JP2019519199A5 - - Google Patents
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- JP2019519199A5 JP2019519199A5 JP2018553410A JP2018553410A JP2019519199A5 JP 2019519199 A5 JP2019519199 A5 JP 2019519199A5 JP 2018553410 A JP2018553410 A JP 2018553410A JP 2018553410 A JP2018553410 A JP 2018553410A JP 2019519199 A5 JP2019519199 A5 JP 2019519199A5
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- Prior art keywords
- seq
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- amino acid
- antibody
- tim
- Prior art date
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 22
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 19
- 230000027455 binding Effects 0.000 claims 18
- 239000000427 antigen Substances 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 125000000539 amino acid group Chemical group 0.000 claims 11
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 5
- 102000049109 human HAVCR2 Human genes 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 230000028327 secretion Effects 0.000 claims 4
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 3
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 238000007799 mixed lymphocyte reaction assay Methods 0.000 claims 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 2
- 102100037850 Interferon gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022128330A JP2022172142A (ja) | 2016-04-12 | 2022-08-10 | 抗ｔｉｍ－３抗体および組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662321476P | 2016-04-12 | 2016-04-12 | |
| US62/321,476 | 2016-04-12 | ||
| PCT/EP2017/058696 WO2017178493A1 (en) | 2016-04-12 | 2017-04-11 | Anti-tim-3 antibodies and compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022128330A Division JP2022172142A (ja) | 2016-04-12 | 2022-08-10 | 抗ｔｉｍ－３抗体および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019519199A JP2019519199A (ja) | 2019-07-11 |
| JP2019519199A5 true JP2019519199A5 (enExample) | 2020-05-14 |
| JP7123804B2 JP7123804B2 (ja) | 2022-08-23 |
Family
ID=58547516
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018553410A Active JP7123804B2 (ja) | 2016-04-12 | 2017-04-11 | 抗ｔｉｍ－３抗体および組成物 |
| JP2022128330A Pending JP2022172142A (ja) | 2016-04-12 | 2022-08-10 | 抗ｔｉｍ－３抗体および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022128330A Pending JP2022172142A (ja) | 2016-04-12 | 2022-08-10 | 抗ｔｉｍ－３抗体および組成物 |
Country Status (34)
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6815329B2 (ja) | 2015-03-23 | 2021-01-20 | バイエル ファーマ アクチエンゲゼルシャフト | 抗ｃｅａｃａｍ６抗体およびその使用 |
| US20190248893A1 (en) | 2016-07-14 | 2019-08-15 | Bristol-Myers Squibb Company | Antibodies against tim3 and uses thereof |
| AU2018247916B2 (en) | 2017-04-05 | 2025-04-24 | Les Laboratoires Servier | Combination therapies targeting PD-1, TIM-3, and LAG-3 |
| AU2018323462A1 (en) | 2017-08-28 | 2020-03-26 | Bristol-Myers Squibb Company | TIM-3 antagonists for the treatment and diagnosis of cancers |
| JP7358361B2 (ja) * | 2018-01-12 | 2023-10-10 | ブリストル－マイヤーズ スクイブ カンパニー | Ｔｉｍ３に対する抗体およびその使用 |
| WO2019179420A1 (en) * | 2018-03-20 | 2019-09-26 | Wuxi Biologics (Shanghai) Co., Ltd. | Novel anti-tim-3 antibodies |
