|
IL104314A0
(en)
*
|
1992-01-07 |
1993-05-13 |
Novo Nordisk As |
Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them
|
|
US5489508A
(en)
|
1992-05-13 |
1996-02-06 |
University Of Texas System Board Of Regents |
Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
|
|
US5643890A
(en)
|
1995-01-31 |
1997-07-01 |
The Board Of Regents Of The University Of Nebraska |
Synthetic oligonucleotides which mimic telomeric sequences for use in treatment of cancer and other diseases
|
|
WO1998055495A2
(en)
|
1997-06-06 |
1998-12-10 |
Dynavax Technologies Corporation |
Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
|
|
US6551795B1
(en)
*
|
1998-02-18 |
2003-04-22 |
Genome Therapeutics Corporation |
Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
|
|
EP1181304B1
(en)
|
1999-04-08 |
2007-10-10 |
Antisoma Research Limited |
Antiproliferative activity of g-righ oligonucleotides and method of using same to bind to nucleolin
|
|
SK287400B6
(sk)
|
1999-09-25 |
2010-08-09 |
University Of Iowa Research Foundation |
Prostriedok s obsahom imunostimulačnej nukleovej kyseliny a jeho použitie na stimuláciu imunitnej reakcie
|
|
MXPA00011713A
(es)
*
|
2000-11-28 |
2002-05-31 |
Tgt Lab S A De C V |
Vectores recombinantes virales y no virales conteniendo el gen humano del activador de plasminogeno derivado de urocinasa y su utilidad en el tratamiento de diversos tipos de fibrosis hepatica, renal, pulmonar, pancreatica, cardiaca y cicatrices hipe
|
|
AU2002241952A1
(en)
|
2001-01-22 |
2002-07-30 |
Genta Incorporated |
Cell-proliferative disorder treatments using cre decoy oligomers, bcl-2 antisense and hybrid oligomers
|
|
US7514414B2
(en)
|
2001-09-24 |
2009-04-07 |
The United States Of America As Represented By The Department Of Health And Human Services |
Suppressors of CpG oligonucleotides and methods of use
|
|
WO2004012669A2
(en)
|
2002-08-01 |
2004-02-12 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method of treating inflammatory arthropathies with suppressors of cpg oligonucleotides
|
|
US8153141B2
(en)
|
2002-04-04 |
2012-04-10 |
Coley Pharmaceutical Gmbh |
Immunostimulatory G, U-containing oligoribonucleotides
|
|
US7357928B2
(en)
|
2002-04-08 |
2008-04-15 |
University Of Louisville Research Foundation, Inc. |
Method for the diagnosis and prognosis of malignant diseases
|
|
WO2003103586A2
(en)
|
2002-06-05 |
2003-12-18 |
Coley Pharmaceutical Group, Inc. |
Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory cpg nucleic acids
|
|
US8043622B2
(en)
|
2002-10-08 |
2011-10-25 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides
|
|
US7790867B2
(en)
|
2002-12-05 |
2010-09-07 |
Rosetta Genomics Inc. |
Vaccinia virus-related nucleic acids and microRNA
|
|
