JP2019521984A5 - - Google Patents
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- JP2019521984A5 JP2019521984A5 JP2018565694A JP2018565694A JP2019521984A5 JP 2019521984 A5 JP2019521984 A5 JP 2019521984A5 JP 2018565694 A JP2018565694 A JP 2018565694A JP 2018565694 A JP2018565694 A JP 2018565694A JP 2019521984 A5 JP2019521984 A5 JP 2019521984A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- pharmaceutically acceptable
- alkyl
- acceptable salt
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 deuterated analog Substances 0.000 claims description 81
- 150000001875 compounds Chemical class 0.000 claims description 62
- 125000000217 alkyl group Chemical group 0.000 claims description 39
- 150000003839 salts Chemical class 0.000 claims description 31
- 239000011780 sodium chloride Substances 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 27
- 125000005843 halogen group Chemical group 0.000 claims description 25
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 23
- 229910052739 hydrogen Inorganic materials 0.000 claims description 21
- 239000001257 hydrogen Substances 0.000 claims description 21
- 125000003545 alkoxy group Chemical group 0.000 claims description 17
- 239000000651 prodrug Substances 0.000 claims description 17
- 229940002612 prodrugs Drugs 0.000 claims description 17
- 201000010099 disease Diseases 0.000 claims description 16
- 201000011510 cancer Diseases 0.000 claims description 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 14
- 125000001072 heteroaryl group Chemical group 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- WTDRDQBEARUVNC-LURJTMIESA-N 3-hydroxy-L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims description 12
- 125000000623 heterocyclic group Chemical group 0.000 claims description 12
- 150000002431 hydrogen Chemical class 0.000 claims description 11
- 206010002026 Amyotrophic lateral sclerosis Diseases 0.000 claims description 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 10
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 9
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 9
- 206010053643 Neurodegenerative disease Diseases 0.000 claims description 8
- 200000000018 inflammatory disease Diseases 0.000 claims description 8
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 7
- 206010000880 Acute myeloid leukaemia Diseases 0.000 claims description 6
- 206010001897 Alzheimer's disease Diseases 0.000 claims description 6
- 206010002556 Ankylosing spondylitis Diseases 0.000 claims description 6
- 206010006187 Breast cancer Diseases 0.000 claims description 6
- 210000003169 Central Nervous System Anatomy 0.000 claims description 6
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 6
- 206010011401 Crohn's disease Diseases 0.000 claims description 6
- 206010012289 Dementia Diseases 0.000 claims description 6
- 208000001187 Dyskinesias Diseases 0.000 claims description 6
- 206010024229 Leprosy Diseases 0.000 claims description 6
- 208000007046 Leukemia, Myeloid, Acute Diseases 0.000 claims description 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 6
- 206010061536 Parkinson's disease Diseases 0.000 claims description 6
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 6
- 206010060862 Prostate cancer Diseases 0.000 claims description 6
- 206010038389 Renal cancer Diseases 0.000 claims description 6
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims description 6
- 201000005787 hematologic cancer Diseases 0.000 claims description 6
- 201000010982 kidney cancer Diseases 0.000 claims description 6
- 201000005202 lung cancer Diseases 0.000 claims description 6
- 201000009251 multiple myeloma Diseases 0.000 claims description 6
- 125000005338 substituted cycloalkoxy group Chemical group 0.000 claims description 6
- 201000006704 ulcerative colitis Diseases 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 5
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims description 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 4
- 125000002944 cyanoaryl group Chemical group 0.000 claims description 4
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 4
