JP2019500876A5 - - Google Patents

Info

Publication number

JP2019500876A5

JP2019500876A5 JP2018535126A JP2018535126A JP2019500876A5 JP 2019500876 A5 JP2019500876 A5 JP 2019500876A5 JP 2018535126 A JP2018535126 A JP 2018535126A JP 2018535126 A JP2018535126 A JP 2018535126A JP 2019500876 A5 JP2019500876 A5 JP 2019500876A5

Authority

JP

Japan

Prior art keywords

culture

glycan

monoclonal antibody

man

cell

Prior art date

2017-01-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 claims 19
• 210000004027 cell Anatomy 0.000 claims 10
• 150000004676 glycans Chemical class 0.000 claims 9
• 241000894007 species Species 0.000 claims 5
• SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 4
• PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims 4
• SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims 4
• -1 Man 8 glycan Chemical class 0.000 claims 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 239000012526 feed medium Substances 0.000 claims 2
• 102000003390 tumor necrosis factor Human genes 0.000 claims 2
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
• 230000007423 decrease Effects 0.000 claims 1
• 230000003247 decreasing effect Effects 0.000 claims 1
• 210000004962 mammalian cell Anatomy 0.000 claims 1
• JMUPMJGUKXYCMF-IWDIICGPSA-N n-[(2s,3r,4r,5s,6r)-2-[(2s,3s,4s,5s,6r)-2-[[(2r,3r,4s,5s,6s)-6-[(2r,3s,4r,5r,6s)-5-acetamido-6-[(2r,3s,4r,5r)-5-acetamido-1,2,4-trihydroxy-6-oxohexan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-[(2r,3s,4s,5s,6r)-3-[(2s,3r,4r,5s,6r)-3-acetamido-4-h Chemical compound O[C@@H]1[C@@H](NC(C)=O)[C@H](O[C@@H]([C@H](O)[C@H](C=O)NC(=O)C)[C@H](O)CO)O[C@H](CO)[C@H]1O[C@H]1[C@@H](O)[C@@H](O[C@@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O[C@H]2[C@@H]([C@@H](O)[C@H](O[C@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)[C@@H](CO)O2)NC(C)=O)[C@H](O)[C@@H](CO[C@@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O[C@H]2[C@@H]([C@@H](O)[C@H](O[C@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)[C@@H](CO)O2)NC(C)=O)O1 JMUPMJGUKXYCMF-IWDIICGPSA-N 0.000 claims 1