JP2019515652A5 - - Google Patents
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- JP2019515652A5 JP2019515652A5 JP2018548420A JP2018548420A JP2019515652A5 JP 2019515652 A5 JP2019515652 A5 JP 2019515652A5 JP 2018548420 A JP2018548420 A JP 2018548420A JP 2018548420 A JP2018548420 A JP 2018548420A JP 2019515652 A5 JP2019515652 A5 JP 2019515652A5
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- 108091033319 polynucleotide Proteins 0.000 claims description 66
- 102000040430 polynucleotide Human genes 0.000 claims description 66
- 239000002157 polynucleotide Substances 0.000 claims description 66
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 61
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 61
- 210000004027 cell Anatomy 0.000 claims description 52
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 47
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 43
- 239000000203 mixture Substances 0.000 claims description 39
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 37
- 102000037865 fusion proteins Human genes 0.000 claims description 35
- 108020001507 fusion proteins Proteins 0.000 claims description 35
- 201000010099 disease Diseases 0.000 claims description 26
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- 239000012636 effector Substances 0.000 claims description 18
- 208000035475 disorder Diseases 0.000 claims description 17
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- 150000007523 nucleic acids Chemical class 0.000 claims description 14
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 13
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 13
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- 238000010361 transduction Methods 0.000 claims description 13
- 229960004641 rituximab Drugs 0.000 claims description 12
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- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 10
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 10
- 230000003834 intracellular effect Effects 0.000 claims description 10
- 229950005751 ocrelizumab Drugs 0.000 claims description 10
- 229960002450 ofatumumab Drugs 0.000 claims description 10
- 229950000815 veltuzumab Drugs 0.000 claims description 10
- 206010025323 Lymphomas Diseases 0.000 claims description 9
- 208000003950 B-cell lymphoma Diseases 0.000 claims description 8
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims description 8
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims description 8
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims description 8
- 206010021263 IgA nephropathy Diseases 0.000 claims description 8
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- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims description 8
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- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims description 8
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- 229920001184 polypeptide Polymers 0.000 claims description 8
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- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims description 4
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- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 claims description 4
- 208000032568 B-cell prolymphocytic leukaemia Diseases 0.000 claims description 4
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 4
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- 208000011691 Burkitt lymphomas Diseases 0.000 claims description 4
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 4
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- 208000011231 Crohn disease Diseases 0.000 claims description 4
- 208000015023 Graves' disease Diseases 0.000 claims description 4
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 4
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims description 4
- 208000003456 Juvenile Arthritis Diseases 0.000 claims description 4
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims description 4
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims description 4
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims description 4
- 201000003791 MALT lymphoma Diseases 0.000 claims description 4
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims description 4
- 208000034578 Multiple myelomas Diseases 0.000 claims description 4
- 201000002481 Myositis Diseases 0.000 claims description 4
