JP2019518732A5 - - Google Patents
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- Publication number
- JP2019518732A5 JP2019518732A5 JP2018558728A JP2018558728A JP2019518732A5 JP 2019518732 A5 JP2019518732 A5 JP 2019518732A5 JP 2018558728 A JP2018558728 A JP 2018558728A JP 2018558728 A JP2018558728 A JP 2018558728A JP 2019518732 A5 JP2019518732 A5 JP 2019518732A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- formula
- sleep
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 9
- 230000001788 irregular Effects 0.000 claims 8
- 230000008454 sleep-wake cycle Effects 0.000 claims 8
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 206010012289 Dementia Diseases 0.000 claims 2
- 229920004142 LEXAN™ Polymers 0.000 claims 2
- 239000004418 Lexan Substances 0.000 claims 2
- 230000027288 circadian rhythm Effects 0.000 claims 2
- 230000008451 emotion Effects 0.000 claims 2
- MUGXRYIUWFITCP-PGRDOPGGSA-N (1r,2s)-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-2-(3-fluorophenyl)-n-(5-fluoropyridin-2-yl)cyclopropane-1-carboxamide Chemical compound CC1=NC(C)=NC=C1OC[C@]1(C=2C=C(F)C=CC=2)[C@H](C(=O)NC=2N=CC(F)=CC=2)C1 MUGXRYIUWFITCP-PGRDOPGGSA-N 0.000 claims 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 1
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims 1
- 208000029726 Neurodevelopmental disease Diseases 0.000 claims 1
- 206010062519 Poor quality sleep Diseases 0.000 claims 1
- 206010041349 Somnolence Diseases 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 230000036626 alertness Effects 0.000 claims 1
- 230000003542 behavioural effect Effects 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
- 229950003528 lemborexant Drugs 0.000 claims 1
- 208000027061 mild cognitive impairment Diseases 0.000 claims 1
- 230000000422 nocturnal effect Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021084719A JP7150096B2 (ja) | 2016-05-12 | 2021-05-19 | 概日リズム睡眠障害群を治療する方法 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662335611P | 2016-05-12 | 2016-05-12 | |
| US201662335599P | 2016-05-12 | 2016-05-12 | |
| US62/335,611 | 2016-05-12 | ||
| US62/335,599 | 2016-05-12 | ||
| US201662413976P | 2016-10-27 | 2016-10-27 | |
| US62/413,976 | 2016-10-27 | ||
| US201662414599P | 2016-10-28 | 2016-10-28 | |
| US201662414606P | 2016-10-28 | 2016-10-28 | |
| US62/414,606 | 2016-10-28 | ||
| US62/414,599 | 2016-10-28 | ||
| PCT/US2017/032228 WO2017197160A1 (en) | 2016-05-12 | 2017-05-11 | Methods of treating circadian rhythm sleep disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021084719A Division JP7150096B2 (ja) | 2016-05-12 | 2021-05-19 | 概日リズム睡眠障害群を治療する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019518732A JP2019518732A (ja) | 2019-07-04 |
| JP2019518732A5 true JP2019518732A5 (enExample) | 2020-06-18 |
| JP6888026B2 JP6888026B2 (ja) | 2021-06-16 |
Family
ID=58745465
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018558728A Active JP6888026B2 (ja) | 2016-05-12 | 2017-05-11 | 概日リズム睡眠障害群を治療する方法 |
| JP2021084719A Active JP7150096B2 (ja) | 2016-05-12 | 2021-05-19 | 概日リズム睡眠障害群を治療する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021084719A Active JP7150096B2 (ja) | 2016-05-12 | 2021-05-19 | 概日リズム睡眠障害群を治療する方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11096941B2 (enExample) |
| EP (2) | EP3454859B1 (enExample) |
| JP (2) | JP6888026B2 (enExample) |
| KR (2) | KR20230043227A (enExample) |
| CN (1) | CN109640998A (enExample) |
| AU (3) | AU2017264871B2 (enExample) |
| CA (1) | CA3022068A1 (enExample) |
| ES (1) | ES2904625T3 (enExample) |
| IL (2) | IL291791B2 (enExample) |
| MX (1) | MX379318B (enExample) |
| MY (1) | MY199382A (enExample) |
| RU (1) | RU2763493C2 (enExample) |
| SG (1) | SG11201809527UA (enExample) |
| TW (1) | TWI795359B (enExample) |
| WO (1) | WO2017197160A1 (enExample) |
| ZA (1) | ZA201807903B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2763493C2 (ru) * | 2016-05-12 | 2021-12-29 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Способы лечения расстройств циркадного ритма сна |
