JP2019524772A5 - - Google Patents
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- JP2019524772A5 JP2019524772A5 JP2019505229A JP2019505229A JP2019524772A5 JP 2019524772 A5 JP2019524772 A5 JP 2019524772A5 JP 2019505229 A JP2019505229 A JP 2019505229A JP 2019505229 A JP2019505229 A JP 2019505229A JP 2019524772 A5 JP2019524772 A5 JP 2019524772A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- treating
- disease
- liver
- hyperlipidemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000000034 method Methods 0.000 claims description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 208000031226 Hyperlipidaemia Diseases 0.000 claims description 12
- 208000028867 ischemia Diseases 0.000 claims description 12
- 229920000858 Cyclodextrin Polymers 0.000 claims description 10
- 201000004624 Dermatitis Diseases 0.000 claims description 10
- 208000027418 Wounds and injury Diseases 0.000 claims description 10
- 230000006378 damage Effects 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 10
- 208000014674 injury Diseases 0.000 claims description 10
- 230000004064 dysfunction Effects 0.000 claims description 8
- 208000019423 liver disease Diseases 0.000 claims description 8
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 8
- 210000000056 organ Anatomy 0.000 claims description 8
- 206010040882 skin lesion Diseases 0.000 claims description 8
- -1 cyclic oligosaccharide Chemical class 0.000 claims description 7
- 229920001542 oligosaccharide Polymers 0.000 claims description 7
- 208000001395 Acute radiation syndrome Diseases 0.000 claims description 6
- 201000001320 Atherosclerosis Diseases 0.000 claims description 6
- 206010068142 Radiation sickness syndrome Diseases 0.000 claims description 6
- 206010040047 Sepsis Diseases 0.000 claims description 6
- 208000035475 disorder Diseases 0.000 claims description 6
- 230000003902 lesion Effects 0.000 claims description 6
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 208000017170 Lipid metabolism disease Diseases 0.000 claims description 4
- 206010067125 Liver injury Diseases 0.000 claims description 4
- 150000002009 diols Chemical class 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000006372 lipid accumulation Effects 0.000 claims description 4
- 208000030159 metabolic disease Diseases 0.000 claims description 4
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims description 4
- 231100000234 hepatic damage Toxicity 0.000 claims description 3
- 230000008818 liver damage Effects 0.000 claims description 3
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims description 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 2
- 206010019663 Hepatic failure Diseases 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 206010063837 Reperfusion injury Diseases 0.000 claims description 2
- PIUZYOCNZPYXOA-ZHHJOTBYSA-N [(3s,8s,9s,10r,13r,14s,17r)-17-[(2r)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@H](CCCC(C)(C)O)C)[C@@]1(C)CC2 PIUZYOCNZPYXOA-ZHHJOTBYSA-N 0.000 claims description 2
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims description 2
- 229940043377 alpha-cyclodextrin Drugs 0.000 claims description 2
- 201000008937 atopic dermatitis Diseases 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims description 2
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims description 2
- 210000002216 heart Anatomy 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 claims description 2
- 230000005976 liver dysfunction Effects 0.000 claims description 2
