IL291791B2 - Methods for treating sleep timing disorders - Google Patents
Methods for treating sleep timing disordersInfo
- Publication number
- IL291791B2 IL291791B2 IL291791A IL29179122A IL291791B2 IL 291791 B2 IL291791 B2 IL 291791B2 IL 291791 A IL291791 A IL 291791A IL 29179122 A IL29179122 A IL 29179122A IL 291791 B2 IL291791 B2 IL 291791B2
- Authority
- IL
- Israel
- Prior art keywords
- compound
- pharmaceutically acceptable
- solvate
- acceptable salt
- use according
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662335611P | 2016-05-12 | 2016-05-12 | |
| US201662335599P | 2016-05-12 | 2016-05-12 | |
| US201662413976P | 2016-10-27 | 2016-10-27 | |
| US201662414599P | 2016-10-28 | 2016-10-28 | |
| US201662414606P | 2016-10-28 | 2016-10-28 | |
| PCT/US2017/032228 WO2017197160A1 (en) | 2016-05-12 | 2017-05-11 | Methods of treating circadian rhythm sleep disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL291791A IL291791A (en) | 2022-06-01 |
| IL291791B1 IL291791B1 (en) | 2025-05-01 |
| IL291791B2 true IL291791B2 (en) | 2025-09-01 |
Family
ID=58745465
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL291791A IL291791B2 (en) | 2016-05-12 | 2017-05-11 | Methods for treating sleep timing disorders |
| IL262803A IL262803B (en) | 2016-05-12 | 2018-11-06 | Methods of treating circadian rhythm sleep disorders |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL262803A IL262803B (en) | 2016-05-12 | 2018-11-06 | Methods of treating circadian rhythm sleep disorders |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11096941B2 (enExample) |
| EP (2) | EP4056180A1 (enExample) |
| JP (2) | JP6888026B2 (enExample) |
| KR (2) | KR20230043227A (enExample) |
| CN (1) | CN109640998A (enExample) |
| AU (3) | AU2017264871B2 (enExample) |
| CA (1) | CA3022068A1 (enExample) |
| ES (1) | ES2904625T3 (enExample) |
| IL (2) | IL291791B2 (enExample) |
| MX (1) | MX379318B (enExample) |
| MY (1) | MY199382A (enExample) |
| RU (1) | RU2763493C2 (enExample) |
| SG (1) | SG11201809527UA (enExample) |
| TW (1) | TWI795359B (enExample) |
| WO (1) | WO2017197160A1 (enExample) |
| ZA (1) | ZA201807903B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3022068A1 (en) * | 2016-05-12 | 2017-11-16 | Eisai R&D Management Co., Ltd. | Methods of treating circadian rhythm sleep disorders |
| AU2020307991A1 (en) * | 2019-06-26 | 2022-02-10 | Eisai R&D Management Co., Ltd. | Lemborexant for treating sleep issues |
| JP2022538170A (ja) * | 2019-06-26 | 2022-08-31 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 睡眠問題の治療のためのレンボレキサント |
| WO2020263253A1 (en) * | 2019-06-26 | 2020-12-30 | Moline Margaret | Lemborexant for treating sleep issues |
| CN114502167A (zh) * | 2019-09-13 | 2022-05-13 | 卫材R&D管理有限公司 | 用于治疗失眠的药物组合物 |
| JP2023506025A (ja) * | 2019-12-11 | 2023-02-14 | テバ チェコ インダストリーズ エス．アール．オー． | レンボレキサントの固体形態 |
| KR20220129538A (ko) * | 2020-01-16 | 2022-09-23 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 렘보렉산트의 약물 물질 및 이를 포함하는 의약 조성물 |
| CN111450076A (zh) * | 2020-05-25 | 2020-07-28 | 安徽省逸欣铭医药科技有限公司 | 一种Lemborexant软胶囊组合物及其制备方法 |
| CN114159568B (zh) * | 2020-09-11 | 2025-08-01 | 北京原基华毅生物科技有限公司 | Sik抑制剂在制备用于预防和/或治疗睡眠障碍的药物中的应用 |