- 206010029461 Nodal marginal zone B-cell lymphomas Diseases 0.000 claims description 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 4
- 206010036524 Precursor B-lymphoblastic lymphomas Diseases 0.000 claims description 4
- 208000035416 Prolymphocytic B-Cell Leukemia Diseases 0.000 claims description 4
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 4
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 4
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 claims description 4
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims description 4
- 201000008244 anti-basement membrane glomerulonephritis Diseases 0.000 claims description 4
- 208000019069 chronic childhood arthritis Diseases 0.000 claims description 4
- 231100000433 cytotoxic Toxicity 0.000 claims description 4
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- 210000004443 dendritic cell Anatomy 0.000 claims description 4
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- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims description 4
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims description 4
- 201000003444 follicular lymphoma Diseases 0.000 claims description 4
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- 208000026876 intravascular large B-cell lymphoma Diseases 0.000 claims description 4
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- 210000003563 lymphoid tissue Anatomy 0.000 claims description 4
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- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 4
- 208000008795 neuromyelitis optica Diseases 0.000 claims description 4
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- 201000008158 rapidly progressive glomerulonephritis Diseases 0.000 claims description 4
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- 230000000638 stimulation Effects 0.000 claims description 4
- 230000002992 thymic effect Effects 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 3
- 102100027205 B-cell antigen receptor complex-associated protein alpha chain Human genes 0.000 claims description 2
- 102100027203 B-cell antigen receptor complex-associated protein beta chain Human genes 0.000 claims description 2
- 101100364669 Caenorhabditis elegans lin-18 gene Proteins 0.000 claims description 2
- 102100024965 Caspase recruitment domain-containing protein 11 Human genes 0.000 claims description 2
- 108020004705 Codon Proteins 0.000 claims description 2
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims description 2
- 101000914489 Homo sapiens B-cell antigen receptor complex-associated protein alpha chain Proteins 0.000 claims description 2
- 101000914491 Homo sapiens B-cell antigen receptor complex-associated protein beta chain Proteins 0.000 claims description 2
- 101000761179 Homo sapiens Caspase recruitment domain-containing protein 11 Proteins 0.000 claims description 2
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims description 2
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims description 2
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims description 2
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims description 2
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims description 2
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims description 2
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims description 2
- 101001103033 Homo sapiens Tyrosine-protein kinase transmembrane receptor ROR2 Proteins 0.000 claims description 2
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims description 2
- 102000017578 LAG3 Human genes 0.000 claims description 2
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims description 2
- 101100364671 Mus musculus Ryk gene Proteins 0.000 claims description 2
- 101100268066 Mus musculus Zap70 gene Proteins 0.000 claims description 2
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims description 2
- 102000007497 Patched-2 Receptor Human genes 0.000 claims description 2
- 108010071083 Patched-2 Receptor Proteins 0.000 claims description 2
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims description 2
- 102100029215 Signaling lymphocytic activation molecule Human genes 0.000 claims description 2
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims description 2
- 108010023649 Tripartite Motif Proteins Proteins 0.000 claims description 2
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims description 2
