JP2019518569A5 - - Google Patents
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- Publication number
- JP2019518569A5 JP2019518569A5 JP2018567639A JP2018567639A JP2019518569A5 JP 2019518569 A5 JP2019518569 A5 JP 2019518569A5 JP 2018567639 A JP2018567639 A JP 2018567639A JP 2018567639 A JP2018567639 A JP 2018567639A JP 2019518569 A5 JP2019518569 A5 JP 2019518569A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- esophagus
- target area
- item
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 claims description 47
- 210000003238 esophagus Anatomy 0.000 claims description 30
- 150000001413 amino acids Chemical class 0.000 claims description 13
- 208000007217 Esophageal Stenosis Diseases 0.000 claims description 12
- 206010030194 Oesophageal stenosis Diseases 0.000 claims description 12
- 230000002265 prevention Effects 0.000 claims description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 11
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 7
- 230000029663 wound healing Effects 0.000 claims description 7
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 101800002011 Amphipathic peptide Proteins 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 230000002209 hydrophobic effect Effects 0.000 claims description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 3
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 3
- 239000000920 calcium hydroxide Substances 0.000 claims description 3
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 3
- 239000007951 isotonicity adjuster Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000001632 sodium acetate Substances 0.000 claims description 3
- 235000017281 sodium acetate Nutrition 0.000 claims description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 229910052979 sodium sulfide Inorganic materials 0.000 claims description 3
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 claims description 3
- 235000000346 sugar Nutrition 0.000 claims description 3
- 150000008163 sugars Chemical class 0.000 claims description 3
- 238000012323 Endoscopic submucosal dissection Methods 0.000 claims description 2
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims description 2
- 101800003838 Epidermal growth factor Proteins 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims description 2
- 239000003513 alkali Substances 0.000 claims description 2
- 208000035269 cancer or benign tumor Diseases 0.000 claims description 2
- 239000003246 corticosteroid Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 238000012326 endoscopic mucosal resection Methods 0.000 claims description 2
- 238000012143 endoscopic resection Methods 0.000 claims description 2
- 238000001839 endoscopy Methods 0.000 claims description 2
- 229940116977 epidermal growth factor Drugs 0.000 claims description 2
- 230000010393 epithelial cell migration Effects 0.000 claims description 2
- 210000003236 esophagogastric junction Anatomy 0.000 claims description 2
- 230000003176 fibrotic effect Effects 0.000 claims description 2
- 230000035876 healing Effects 0.000 claims description 2
- 239000000017 hydrogel Substances 0.000 claims description 2
- 230000002757 inflammatory effect Effects 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 230000005855 radiation Effects 0.000 claims description 2
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical group O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 claims description 2
- 229960005294 triamcinolone Drugs 0.000 claims description 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical group C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims 63
- 210000004027 cell Anatomy 0.000 claims 1
- 230000015271 coagulation Effects 0.000 claims 1
- 238000005345 coagulation Methods 0.000 claims 1
- 159000000011 group IA salts Chemical class 0.000 claims 1
