MX2018004831A - Metodos para confeccionar formas fucosiladas y afucosiladas de una proteina. - Google Patents
Metodos para confeccionar formas fucosiladas y afucosiladas de una proteina.Info
- Publication number
- MX2018004831A MX2018004831A MX2018004831A MX2018004831A MX2018004831A MX 2018004831 A MX2018004831 A MX 2018004831A MX 2018004831 A MX2018004831 A MX 2018004831A MX 2018004831 A MX2018004831 A MX 2018004831A MX 2018004831 A MX2018004831 A MX 2018004831A
- Authority
- MX
- Mexico
- Prior art keywords
- fucosylated
- protein
- methods
- making
- afucosylated forms
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01271—GDP-L-fucose synthase (1.1.1.271)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01047—GDP-mannose 4,6-dehydratase (4.2.1.47), i.e. GMD
Abstract
La presente solicitud hace referencia a métodos para producir una proteína en forma fucosilada y afucosilada con una relación predeterminada.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562249828P | 2015-11-02 | 2015-11-02 | |
US201662338280P | 2016-05-18 | 2016-05-18 | |
PCT/US2016/059922 WO2017079165A1 (en) | 2015-11-02 | 2016-11-01 | Methods of making fucosylated and afucosylated forms of a protein |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018004831A true MX2018004831A (es) | 2018-08-01 |
Family
ID=57326491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018004831A MX2018004831A (es) | 2015-11-02 | 2016-11-01 | Metodos para confeccionar formas fucosiladas y afucosiladas de una proteina. |
Country Status (14)
Country | Link |
---|---|
US (2) | US10975168B2 (es) |
EP (2) | EP3925970A1 (es) |
JP (1) | JP6983772B2 (es) |
KR (1) | KR20180068967A (es) |
CN (2) | CN108431026B (es) |
AU (2) | AU2016350732A1 (es) |
BR (1) | BR112018007356A2 (es) |
CA (1) | CA2999047A1 (es) |
ES (1) | ES2875274T3 (es) |
IL (1) | IL258161B2 (es) |
MX (1) | MX2018004831A (es) |
PL (1) | PL3371206T3 (es) |
SG (2) | SG11201802773RA (es) |
WO (1) | WO2017079165A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2016350732A1 (en) | 2015-11-02 | 2018-04-05 | Genentech, Inc. | Methods of making fucosylated and afucosylated forms of a protein |
EP3400241B1 (en) * | 2016-01-06 | 2020-07-22 | Outlook Therapeutics, Inc. | Modulation of afucosylated species in a monoclonal antibody composition |
WO2019011918A1 (en) | 2017-07-10 | 2019-01-17 | International - Drug - Development - Biotech | TREATMENT OF LYMPHOCYTE B MALIGNANCIES USING AFUCOSYLATED PRO-APOPTOTIC ANTI-CD19 ANTIBODIES IN COMBINATION WITH ANTI-CD20 ANTIBODIES OR CHEMOTHERAPEUTIC AGENTS |
SG11202009216YA (en) * | 2018-03-26 | 2020-10-29 | Amgen Inc | Total afucosylated glycoforms of antibodies produced in cell culture |
MA52783A (fr) | 2018-06-05 | 2021-04-14 | Amgen Inc | Modulation de la phagocytose cellulaire dépendant de l'anticorps |
MY197429A (en) * | 2018-08-29 | 2023-06-16 | United Biopharma Inc | Afucosylated antibodies and manufacture thereof |
MX2021002792A (es) | 2018-09-11 | 2021-05-12 | Amgen Inc | Metodos para modular la citotoxicidad mediada por celulas dependiente de anticuerpos. |
HUP1800376A2 (hu) * | 2018-11-07 | 2020-05-28 | Richter Gedeon Nyrt | Sejttenyészetben elõállított rekombináns glikoprotein glikozilációs-mintázatának megváltoztatására szolgáló módszer |
CN114174340A (zh) | 2019-03-20 | 2022-03-11 | 加利福尼亚大学董事会 | 密封蛋白-6抗体和药物缀合物 |
CN114144434A (zh) | 2019-05-06 | 2022-03-04 | 美国安进公司 | 调节抗体效应子功能 |
WO2021072244A1 (en) * | 2019-10-11 | 2021-04-15 | Beth Israel Deaconess Medical Center, Inc. | Anti-tn antibodies and uses thereof |
AU2022289365A1 (en) | 2021-06-07 | 2023-12-14 | Amgen Inc. | Using fucosidase to control afucosylation level of glycosylated proteins |
KR20240045239A (ko) * | 2021-08-06 | 2024-04-05 | 안야디, 엘엘씨 | 개인 맞춤형 암 면역치료제 제조방법 |
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US30985A (en) | 1860-12-18 | Thomas l | ||
USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
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IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
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US6177612B1 (en) | 1998-07-31 | 2001-01-23 | Her Majesty The Queen In Right Of Canada, As Represented By The Department Of Agriculture And Agri-Food Canada | Matrix attachment regions |