US20050013812A1
(en)
|
2003-07-14 |
2005-01-20 |
Dow Steven W. |
Vaccines using pattern recognition receptor-ligand:lipid complexes
|
|
US20050239733A1
(en)
|
2003-10-31 |
2005-10-27 |
Coley Pharmaceutical Gmbh |
Sequence requirements for inhibitory oligonucleotides
|
|
US20050255451A1
(en)
|
2003-12-16 |
2005-11-17 |
Eicke Latz |
Toll-like receptor 9 modulators
|
|
CN1989439B
(zh)
|
2004-05-06 |
2010-12-29 |
美国政府健康及人类服务部 |
治疗葡萄膜炎的方法以及组合物
|
|
CA2566519C
(en)
|
2004-05-14 |
2020-04-21 |
Rosetta Genomics Ltd. |
Micrornas and uses thereof
|
|
JP2008500039A
(ja)
|
2004-05-26 |
2008-01-10 |
ロゼッタ ジノミクス リミテッド |
ウイルスｍｉＲＮＡおよびウイルス関連ｍｉＲＮＡならびにその使用
|
|
JP2008514187A
(ja)
|
2004-09-01 |
2008-05-08 |
ダイナバックス テクノロジーズ コーポレイション |
先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物
|
|
JP2008000001A
(ja)
|
2004-09-30 |
2008-01-10 |
Osaka Univ |
免疫刺激オリゴヌクレオチドおよびその医薬用途
|
|
EP1836218A2
(en)
|
2004-12-17 |
2007-09-26 |
Dynavax Technologies Corporation |
Methods and compositions for induction or promotion of immune tolerance
|
|
US20070077231A1
(en)
*
|
2005-09-30 |
2007-04-05 |
Contag Christopher H |
Immune effector cells pre-infected with oncolytic virus
|
|
ES2544877T3
(es)
|
2005-10-12 |
2015-09-04 |
Idera Pharmaceuticals |
Compuestos oligonucleótidos inmuno reguladores (IRO) para modular la respuesta inmune basada en receptor semejante a Toll
|
|
CA2636424A1
(en)
|
2006-01-09 |
2007-10-25 |
The Regents Of The University Of California |
Immunostimulatory combinations of tnfrsf, tlr, nlr, rhr, purinergic receptor, and cytokine receptor agonists for vaccines and tumor immunotherapy
|
|
US8298818B2
(en)
*
|
2006-04-28 |
2012-10-30 |
University Of Florida Research Foundation, Inc. |
Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter
|
|
CN101489382A
(zh)
|
2006-06-13 |
2009-07-22 |
贝希尔治疗学股份有限公司 |
多核苷酸疗法
|
|
US8377898B2
(en)
|
2006-10-12 |
2013-02-19 |
Idera Pharmaceuticals, Inc. |
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
|
|
WO2008076981A2
(en)
|
2006-12-15 |
2008-06-26 |
Board Of Regents, The University Of Texas System |
Inhibitors of ll-37- mediated immune reactivity to self nucleic acids
|
|
JP2010519899A
(ja)
|
2007-03-01 |
2010-06-10 |
ロゼッタ ゲノミックス エルティーディー． |
肺扁平上皮癌とその他の非小細胞肺癌とを見分けるための方法
|
|
WO2009006141A2
(en)
|
2007-07-05 |
2009-01-08 |
Bausch & Lomb Incorporated |
Authority to read as follows: compositions and methods for treating or controlling infections of the eye a sequelae thereof
|
|
US7879812B2
(en)
|
2007-08-06 |
2011-02-01 |
University Of Iowa Research Foundation |
Immunomodulatory oligonucleotides and methods of use therefor
|
|
MX2010001785A
(es)
|
2007-08-15 |
2010-03-10 |
Idera Pharmaceuticals Inc |
Moduladores de receptores tipo larga distancia.