- 102100039616 Tyrosine-protein kinase transmembrane receptor ROR2 Human genes 0.000 claims description 2
- 239000000611 antibody drug conjugate Substances 0.000 claims description 2
- 229940049595 antibody-drug conjugate Drugs 0.000 claims description 2
- 229960003008 blinatumomab Drugs 0.000 claims description 2
- 229960005395 cetuximab Drugs 0.000 claims description 2
- 229940050282 inebilizumab-cdon Drugs 0.000 claims description 2
- 229950001603 taplitumomab paptox Drugs 0.000 claims description 2
- 239000013598 vector Substances 0.000 claims 3
- 208000019758 Hypergammaglobulinemia Diseases 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- 229940124292 CD20 monoclonal antibody Drugs 0.000 claims 1
- 239000013066 combination product Substances 0.000 claims 1
- 229940127555 combination product Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 description 40
- 238000009169 immunotherapy Methods 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021172976A JP7397840B2 (ja) | 2016-03-18 | 2021-10-22 | Ｃｄ２０免疫療法のための組成物および方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662310541P | 2016-03-18 | 2016-03-18 | |
| US62/310,541 | 2016-03-18 | ||
| US201662320327P | 2016-04-08 | 2016-04-08 | |
| US62/320,327 | 2016-04-08 | ||
| PCT/US2017/023098 WO2017161353A1 (en) | 2016-03-18 | 2017-03-17 | Compositions and methods for cd20 immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021172976A Division JP7397840B2 (ja) | 2016-03-18 | 2021-10-22 | Ｃｄ２０免疫療法のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019515652A JP2019515652A (ja) | 2019-06-13 |
| JP2019515652A5 true JP2019515652A5 (enExample) | 2020-04-30 |
| JP7065782B2 JP7065782B2 (ja) | 2022-05-12 |
Family
ID=58448653
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018548420A Active JP7065782B2 (ja) | 2016-03-18 | 2017-03-17 | Ｃｄ２０免疫療法のための組成物および方法 |
| JP2021172976A Active JP7397840B2 (ja) | 2016-03-18 | 2021-10-22 | Ｃｄ２０免疫療法のための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021172976A Active JP7397840B2 (ja) | 2016-03-18 | 2021-10-22 | Ｃｄ２０免疫療法のための組成物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10875927B2 (enExample) |
| EP (2) | EP3430038B1 (enExample) |
| JP (2) | JP7065782B2 (enExample) |
| KR (2) | KR102366611B1 (enExample) |
| CN (1) | CN108884144B (enExample) |
| AU (1) | AU2017235657B2 (enExample) |
| BR (1) | BR112018067977A8 (enExample) |
| CA (1) | CA3015369A1 (enExample) |
| DK (1) | DK3430038T3 (enExample) |
| ES (1) | ES2893840T3 (enExample) |
| IL (1) | IL261316B2 (enExample) |
| MX (1) | MX2018010415A (enExample) |
| NZ (1) | NZ744913A (enExample) |
| WO (1) | WO2017161353A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11400115B2 (en) | 2014-04-23 | 2022-08-02 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| CN105985444B (zh) * | 2015-02-05 | 2024-02-13 | 博生吉安科细胞技术有限公司 | 一种嵌合抗原受体、以及快速构建嵌合抗原受体的方法及应用 |
| CN108395482B (zh) | 2017-02-08 | 2021-02-05 | 西比曼生物科技（香港）有限公司 | 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定 |
| WO2019089855A1 (en) * | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| US20230158070A1 (en) * | 2018-01-30 | 2023-05-25 | Cellectis | Combination comprising allogeneic immune cells deficient for an antigen present on both t-cells and pathological cells and therapeutic antibody against said antigen |
| BR112020025439A2 (pt) | 2018-06-14 | 2021-03-16 | Bluebird Bio, Inc. | Receptores de antígenos quiméricos cd79a |
| CN109293781A (zh) * | 2018-09-12 | 2019-02-01 | 中国人民解放军总医院 | 嵌合抗原受体及其基因和重组表达载体、cd19-cd20双靶向性的t细胞及其应用 |
| US11312963B2 (en) * | 2018-10-18 | 2022-04-26 | Synerk Inc. | Compositions and methods for inhibiting TIGIT gene expression |
| IL283734B2 (en) | 2018-12-12 | 2025-03-01 | Kite Pharma Inc | Chimeric antigen receptors and CAR-T cells and methods of use |
| JP2022522802A (ja) * | 2019-03-01 | 2022-04-20 | グリットストーン バイオ， インコーポレイテッド | Ｔ細胞受容体の選択 |
| GB201906685D0 (en) * | 2019-05-13 | 2019-06-26 | Ultrahuman Six Ltd | Activatable protein constructs and uses thereof |
| US20220280567A1 (en) * | 2019-06-14 | 2022-09-08 | 2Seventy Bio, Inc. | Compositions and methods for treating cancer |
| WO2021087305A1 (en) * | 2019-10-30 | 2021-05-06 | Precision Biosciences, Inc. | Cd20 chimeric antigen receptors and methods of use for immunotherapy |
| CN111944062B (zh) * | 2019-12-09 | 2023-11-07 | 深圳市体内生物医药科技有限公司 | 一种识别Fc片段的嵌合抗原受体及其应用 |