- 230000037309 reepithelialization Effects 0.000 claims 1
- 239000012266 salt solution Substances 0.000 claims 1
- 150000001447 alkali salts Chemical class 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021192987A JP2022023249A (ja) | 2016-06-27 | 2021-11-29 | 内視鏡的剥離術後の食道狭窄を予防するための自己集合性ペプチドマトリックス |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662355111P | 2016-06-27 | 2016-06-27 | |
| US62/355,111 | 2016-06-27 | ||
| PCT/US2017/039407 WO2018005427A1 (en) | 2016-06-27 | 2017-06-27 | Self-assembling peptide matrix for the prevention of esophageal stricture after endoscopic dissection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021192987A Division JP2022023249A (ja) | 2016-06-27 | 2021-11-29 | 内視鏡的剥離術後の食道狭窄を予防するための自己集合性ペプチドマトリックス |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019518569A JP2019518569A (ja) | 2019-07-04 |
| JP2019518569A5 true JP2019518569A5 (enExample) | 2020-07-30 |
Family
ID=59295359
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567639A Withdrawn JP2019518569A (ja) | 2016-06-27 | 2017-06-27 | 内視鏡的剥離術後の食道狭窄を予防するための自己集合性ペプチドマトリックス |
| JP2021192987A Pending JP2022023249A (ja) | 2016-06-27 | 2021-11-29 | 内視鏡的剥離術後の食道狭窄を予防するための自己集合性ペプチドマトリックス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021192987A Pending JP2022023249A (ja) | 2016-06-27 | 2021-11-29 | 内視鏡的剥離術後の食道狭窄を予防するための自己集合性ペプチドマトリックス |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20190358290A1 (enExample) |
| EP (1) | EP3474880A1 (enExample) |
| JP (2) | JP2019518569A (enExample) |
| CN (1) | CN109996553A (enExample) |
| AU (1) | AU2017289150A1 (enExample) |
| BR (1) | BR112018077219A2 (enExample) |
| CA (1) | CA3029455A1 (enExample) |
| WO (1) | WO2018005427A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021529024A (ja) * | 2018-06-21 | 2021-10-28 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 食道粘膜下流体クッションとしての細胞外マトリックス（ｅｃｍ）ヒドロゲルの使用 |
| AU2019288588B2 (en) | 2018-06-21 | 2024-06-13 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Extracellular matrix (ECM) hydrogel as a submucosal fluid cushion |
| WO2021202577A1 (en) | 2020-03-31 | 2021-10-07 | 3-D Matrix, Ltd. | Sterilization of self-assembling peptides by irradiation |
| RU2751285C1 (ru) * | 2020-07-22 | 2021-07-12 | Федеральное государственное бюджетное научное учреждение "Российский научный центр хирургии имени академика Б.В. Петровского" | Способ хирургического лечения стриктур пищеводных анастомозов |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050245788A1 (en) * | 2004-04-28 | 2005-11-03 | Medtronic, Inc. | Esophageal delivery system and method with position indexing |
| US9162005B2 (en) * | 2005-04-25 | 2015-10-20 | Arch Biosurgery, Inc. | Compositions for prevention of adhesions and other barrier applications |
| JP5263756B2 (ja) * | 2005-09-30 | 2013-08-14 | 国立大学法人 岡山大学 | 細胞の培養方法および細胞培養物 |
| US20150105336A1 (en) * | 2012-03-09 | 2015-04-16 | 3-D Matrix, Ltd. | Mucosa-elevating agent |
| KR20160003651A (ko) * | 2013-03-14 | 2016-01-11 | 가부시끼가이샤 쓰리디 매트릭스 | 위장 폐색 예방용 물질 |
| CA2939696C (en) * | 2014-03-10 | 2023-01-10 | 3-D Matrix, Ltd. | Self-assembling peptide compositions |
-
2017
- 2017-06-27 WO PCT/US2017/039407 patent/WO2018005427A1/en not_active Ceased
- 2017-06-27 CN CN201780052885.1A patent/CN109996553A/zh active Pending
- 2017-06-27 EP EP17736859.4A patent/EP3474880A1/en not_active Withdrawn
- 2017-06-27 CA CA3029455A patent/CA3029455A1/en not_active Abandoned
- 2017-06-27 AU AU2017289150A patent/AU2017289150A1/en not_active Abandoned
- 2017-06-27 BR BR112018077219-4A patent/BR112018077219A2/pt not_active IP Right Cessation
- 2017-06-27 JP JP2018567639A patent/JP2019518569A/ja not_active Withdrawn
- 2017-06-27 US US16/312,878 patent/US20190358290A1/en not_active Abandoned
-
2021
- 2021-11-29 JP JP2021192987A patent/JP2022023249A/ja active Pending
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