- 208000007903 liver failure Diseases 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 210000000496 pancreas Anatomy 0.000 claims description 2
- 229960005489 paracetamol Drugs 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 235000013772 propylene glycol Nutrition 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 229940097346 sulfobutylether-beta-cyclodextrin Drugs 0.000 claims description 2
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 2
- 230000001771 impaired effect Effects 0.000 claims 4
- 230000037356 lipid metabolism Effects 0.000 claims 2
- 230000013190 lipid storage Effects 0.000 claims 2
- 230000004060 metabolic process Effects 0.000 claims 2
- 231100000444 skin lesion Toxicity 0.000 claims 2
- DTGDZMYNKLTSKC-HKQCOZBKSA-N cholest-5-ene Chemical compound C1C=C2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 DTGDZMYNKLTSKC-HKQCOZBKSA-N 0.000 claims 1
- DTGDZMYNKLTSKC-UHFFFAOYSA-N cholest-5-ene Natural products C1C=C2CCCCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 DTGDZMYNKLTSKC-UHFFFAOYSA-N 0.000 claims 1
- 229910021653 sulphate ion Inorganic materials 0.000 claims 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 11
- 125000000217 alkyl group Chemical group 0.000 description 4
- 230000030833 cell death Effects 0.000 description 3
- 150000005215 alkyl ethers Chemical group 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022122494A JP7487264B2 (ja) | 2016-08-02 | 2022-08-01 | ５－コレステン－３，２５－ジオール，３－サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物 |
| JP2024075682A JP2024105442A (ja) | 2016-08-02 | 2024-05-08 | ５－コレステン－３，２５－ジオール，３－サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662370024P | 2016-08-02 | 2016-08-02 | |
| US62/370,024 | 2016-08-02 | ||
| US201762470578P | 2017-03-13 | 2017-03-13 | |
| US62/470,578 | 2017-03-13 | ||
| PCT/US2017/044840 WO2018026781A1 (en) | 2016-08-02 | 2017-08-01 | Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022122494A Division JP7487264B2 (ja) | 2016-08-02 | 2022-08-01 | ５－コレステン－３，２５－ジオール，３－サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019524772A JP2019524772A (ja) | 2019-09-05 |
| JP2019524772A5 true JP2019524772A5 (https=) | 2020-08-20 |
Family
ID=61073854
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019505229A Pending JP2019524772A (ja) | 2016-08-02 | 2017-08-01 | ５−コレステン−３，２５−ジオール，３−サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物 |
| JP2022122494A Active JP7487264B2 (ja) | 2016-08-02 | 2022-08-01 | ５－コレステン－３，２５－ジオール，３－サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物 |
| JP2024075682A Pending JP2024105442A (ja) | 2016-08-02 | 2024-05-08 | ５－コレステン－３，２５－ジオール，３－サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022122494A Active JP7487264B2 (ja) | 2016-08-02 | 2022-08-01 | ５－コレステン－３，２５－ジオール，３－サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物 |
| JP2024075682A Pending JP2024105442A (ja) | 2016-08-02 | 2024-05-08 | ５－コレステン－３，２５－ジオール，３－サルフェート（２５ｈｃ３ｓ）又は薬学的に許容される塩及び少なくとも１種の環状オリゴ糖を含む組成物 |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US20190269695A1 (https=) |
| EP (2) | EP3494125B1 (https=) |
| JP (3) | JP2019524772A (https=) |
| KR (3) | KR102593667B1 (https=) |
| CN (2) | CN116747233A (https=) |
| AU (2) | AU2017305239C1 (https=) |
| CA (1) | CA3031224A1 (https=) |
| CY (1) | CY1125567T1 (https=) |
| DK (1) | DK3494125T3 (https=) |
| EA (1) | EA201990438A1 (https=) |
| ES (1) | ES2922933T3 (https=) |
| HR (1) | HRP20220932T1 (https=) |
| HU (1) | HUE059768T2 (https=) |
| IL (2) | IL298681A (https=) |
| LT (1) | LT3494125T (https=) |
| MX (2) | MX2019001323A (https=) |
