AU2017264871B2 - Methods of treating circadian rhythm sleep disorders - Google Patents

Methods of treating circadian rhythm sleep disorders Download PDF

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Publication number
AU2017264871B2
AU2017264871B2 AU2017264871A AU2017264871A AU2017264871B2 AU 2017264871 B2 AU2017264871 B2 AU 2017264871B2 AU 2017264871 A AU2017264871 A AU 2017264871A AU 2017264871 A AU2017264871 A AU 2017264871A AU 2017264871 B2 AU2017264871 B2 AU 2017264871B2
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Australia
Prior art keywords
sleep
subject
disorder
wake
pharmaceutically acceptable
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AU2017264871A
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AU2017264871A1 (en
Inventor
Carsten T. Beuckmann
Margaret MOLINE
Andrew Satlin
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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Priority to AU2023203418A priority Critical patent/AU2023203418A1/en
Priority to AU2025205336A priority patent/AU2025205336A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2017264871A 2016-05-12 2017-05-11 Methods of treating circadian rhythm sleep disorders Active AU2017264871B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2023203418A AU2023203418A1 (en) 2016-05-12 2023-05-31 Methods of treating circadian rhythm sleep disorders
AU2025205336A AU2025205336A1 (en) 2016-05-12 2025-07-10 Methods of Treating Circadian Rhythm Sleep Disorders

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201662335599P 2016-05-12 2016-05-12
US201662335611P 2016-05-12 2016-05-12
US62/335,611 2016-05-12
US62/335,599 2016-05-12
US201662413976P 2016-10-27 2016-10-27
US62/413,976 2016-10-27
US201662414599P 2016-10-28 2016-10-28
US201662414606P 2016-10-28 2016-10-28
US62/414,606 2016-10-28
US62/414,599 2016-10-28
PCT/US2017/032228 WO2017197160A1 (en) 2016-05-12 2017-05-11 Methods of treating circadian rhythm sleep disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2023203418A Division AU2023203418A1 (en) 2016-05-12 2023-05-31 Methods of treating circadian rhythm sleep disorders

Publications (2)

Publication Number Publication Date
AU2017264871A1 AU2017264871A1 (en) 2018-11-15
AU2017264871B2 true AU2017264871B2 (en) 2023-03-16

Family

ID=58745465

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2017264871A Active AU2017264871B2 (en) 2016-05-12 2017-05-11 Methods of treating circadian rhythm sleep disorders
AU2023203418A Abandoned AU2023203418A1 (en) 2016-05-12 2023-05-31 Methods of treating circadian rhythm sleep disorders
AU2025205336A Pending AU2025205336A1 (en) 2016-05-12 2025-07-10 Methods of Treating Circadian Rhythm Sleep Disorders

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2023203418A Abandoned AU2023203418A1 (en) 2016-05-12 2023-05-31 Methods of treating circadian rhythm sleep disorders
AU2025205336A Pending AU2025205336A1 (en) 2016-05-12 2025-07-10 Methods of Treating Circadian Rhythm Sleep Disorders

Country Status (16)

Country Link
US (2) US11096941B2 (enExample)
EP (2) EP4056180A1 (enExample)
JP (2) JP6888026B2 (enExample)
KR (2) KR102511855B1 (enExample)
CN (2) CN109640998A (enExample)
AU (3) AU2017264871B2 (enExample)
CA (1) CA3022068A1 (enExample)
ES (1) ES2904625T3 (enExample)
IL (2) IL291791B2 (enExample)
MX (1) MX379318B (enExample)
MY (1) MY199382A (enExample)
RU (1) RU2763493C2 (enExample)
SG (1) SG11201809527UA (enExample)
TW (1) TWI795359B (enExample)
WO (1) WO2017197160A1 (enExample)
ZA (1) ZA201807903B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2763493C2 (ru) * 2016-05-12 2021-12-29 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Способы лечения расстройств циркадного ритма сна
MX2021016090A (es) * 2019-06-26 2022-02-03 Eisai R&D Man Co Ltd Lemborexant para el tratamiento de problemas del sueño.
WO2020263253A1 (en) * 2019-06-26 2020-12-30 Moline Margaret Lemborexant for treating sleep issues
JP2022538170A (ja) * 2019-06-26 2022-08-31 エーザイ・アール・アンド・ディー・マネジメント株式会社 睡眠問題の治療のためのレンボレキサント
KR20220061950A (ko) * 2019-09-13 2022-05-13 에자이 알앤드디 매니지먼트 가부시키가이샤 불면증을 치료하기 위한 약제학적 조성물
JP2023506025A (ja) * 2019-12-11 2023-02-14 テバ チェコ インダストリーズ エス．アール．オー． レンボレキサントの固体形態
IL328515A (en) * 2020-01-16 2026-07-01 Eisai R&D Man Co Ltd Lamborxant drug substance and medical preparation containing it
CN111450076A (zh) * 2020-05-25 2020-07-28 安徽省逸欣铭医药科技有限公司 一种Lemborexant软胶囊组合物及其制备方法
CN114159568B (zh) * 2020-09-11 2025-08-01 北京原基华毅生物科技有限公司 Sik抑制剂在制备用于预防和/或治疗睡眠障碍的药物中的应用
WO2023007320A1 (en) * 2021-07-26 2023-02-02 Eisai R&D Mangement Co., Ltd. Lemborexant for use in methods of treating irregular sleep-wake rhythm disorder and circadian rhythm sleep disorders associated with neurodegenerative diseases
CN116421605B (zh) * 2022-01-04 2024-08-02 中国科学院脑科学与智能技术卓越创新中心 Isx-9在治疗衰老相关的昼夜节律幅度下降和睡眠障碍方面的应用
CN120076808A (zh) 2022-09-23 2025-05-30 卫材R&D管理有限公司 减少与神经退行性疾病相关的神经退行性变的方法
JPWO2025033432A1 (enExample) 2023-08-08 2025-02-13

