JP2019514411A5 - - Google Patents
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- Publication number
- JP2019514411A5 JP2019514411A5 JP2018559273A JP2018559273A JP2019514411A5 JP 2019514411 A5 JP2019514411 A5 JP 2019514411A5 JP 2018559273 A JP2018559273 A JP 2018559273A JP 2018559273 A JP2018559273 A JP 2018559273A JP 2019514411 A5 JP2019514411 A5 JP 2019514411A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant protein
- protein
- antigen
- altered
- galactosylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 9
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 7
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 7
- HXBYBCASAVUYKF-YTQLPXDHSA-N (4r,5s,6s,7r)-4,5,6,7,8-pentahydroxyoctane-2,3-dione Chemical compound CC(=O)C(=O)[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO HXBYBCASAVUYKF-YTQLPXDHSA-N 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 239000006143 cell culture medium Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000000122 growth hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 238000011081 inoculation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 150000002978 peroxides Chemical class 0.000 claims 1
- 238000009331 sowing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16169062 | 2016-05-10 | ||
| EP16169062.3 | 2016-05-10 | ||
| PCT/EP2017/061181 WO2017194605A1 (en) | 2016-05-10 | 2017-05-10 | Methods for modulating protein galactosylation profiles of recombinant proteins using peracetyl galactose |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019514411A JP2019514411A (ja) | 2019-06-06 |
| JP2019514411A5 true JP2019514411A5 (enExample) | 2020-06-18 |
| JP6882339B2 JP6882339B2 (ja) | 2021-06-02 |
Family
ID=56026651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018559273A Active JP6882339B2 (ja) | 2016-05-10 | 2017-05-10 | ペルアセチルガラクトースを使った組換えタンパク質のタンパク質ガラクトシル化プロファイルを改変する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11118208B2 (enExample) |
| EP (1) | EP3455363B1 (enExample) |
| JP (1) | JP6882339B2 (enExample) |
| CN (1) | CN109072273B (enExample) |
| AU (2) | AU2017264541A1 (enExample) |
| CA (1) | CA3022769A1 (enExample) |
| ES (1) | ES2908067T3 (enExample) |
| IL (1) | IL262875B (enExample) |
| WO (1) | WO2017194605A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017117218A1 (en) | 2015-12-30 | 2017-07-06 | Momenta Pharmaceuticals, Inc. | Methods related to biologics |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| MX2021008030A (es) * | 2018-12-31 | 2021-08-05 | Momenta Pharmaceuticals Inc | Metodos para producir ustekinumab. |
| CN113549667A (zh) * | 2021-07-21 | 2021-10-26 | 杭州奕安济世生物药业有限公司 | 一种降低抗体半乳糖基化的方法 |
| WO2023161885A1 (en) * | 2022-02-25 | 2023-08-31 | Kashiv Biosciences, Llc | A process for improving polypeptide expression in mammalian cell culture |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102076865B (zh) * | 2008-05-02 | 2016-03-16 | 西雅图基因公司 | 用于制造核心岩藻糖基化降低的抗体和抗体衍生物的方法和组合物 |
| WO2012019165A2 (en) * | 2010-08-05 | 2012-02-09 | Seattle Genetics, Inc. | Methods of inhibition of protein fucosylation in vivo using fucose analogs |
| CA2943667C (en) * | 2014-01-29 | 2022-11-08 | Lg Life Sciences Ltd. | Method for modulating galactosylation of recombinant protein through optimization of culture medium |
| WO2016022377A2 (en) * | 2014-08-05 | 2016-02-11 | Abbvie Inc. | Methods for modulating the glycosylation profile of recombinant proteins using dissolved oxygen |
-
2017
- 2017-05-10 CN CN201780028831.1A patent/CN109072273B/zh active Active
- 2017-05-10 ES ES17728776T patent/ES2908067T3/es active Active
- 2017-05-10 WO PCT/EP2017/061181 patent/WO2017194605A1/en not_active Ceased
- 2017-05-10 JP JP2018559273A patent/JP6882339B2/ja active Active
- 2017-05-10 AU AU2017264541A patent/AU2017264541A1/en not_active Abandoned
- 2017-05-10 US US16/300,066 patent/US11118208B2/en active Active
- 2017-05-10 EP EP17728776.0A patent/EP3455363B1/en active Active
- 2017-05-10 CA CA3022769A patent/CA3022769A1/en active Pending
-
2018
- 2018-11-08 IL IL262875A patent/IL262875B/en unknown
-
2021
- 2021-10-28 AU AU2021258023A patent/AU2021258023B2/en not_active Ceased
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