| JP7351845B2 (ja) | 2018-03-23 | 2023-09-27 | ブリストル－マイヤーズ スクイブ カンパニー | Ｍｉｃａおよび／またはｍｉｃｂに対する抗体ならびにそれらの使用 |
| US11807683B2 (en) | 2018-04-12 | 2023-11-07 | Nanjing Leads Biolabs Co., Ltd. | Antibody binding TIM-3 and use thereof |
| US11884725B2 (en) | 2018-04-24 | 2024-01-30 | Ampsource Biopharma Shanghai Inc. | Antibody against TIM-3 and application thereof |
| KR102917630B1 (ko) | 2018-08-21 | 2026-01-27 | 앨버트 아인슈타인 컬리지 오브 메디신 | 인간 Tim-3에 대한 모노클로날 항체 |
| CN111253485A (zh) * | 2018-11-30 | 2020-06-09 | 上海开拓者生物医药有限公司 | 抗人tim-3单克隆抗体及其应用 |
| JP7521163B2 (ja) | 2018-12-19 | 2024-07-24 | ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ | 抗ｃｅａｃａｍ６及びｔｉｍ３抗体の医薬組み合わせ |
| JP2022534982A (ja) | 2019-05-30 | 2022-08-04 | ブリストル－マイヤーズ スクイブ カンパニー | 細胞局在化シグネチャーおよびその使用 |
| US20220363760A1 (en) | 2019-05-30 | 2022-11-17 | Bristol-Myers Squibb Company | Multi-tumor gene signature for suitability to immuno-oncology therapy |
| WO2020243570A1 (en) | 2019-05-30 | 2020-12-03 | Bristol-Myers Squibb Company | Cell localization signature and combination therapy |
| JP2022548627A (ja) * | 2019-09-16 | 2022-11-21 | ノバルティス アーゲー | 骨髄線維症の治療のための、高親和性のリガンドを遮断するヒト化抗ｔ細胞免疫グロブリンドメイン及びムチンドメイン３（ｔｉｍ－３）ｉｇｇ４抗体の使用 |
| KR102572804B1 (ko) * | 2020-02-25 | 2023-08-31 | 국립암센터 | CD11b+ 세포에서 TIM-3의 발현 수준을 측정하는 암 진단 또는 예후 예측을 위한 정보제공 방법 |
| US11807688B2 (en) * | 2020-02-28 | 2023-11-07 | Les Laboratoires Servier | Anti-AXL antibodies and compositions |
| CN113214396B (zh) * | 2020-07-31 | 2022-04-19 | 北京市神经外科研究所 | 抗tim3的单链抗体及其在制备治疗肿瘤的药物中的用途 |
| CN114057874B (zh) * | 2020-07-31 | 2023-05-05 | 北京市神经外科研究所 | 抗cd44的单链抗体及其在制备治疗肿瘤的药物中的用途 |
| IL300916A (en) | 2020-08-31 | 2023-04-01 | Bristol Myers Squibb Co | Cell localization signature and immunotherapy |
| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
| PT4267105T (pt) | 2020-12-28 | 2025-04-30 | Bristol Myers Squibb Co | Composições de anticorpos e métodos de utilização das mesmas |
| AU2021416156A1 (en) | 2020-12-28 | 2023-06-22 | Bristol-Myers Squibb Company | Methods of treating tumors |
| JP2024514530A (ja) | 2021-04-02 | 2024-04-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 切断型ｃｄｃｐ１に対する抗体およびその使用 |
| CN117377692A (zh) | 2021-04-23 | 2024-01-09 | 苏州逻晟生物医药有限公司 | Tim-3-靶向抗体及其用途 |
| CA3222040A1 (en) * | 2021-06-01 | 2022-12-08 | Les Laboratoires Servier | Anti-nkg2a antibodies and compositions |
| JPWO2023286854A1 (enExample) * | 2021-07-16 | 2023-01-19 | ||
| KR20240051162A (ko) | 2021-09-02 | 2024-04-19 | 도이체스크레브스포르슝스젠트룸스티프퉁데스외펜트리헨레크츠 | 부작용이 감소된 항-cecam6 항체 |
| AU2022336665A1 (en) | 2021-09-03 | 2024-03-21 | Oncoone Research & Development Gmbh | IMPROVED Fc SILENCED ANTI-oxMIF ANTIBODIES WITH REDUCED AGGREGATION POTENTIAL AND REDUCED HYDROPHOBICITY |
| US20250206775A1 (en) | 2022-03-18 | 2025-06-26 | Bristol-Myers Squibb Company | Methods of isolating polypeptides |
| AU2023281061A1 (en) | 2022-06-02 | 2024-12-05 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| WO2024224323A1 (en) | 2023-04-24 | 2024-10-31 | King Abdullah University Of Science Of Technology | Compositions, systems and methods for multiplex detection of target biomarkers in a sample |