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016063995A1 (en) * 2014-10-23 2016-04-28 Eisai R&D Management Co., Ltd. Compositions and methods for treating insomnia

Family Cites Families (5)

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MXPA06009377A (es) 2004-02-20 2007-03-07 Lifescape Biosciences Inc Composiciones y metodos para regulacion del sueno.
ATE458740T1 (de) * 2006-08-28 2010-03-15 Actelion Pharmaceuticals Ltd 1,4,5,6,7,8-hexahydro-1,2,5-triaza-azulen- derivate als orexinrezeptor-antagonisten
RU2571414C2 (ru) 2010-09-22 2015-12-20 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Циклопропановые соединения
JP6346862B2 (ja) * 2012-02-07 2018-06-20 エオラス セラピューティクス， インコーポレイテッド オレキシンレセプターアンタゴニストとしての置換プロリン／ピペリジン
RU2763493C2 (ru) * 2016-05-12 2021-12-29 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Способы лечения расстройств циркадного ритма сна

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016063995A1 (en) * 2014-10-23 2016-04-28 Eisai R&D Management Co., Ltd. Compositions and methods for treating insomnia

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BOSS, C. et al., "Recent trends in orexin research—2010 to 2015", Bioorganic & Medicinal Chemistry Letters, 2015, vol. 25, pp. 2875-2887 *
Mayo Clinic, "Alzheimer's: Managing sleep problems" (viewed on internet on 3 March 2022) [URL: https://www.mayoclinic.org/healthy-lifestyle/caregivers/in-depth/alzheimers/art-20047832] published on 5 May 2015 as per Wayback Machine *
YOSHIDA, Y. et al., Journal of Medicinal Chemistry, 2015, vol. 58, pp. 4648-4664, DOI: 10.1021/acs.jmedchem.5b00217 *

Also Published As

Publication number Publication date
CA3022068A1 (en) 2017-11-16
AU2017264871A1 (en) 2018-11-15
JP2021120410A (ja) 2021-08-19
AU2025205336A1 (en) 2025-07-31
IL262803B (en) 2022-05-01
US20210353625A1 (en) 2021-11-18
CN109640998A (zh) 2019-04-16
KR20230043227A (ko) 2023-03-30
TW201740952A (zh) 2017-12-01
EP3454859B1 (en) 2021-12-01
RU2763493C2 (ru) 2021-12-29
ZA201807903B (en) 2021-04-28
WO2017197160A1 (en) 2017-11-16
RU2018143809A (ru) 2020-06-15
JP7150096B2 (ja) 2022-10-07
EP4056180A1 (en) 2022-09-14
JP6888026B2 (ja) 2021-06-16
KR20190013820A (ko) 2019-02-11
JP2019518732A (ja) 2019-07-04
TWI795359B (zh) 2023-03-11
BR112018073037A2 (pt) 2019-02-26
MX379318B (es) 2025-03-10
MY199382A (en) 2023-10-25
SG11201809527UA (en) 2018-11-29
NZ748555A (en) 2025-06-27
RU2018143809A3 (enExample) 2020-09-17
IL291791B1 (en) 2025-05-01
US11096941B2 (en) 2021-08-24
IL291791B2 (en) 2025-09-01
CN122208605A (zh) 2026-06-16
IL291791A (en) 2022-06-01
KR102511855B1 (ko) 2023-03-20
US20200179382A1 (en) 2020-06-11
MX2018013663A (es) 2019-07-18
AU2023203418A1 (en) 2023-06-29
IL262803A (en) 2018-12-31
ES2904625T3 (es) 2022-04-05
EP3454859A1 (en) 2019-03-20

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