| EP4376954A1 (en) * | 2021-07-26 | 2024-06-05 | Eisai R&D Management Co., Ltd. | Lemborexant for use in methods of treating irregular sleep-wake rhythm disorder and circadian rhythm sleep disorders associated with neurodegenerative diseases |
| CN116421605B (zh) * | 2022-01-04 | 2024-08-02 | 中国科学院脑科学与智能技术卓越创新中心 | Isx-9在治疗衰老相关的昼夜节律幅度下降和睡眠障碍方面的应用 |
| TW202425995A (zh) | 2022-09-23 | 2024-07-01 | 日商衛材R&D企管股份有限公司 | 減少與神經退化疾病相關的神經退化的方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016063995A1 (en) * | 2014-10-23 | 2016-04-28 | Eisai R&D Management Co., Ltd. | Compositions and methods for treating insomnia |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1715742A4 (en) | 2004-02-20 | 2009-06-17 | Lifescape Biosciences Inc | COMPOSITIONS AND METHODS FOR SLEEPING |
| WO2008026149A1 (en) * | 2006-08-28 | 2008-03-06 | Actelion Pharmaceuticals Ltd | 1,4,5,6, 7,8-hexahydro-i^1s-triaza-azulene derivatives as orexin receptor antagonists |
| SI2626350T1 (sl) | 2010-09-22 | 2015-09-30 | Eisai R&D Management Co., Ltd. | Spojina ciklopropana |
| EP2811997B1 (en) * | 2012-02-07 | 2018-04-11 | Eolas Therapeutics Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| CA3022068A1 (en) | 2016-05-12 | 2017-11-16 | Eisai R&D Management Co., Ltd. | Methods of treating circadian rhythm sleep disorders |
-
2017
- 2017-05-11 CA CA3022068A patent/CA3022068A1/en active Pending
- 2017-05-11 KR KR1020237009013A patent/KR20230043227A/ko not_active Ceased
- 2017-05-11 RU RU2018143809A patent/RU2763493C2/ru active
- 2017-05-11 US US16/300,335 patent/US11096941B2/en active Active
- 2017-05-11 MY MYPI2018002456A patent/MY199382A/en unknown
- 2017-05-11 CN CN201780039758.8A patent/CN109640998A/zh active Pending
- 2017-05-11 MX MX2018013663A patent/MX379318B/es unknown
- 2017-05-11 SG SG11201809527UA patent/SG11201809527UA/en unknown
- 2017-05-11 ES ES17725084T patent/ES2904625T3/es active Active
- 2017-05-11 IL IL291791A patent/IL291791B2/en unknown
- 2017-05-11 AU AU2017264871A patent/AU2017264871B2/en active Active
- 2017-05-11 EP EP21208238.2A patent/EP4056180A1/en active Pending
- 2017-05-11 WO PCT/US2017/032228 patent/WO2017197160A1/en not_active Ceased
- 2017-05-11 EP EP17725084.2A patent/EP3454859B1/en active Active
- 2017-05-11 KR KR1020187035708A patent/KR102511855B1/ko active Active
- 2017-05-11 JP JP2018558728A patent/JP6888026B2/ja active Active
- 2017-05-12 TW TW106115904A patent/TWI795359B/zh active
-
2018
- 2018-11-06 IL IL262803A patent/IL262803B/en unknown
- 2018-11-22 ZA ZA2018/07903A patent/ZA201807903B/en unknown
-
2021
- 2021-05-19 JP JP2021084719A patent/JP7150096B2/ja active Active
- 2021-07-27 US US17/443,650 patent/US20210353625A1/en active Pending
-
2023
- 2023-05-31 AU AU2023203418A patent/AU2023203418A1/en not_active Abandoned
-
2025
- 2025-07-10 AU AU2025205336A patent/AU2025205336A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016063995A1 (en) * | 2014-10-23 | 2016-04-28 | Eisai R&D Management Co., Ltd. | Compositions and methods for treating insomnia |
Non-Patent Citations (3)
| Title |
|---|
| BOSS, CHRISTOPH, ET AL.:, RECENT TRENDS IN OREXIN RESEARCH—2010 TO 2015., 15 May 2015 (2015-05-15) * |
