JP2019524675A5 - - Google Patents
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- JP2019524675A5 JP2019524675A5 JP2018568310A JP2018568310A JP2019524675A5 JP 2019524675 A5 JP2019524675 A5 JP 2019524675A5 JP 2018568310 A JP2018568310 A JP 2018568310A JP 2018568310 A JP2018568310 A JP 2018568310A JP 2019524675 A5 JP2019524675 A5 JP 2019524675A5
- Authority
- JP
- Japan
- Prior art keywords
- cysteine
- lysine
- peptide
- valine
- arginine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 30
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- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 27
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 6
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| KR20130049671A (ko) | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
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| US10071079B2 (en) | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
| UA122851C2 (uk) | 2016-12-29 | 2021-01-06 | Ф. Хоффманн-Ля Рош Аг | Сполуки піразолопіримідинів і способи їх застосування |
| KR102645064B1 (ko) * | 2017-02-03 | 2024-03-08 | 한미약품 주식회사 | 지속성이 증가된 생리활성 물질의 결합체 및 이의 용도 |
| EP3862019A4 (en) * | 2018-10-04 | 2022-08-17 | Hanmi Pharm. Co., Ltd. | Therapeutic uses of glucagon and combined product comprising same |
| KR20200078414A (ko) * | 2018-12-21 | 2020-07-01 | 한미약품 주식회사 | 인슐린 및 글루카곤을 포함하는 약학 조성물 |
| CN110551203B (zh) * | 2019-09-25 | 2023-02-10 | 成都奥达生物科技有限公司 | 一种艾塞那肽类似物 |
| JP7761557B2 (ja) * | 2019-10-04 | 2025-10-28 | ハンミ ファーマシューティカル カンパニー リミテッド | グルカゴン、及びｇｌｐ－１受容体及びｇｉｐ受容体二重アゴニストを含む組成物及びその治療学的使用 |
| CN110845601B (zh) * | 2019-10-12 | 2021-01-19 | 广东药科大学 | 不同构型的glp-1类似肽修饰二聚体及其制备方法在治疗ii型糖尿病中的应用 |
| CA3173353A1 (en) * | 2020-04-03 | 2021-10-07 | Jin Bong Lee | Pharmaceutical composition for preventing or treating mucositis induced by radiotherapy, chemotherapy, or combination thereof, comprising glp-2 derivatives or long-acting conjugate of same |
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| EP4181881A1 (en) | 2020-07-14 | 2023-05-24 | Universität Heidelberg | Oral pharmaceutical compositions comprising lipid conjugates |
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-
2017
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- 2017-06-29 WO PCT/KR2017/006922 patent/WO2018004283A2/ko not_active Ceased
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2018
- 2018-12-21 PH PH12018502742A patent/PH12018502742A1/en unknown
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- 2018-12-27 US US16/233,890 patent/US11142559B2/en active Active
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2019
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- 2019-07-24 KR KR1020190089585A patent/KR102395856B1/ko active Active
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2022
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