CA3010598A1 - Modulation of afucosylated species in a monoclonal antibody composition - Google Patents
Modulation of afucosylated species in a monoclonal antibody composition Download PDFInfo
- Publication number
- CA3010598A1 CA3010598A1 CA3010598A CA3010598A CA3010598A1 CA 3010598 A1 CA3010598 A1 CA 3010598A1 CA 3010598 A CA3010598 A CA 3010598A CA 3010598 A CA3010598 A CA 3010598A CA 3010598 A1 CA3010598 A1 CA 3010598A1
- Authority
- CA
- Canada
- Prior art keywords
- culture
- monoclonal antibody
- glycan
- fucose
- species
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662275384P | 2016-01-06 | 2016-01-06 | |
| US62/275,384 | 2016-01-06 | ||
| PCT/US2017/012349 WO2017120347A1 (en) | 2016-01-06 | 2017-01-05 | Modulation of afucosylated species in a monoclonal antibody composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3010598A1 true CA3010598A1 (en) | 2017-07-13 |
Family
ID=57944513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3010598A Pending CA3010598A1 (en) | 2016-01-06 | 2017-01-05 | Modulation of afucosylated species in a monoclonal antibody composition |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20190161543A1 (enExample) |
| EP (1) | EP3400241B1 (enExample) |
| JP (1) | JP6674028B2 (enExample) |
| CN (1) | CN109153716A (enExample) |
| AU (1) | AU2017206006B2 (enExample) |
| CA (1) | CA3010598A1 (enExample) |
| MX (1) | MX2018008447A (enExample) |
| WO (1) | WO2017120347A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10376582B2 (en) | 2013-10-16 | 2019-08-13 | Outlook Therapeutics, Inc. | Buffer formulations for enhanced antibody stability |
| WO2016118707A1 (en) | 2015-01-21 | 2016-07-28 | Oncobiologics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
| AU2017213775A1 (en) | 2016-02-03 | 2018-08-16 | Outlook Therapeutics, Inc. | Buffer formulations for enhanced antibody stability |
| SG11202009216YA (en) * | 2018-03-26 | 2020-10-29 | Amgen Inc | Total afucosylated glycoforms of antibodies produced in cell culture |
| HU231514B1 (hu) | 2018-11-07 | 2024-07-28 | Richter Gedeon Nyrt. | Sejttenyészetben előállított rekombináns glikoprotein glikozilációs mintázatának megváltoztatására szolgáló módszer |
| JP2022514299A (ja) * | 2018-12-19 | 2022-02-10 | シージェン インコーポレイテッド | 抗体の制御されたフコシル化 |
| WO2021066772A1 (en) * | 2019-10-01 | 2021-04-08 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Cell culture medium for reducing fucosylation and basic variants in the production of antibodies |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| US8227241B2 (en) | 2004-03-12 | 2012-07-24 | Unigene Laboratories, Inc. | Bacterial host cell for the direct expression of peptides |
| JP5442251B2 (ja) | 2005-05-26 | 2014-03-12 | サイトス バイオテクノロジー アーゲー | 拡張可能な発酵方法 |
| US7846724B2 (en) | 2006-04-11 | 2010-12-07 | Hoffmann-La Roche Inc. | Method for selecting CHO cell for production of glycosylated antibodies |
| CN102076865B (zh) * | 2008-05-02 | 2016-03-16 | 西雅图基因公司 | 用于制造核心岩藻糖基化降低的抗体和抗体衍生物的方法和组合物 |
| PL2438171T3 (pl) * | 2009-06-02 | 2015-04-30 | Regeneron Pharma | Komórki z niedoborem fukozylacji |
| WO2010141855A1 (en) * | 2009-06-05 | 2010-12-09 | Momenta Pharmaceuticals, Inc. | Methods of modulating fucosylation of glycoproteins |
| US20120258496A1 (en) * | 2010-09-27 | 2012-10-11 | Boehringer Ingelheim International Gmbh | Production of low fucose antibodies in h4-ii-e rat cells |
| WO2013114165A1 (en) * | 2012-01-30 | 2013-08-08 | Dr Reddy's Laboratories Limited | Process of obtaining glycoprotein composition with increased afucosylation content |
| NO2760138T3 (enExample) * | 2012-10-01 | 2018-08-04 | ||
| WO2015140700A1 (en) * | 2014-03-19 | 2015-09-24 | Dr. Reddy's Laboratories Limited | Cell culture process |
| MX2018004831A (es) * | 2015-11-02 | 2018-08-01 | Genentech Inc | Metodos para confeccionar formas fucosiladas y afucosiladas de una proteina. |
-
2017
- 2017-01-05 JP JP2018535126A patent/JP6674028B2/ja active Active
- 2017-01-05 AU AU2017206006A patent/AU2017206006B2/en active Active
- 2017-01-05 MX MX2018008447A patent/MX2018008447A/es unknown
- 2017-01-05 CN CN201780015362.XA patent/CN109153716A/zh active Pending
- 2017-01-05 US US16/067,193 patent/US20190161543A1/en not_active Abandoned
- 2017-01-05 CA CA3010598A patent/CA3010598A1/en active Pending
- 2017-01-05 EP EP17702444.5A patent/EP3400241B1/en not_active Revoked
- 2017-01-05 WO PCT/US2017/012349 patent/WO2017120347A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| MX2018008447A (es) | 2019-05-30 |
| JP6674028B2 (ja) | 2020-04-01 |
| AU2017206006A1 (en) | 2018-07-19 |
| CN109153716A (zh) | 2019-01-04 |
| WO2017120347A1 (en) | 2017-07-13 |
| AU2017206006B2 (en) | 2019-08-29 |
| JP2019500876A (ja) | 2019-01-17 |
| EP3400241A1 (en) | 2018-11-14 |
| US20190161543A1 (en) | 2019-05-30 |
| EP3400241B1 (en) | 2020-07-22 |
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