CA2343080A1 (en) | 1998-09-29 | 2000-04-06 | Pioneer Hi-Bred International, Inc. | Mar/sar elements flanking rsyn7-driven construct |
KR100408844B1 (ko) | 2000-07-29 | 2003-12-06 | 한국산업기술평가원 | 동물세포 발현벡터 |
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EP1395669B1 (en) | 2001-01-26 | 2009-07-22 | Selexis S.A. | Matrix attachment regions and methods for use thereof |
HUP0600342A3 (en) * | 2001-10-25 | 2011-03-28 | Genentech Inc | Glycoprotein compositions |
ATE514783T1 (de) | 2003-11-12 | 2011-07-15 | Schering Corp | Plasmidsystem zur expression mehrerer gene |
EP1888638A2 (en) * | 2005-06-03 | 2008-02-20 | Genentech, Inc. | Method of producing antibodies with modified fucosylation level |
TWI414531B (zh) * | 2006-10-12 | 2013-11-11 | Genentech Inc | 淋巴毒素α之抗體 |
EP3279326B1 (en) * | 2009-06-02 | 2020-10-14 | Regeneron Pharmaceuticals, Inc. | Fucosylation-deficient cells |
AU2010256455A1 (en) * | 2009-06-05 | 2012-01-19 | Momenta Pharmaceuticals, Inc. | Methods of modulating fucosylation of glycoproteins |
CN103597073B (zh) * | 2011-03-06 | 2019-06-07 | 默克雪兰诺有限公司 | 低岩藻糖细胞系及其应用 |
WO2013013013A2 (en) * | 2011-07-21 | 2013-01-24 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for producing modified glycoproteins |
WO2015026846A1 (en) * | 2013-08-19 | 2015-02-26 | Biogen Idec Ma Inc. | Control of protein glycosylation by culture medium supplementation and cell culture process parameters |
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US11267899B2 (en) * | 2015-05-13 | 2022-03-08 | Zumutor Biologics Inc. | Afucosylated protein, cell expressing said protein and associated methods |
AU2016350732A1 (en) | 2015-11-02 | 2018-04-05 | Genentech, Inc. | Methods of making fucosylated and afucosylated forms of a protein |
-
2016
- 2016-11-01 AU AU2016350732A patent/AU2016350732A1/en not_active Abandoned
- 2016-11-01 PL PL16797693T patent/PL3371206T3/pl unknown
- 2016-11-01 CN CN201680077178.3A patent/CN108431026B/zh active Active
- 2016-11-01 EP EP21162187.5A patent/EP3925970A1/en active Pending
- 2016-11-01 MX MX2018004831A patent/MX2018004831A/es unknown
- 2016-11-01 ES ES16797693T patent/ES2875274T3/es active Active
- 2016-11-01 KR KR1020187009379A patent/KR20180068967A/ko not_active Application Discontinuation
- 2016-11-01 CN CN202310074105.0A patent/CN116731147A/zh active Pending
- 2016-11-01 EP EP16797693.5A patent/EP3371206B1/en active Active
- 2016-11-01 SG SG11201802773RA patent/SG11201802773RA/en unknown
- 2016-11-01 CA CA2999047A patent/CA2999047A1/en active Pending
- 2016-11-01 WO PCT/US2016/059922 patent/WO2017079165A1/en active Application Filing
- 2016-11-01 SG SG10202103875WA patent/SG10202103875WA/en unknown
- 2016-11-01 JP JP2018522671A patent/JP6983772B2/ja active Active
- 2016-11-01 BR BR112018007356A patent/BR112018007356A2/pt not_active Application Discontinuation
-
2018
- 2018-03-15 IL IL258161A patent/IL258161B2/en unknown
- 2018-05-01 US US15/968,214 patent/US10975168B2/en active Active
-
2021
- 2021-01-13 US US17/148,456 patent/US11802165B2/en active Active
-
2022
- 2022-04-13 AU AU2022202460A patent/AU2022202460A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
IL258161A (en) | 2018-05-31 |
AU2022202460A1 (en) | 2022-05-05 |
AU2016350732A1 (en) | 2018-04-05 |
EP3371206A1 (en) | 2018-09-12 |
EP3925970A1 (en) | 2021-12-22 |
KR20180068967A (ko) | 2018-06-22 |
IL258161B1 (en) | 2023-04-01 |
US11802165B2 (en) | 2023-10-31 |
BR112018007356A2 (pt) | 2018-10-23 |
US20210214462A1 (en) | 2021-07-15 |
CA2999047A1 (en) | 2017-05-11 |
JP6983772B2 (ja) | 2021-12-17 |
ES2875274T3 (es) | 2021-11-10 |
JP2019505164A (ja) | 2019-02-28 |
SG10202103875WA (en) | 2021-06-29 |
CN108431026A (zh) | 2018-08-21 |
CN108431026B (zh) | 2023-02-17 |
CN116731147A (zh) | 2023-09-12 |
WO2017079165A1 (en) | 2017-05-11 |
PL3371206T3 (pl) | 2021-09-27 |
IL258161B2 (en) | 2023-08-01 |
SG11201802773RA (en) | 2018-05-30 |
US20180251572A1 (en) | 2018-09-06 |
EP3371206B1 (en) | 2021-04-14 |
US10975168B2 (en) | 2021-04-13 |
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