- 125000005027 hydroxyaryl group Chemical group 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 102000009784 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Human genes 0.000 claims description 3
- 108010020246 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Proteins 0.000 claims description 3
- 230000001149 cognitive Effects 0.000 claims description 3
- 230000001404 mediated Effects 0.000 claims description 3
- 125000004043 oxo group Chemical group O=* 0.000 claims description 3
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims description 2
- PPGAFAOTXHZHCA-UHFFFAOYSA-N 2-methylpropanenitrile Chemical group C[C](C)C#N PPGAFAOTXHZHCA-UHFFFAOYSA-N 0.000 claims description 2
- 125000002252 acyl group Chemical group 0.000 claims description 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 125000001246 bromo group Chemical group Br* 0.000 claims description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 2
- 125000006317 cyclopropyl amino group Chemical group 0.000 claims description 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 2
- 229910052805 deuterium Inorganic materials 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- QKIUAMUSENSFQQ-UHFFFAOYSA-N dimethylazanide Chemical compound C[N-]C QKIUAMUSENSFQQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000002708 enhancing Effects 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000001188 haloalkyl group Chemical group 0.000 claims description 2
- 125000003106 haloaryl group Chemical group 0.000 claims description 2
- 125000005842 heteroatoms Chemical group 0.000 claims description 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 2
- 230000002757 inflammatory Effects 0.000 claims description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 claims description 2
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims description 2
- 125000004289 pyrazol-3-yl group Chemical group [H]N1N=C(*)C([H])=C1[H] 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 238000010276 construction Methods 0.000 claims 14
- 238000000034 method Methods 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 230000001808 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 238000005859 coupling reaction Methods 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- ZMANZCXQSJIPKH-UHFFFAOYSA-N triethylamine Chemical group CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-methylbenzenesulfonic acid Chemical compound CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 125000000304 alkynyl group Chemical group 0.000 description 2
- UBBRRFLIYRTWNC-UHFFFAOYSA-N CCNc1nc(Nc(c(C2CC2)n2)c[n]2S=O)ncc1C(F)(F)F Chemical compound CCNc1nc(Nc(c(C2CC2)n2)c[n]2S=O)ncc1C(F)(F)F UBBRRFLIYRTWNC-UHFFFAOYSA-N 0.000 description 1
- 0 CCNc1nc(Nc2cc(C(C)(C)[n]3nccn3)n[n]2C(*)(*)*)ncc1Br Chemical compound CCNc1nc(Nc2cc(C(C)(C)[n]3nccn3)n[n]2C(*)(*)*)ncc1Br 0.000 description 1
- VQTCKJUIBCFTNY-UHFFFAOYSA-N CNc1nc(Nc2c[n](C(C3)C3N)nc2C2CC2)ncc1C(F)(F)F Chemical compound CNc1nc(Nc2c[n](C(C3)C3N)nc2C2CC2)ncc1C(F)(F)F VQTCKJUIBCFTNY-UHFFFAOYSA-N 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006011 modification reaction Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662350876P | 2016-06-16 | 2016-06-16 | |
| US62/350,876 | 2016-06-16 | ||
| US201662417151P | 2016-11-03 | 2016-11-03 | |
| US62/417,151 | 2016-11-03 | ||
| US201762476581P | 2017-03-24 | 2017-03-24 | |
| US62/476,581 | 2017-03-24 | ||
| US201762510711P | 2017-05-24 | 2017-05-24 | |
| US62/510,711 | 2017-05-24 | ||
| PCT/US2017/037782 WO2017218843A1 (en) | 2016-06-16 | 2017-06-15 | Pyrimidin-2-ylamino-1h-pyrazols as lrrk2 inhibitors for use in the treatment of neurodegenerative disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019521984A JP2019521984A (ja) | 2019-08-08 |
| JP2019521984A5 true JP2019521984A5 (es) | 2020-07-30 |
| JP7004459B2 JP7004459B2 (ja) | 2022-02-10 |
Family
ID=59216078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018565694A Active JP7004459B2 (ja) | 2016-06-16 | 2017-06-15 | 神経変性疾患の治療に用いるｌｒｒｋ２阻害剤としてのピリミジン－２－イルアミノ－１ｈ－ピラゾール |
Country Status (35)
| Country | Link |
|---|---|
| US (6) | US20170362206A1 (es) |