| MUSIEK, ERIK S ET AL., SLEEP, CIRCADIAN RHYTHMS, AND THE PATHOGENESIS OF ALZHEIMER DISEASE, 13 March 2015 (2015-03-13) * |
| YOSHIDA, YU, ET AL.:, DISCOVERY OF (1 R, 2 S)-2-{[(2, 4-DIMETHYLPYRIMIDIN-5-YL) OXY] METHYL}-2-(3-FLUOROPHENYL)-N-(5-FLUOROPYRIDIN-2-YL) CYCLOPROPANECARBOXAMIDE (E2006): A POTENT AND EFFICACIOUS ORAL OREXIN RECEPTOR ANTAGONIST, 11 June 2015 (2015-06-11) * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL291791B1 (en) | Methods for treating sleep timing disorders | |
| JP2019518732A5 (enExample) | ||
| Ang et al. | Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders | |
| Adamchic et al. | Acute effects and after-effects of acoustic coordinated reset neuromodulation in patients with chronic subjective tinnitus | |
| JP2020528075A5 (enExample) | ||
| RU2680247C2 (ru) | Средство, усиливающее эффект реабилитации после нервного повреждения, которое содержит производное простого алкилового эфира или его соль | |
| PH12021553232A1 (en) | 2h-indazole derivatives and their use in the treatment of disease | |
| Bennett et al. | Therapeutic hypothermia for status epilepticus: a report, historical perspective, and review | |
| Carano et al. | Glycopyrrolate and theophylline for the treatment of severe pallid breath-holding spells | |
| WO2023108170A3 (en) | Systems, devices, and methods for enhancing the neuroprotective effects of non-invasive gamma stimulation with pharmacological agents | |
| ATE482711T1 (de) | Kombinationsprodukt mit einem antagonisten oder inversen agonisten von histamine-rezeptor h3 und einem antipsychotischen oder antidepressiven mittel, und ihre verwendung zur herstellung eines medikaments zur verhinderung der nachteiligen wirkungen von psychotropika | |
| Bhat et al. | Increasing off-time improves sleep-disordered breathing induced by vagal nerve stimulation | |
| PH12022552763A1 (en) | Medical use of daridorexant | |
| NZ748555B2 (en) | Methods of treating circadian rhythm sleep disorders | |
| Roth et al. | Effects of medial thalamotomy and pallido-thalamic tractotomy on sleep and waking EEG in pain and Parkinsonian patients | |
| MX2020012912A (es) | Método de tratamiento con el agonista inverso del receptor de histamina-3. | |
| Khachatryan et al. | Sleep-onset central apneas as triggers of severe nocturnal seizures | |
| Peyvandi et al. | Comparison of Peritonsillar Infiltration of Lidocaine and Bupivacaine for Management of Postoperative Pain of Tonsillectomy | |
| Millichap et al. | Controlled evaluation of primidone and diphenylhydantoin sodium: comparative anticonvulsant efficacy and toxicity in children | |
| Langenbruch et al. | P138. Acute onset and reversibility of triphasic waves in the EEG correlating with hypercapnia | |
| Pedrera-Mazarro et al. | Nocturnal panic attacks | |
| Kanzaki et al. | The damped pendular rotation test in central vestibular disorders | |
| Sergeeva et al. | Effect of adrenoblockers on slow (LF) waves in rabbit heart rate | |
| Deak | Sleep and neurological disorders | |
| Preisig et al. | Mental disorders and cardio-vascular risk factors: Results of a population-based survey |