| CN121712571A (zh) | 2023-08-15 | 2026-03-20 | 百时美施贵宝公司 | 陶瓷羟基磷灰石色谱流通法 |
| CN122459678A (zh) | 2023-12-29 | 2026-07-24 | 百时美施贵宝公司 | KRAS抑制剂与Treg耗竭剂的组合疗法 |
| CN118373913B (zh) * | 2024-05-08 | 2024-11-01 | 上海百英生物科技股份有限公司 | 一种抗人Tim-3单克隆抗体及其制备方法 |
| CN118165111B (zh) * | 2024-05-15 | 2024-08-13 | 中国人民解放军军事科学院军事医学研究院 | 针对Tim-3的抗体 |
| CN121800906A (zh) * | 2026-01-06 | 2026-04-07 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 一种能够增强t细胞功能的tim3蛋白突变体及其应用 |
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2017
- 2017-04-11 CN CN202310660864.5A patent/CN116693685A/zh active Pending
- 2017-04-11 MX MX2018012076A patent/MX2018012076A/es unknown
- 2017-04-11 DK DK17717393.7T patent/DK3443009T3/da active
- 2017-04-11 SI SI201731008T patent/SI3443009T1/sl unknown
- 2017-04-11 TN TNP/2018/000333A patent/TN2018000333A1/en unknown
- 2017-04-11 EP EP21194637.1A patent/EP3978531B1/en active Active
- 2017-04-11 TW TW106112034A patent/TWI752950B/zh active
- 2017-04-11 WO PCT/EP2017/058696 patent/WO2017178493A1/en not_active Ceased
- 2017-04-11 IL IL262176A patent/IL262176B2/en unknown
- 2017-04-11 SG SG11201808724SA patent/SG11201808724SA/en unknown
- 2017-04-11 PH PH1/2018/502112A patent/PH12018502112B1/en unknown
- 2017-04-11 CN CN201780023412.9A patent/CN109451741B/zh active Active
- 2017-04-11 HU HUE17717393A patent/HUE056677T2/hu unknown
- 2017-04-11 PL PL17717393T patent/PL3443009T3/pl unknown
- 2017-04-11 ES ES17717393T patent/ES2900381T3/es active Active
- 2017-04-11 UA UAA201811058A patent/UA126854C2/uk unknown
- 2017-04-11 JP JP2018553410A patent/JP7123804B2/ja active Active
- 2017-04-11 LT LTEPPCT/EP2017/058696T patent/LT3443009T/lt unknown
- 2017-04-11 US US16/093,024 patent/US11390674B2/en active Active
- 2017-04-11 RS RS20211517A patent/RS62736B1/sr unknown
- 2017-04-11 CA CA3020647A patent/CA3020647A1/en active Pending
- 2017-04-11 MY MYPI2018703580A patent/MY199098A/en unknown
- 2017-04-11 EP EP17717393.7A patent/EP3443009B1/en active Active
- 2017-04-11 EA EA201892294A patent/EA039020B1/ru unknown
- 2017-04-11 AU AU2017251250A patent/AU2017251250B2/en active Active
- 2017-04-11 HR HRP20211820TT patent/HRP20211820T1/hr unknown
- 2017-04-11 PT PT177173937T patent/PT3443009T/pt unknown
- 2017-04-11 SG SG10201912937SA patent/SG10201912937SA/en unknown
- 2017-04-11 KR KR1020187032586A patent/KR102473028B1/ko active Active
- 2017-04-11 PE PE2018001979A patent/PE20181805A1/es unknown
- 2017-04-11 MA MA44659A patent/MA44659B1/fr unknown
- 2017-04-11 MD MDE20190216T patent/MD3443009T2/ro unknown
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2018
- 2018-09-27 ZA ZA2018/06429A patent/ZA201806429B/en unknown
- 2018-09-28 CO CONC2018/0010458A patent/CO2018010458A2/es unknown
- 2018-10-09 CL CL2018002878A patent/CL2018002878A1/es unknown
- 2018-10-11 SA SA518400222A patent/SA518400222B1/ar unknown
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2021
- 2021-12-08 CY CY20211101076T patent/CY1125440T1/el unknown
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2022
- 2022-05-11 US US17/741,967 patent/US12577302B2/en active Active
- 2022-08-10 JP JP2022128330A patent/JP2022172142A/ja active Pending