| EP (2) | EP3472153B1 (es) |
| JP (1) | JP7004459B2 (es) |
| KR (3) | KR20240137707A (es) |
| CN (2) | CN114315819A (es) |
| AU (3) | AU2017286653B2 (es) |
| CA (1) | CA3025672A1 (es) |
| CL (1) | CL2018003597A1 (es) |
| CO (1) | CO2018013585A2 (es) |
| CR (2) | CR20220182A (es) |
| CU (1) | CU24605B1 (es) |
| CY (1) | CY1124789T1 (es) |
| DO (2) | DOP2018000285A (es) |
| EC (1) | ECSP18092481A (es) |
| ES (1) | ES2900368T3 (es) |
| HR (1) | HRP20211923T1 (es) |
| HU (1) | HUE056678T2 (es) |
| IL (3) | IL263484B2 (es) |
| JO (1) | JOP20180113B1 (es) |
| LT (1) | LT3472153T (es) |
| MD (1) | MD3472153T2 (es) |
| MX (3) | MX2018015630A (es) |
| PE (2) | PE20240221A1 (es) |
| PH (1) | PH12018502427A1 (es) |
| PL (1) | PL3472153T3 (es) |
| PT (1) | PT3472153T (es) |
| RS (1) | RS62868B1 (es) |
| SA (2) | SA518400660B1 (es) |
| SG (2) | SG10201912632YA (es) |
| SI (1) | SI3472153T1 (es) |
| TN (1) | TN2018000422A1 (es) |
| TW (1) | TWI786049B (es) |
| UA (1) | UA126231C2 (es) |
| WO (1) | WO2017218843A1 (es) |
| ZA (1) | ZA201900229B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017156493A1 (en) | 2016-03-11 | 2017-09-14 | Denali Therapeutics Inc. | Compounds, compositions, and methods |
| US11214565B2 (en) | 2015-11-20 | 2022-01-04 | Denali Therapeutics Inc. | Compound, compositions, and methods |
| PE20240221A1 (es) | 2016-06-16 | 2024-02-16 | Denali Therapeutics Inc | Pirimidin-2-ilamino-1h-pirazoles como inhibidores de lrrk2 para el uso en el tratamiento de trastornos neurodegenerativos |
| AR113893A1 (es) * | 2017-11-21 | 2020-06-24 | Denali Therapeutics Inc | Polimorfos y formas sólidas de un compuesto de pirimidinilamino-pirazol y métodos de producción |
| AU2018392599A1 (en) | 2017-12-20 | 2020-07-09 | Denali Therapeutics Inc. | Process for the preparation of pyrimidinyl-4-aminopyrazole compounds |
| KR20190131981A (ko) * | 2018-05-18 | 2019-11-27 | 재단법인 대구경북첨단의료산업진흥재단 | 외상성 뇌손상 또는 뇌졸중의 예방 또는 치료용 약학적 조성물 |
| AR118641A1 (es) * | 2019-04-11 | 2021-10-20 | Denali Therapeutics Inc | Compuestos, composiciones y métodos |
| MX2021014705A (es) * | 2019-05-31 | 2022-04-06 | Denali Therapeutics Inc | Formulacion de liberacion modificada de un compuesto de pirimidinilamino-pirazol y metodos de tratamiento. |
| EP3769768A1 (en) | 2019-07-23 | 2021-01-27 | Consejo Superior de Investigaciones Cientificas (CSIC) | Compounds useful for the treatment of parkinson s disease |
| JP2023501949A (ja) * | 2019-10-29 | 2023-01-20 | バイオジェン・エムエイ・インコーポレイテッド | スピロ環ｏ－糖タンパク質－２－アセトアミド－２－デオキシ－３－ｄ－グルコピラノシダーゼ阻害剤 |
| AU2021243887A1 (en) | 2020-03-23 | 2022-11-03 | Korea Research Institute Of Chemical Technology | Novel pyrimidine derivative, and composition for preventing or treating neurodegenerative diseases and cancer, comprising same |
| KR102342803B1 (ko) | 2020-03-23 | 2021-12-24 | 환인제약 주식회사 | 신규한 피리미딘 유도체 및 이를 포함하는 신경퇴행성 질환 및 암의 예방 또는 치료용 조성물 |
| CN114426542B (zh) * | 2020-10-29 | 2023-06-30 | 苏州亚宝药物研发有限公司 | 取代的二芳基胺化合物及其药物组合物、制备方法和用途 |
| US20240207266A1 (en) * | 2021-04-30 | 2024-06-27 | Denali Therapeutics Inc. | Methods for treating and monitoring parkinson's disease |
| BR112023012947A2 (pt) | 2021-10-27 | 2024-04-30 | H Lundbeck As | Inibidores de lrrk2 |
| MX2024007383A (es) | 2021-12-15 | 2024-08-28 | Whan In Pharmaceutical Co Ltd | Derivado de pirimidina macrocíclica, método para preparar el mismo y composición farmacéutica para prevención o tratamiento de una enfermedad neurodegenerativa que contiene el mismo como ingrediente activo. |
| TW202412777A (zh) | 2022-09-15 | 2024-04-01 | 丹麥商Ｈ 朗德貝克公司 | 富白胺酸重複激酶2（lrrk2）抑制劑 |
| WO2024097394A1 (en) | 2022-11-03 | 2024-05-10 | Denali Therapeutics Inc. | Solid and co-crystal forms of a pyrimidine triazole compound |
| CN115894456A (zh) * | 2022-11-13 | 2023-04-04 | 药康众拓(江苏)医药科技有限公司 | 一种氘代吡唑氨基嘧啶类化合物、药物组合物和用途 |
| WO2024112746A1 (en) | 2022-11-22 | 2024-05-30 | Denali Therapeutics Inc. | Processes and intermediates for the preparation of a pyrimidine aminopyrazole compound |
| CN115819405A (zh) * | 2022-12-20 | 2023-03-21 | 沪渝人工智能研究院 | 嘧啶氨基吡唑衍生物及其作为富亮氨酸重复激酶2抑制剂的应用 |
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