| JP2022538170A (ja) * | 2019-06-26 | 2022-08-31 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 睡眠問題の治療のためのレンボレキサント |
| WO2020263253A1 (en) * | 2019-06-26 | 2020-12-30 | Moline Margaret | Lemborexant for treating sleep issues |
| CA3144067A1 (en) * | 2019-06-26 | 2020-12-30 | Eisai R&D Management Co., Ltd. | Lemborexant for treating sleep issues |
| CA3151634A1 (en) * | 2019-09-13 | 2021-03-18 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating insomnia |
| EP4073058A1 (en) * | 2019-12-11 | 2022-10-19 | Teva Czech Industries s.r.o. | Solid state form of lemborexant |
| MX2022008260A (es) * | 2020-01-16 | 2022-08-04 | Eisai R&D Man Co Ltd | Sustancia farmacologica de lemborexant y composicion medicinal que la comprende. |
| CN111450076A (zh) * | 2020-05-25 | 2020-07-28 | 安徽省逸欣铭医药科技有限公司 | 一种Lemborexant软胶囊组合物及其制备方法 |
| CN114159568B (zh) * | 2020-09-11 | 2025-08-01 | 北京原基华毅生物科技有限公司 | Sik抑制剂在制备用于预防和/或治疗睡眠障碍的药物中的应用 |
| EP4376954A1 (en) * | 2021-07-26 | 2024-06-05 | Eisai R&D Management Co., Ltd. | Lemborexant for use in methods of treating irregular sleep-wake rhythm disorder and circadian rhythm sleep disorders associated with neurodegenerative diseases |
| CN116421605B (zh) * | 2022-01-04 | 2024-08-02 | 中国科学院脑科学与智能技术卓越创新中心 | Isx-9在治疗衰老相关的昼夜节律幅度下降和睡眠障碍方面的应用 |
| CA3266968A1 (en) | 2022-09-23 | 2024-03-28 | Eisai R&D Management Co., Ltd. | Methods of reducing neurodegeneration associated with neurodegenerative diseases |
| CN121646412A (zh) | 2023-08-08 | 2026-03-10 | 株式会社明治 | 昼夜节律的调整 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2556753C (en) * | 2004-02-20 | 2014-11-25 | Lifescape Biosciences Incorporated | Compositions and methods for sleep regulation |
| WO2008026149A1 (en) * | 2006-08-28 | 2008-03-06 | Actelion Pharmaceuticals Ltd | 1,4,5,6, 7,8-hexahydro-i^1s-triaza-azulene derivatives as orexin receptor antagonists |
| MY160969A (en) | 2010-09-22 | 2017-03-31 | Eisai R&D Man Co Ltd | Cyclopropane compounds |
| RU2014136339A (ru) * | 2012-02-07 | 2016-03-27 | Иолас Терапьютикс, Инк. | Замещенные пролины/пиперидины как антагонисты орексиновых рецепторов |
| MX376164B (es) * | 2014-10-23 | 2025-03-07 | Eisai R&D Man Co Ltd | Composiciones y metodos para tratar el insomnio. |
| RU2763493C2 (ru) * | 2016-05-12 | 2021-12-29 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Способы лечения расстройств циркадного ритма сна |
-
2017
- 2017-05-11 RU RU2018143809A patent/RU2763493C2/ru active
- 2017-05-11 AU AU2017264871A patent/AU2017264871B2/en active Active
- 2017-05-11 EP EP17725084.2A patent/EP3454859B1/en active Active
- 2017-05-11 WO PCT/US2017/032228 patent/WO2017197160A1/en not_active Ceased
- 2017-05-11 MY MYPI2018002456A patent/MY199382A/en unknown
- 2017-05-11 SG SG11201809527UA patent/SG11201809527UA/en unknown
- 2017-05-11 IL IL291791A patent/IL291791B2/en unknown
- 2017-05-11 CA CA3022068A patent/CA3022068A1/en active Pending
- 2017-05-11 KR KR1020237009013A patent/KR20230043227A/ko not_active Ceased
- 2017-05-11 CN CN201780039758.8A patent/CN109640998A/zh active Pending
- 2017-05-11 EP EP21208238.2A patent/EP4056180A1/en active Pending
- 2017-05-11 US US16/300,335 patent/US11096941B2/en active Active
- 2017-05-11 KR KR1020187035708A patent/KR102511855B1/ko active Active
- 2017-05-11 ES ES17725084T patent/ES2904625T3/es active Active
- 2017-05-11 MX MX2018013663A patent/MX379318B/es unknown
- 2017-05-11 JP JP2018558728A patent/JP6888026B2/ja active Active
- 2017-05-12 TW TW106115904A patent/TWI795359B/zh active
-
2018
- 2018-11-06 IL IL262803A patent/IL262803B/en unknown
- 2018-11-22 ZA ZA2018/07903A patent/ZA201807903B/en unknown
-
2021
- 2021-05-19 JP JP2021084719A patent/JP7150096B2/ja active Active
- 2021-07-27 US US17/443,650 patent/US20210353625A1/en active Pending
-
2023
- 2023-05-31 AU AU2023203418A patent/AU2023203418A1/en not_active Abandoned
-
2025
- 2025-07-10 AU AU2025205336A patent/AU2025205336A1/en active Pending
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