AU2017206006B2 - Modulation of afucosylated species in a monoclonal antibody composition - Google Patents

Modulation of afucosylated species in a monoclonal antibody composition Download PDF

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Publication number
AU2017206006B2
AU2017206006B2 AU2017206006A AU2017206006A AU2017206006B2 AU 2017206006 B2 AU2017206006 B2 AU 2017206006B2 AU 2017206006 A AU2017206006 A AU 2017206006A AU 2017206006 A AU2017206006 A AU 2017206006A AU 2017206006 B2 AU2017206006 B2 AU 2017206006B2
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Australia
Prior art keywords
culture
monoclonal antibody
species
fucose
feed
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AU2017206006A
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AU2017206006A1 (en
Inventor
Scott Gangloff
Kevin John JOSE
Sri MADABHUSHI
Marc Santoro
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Outlook Therapeutics Inc
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Outlook Therapeutics Inc
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Application filed by Outlook Therapeutics Inc filed Critical Outlook Therapeutics Inc
Publication of AU2017206006A1 publication Critical patent/AU2017206006A1/en
Assigned to OUTLOOK THERAPEUTICS, INC. reassignment OUTLOOK THERAPEUTICS, INC. Amend patent request/document other than specification (104) Assignors: ONCOBIOLOGICS, INC.
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AU2017206006A 2016-01-06 2017-01-05 Modulation of afucosylated species in a monoclonal antibody composition Active AU2017206006B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662275384P 2016-01-06 2016-01-06
US62/275,384 2016-01-06
PCT/US2017/012349 WO2017120347A1 (en) 2016-01-06 2017-01-05 Modulation of afucosylated species in a monoclonal antibody composition

Publications (2)

Publication Number Publication Date
AU2017206006A1 AU2017206006A1 (en) 2018-07-19
AU2017206006B2 true AU2017206006B2 (en) 2019-08-29

Family

ID=57944513

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017206006A Active AU2017206006B2 (en) 2016-01-06 2017-01-05 Modulation of afucosylated species in a monoclonal antibody composition

Country Status (8)

Country Link
US (1) US20190161543A1 (enExample)
EP (1) EP3400241B1 (enExample)
JP (1) JP6674028B2 (enExample)
CN (1) CN109153716A (enExample)
AU (1) AU2017206006B2 (enExample)
CA (1) CA3010598A1 (enExample)
MX (1) MX2018008447A (enExample)
WO (1) WO2017120347A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6526025B2 (ja) 2013-10-16 2019-06-05 オンコバイオロジクス，インコーポレイティド 抗体安定性を増強する緩衝液製剤
US10696735B2 (en) 2015-01-21 2020-06-30 Outlook Therapeutics, Inc. Modulation of charge variants in a monoclonal antibody composition
CN109563161A (zh) 2016-02-03 2019-04-02 安口生物公司 用于提高抗体稳定性的缓冲制剂
CN119639849A (zh) * 2018-03-26 2025-03-18 美国安进公司 细胞培养物中产生的抗体的总去岩藻糖基化糖型
HU231514B1 (hu) 2018-11-07 2024-07-28 Richter Gedeon Nyrt. Sejttenyészetben előállított rekombináns glikoprotein glikozilációs mintázatának megváltoztatására szolgáló módszer
SG11202106481SA (en) * 2018-12-19 2021-07-29 Seagen Inc Controlled fucosylation of antibodies
WO2021066772A1 (en) * 2019-10-01 2021-04-08 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Cell culture medium for reducing fucosylation and basic variants in the production of antibodies
KR20230145083A (ko) * 2021-02-12 2023-10-17 론자 벤드 인코포레이티드 항체 생성물의 비푸코실화를 조절하는 방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010141855A1 (en) * 2009-06-05 2010-12-09 Momenta Pharmaceuticals, Inc. Methods of modulating fucosylation of glycoproteins
WO2014055370A1 (en) * 2012-10-01 2014-04-10 Abbvie Biotherapeutics Inc. Compostions and methods for producing glycoproteins

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
US8227241B2 (en) 2004-03-12 2012-07-24 Unigene Laboratories, Inc. Bacterial host cell for the direct expression of peptides
ATE515566T1 (de) 2005-05-26 2011-07-15 Cytos Biotechnology Ag Skalierbares fermentationsverfahren
US7846724B2 (en) 2006-04-11 2010-12-07 Hoffmann-La Roche Inc. Method for selecting CHO cell for production of glycosylated antibodies
CN102076865B (zh) * 2008-05-02 2016-03-16 西雅图基因公司 用于制造核心岩藻糖基化降低的抗体和抗体衍生物的方法和组合物
US8409838B2 (en) * 2009-06-02 2013-04-02 Regeneron Pharmaceuticals, Inc. Fucosylation-deficient cells
US20120258496A1 (en) 2010-09-27 2012-10-11 Boehringer Ingelheim International Gmbh Production of low fucose antibodies in h4-ii-e rat cells
WO2013114165A1 (en) * 2012-01-30 2013-08-08 Dr Reddy's Laboratories Limited Process of obtaining glycoprotein composition with increased afucosylation content
WO2015140700A1 (en) * 2014-03-19 2015-09-24 Dr. Reddy's Laboratories Limited Cell culture process
WO2017079165A1 (en) * 2015-11-02 2017-05-11 Genentech, Inc. Methods of making fucosylated and afucosylated forms of a protein

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010141855A1 (en) * 2009-06-05 2010-12-09 Momenta Pharmaceuticals, Inc. Methods of modulating fucosylation of glycoproteins
WO2014055370A1 (en) * 2012-10-01 2014-04-10 Abbvie Biotherapeutics Inc. Compostions and methods for producing glycoproteins

Also Published As

Publication number Publication date
CA3010598A1 (en) 2017-07-13
EP3400241B1 (en) 2020-07-22
MX2018008447A (es) 2019-05-30
CN109153716A (zh) 2019-01-04
US20190161543A1 (en) 2019-05-30
JP6674028B2 (ja) 2020-04-01
AU2017206006A1 (en) 2018-07-19
JP2019500876A (ja) 2019-01-17
EP3400241A1 (en) 2018-11-14
WO2017120347A1 (en) 2017-07-13

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Owner name: OUTLOOK THERAPEUTICS, INC.

Free format text: FORMER NAME(S): ONCOBIOLOGICS, INC.

FGA Letters patent sealed or granted (standard patent)