|
|
CA2703931C
(en)
|
2007-10-26 |
2016-08-16 |
Dynavax Technologies Corporation |
Methods and compositions for inhibition of immune responses and autoimmunity
|
|
WO2009089399A2
(en)
|
2008-01-10 |
2009-07-16 |
Bausch & Lomb Incorporated |
Compositions comprising toll-like receptor or coreceptor antagonists and methods for ocular neuroprotection
|
|
WO2009089401A2
(en)
|
2008-01-10 |
2009-07-16 |
Bausch & Lomb Incorporated |
Compositions comprising toll-like receptor or coreceptor antagonists and methods for treating or controlling ocular allergy using same
|
|
WO2009143292A2
(en)
|
2008-05-21 |
2009-11-26 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method of treating pneumoconiosis with oligodeoxynucleotides
|
|
JP5415724B2
(ja)
*
|
2008-08-05 |
2014-02-12 |
長春華普生物技術有限公司 |
一種のオリゴヌクレオチド及びその応用
|
|
US8030289B2
(en)
|
2008-08-06 |
2011-10-04 |
Changchun Huapu Biotechnology Co., Ltd. |
Oligonucleotide and use thereof
|
|
WO2010034779A2
(en)
*
|
2008-09-24 |
2010-04-01 |
The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin |
Composition and method for treatment of preterm labor
|
|
GB0906130D0
(en)
|
2008-10-03 |
2009-05-20 |
Procrata Biosystems Ltd |
Transcription factor decoys
|
|
AU2009302468A1
(en)
|
2008-10-06 |
2010-04-15 |
Idera Pharmaceuticals, Inc. |
Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto
|
|
US8053422B2
(en)
|
2008-12-04 |
2011-11-08 |
The United States Of America As Represented By The Department Of Health And Human Services |
Anti-cancer oligodeoxynucleotides
|
|
WO2010108035A1
(en)
*
|
2009-03-18 |
2010-09-23 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating toxic and proinflammatory effects
|
|
US8728458B2
(en)
|
2009-04-30 |
2014-05-20 |
The Regents Of The University Of California |
Combination anti-HIV vectors, targeting vectors, and methods of use
|
|
US8987221B2
(en)
|
2009-06-01 |
2015-03-24 |
Idera Pharmaceuticals, Inc. |
Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (IRO) antagonists of TLR7 and TLR9
|
|
US20110070241A1
(en)
|
2009-06-30 |
2011-03-24 |
Duke University |
Methods for modulating immune responses to aav gene therapy vectors
|
|
WO2011005942A2
(en)
|
2009-07-08 |
2011-01-13 |
Idera Pharmaceuticals, Inc. |
Oligonucleotide-based compounds as inhibitors of toll-like receptors
|
|
CN101712957B
(zh)
*
|
2009-11-25 |
2011-11-23 |
中国人民解放军第三军医大学第一附属医院 |
Toll样受体9阻断剂及应用
|
|
US8771669B1
(en)
*
|
2010-02-09 |
2014-07-08 |
David Gordon Bermudes |
Immunization and/or treatment of parasites and infectious agents by live bacteria
|
|
EP2561075B1
(en)
|
2010-04-23 |
2018-06-27 |
University of Massachusetts |
Aav-based treatment of cholesterol-related disorders
|
|
CN103153346A
(zh)
|
2010-06-16 |
2013-06-12 |
戴纳瓦克斯技术公司 |
使用tlr7和/或tlr9抑制剂的治疗方法
|
|
JP5921535B2
(ja)
|
2010-06-16 |
2016-05-24 |
ディナバックス テクノロジーズ コーポレイション |
Ｔｌｒ７および／またはｔｌｒ９阻害剤を用いる治療の方法
|
|
GB201014026D0
(en)
|
2010-08-20 |
2010-10-06 |
Ucl Business Plc |
Treatment
|
|
WO2012051491A1
(en)
*
|
2010-10-14 |
2012-04-19 |
The United States Of America, As Represented By The Secretary National Institutes Of Health |
Compositions and methods for controlling neurotropic viral pathogenesis by micro-rna targeting
|
|
KR101985382B1
(ko)
|
2010-11-19 |
2019-06-03 |
이데라 파마슈티칼즈, 인코포레이티드 |
톨-유사 수용체 기반 면역 반응을 조절하기 위한 면역 조절 올리고뉴클레오타이드(ｉｒｏ) 화합물
|
|
US20140378531A1
(en)
|
2012-02-01 |
2014-12-25 |
New York University |