| PL (1) | PL3494125T3 (https=) |
| PT (1) | PT3494125T (https=) |
| RS (1) | RS63529B1 (https=) |
| SI (1) | SI3494125T1 (https=) |
| SM (1) | SMT202200330T1 (https=) |
| TW (1) | TWI815796B (https=) |
| WO (1) | WO2018026781A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006047022A1 (en) | 2004-10-25 | 2006-05-04 | Virginia Commonwealth University | Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis |
| PL3639828T3 (pl) | 2013-12-24 | 2022-05-02 | Virginia Commonwealth University | Zastosowanie utlenowanych siarczanów cholesterolu (ocs) w leczeniu ostrej niewydolności wątroby |
| EP3494125B1 (en) * | 2016-08-02 | 2022-06-22 | Virginia Commonwealth University | Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide |
| BR112022005039A2 (pt) * | 2019-09-30 | 2022-06-21 | Durect Corp | Tratamento de hepatite alcoólica |
| EP4081028A4 (en) * | 2019-12-27 | 2024-03-06 | Durect Corporation | CRYSTALLINE AND LIQUID CRYSTALLINE 25-HYDROXY-CHOLEST-5-EN-3-SULFATE SODIUM AND METHOD FOR THE PRODUCTION THEREOF |
| WO2021163199A1 (en) * | 2020-02-11 | 2021-08-19 | Durect Corporation | Treatment of infectious diseases |
| WO2021202608A1 (en) * | 2020-03-31 | 2021-10-07 | The Regents Of The University Of Michigan | Serum metabolites as biomarkers for carnitine treatment of sepsis |
| CN115916181A (zh) * | 2020-05-22 | 2023-04-04 | 度勒科特公司 | 非酒精性脂肪性肝炎(nash)的治疗 |
| EP4171573A4 (en) * | 2020-06-26 | 2025-04-09 | Durect Corporation | USE OF OXYGENATED CHOLESTEROL SULFATES FOR THE TREATMENT OF NEUROLOGICAL CONDITIONS, NEURODEGENERATIVE DISEASES AND ADDICTION |
| CN112967234B (zh) * | 2021-02-09 | 2022-12-09 | 复旦大学附属中山医院 | 冠状动脉功能生理学病变模式定量评价方法 |
| US20240425545A1 (en) * | 2021-06-25 | 2024-12-26 | Durect Corporation | 25-Hydroxy-Cholest-5-En-3-Sulfate Choline and Methods for Preparing, and Uses of, Same |
| CN113750039B (zh) * | 2021-10-26 | 2023-08-18 | 浙江中医药大学 | 一种黄芩苷-海藻酸钙温敏纳米凝胶、制备方法及其应用 |
| WO2023196412A1 (en) * | 2022-04-06 | 2023-10-12 | Nobias Therapeutics, Inc. | Liquid formulations comprising mitogen-activated protein kinase kinase (mek) inhibitors and methods using same |
| CN119896674A (zh) * | 2023-10-27 | 2025-04-29 | 上海交通大学医学院附属新华医院 | 胆固醇硫酸酯在制备治疗特应性皮炎的药物中的应用 |
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| PL3639828T3 (pl) | 2013-12-24 | 2022-05-02 | Virginia Commonwealth University | Zastosowanie utlenowanych siarczanów cholesterolu (ocs) w leczeniu ostrej niewydolności wątroby |
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| EP3494125B1 (en) | 2016-08-02 | 2022-06-22 | Virginia Commonwealth University | Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide |
| CA3031211A1 (en) | 2016-08-02 | 2018-02-08 | Virginia Commonwealth University | Use of oxygenated cholesterol sulfates (ocs) to treat inflammatory skin disease and skin lesions |
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| BR112022005039A2 (pt) | 2019-09-30 | 2022-06-21 | Durect Corp | Tratamento de hepatite alcoólica |
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| WO2021163199A1 (en) | 2020-02-11 | 2021-08-19 | Durect Corporation | Treatment of infectious diseases |
| AU2021273937A1 (en) | 2020-05-22 | 2022-12-15 | Durect Corporation | Treatment of non-alcoholic steatohepatitis (NASH) |
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| EP4171573A4 (en) | 2020-06-26 | 2025-04-09 | Durect Corporation | USE OF OXYGENATED CHOLESTEROL SULFATES FOR THE TREATMENT OF NEUROLOGICAL CONDITIONS, NEURODEGENERATIVE DISEASES AND ADDICTION |
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