SG11202104518WA - Pharmaceutical combination of anti ceacam6 and tim3 antibodies - Google Patents

Pharmaceutical combination of anti ceacam6 and tim3 antibodies

Info

Publication number
SG11202104518WA
SG11202104518WA SG11202104518WA SG11202104518WA SG11202104518WA SG 11202104518W A SG11202104518W A SG 11202104518WA SG 11202104518W A SG11202104518W A SG 11202104518WA SG 11202104518W A SG11202104518W A SG 11202104518WA SG 11202104518W A SG11202104518W A SG 11202104518WA
Authority
SG
Singapore
Prior art keywords
pharmaceutical combination
tim3 antibodies
ceacam6
anti ceacam6
tim3
Prior art date
Application number
SG11202104518WA
Inventor
Jörg Willuda
Mark Trautwein
Rienk Offringa
Hans-Henning Böhm
Philipp Beckhove
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of SG11202104518WA publication Critical patent/SG11202104518WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11202104518WA 2018-12-19 2019-12-12 Pharmaceutical combination of anti ceacam6 and tim3 antibodies SG11202104518WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18214059 2018-12-19
PCT/EP2019/084849 WO2020126808A1 (en) 2018-12-19 2019-12-12 Pharmaceutical combination of anti ceacam6 and tim3 antibodies

Publications (1)

Publication Number Publication Date
SG11202104518WA true SG11202104518WA (en) 2021-05-28

Family

ID=65009547

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202104518WA SG11202104518WA (en) 2018-12-19 2019-12-12 Pharmaceutical combination of anti ceacam6 and tim3 antibodies

Country Status (12)

Country Link
US (1) US20220089721A1 (en)
EP (1) EP3897844B1 (en)
JP (1) JP2022513246A (en)
KR (1) KR20210104704A (en)
CN (1) CN113164778A (en)
AU (1) AU2019407364A1 (en)
BR (1) BR112021007968A2 (en)
CA (1) CA3123735A1 (en)
IL (1) IL283746B1 (en)
MX (1) MX2021007369A (en)
SG (1) SG11202104518WA (en)
WO (1) WO2020126808A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118043352A (en) 2021-09-02 2024-05-14 德国癌症研究中心公共法律基金会 Anti-CECAM antibody with reduced side effects

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
DE8808645U1 (en) 1988-07-06 1988-08-25 Hofer, Daniel, 7730 Villingen-Schwenningen Display device for fire extinguishers
DOP2006000277A (en) 2005-12-12 2007-08-31 Bayer Pharmaceuticals Corp ANTI MN ANTIBODIES AND METHODS FOR USE
US10131712B2 (en) * 2012-08-14 2018-11-20 Ibc Pharmaceuticals, Inc. Combination therapy with T-cell redirecting bispecific antibodies and checkpoint inhibitors
JP6361039B2 (en) * 2013-04-03 2018-07-25 アイビーシー ファーマスーティカルズ，インコーポレイテッド Combination therapy to induce immune response to disease
JOP20200096A1 (en) * 2014-01-31 2017-06-16 Children’S Medical Center Corp Antibody molecules to tim-3 and uses thereof
CN106132436B (en) * 2014-02-21 2021-06-15 Ibc药品公司 Disease therapy by inducing an immune response to TROP-2 expressing cells
PE20171790A1 (en) 2015-03-23 2017-12-28 Bayer Pharma AG ANTI-CEACAM6 ANTIBODIES AND THEIR USES
MA41867A (en) 2015-04-01 2018-02-06 Anaptysbio Inc T-CELL IMMUNOGLOBULIN AND MUCINE PROTEIN 3 ANTIBODIES (TIM-3)
DK3443009T3 (en) 2016-04-12 2021-12-13 Symphogen As ANTI-HOUR-3 ANTIBODIES AND COMPOSITIONS
SG11201810023QA (en) 2016-05-27 2018-12-28 Agenus Inc Anti-tim-3 antibodies and methods of use thereof
WO2017210058A1 (en) * 2016-06-01 2017-12-07 Ibc Pharmaceuticals, Inc. Combination therapy with t-cell redirecting bispecific antibodies and checkpoint inhibitors
CN117683135A (en) 2016-07-14 2024-03-12 百时美施贵宝公司 Antibodies against TIM3 and uses thereof
JOP20190013A1 (en) 2016-08-25 2019-01-31 Lilly Co Eli Anti-tim-3 antibodies
EP3565594A1 (en) 2017-01-09 2019-11-13 Tesaro Inc. Methods of treating cancer with anti-tim-3 antibodies
WO2020099230A1 (en) * 2018-11-14 2020-05-22 Bayer Aktiengesellschaft Pharmaceutical combination of anti-ceacam6 and either anti-pd-1 or anti-pd-l1 antibodies for the treatment of cancer

Also Published As

Publication number Publication date
AU2019407364A1 (en) 2021-05-27
BR112021007968A2 (en) 2021-09-08
CN113164778A (en) 2021-07-23
IL283746B1 (en) 2024-04-01
JP2022513246A (en) 2022-02-07
KR20210104704A (en) 2021-08-25
IL283746A (en) 2021-07-29
EP3897844A1 (en) 2021-10-27
EP3897844B1 (en) 2023-11-15
CA3123735A1 (en) 2020-06-25
EP3897844C0 (en) 2023-11-15
MX2021007369A (en) 2021-07-15
WO2020126808A1 (en) 2020-06-25
US20220089721A1 (en) 2022-03-24

Similar Documents

Publication Publication Date Title
ZA202004494B (en) Anti-tmprss2 antibodies and antigen-binding fragments
IL278846A (en) Anti-cd3 antibodies and uses thereof
IL276731A (en) Anti-cd73 antibodies and methods of use thereof
EP3621642A4 (en) Human monoclonal antibodies against lag3 and uses thereof
IL269593A (en) Anti-ilt4 antibodies and antigen-binding fragments
IL272274A (en) B7-h4 antibodies and methods of use thereof
IL279974A (en) Bispecific anti-bcma x anti-cd3 antibodies and uses thereof
IL276277A (en) Anti-ctla4 antibodies and methods of making and using the same
IL278821A (en) Anti-sirpa antibodies and methods of use thereof
IL278772A (en) Anti-ox40 antibodies and methods of use
IL275734B (en) Anti-pd-l1 antibodies and uses thereof
IL276790A (en) B7-h4 antibodies and methods of use thereof
IL270214A (en) Anti-sortilin antibodies and methods of use thereof
SG11202106498XA (en) Anti-ctla4 antibodies and methods of use thereof
IL279648A (en) Anti-sirp-beta1 antibodies and methods of use thereof
IL283884A (en) Anti-il-36 antibodies and methods of use thereof
IL280338A (en) Anti-siglec-5 antibodies and methods of use thereof
EP3676294A4 (en) Anti-cd3 antibodies and methods of making and using thereof
EP3645738A4 (en) Anti-pd-l1 antibodies and methods of making and using thereof
IL277296A (en) Anti-pfrh5 antibodies and antigen-binding fragments thereof
IL283746A (en) Pharmaceutical combination of anti ceacam6 and tim3 antibodies
IL279227A (en) Anti-siglec-7 antibodies and methods of use thereof
IL273538A (en) Anti-trkb monoclonal antibodies and methods of use
EP3893930A4 (en) Monoclonal antibodies against human dickkopf3 and uses thereof