Inhibition of pattern recognition receptors in pancreatic cancer treatment using tlr inhibitors
|
|
AR091569A1
(es)
|
2012-06-28 |
2015-02-11 |
Intervet Int Bv |
Receptores de tipo toll
|
|
US9636370B2
(en)
|
2012-09-28 |
2017-05-02 |
The University Of North Carolina At Chapel Hill |
AAV vectors targeted to oligodendrocytes
|
|
CN102925485B
(zh)
|
2012-11-09 |
2014-07-09 |
中国农业科学院兰州兽医研究所 |
双表达的aav重组病毒的制备方法
|
|
KR102027023B1
(ko)
|
2012-11-29 |
2019-09-30 |
에스비아이 바이오테크 가부시키가이샤 |
저해성 올리고뉴클레오티드 및 그의 용도
|
|
US9453209B2
(en)
*
|
2012-12-27 |
2016-09-27 |
Sierra Sciences, Llc |
Enhancing health in mammals using telomerase reverse transcriptase gene therapy
|
|
KR101898177B1
(ko)
|
2013-01-08 |
2018-09-12 |
이데라 파마슈티칼즈, 인코포레이티드 |
톨－유사 수용체 기반 면역 반응을 조절하기 위한 면역 조절 올리고누클레오티드 （ｉｒｏ） 화합물
|
|
US20140271550A1
(en)
*
|
2013-03-14 |
2014-09-18 |
The Trustees Of The University Of Pennsylvania |
Constructs and Methods for Delivering Molecules via Viral Vectors with Blunted Innate Immune Responses
|
|
JP2017500313A
(ja)
|
2013-12-09 |
2017-01-05 |
ブレット バイオテクノロジー， インコーポレーテッドＢｕｌｌｅｔ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， Ｉｎｃ． |
特異的ウイルス様粒子−ＣｐＧオリゴヌクレオチドワクチンおよびその使用
|
|
WO2015109391A1
(en)
|
2014-01-24 |
2015-07-30 |
Children's Hospital Of Eastern Ontario Research Institute Inc. |
Smc combination therapy for the treatment of cancer
|
|
WO2015183943A2
(en)
|
2014-05-27 |
2015-12-03 |
Trustees Of Boston University |
Inhibitors of fibroproliferative disorders and cancer
|
|
EP2982756A1
(en)
|
2014-08-04 |
2016-02-10 |
Berlin Cures Holding AG |
Aptamers for use against autoantibody-associated diseases
|
|
CA2970927A1
(en)
|
2014-10-31 |
2016-05-06 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Tlr9 targeted cytotoxic agents
|
|
US9688993B2
(en)
|
2015-02-13 |
2017-06-27 |
Idera Pharmaceuticals, Inc. |
Toll-like receptor 9 antagonist and methods of use thereof
|
|
WO2016149612A2
(en)
|
2015-03-19 |
2016-09-22 |
The Johns Hopkins University |
Assay for telomere length regulators
|
|
US10775367B2
(en)
|
2015-04-15 |
2020-09-15 |
Ji Hoon Lee |
Aptasensor and method of detecting target material
|
|
WO2016183370A1
(en)
|
2015-05-13 |
2016-11-17 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Synthetic immunosuppressive oligodeoxynucleotides reduce ischemic tissue damage
|
|
EP3329004B1
(en)
|
2015-07-29 |
2020-01-15 |
IFOM Fondazione Istituto Firc di Oncologia Molecolare |
Therapeutic oligonucleotides
|
|
ES2770367T3
(es)
|
2015-11-18 |
2020-07-01 |
Inserm - Institut National De La Santé Et De La Rech Médicale |
Métodos y composiciones farmacéuticas para tratar la rabdomiólisis
|
|
US10806749B2
(en)
|
2015-12-25 |
2020-10-20 |
Sbi Biotech Co., Ltd. |
TLR inhibitory oligonucleotides and their use
|
|
CN105597079A
(zh)
*
|
2016-01-11 |
2016-05-25 |
中国人民解放军第三军医大学第一附属医院 |
用于治疗银屑病的药物
|
|
US10124062B2
(en)
|
2016-02-26 |
2018-11-13 |
The United States Of America As Represented By The Department Of Veterans Affairs |
Methods of treating, inhibiting and/or preventing an auditory impairment
|
|
US11339396B2
(en)
|
2016-06-08 |
2022-05-24 |
President And Fellows Of Harvard College |
Engineered viral vector reduces induction of inflammatory and immune responses
|
|
CN109983129A
(zh)
|
2016-11-23 |
2019-07-05 |
柏林制药股份有限公司 |
用于抑制和/或压制tlr9激活的适体
|
|
AU2018364542A1
(en)
|
2017-11-08 |
2020-04-16 |
President And Fellows Of Harvard College |
Compositions and methods for inhibiting viral vector-induced inflammatory responses
|