(CCC1)N1C(C=C)=O BEQQDUWUAIDHNZ-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022017081A JP2022058912A (ja) | 2016-08-15 | 2022-02-07 | 特定の化学的実体、組成物、および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662375382P | 2016-08-15 | 2016-08-15 | |
| US62/375,382 | 2016-08-15 | ||
| PCT/US2017/046819 WO2018035061A1 (en) | 2016-08-15 | 2017-08-14 | Certain chemical entities, compositions, and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022017081A Division JP2022058912A (ja) | 2016-08-15 | 2022-02-07 | 特定の化学的実体、組成物、および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019526550A JP2019526550A (ja) | 2019-09-19 |
| JP2019526550A5 true JP2019526550A5 (enExample) | 2020-09-03 |
| JP7101165B2 JP7101165B2 (ja) | 2022-07-14 |
Family
ID=61196987
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508173A Expired - Fee Related JP7101165B2 (ja) | 2016-08-15 | 2017-08-14 | 特定の化学的実体、組成物、および方法 |
| JP2022017081A Ceased JP2022058912A (ja) | 2016-08-15 | 2022-02-07 | 特定の化学的実体、組成物、および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022017081A Ceased JP2022058912A (ja) | 2016-08-15 | 2022-02-07 | 特定の化学的実体、組成物、および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10544106B2 (enExample) |
| EP (2) | EP3497087B1 (enExample) |
| JP (2) | JP7101165B2 (enExample) |
| CN (1) | CN109843858B (enExample) |
| AU (1) | AU2017312561B2 (enExample) |
| CA (1) | CA3033370A1 (enExample) |
| WO (1) | WO2018035061A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3035936T3 (da) | 2013-08-23 | 2019-06-11 | Neupharma Inc | Visse kemiske enheder, sammensætninger og fremgangsmåder |
| EP3270694A4 (en) | 2015-02-17 | 2018-09-05 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| EP3497087B1 (en) | 2016-08-15 | 2021-11-10 | Neupharma, Inc. | Pyrrolo[1,2-c]pyrimidine, imidazo[1,5-c]pyrimidine, quinazoline, purine and imidazo[1,5-a][1,3,5]triazine derivatives as tyrosine kinase inhibitors for the treatment of cancer |
| CN110386921A (zh) * | 2018-04-23 | 2019-10-29 | 南京药捷安康生物科技有限公司 | 成纤维细胞生长因子受体抑制剂化合物 |
| EP3876930A4 (en) | 2018-11-07 | 2022-07-20 | Dana-Farber Cancer Institute, Inc. | BENZIMIDAZOLE DERIVATIVES AND AZA-BENZIMIDAZOLE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF |
| WO2020097400A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof |
| EP3876939A4 (en) | 2018-11-07 | 2022-08-10 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| CN111574521A (zh) * | 2019-02-18 | 2020-08-25 | 深圳市塔吉瑞生物医药有限公司 | 取代的芳香稠合环衍生物及其组合物及用途 |
| BR112021021738A2 (pt) * | 2019-05-31 | 2021-12-28 | Chiesi Farm Spa | Derivados de amino quinazolina como inibidores de p2x3 |
| CN110724143B (zh) * | 2019-10-09 | 2021-03-23 | 清华大学 | 一种靶向btk蛋白降解化合物的制备及其在治疗自身免疫系统疾病与肿瘤中的应用 |
| GB201915831D0 (en) * | 2019-10-31 | 2019-12-18 | Cancer Research Tech Ltd | Compounds, compositions and therapeutic uses thereof |
| BR112022009881A2 (pt) * | 2019-11-22 | 2022-10-11 | Univ California | Inibidores de caspase 6 e usos dos mesmos |
| WO2021102299A1 (en) * | 2019-11-22 | 2021-05-27 | The Regents Of The University Of California | Caspase 6 inhibitors and uses thereof |