| EP4114861A4 (en) * | 2020-03-02 | 2024-05-08 | The Regents Of The University Of California | CHIMERIC ANTIGEN RECEPTORS AND RELATED COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER |
| CN113402612A (zh) | 2020-03-17 | 2021-09-17 | 西比曼生物科技（香港）有限公司 | 靶向cd19和cd20的联合嵌合抗原受体及其应用 |
| US20230192807A1 (en) * | 2020-05-15 | 2023-06-22 | Precision Biosciences, Inc. | Methods for immunotherapy |
| US20230190780A1 (en) * | 2020-05-15 | 2023-06-22 | Precision Biosciences, Inc. | Methods for immunotherapy |
| CN118256444A (zh) * | 2022-04-26 | 2024-06-28 | 深圳市体内生物医药科技有限公司 | 一种嵌合抗原受体t细胞及其制备方法和应用 |
| WO2024097313A1 (en) * | 2022-11-02 | 2024-05-10 | Sana Biotechnology, Inc. | Methods for producing t cell therapy products |
| KR20250131823A (ko) | 2023-03-31 | 2025-09-03 | 아벨제타 인크. | Cd20 및 bcma를 표적화하는 이중특이적 키메라 항원 수용체 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| US6759243B2 (en) | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
| AU2472400A (en) * | 1998-10-20 | 2000-05-08 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
| US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
| US7514537B2 (en) | 2001-04-30 | 2009-04-07 | City Of Hope | Chimeric immunoreceptor useful in treating human gliomas |
| US20110129412A1 (en) * | 2005-06-02 | 2011-06-02 | Astrazeneca Ab | Antibodies Directed to CD20 and Uses Thereof |
| US8119772B2 (en) | 2006-09-29 | 2012-02-21 | California Institute Of Technology | MART-1 T cell receptors |
| CA2707791A1 (en) | 2007-12-21 | 2009-07-09 | Genentech, Inc. | Therapy of rituximab-refractory rheumatoid arthritis patients |
| KR101319499B1 (ko) | 2008-02-22 | 2013-10-17 | 엘지디스플레이 주식회사 | 화학적 자기조립 방법을 이용한 나노선 혹은탄소나노튜브의 적층 및 패턴형성 방법과, 이를 적용한액정표시장치의 제조방법 |
| PL3006459T3 (pl) | 2008-08-26 | 2022-01-17 | City Of Hope | Sposób i kompozycje dla wzmocnionego działania efektorowego komórek t przeciw guzowi nowotworowemu |
| ES2911246T3 (es) | 2009-11-03 | 2022-05-18 | Hope City | Receptor del factor de crecimiento epidérmico truncado (EGFRT) para selección de células T transducidas |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| KR101976882B1 (ko) * | 2011-03-23 | 2019-05-09 | 프레드 헛친슨 켄서 리서치 센터 | 세포 면역요법용 방법 및 조성물 |
| CA2833212C (en) | 2011-05-12 | 2020-06-09 | Genentech, Inc. | Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature peptides |
| US20140004037A1 (en) | 2012-01-19 | 2014-01-02 | Therapeutic Proteins, Inc. | Stabilization of the anti-cd20 antibody rituximab |
| PL2884999T3 (pl) | 2012-08-20 | 2021-07-05 | Fred Hutchinson Cancer Research Center | Sposób i kompozycje do immunoterapii komórkowej |
| KR102341275B1 (ko) | 2012-11-02 | 2021-12-21 | 티지 쎄라퓨틱스, 인코포레이티드 | 항cd20 항체와 pi3 키나아제 선택적 억제제의 조합물 |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| WO2015042807A1 (zh) * | 2013-09-25 | 2015-04-02 | 北京安保康生物医药科技有限公司 | 抗cd20的全人源单克隆抗体及其应用 |
| HRP20201906T1 (hr) | 2013-12-20 | 2021-04-02 | Fred Hutchinson Cancer Research Center | Označene kimerne efektorske molekule i njihovi receptori |
| BR112017001242A2 (pt) * | 2014-07-21 | 2017-12-05 | Novartis Ag | tratamento de câncer usando um receptor antigênico quimérico a cd33 |
| CN105330750B (zh) * | 2015-11-20 | 2019-02-01 | 上海细胞治疗研究院 | 一种快速中止car-t细胞杀伤作用的分子刹车及其用途 |
-
2017
- 2017-03-17 EP EP17714373.2A patent/EP3430038B1/en active Active
- 2017-03-17 JP JP2018548420A patent/JP7065782B2/ja active Active
- 2017-03-17 MX MX2018010415A patent/MX2018010415A/es unknown
- 2017-03-17 CN CN201780018083.9A patent/CN108884144B/zh active Active
- 2017-03-17 KR KR1020187026926A patent/KR102366611B1/ko active Active
- 2017-03-17 WO PCT/US2017/023098 patent/WO2017161353A1/en not_active Ceased
- 2017-03-17 DK DK17714373.2T patent/DK3430038T3/da active
- 2017-03-17 US US16/086,290 patent/US10875927B2/en active Active
- 2017-03-17 NZ NZ744913A patent/NZ744913A/en unknown
- 2017-03-17 ES ES17714373T patent/ES2893840T3/es active Active
- 2017-03-17 IL IL261316A patent/IL261316B2/en unknown
- 2017-03-17 AU AU2017235657A patent/AU2017235657B2/en active Active
- 2017-03-17 BR BR112018067977A patent/BR112018067977A8/pt active Search and Examination
- 2017-03-17 KR KR1020227005550A patent/KR102499191B1/ko active Active
- 2017-03-17 CA CA3015369A patent/CA3015369A1/en active Pending
- 2017-03-17 EP EP21179474.8A patent/EP3939994A3/en active Pending
-
2020
- 2020-11-24 US US17/103,762 patent/US11834511B2/en active Active
-
2021
- 2021-10-22 JP JP2021172976A patent/JP7397840B2/ja active Active
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