| WO2021138391A1 (en) | 2019-12-30 | 2021-07-08 | Tyra Biosciences, Inc. | Indazole compounds |
| WO2021198981A1 (en) | 2020-04-01 | 2021-10-07 | Janssen Biopharma, Inc. | Antiviral compounds and uses thereof |
| BR112022022409A2 (pt) | 2020-05-06 | 2023-02-07 | Ajax Therapeutics Inc | 6-heteroarilóxi benzimidazóis e azabenzimidazóis como inibidores de jak2 |
| CN115916759B (zh) * | 2020-06-19 | 2025-07-15 | 泰州红云制药有限公司 | 取代喹唑啉类化合物、其制备方法、药物组合及应用 |
| CN115836070B (zh) * | 2020-08-10 | 2024-08-09 | 上海和誉生物医药科技有限公司 | 作为egfr抑制剂的稠环化合物及其制备方法和应用 |
| JP2023538060A (ja) * | 2020-08-17 | 2023-09-06 | 貝達薬業股▲ふん▼有限公司 | 二環化合物、それを含む組成物、及びそれらの使用 |
| WO2022053000A1 (zh) * | 2020-09-10 | 2022-03-17 | 四川海思科制药有限公司 | 一种碳环酰胺衍生物及其在医药上的应用 |
| US12115154B2 (en) | 2020-12-16 | 2024-10-15 | Srx Cardio, Llc | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) |
| US20240100172A1 (en) | 2020-12-21 | 2024-03-28 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| WO2022140527A1 (en) | 2020-12-23 | 2022-06-30 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| CN113603695B (zh) * | 2021-08-05 | 2022-06-14 | 青岛恒宁生物科技有限公司 | 一种取代的嘧啶胺类化合物或其作为农药可接受的盐、组合物及其用途 |
| CA3234638A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| WO2023086320A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of jak2 |
| CN119841806A (zh) * | 2023-10-16 | 2025-04-18 | 中国医学科学院药物研究所 | 多取代的喹唑啉类化合物及其制备方法、用途和药物组合物 |
| WO2025212165A1 (en) * | 2024-04-05 | 2025-10-09 | Board Of Regents Of The University Of Nebraska | Targeted heterobifunctional small molecule proteolysis targeting chimeras |
| WO2025235874A1 (en) * | 2024-05-10 | 2025-11-13 | Schrödinger, Inc. | Heterocyclics as egfr inhibitors |
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| EP3270694A4 (en) | 2015-02-17 | 2018-09-05 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| CN105777759B (zh) * | 2016-04-29 | 2018-01-26 | 杭州和正医药有限公司 | 一种布鲁顿酪氨酸激酶抑制剂 |
| EP3497087B1 (en) | 2016-08-15 | 2021-11-10 | Neupharma, Inc. | Pyrrolo[1,2-c]pyrimidine, imidazo[1,5-c]pyrimidine, quinazoline, purine and imidazo[1,5-a][1,3,5]triazine derivatives as tyrosine kinase inhibitors for the treatment of cancer |
-
2017
- 2017-08-14 EP EP17841949.5A patent/EP3497087B1/en active Active
- 2017-08-14 CA CA3033370A patent/CA3033370A1/en active Pending
- 2017-08-14 CN CN201780063561.8A patent/CN109843858B/zh active Active
- 2017-08-14 WO PCT/US2017/046819 patent/WO2018035061A1/en not_active Ceased
- 2017-08-14 EP EP21201676.0A patent/EP4006035B1/en active Active
- 2017-08-14 US US15/676,852 patent/US10544106B2/en active Active
- 2017-08-14 JP JP2019508173A patent/JP7101165B2/ja not_active Expired - Fee Related
- 2017-08-14 AU AU2017312561A patent/AU2017312561B2/en not_active Ceased
-
2019
- 2019-12-04 US US16/702,936 patent/US11208388B2/en active Active
-
2021
- 2021-10-20 US US17/506,367 patent/US12018002B2/en active Active
-
2022
- 2022-02-07 JP JP2022017081A patent/JP2022058912A/ja not_active Ceased
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